UA79440C2 - Аналоги гормону, що вивільнюють гормон росту людини, спосіб їх одержання, фармацевтична композиція та спосіб лікування - Google Patents

Аналоги гормону, що вивільнюють гормон росту людини, спосіб їх одержання, фармацевтична композиція та спосіб лікування Download PDF

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Publication number: UA79440C2
Authority: UA; Ukraine
Prior art keywords: aia; sar; pago; zeg; azr
Prior art date: 2001-10-31

Application number

UA20040504092A

Other languages

English (en)

Russian (ru)

Ukrainian (uk)

Inventor

Ян Іздєбскі

Данута Кунце

Алісья Орловська

Єва Вітковська

Веслав Шелеєвскі

Анджей Кутнер

Кжиштоф Банковські

Ельзбета Фрацкевич

Original Assignee

Інститут Фармацевтични

Заклади Фармацевтичне Польфарма С.А.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-31

Filing date

2002-10-30

Publication date

2007-06-25

2002-10-30 Application filed by Інститут Фармацевтични, Заклади Фармацевтичне Польфарма С.А. filed Critical Інститут Фармацевтични

2007-06-25 Publication of UA79440C2 publication Critical patent/UA79440C2/uk

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WZHCOOQXZCIUNC-UHFFFAOYSA-N cyclandelate Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C(O)C1=CC=CC=C1 WZHCOOQXZCIUNC-UHFFFAOYSA-N 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
235000019700 dicalcium phosphate Nutrition 0.000 description 1
HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
102000038379 digestive enzymes Human genes 0.000 description 1
108091007734 digestive enzymes Proteins 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
MGHPNCMVUAKAIE-UHFFFAOYSA-N diphenylmethanamine Chemical compound C=1C=CC=CC=1C(N)C1=CC=CC=C1 MGHPNCMVUAKAIE-UHFFFAOYSA-N 0.000 description 1
239000008298 dragée Substances 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 1
238000010828 elution Methods 0.000 description 1
229940028334 follicle stimulating hormone Drugs 0.000 description 1
235000013305 food Nutrition 0.000 description 1
239000012634 fragment Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
239000002622 gonadotropin Substances 0.000 description 1
150000004679 hydroxides Chemical class 0.000 description 1
NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 1
239000000601 hypothalamic hormone Substances 0.000 description 1
229940043650 hypothalamic hormone Drugs 0.000 description 1
208000021267 infertility disease Diseases 0.000 description 1
238000001802 infusion Methods 0.000 description 1
239000007972 injectable composition Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
229960000310 isoleucine Drugs 0.000 description 1
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
235000010445 lecithin Nutrition 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
125000005647 linker group Chemical group 0.000 description 1
239000007791 liquid phase Substances 0.000 description 1
229940040129 luteinizing hormone Drugs 0.000 description 1
125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
239000000391 magnesium silicate Substances 0.000 description 1
229910052919 magnesium silicate Inorganic materials 0.000 description 1
235000019792 magnesium silicate Nutrition 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
239000002207 metabolite Substances 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
150000004702 methyl esters Chemical class 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
239000003094 microcapsule Substances 0.000 description 1
239000011707 mineral Substances 0.000 description 1
RIVIDPPYRINTTH-UHFFFAOYSA-N n-ethylpropan-2-amine Chemical group CCNC(C)C RIVIDPPYRINTTH-UHFFFAOYSA-N 0.000 description 1
230000000720 neurosecretory effect Effects 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
239000012457 nonaqueous media Substances 0.000 description 1
230000000269 nucleophilic effect Effects 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
229960003104 ornithine Drugs 0.000 description 1
230000016087 ovulation Effects 0.000 description 1
230000001175 peptic effect Effects 0.000 description 1
210000005259 peripheral blood Anatomy 0.000 description 1
239000011886 peripheral blood Substances 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 description 1
VBQCHPIMZGQLAZ-UHFFFAOYSA-N phosphorane Chemical class [PH5] VBQCHPIMZGQLAZ-UHFFFAOYSA-N 0.000 description 1
239000006187 pill Substances 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
229920000193 polymethacrylate Polymers 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229940068965 polysorbates Drugs 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
239000011253 protective coating Substances 0.000 description 1
239000011241 protective layer Substances 0.000 description 1
230000002685 pulmonary effect Effects 0.000 description 1
230000006340 racemization Effects 0.000 description 1
239000012429 reaction media Substances 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
230000003578 releasing effect Effects 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1
BVLCEKWPOSAKSZ-YQMCHIOTSA-N sermorelin acetate Chemical compound CC(O)=O.C([C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O)C1=CC=C(O)C=C1 BVLCEKWPOSAKSZ-YQMCHIOTSA-N 0.000 description 1
229960003137 sermorelin acetate Drugs 0.000 description 1
239000004208 shellac Substances 0.000 description 1
229940113147 shellac Drugs 0.000 description 1
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
235000013874 shellac Nutrition 0.000 description 1
231100000075 skin burn Toxicity 0.000 description 1
239000007787 solid Substances 0.000 description 1
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
229960000553 somatostatin Drugs 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
238000007619 statistical method Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
230000008961 swelling Effects 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000036962 time dependent Effects 0.000 description 1
230000001256 tonic effect Effects 0.000 description 1
230000001810 trypsinlike Effects 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
238000009827 uniform distribution Methods 0.000 description 1
239000004474 valine Substances 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1
230000029663 wound healing Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

UA20040504092A 2001-10-31 2002-10-30 Аналоги гормону, що вивільнюють гормон росту людини, спосіб їх одержання, фармацевтична композиція та спосіб лікування UA79440C2 (uk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PL350463A PL195917B1 (pl)	2001-10-31	2001-10-31	Nowe peptydy - analogi ludzkiego hormonu uwalniającego hormon wzrostu
PCT/PL2002/000080 WO2003037928A2 (fr)	2001-10-31	2002-10-30	Nouveaux peptides, analogues de l'hormone de liberation de l'hormone de croissance

Publications (1)

Publication Number	Publication Date
UA79440C2 true UA79440C2 (uk)	2007-06-25

Family

ID=20079564

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA20040504092A UA79440C2 (uk)	2001-10-31	2002-10-30	Аналоги гормону, що вивільнюють гормон росту людини, спосіб їх одержання, фармацевтична композиція та спосіб лікування

Country Status (14)

Country	Link
US (1)	US7928063B2 (fr)
EP (1)	EP1442059B1 (fr)
JP (1)	JP4401170B2 (fr)
AT (1)	ATE353917T1 (fr)
AU (1)	AU2002351536A1 (fr)
CA (1)	CA2465667C (fr)
DE (1)	DE60218199T2 (fr)
EA (1)	EA007841B1 (fr)
ES (1)	ES2282494T3 (fr)
HU (1)	HU229220B1 (fr)
PL (1)	PL195917B1 (fr)
SI (1)	SI1442059T1 (fr)
UA (1)	UA79440C2 (fr)
WO (1)	WO2003037928A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20050071498A (ko) *	2002-09-18	2005-07-07	상트르 오스피딸리에 드 루니버시떼 드 몬트리알	성장 호르몬 방출 호르몬 유사체
WO2011153491A2 (fr)	2010-06-03	2011-12-08	University Of Miami	Agonistes de l'hormone de libération de l'hormone de croissance en tant qu'effecteurs de la survie et de la prolifération d'îlots pancréatiques
US20130261058A1 (en) *	2010-09-16	2013-10-03	University Of Miami	Acceleration of wound healing by growth hormone releasing hormone and its agonists
WO2012068187A1 (fr) *	2010-11-19	2012-05-24	Merck Sharp & Dohme Corp.	Polymères poly(amide) destinés à l'administration d'oligonucléotides
TW201806968A (zh) *	2011-10-18	2018-03-01	艾利倫治療公司	擬肽巨環化合物
US9079974B2 (en)	2011-12-21	2015-07-14	The University Of Miami	GH-RH analogs with potent agonistic effects
US9855312B2 (en)	2012-12-21	2018-01-02	University Of Miami	GHRH agonists for the treatment of ischemic disorders
WO2014100816A2 (fr)	2012-12-21	2014-06-26	University Of Miami	Agonistes de ghrh pour la greffe et fonction de cellules d'îlot et le traitement du diabète

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5416073A (en) *	1983-08-10	1995-05-16	The Adminstrators Of The Tulane Educational Fund	Growth hormone-releasing peptides and method of treating animals, therewith
US5792747A (en) *	1995-01-24	1998-08-11	The Administrators Of The Tulane Educational Fund	Highly potent agonists of growth hormone releasing hormone
US6072075A (en) *	1997-05-22	2000-06-06	The Regents Of The University Of California	Guanidinylation reagents

2001
- 2001-10-31 PL PL350463A patent/PL195917B1/pl unknown
2002
- 2002-10-30 AU AU2002351536A patent/AU2002351536A1/en not_active Abandoned
- 2002-10-30 HU HU0401589A patent/HU229220B1/hu not_active IP Right Cessation
- 2002-10-30 DE DE60218199T patent/DE60218199T2/de not_active Expired - Lifetime
- 2002-10-30 AT AT02786274T patent/ATE353917T1/de not_active IP Right Cessation
- 2002-10-30 UA UA20040504092A patent/UA79440C2/uk unknown
- 2002-10-30 EA EA200400603A patent/EA007841B1/ru not_active IP Right Cessation
- 2002-10-30 ES ES02786274T patent/ES2282494T3/es not_active Expired - Lifetime
- 2002-10-30 CA CA2465667A patent/CA2465667C/fr not_active Expired - Fee Related
- 2002-10-30 EP EP02786274A patent/EP1442059B1/fr not_active Expired - Lifetime
- 2002-10-30 WO PCT/PL2002/000080 patent/WO2003037928A2/fr not_active Ceased
- 2002-10-30 JP JP2003540209A patent/JP4401170B2/ja not_active Expired - Fee Related
- 2002-10-30 SI SI200230531T patent/SI1442059T1/sl unknown
- 2002-10-30 US US10/494,218 patent/US7928063B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO2003037928A3 (fr)	2004-03-04
DE60218199D1 (de)	2007-03-29
US7928063B2 (en)	2011-04-19
HU229220B1 (hu)	2013-09-30
EA007841B1 (ru)	2007-02-27
EP1442059A2 (fr)	2004-08-04
CA2465667C (fr)	2011-03-08
WO2003037928A2 (fr)	2003-05-08
ATE353917T1 (de)	2007-03-15
PL350463A1 (en)	2003-05-05
AU2002351536A1 (en)	2003-05-12
ES2282494T3 (es)	2007-10-16
PL195917B1 (pl)	2007-11-30
HUP0401589A2 (hu)	2004-11-29
JP4401170B2 (ja)	2010-01-20
SI1442059T1 (sl)	2007-08-31
HUP0401589A3 (en)	2005-11-28
EP1442059B1 (fr)	2007-02-14
EA200400603A1 (ru)	2006-06-30
DE60218199T2 (de)	2007-11-22
CA2465667A1 (fr)	2003-05-08
US20060172927A1 (en)	2006-08-03
JP2005517633A (ja)	2005-06-16

Publication	Publication Date	Title
AU746461B2 (en)	2002-05-02	Peptide parathyroid hormone analogs
FI92326C (fi)	1994-10-25	LHRH:n nonapeptidi- ja dekapeptidianalogeja, jotka ovat käyttökelpoisia LHRH:n antagonisteina
HU217636B (hu)	2000-03-28	Szomatosztatin analógok, ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
HUT64367A (en)	1993-12-28	Method for producing glucagon-like peptides and insulino-tropine derivatives as well as medical preparatives containing said compounds
HU213098B (en)	1997-02-28	Process for producing decapeptides antagonistic to hormone for releazing lutheinizing-hormone and pharmaceutical compositions containing them as active components
EP0736038A1 (fr)	1996-10-09	Composes possedant des proprietes de liberation de l'hormone de croissance
US6211151B1 (en)	2001-04-03	Peptides with organo-protective activity, a process for preparation thereof and their use in therapy
EP1133522B1 (fr)	2006-07-05	Analogues antagonistes de gh-rh inhibant igf-i et igf-ii
HU186729B (en)	1985-09-30	Process for the production of biologycally active pentapeptide-derivatives
JPH085913B2 (ja)	1996-01-24	治療用ソマトスタチン同族体
UA79440C2 (uk)	2007-06-25	Аналоги гормону, що вивільнюють гормон росту людини, спосіб їх одержання, фармацевтична композиція та спосіб лікування
Feurle et al.	1996	Neurokinetic and myokinetic effects of the peptide xenin on the motility of the small and large intestine of guinea pig.
HU205772B (en)	1992-06-29	Process for producing graf-analogs affecting hypophysis of mammals and pharmaceutical compositions comprising same
CA1338302C (fr)	1996-04-30	Octapeptides, analogues de la somastatine, agents therapeutiques
HU215121B (hu)	1998-09-28	Eljárás vazotocinszármazékok és ilyen vegyületeket tartalmazó gyógyászati készítmények előállítására
CA2405724C (fr)	2010-09-07	Analogues de la substance p destines au traitement du cancer
CZ55496A3 (en)	1996-08-14	Tripeptides, processes of their preparation, their use, pharmaceutical compositions and diagnostic agents based thereon
ZA200302505B (en)	2005-05-30	Urotensin-II agonists and antagonists.
EP0200512B1 (fr)	1994-05-25	Peptides et leur emploi en thérapie
JPH09502427A (ja)	1997-03-11	オキシトシン拮抗薬活性を示すペプチド
Abiko et al.	2001	Syntheses of Cholecystokin in (Cck) Fragment Analogues (26-33) and Comparative Effect on Decreased Feeding in Rats by Cck Fragment (26-33)
CN116970040A (zh)	2023-10-31	一类通过酰胺键成环的阿片类多靶点环六肽分子及其制备和应用
Abiko et al.	2001	Syntheses of neurotensin (nt) analogues and their comparative anorectic effect on food intake in rats
CA2405689A1 (fr)	2001-08-23	Analogues peptidiques vasoactifs intestinaux