UA79801C2 - Novel derivatives of cycloalcanodiones, method for the production thereof and their pharmacological applications - Google Patents

Novel derivatives of cycloalcanodiones, method for the production thereof and their pharmacological applications Download PDF

Info

Publication number: UA79801C2
Authority: UA; Ukraine
Prior art keywords: butyl; group formed; alkyl; imidazole; dioxoperhydropyrrolo
Prior art date: 2002-07-31

Application number

UAA200500843A

Other languages

English (en)

Ukrainian (uk)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-31

Filing date

2003-07-29

Publication date

2007-07-25

2003-07-29 Application filed filed Critical

2007-07-25 Publication of UA79801C2 publication Critical patent/UA79801C2/uk

Links

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235000019260 propionic acid Nutrition 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
238000011084 recovery Methods 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
229940076279 serotonin Drugs 0.000 description 1
239000000952 serotonin receptor agonist Substances 0.000 description 1
239000012679 serum free medium Substances 0.000 description 1
238000010898 silica gel chromatography Methods 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000000542 thalamic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
238000000293 three-dimensional nuclear magnetic resonance spectroscopy Methods 0.000 description 1
230000002537 thrombolytic effect Effects 0.000 description 1
231100000816 toxic dose Toxicity 0.000 description 1
230000003612 virological effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Thiazole And Isothizaole Compounds (AREA)

UAA200500843A 2002-07-31 2003-07-29 Novel derivatives of cycloalcanodiones, method for the production thereof and their pharmacological applications UA79801C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES200201811A ES2199086B1 (es)	2002-07-31	2002-07-31	Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
PCT/ES2003/000394 WO2004014915A1 (es)	2002-07-31	2003-07-29	Nuevos derivados de cicloalcanodionas procedimiento para su preparación y sus aplicaciones farmacológicas

Publications (1)

Publication Number	Publication Date
UA79801C2 true UA79801C2 (en)	2007-07-25

Family

ID=31198114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAA200500843A UA79801C2 (en)	2002-07-31	2003-07-29	Novel derivatives of cycloalcanodiones, method for the production thereof and their pharmacological applications

Country Status (23)

Country	Link
US (1)	US7351732B2 (pl)
EP (1)	EP1544201B1 (pl)
JP (1)	JP2005539017A (pl)
KR (1)	KR20050042471A (pl)
CN (2)	CN101172977A (pl)
AT (1)	ATE331717T1 (pl)
AU (1)	AU2003254512A1 (pl)
BR (1)	BR0313375A (pl)
CA (1)	CA2492837A1 (pl)
CY (1)	CY1106170T1 (pl)
DE (1)	DE60306534T2 (pl)
DK (1)	DK1544201T3 (pl)
ES (2)	ES2199086B1 (pl)
IL (1)	IL166469A0 (pl)
MX (1)	MXPA05001245A (pl)
NO (1)	NO20051068L (pl)
NZ (1)	NZ538489A (pl)
PL (1)	PL373644A1 (pl)
PT (1)	PT1544201E (pl)
RU (1)	RU2322445C2 (pl)
UA (1)	UA79801C2 (pl)
WO (1)	WO2004014915A1 (pl)
ZA (1)	ZA200500784B (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2199086B1 (es)	2002-07-31	2005-06-01	Cepa Schwarz Pharma Sl	Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
ES2238015B1 (es) *	2004-01-30	2006-11-01	Cepa Schwarz Pharma, S.L.	Derivados de cicloalcanodionas con actividad neuroprotectora.
WO2008015538A2 (en) *	2006-07-31	2008-02-07	Schwarz Pharma S.L.	Use of diaza- and thiaza-cycloalkanediones for preventing and/or treating pain and /or migraine
EP2338873A1 (en)	2009-12-22	2011-06-29	Gmeiner, Peter	New aminotetraline derivatives

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US4055410A (en) *	1976-03-15	1977-10-25	E. I. Du Pont De Nemours And Company	Substituted bromo- or chloroacetamide herbicides
EP0002978B1 (fr) *	1977-12-29	1982-10-06	Synthelabo	Dérivés de thiazolidinedione-2,4, leur préparation et leur application en thérapeutique
DE3901814A1 (de) *	1988-07-28	1990-02-01	Bayer Ag	Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
CA2067031C (en) *	1991-04-26	2003-02-18	Shigekazu Nagata	Dna coding for human cell surface antigen
TW288010B (pl) *	1992-03-05	1996-10-11	Pfizer
AP486A (en) *	1993-04-27	1996-04-16	Pfizer	Indole derivatives.
AU3079295A (en)	1994-09-01	1996-03-22	Universidad Complutense De Madrid	New arylpiperazine derivatives
ES2082727B1 (es)	1994-09-01	1996-10-16	Univ Madrid Complutense	Nuevos derivados de arilpiperazinas.
ES2094690B1 (es)	1994-11-22	1997-08-01	Univ Madrid Complutense	Nuevos derivados de imida-piperazinas.
ES2109190B1 (es)	1996-03-22	1998-07-01	Univ Madrid Complutense	Nuevos derivados de bencimidazol con afinidad por los receptores serotoninergicos 5-ht /5-ht
ES2129370B1 (es)	1997-09-23	2000-03-01	Univ Madrid Complutense	Procedimiento para la obtencion del 2-(4-(4-(m-etilsulfonamidofenil)p iperazin-1-il(butil)-1,3-dioxoperhidropirrolo)1,2-c(imidazol
US6133277A (en)	1997-12-05	2000-10-17	Janssen Pharmaceutica N.V.	(Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
ES2154605B1 (es)	1999-09-14	2001-11-16	Univ Madrid Complutense	Nuevos derivados mixtos de bencimidazol-arilpiperazina con afinidad por los receptores serotoninergicos 5-ht1a y 5-ht3
DE10148425A1 (de)	2001-10-01	2003-04-17	Bayer Ag	Chromane
ES2199086B1 (es)	2002-07-31	2005-06-01	Cepa Schwarz Pharma Sl	Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
ES2238015B1 (es)	2004-01-30	2006-11-01	Cepa Schwarz Pharma, S.L.	Derivados de cicloalcanodionas con actividad neuroprotectora.
EP1674103A1 (en)	2004-12-27	2006-06-28	Cepa Schwarz Pharma s.l.	Arylpiperazine derivatives and use thereof as 5-HT1A receptor ligands

2002
- 2002-07-31 ES ES200201811A patent/ES2199086B1/es not_active Expired - Fee Related
2003
- 2003-07-29 JP JP2004526925A patent/JP2005539017A/ja active Pending
- 2003-07-29 US US10/522,697 patent/US7351732B2/en not_active Expired - Fee Related
- 2003-07-29 UA UAA200500843A patent/UA79801C2/uk unknown
- 2003-07-29 PT PT03784210T patent/PT1544201E/pt unknown
- 2003-07-29 EP EP03784210A patent/EP1544201B1/en not_active Expired - Lifetime
- 2003-07-29 CA CA002492837A patent/CA2492837A1/en not_active Abandoned
- 2003-07-29 BR BR0313375-3A patent/BR0313375A/pt not_active IP Right Cessation
- 2003-07-29 AT AT03784210T patent/ATE331717T1/de not_active IP Right Cessation
- 2003-07-29 PL PL03373644A patent/PL373644A1/pl not_active Application Discontinuation
- 2003-07-29 KR KR1020057001543A patent/KR20050042471A/ko not_active Ceased
- 2003-07-29 AU AU2003254512A patent/AU2003254512A1/en not_active Abandoned
- 2003-07-29 NZ NZ538489A patent/NZ538489A/en unknown
- 2003-07-29 CN CNA2007101694908A patent/CN101172977A/zh active Pending
- 2003-07-29 ES ES03784210T patent/ES2271673T3/es not_active Expired - Lifetime
- 2003-07-29 DE DE60306534T patent/DE60306534T2/de not_active Expired - Fee Related
- 2003-07-29 DK DK03784210T patent/DK1544201T3/da active
- 2003-07-29 CN CNB038183390A patent/CN100422185C/zh not_active Expired - Fee Related
- 2003-07-29 RU RU2005102821/04A patent/RU2322445C2/ru not_active IP Right Cessation
- 2003-07-29 WO PCT/ES2003/000394 patent/WO2004014915A1/es not_active Ceased
- 2003-07-29 MX MXPA05001245A patent/MXPA05001245A/es active IP Right Grant
2005
- 2005-01-24 IL IL16646905A patent/IL166469A0/xx unknown
- 2005-01-25 ZA ZA200500784A patent/ZA200500784B/xx unknown
- 2005-02-25 NO NO20051068A patent/NO20051068L/no not_active Application Discontinuation
2006
- 2006-09-26 CY CY20061101376T patent/CY1106170T1/el unknown

Also Published As

Publication number	Publication date
PT1544201E (pt)	2006-11-30
IL166469A0 (en)	2006-01-15
KR20050042471A (ko)	2005-05-09
JP2005539017A (ja)	2005-12-22
EP1544201B1 (en)	2006-06-28
CN1671708A (zh)	2005-09-21
ATE331717T1 (de)	2006-07-15
CN101172977A (zh)	2008-05-07
RU2005102821A (ru)	2005-10-10
MXPA05001245A (es)	2005-09-12
EP1544201A1 (en)	2005-06-22
ES2199086B1 (es)	2005-06-01
CN100422185C (zh)	2008-10-01
PL373644A1 (pl)	2005-09-05
BR0313375A (pt)	2005-06-21
ES2271673T3 (es)	2007-04-16
ES2199086A1 (es)	2004-02-01
US7351732B2 (en)	2008-04-01
WO2004014915A1 (es)	2004-02-19
DE60306534D1 (de)	2006-08-10
NZ538489A (en)	2006-09-29
US20050250777A1 (en)	2005-11-10
NO20051068L (no)	2005-02-25
RU2322445C2 (ru)	2008-04-20
ZA200500784B (en)	2006-08-30
DE60306534T2 (de)	2007-04-19
CA2492837A1 (en)	2004-02-19
DK1544201T3 (da)	2006-10-30
CY1106170T1 (el)	2011-06-08
AU2003254512A1 (en)	2004-02-25

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