UA80543C2 - Method for the preparation of o-desmethylvenlafaxine - Google Patents

Method for the preparation of o-desmethylvenlafaxine Download PDF

Info

Publication number: UA80543C2
Authority: UA; Ukraine
Prior art keywords: thiolate; carried out; venlafaxine; alcohol; reaction
Prior art date: 2001-12-04

Application number

UA20040705306A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-04

Filing date

2002-03-12

Publication date

2007-10-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23309595&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA80543(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-03-12 Application filed by Wyeth Corp filed Critical Wyeth Corp

2007-10-10 Publication of UA80543C2 publication Critical patent/UA80543C2/uk

Links

KYYIDSXMWOZKMP-UHFFFAOYSA-N O-desmethylvenlafaxine Chemical compound C1CCCCC1(O)C(CN(C)C)C1=CC=C(O)C=C1 KYYIDSXMWOZKMP-UHFFFAOYSA-N 0.000 title claims abstract description 12
238000000034 method Methods 0.000 title claims description 31
238000002360 preparation method Methods 0.000 title description 2
-1 thiolate anion Chemical class 0.000 claims abstract description 18
PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 claims abstract description 17
229960004688 venlafaxine Drugs 0.000 claims abstract description 16
230000001335 demethylating effect Effects 0.000 claims abstract 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 23
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 21
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 12
WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 claims description 12
125000004432 carbon atom Chemical group C* 0.000 claims description 10
238000006243 chemical reaction Methods 0.000 claims description 8
239000002904 solvent Substances 0.000 claims description 8
WNAHIZMDSQCWRP-UHFFFAOYSA-N dodecane-1-thiol Chemical compound CCCCCCCCCCCCS WNAHIZMDSQCWRP-UHFFFAOYSA-N 0.000 claims description 7
239000002202 Polyethylene glycol Substances 0.000 claims description 5
150000004703 alkoxides Chemical class 0.000 claims description 5
239000000203 mixture Substances 0.000 claims description 5
229920001223 polyethylene glycol Polymers 0.000 claims description 5
150000007944 thiolates Chemical class 0.000 claims description 5
230000017858 demethylation Effects 0.000 claims description 4
238000010520 demethylation reaction Methods 0.000 claims description 4
239000011541 reaction mixture Substances 0.000 claims description 4
150000001335 aliphatic alkanes Chemical class 0.000 claims description 3
125000000217 alkyl group Chemical group 0.000 claims description 3
230000003472 neutralizing effect Effects 0.000 claims description 3
229940068918 polyethylene glycol 400 Drugs 0.000 claims description 3
150000004945 aromatic hydrocarbons Chemical class 0.000 claims description 2
125000003710 aryl alkyl group Chemical group 0.000 claims description 2
NBTOZLQBSIZIKS-UHFFFAOYSA-N methoxide Chemical compound [O-]C NBTOZLQBSIZIKS-UHFFFAOYSA-N 0.000 claims description 2
YFNKIDBQEZZDLK-UHFFFAOYSA-N triglyme Chemical compound COCCOCCOCCOC YFNKIDBQEZZDLK-UHFFFAOYSA-N 0.000 claims description 2
SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims 1
RMVRSNDYEFQCLF-UHFFFAOYSA-M benzenethiolate Chemical compound [S-]C1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-M 0.000 claims 1
238000012876 topography Methods 0.000 claims 1
238000004519 manufacturing process Methods 0.000 abstract 1
RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical compound SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 description 6
XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
229920002565 Polyethylene Glycol 400 Polymers 0.000 description 4
238000001914 filtration Methods 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
239000012065 filter cake Substances 0.000 description 3
239000002244 precipitate Substances 0.000 description 3
XRZRPHKMCVBSLA-UHFFFAOYSA-M sodium;dodecane-1-thiolate Chemical compound [Na+].CCCCCCCCCCCC[S-] XRZRPHKMCVBSLA-UHFFFAOYSA-M 0.000 description 3
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 2
IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
238000000605 extraction Methods 0.000 description 2
238000006386 neutralization reaction Methods 0.000 description 2
239000000047 product Substances 0.000 description 2
238000003756 stirring Methods 0.000 description 2
ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
230000001476 alcoholic effect Effects 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
239000000010 aprotic solvent Substances 0.000 description 1
UENWRTRMUIOCKN-UHFFFAOYSA-N benzyl thiol Chemical compound SCC1=CC=CC=C1 UENWRTRMUIOCKN-UHFFFAOYSA-N 0.000 description 1
125000001743 benzylic group Chemical group 0.000 description 1
150000004946 bicyclic arenes Chemical class 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
210000005056 cell body Anatomy 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
GPAYUJZHTULNBE-UHFFFAOYSA-N diphenylphosphine Chemical compound C=1C=CC=CC=1PC1=CC=CC=C1 GPAYUJZHTULNBE-UHFFFAOYSA-N 0.000 description 1
HHFAWKCIHAUFRX-UHFFFAOYSA-N ethoxide Chemical compound CC[O-] HHFAWKCIHAUFRX-UHFFFAOYSA-N 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
229910000041 hydrogen chloride Inorganic materials 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
150000004947 monocyclic arenes Chemical class 0.000 description 1
125000002950 monocyclic group Chemical group 0.000 description 1
239000003586 protic polar solvent Substances 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000010992 reflux Methods 0.000 description 1
QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000000967 suction filtration Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

UA20040705306A 2001-12-04 2002-03-12 Method for the preparation of o-desmethylvenlafaxine UA80543C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US33495301P	2001-12-04	2001-12-04
PCT/US2002/038403 WO2003048104A1 (en)	2001-12-04	2002-12-03	Methods for preparing o-desmethylvenlafaxine

Publications (1)

Publication Number	Publication Date
UA80543C2 true UA80543C2 (en)	2007-10-10

Family

ID=23309595

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA20040705306A UA80543C2 (en)	2001-12-04	2002-03-12	Method for the preparation of o-desmethylvenlafaxine

Country Status (28)

Country	Link
US (4)	US6689912B2 (es)
EP (1)	EP1451143B9 (es)
JP (1)	JP4342312B2 (es)
KR (1)	KR100939650B1 (es)
CN (1)	CN1319934C (es)
AR (1)	AR037622A1 (es)
AT (1)	ATE403641T1 (es)
AU (1)	AU2002357049B2 (es)
BR (1)	BR0214701A (es)
CA (1)	CA2466779C (es)
CO (1)	CO5580816A2 (es)
DE (1)	DE60228118D1 (es)
DK (1)	DK1451143T3 (es)
EC (1)	ECSP045135A (es)
ES (1)	ES2311647T4 (es)
HU (1)	HUP0402269A3 (es)
IL (3)	IL162253A0 (es)
MX (1)	MXPA04005309A (es)
NO (1)	NO20042680L (es)
NZ (1)	NZ533316A (es)
PL (1)	PL369299A1 (es)
PT (1)	PT1451143E (es)
RU (1)	RU2317286C2 (es)
SI (1)	SI1451143T1 (es)
TW (1)	TWI260982B (es)
UA (1)	UA80543C2 (es)
WO (1)	WO2003048104A1 (es)
ZA (1)	ZA200405250B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6342533B1 (en)	1998-12-01	2002-01-29	Sepracor, Inc.	Derivatives of (−)-venlafaxine and methods of preparing and using the same
DE60039132D1 (de) *	1999-04-06	2008-07-17	Sepracor Inc	O-Desmethylvenlafaxin-Succinat
EP1864967A1 (en) *	2001-02-12	2007-12-12	Wyeth	Method for preparing O-desmethyl-venlafaxine
UA80543C2 (en) *	2001-12-04	2007-10-10	Wyeth Corp	Method for the preparation of o-desmethylvenlafaxine
CA2614209A1 (en) *	2005-07-06	2007-01-11	Sepracor Inc.	Combinations of eszopiclone and o-desmethylvenlafaxine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
US7612210B2 (en) *	2005-12-05	2009-11-03	Wyeth	Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols
EP1973866A1 (en) *	2005-12-20	2008-10-01	Synthon B.V.	Process for making desvenlafaxine
WO2007120923A1 (en)	2006-04-17	2007-10-25	Teva Pharmaceutical Industries Ltd.	Substantially pure o-desmethylvenlafaxine and processes for preparing it
MX2007016179A (es) *	2006-04-17	2008-03-11	Teva Pharma	Formas cristalinas de o-desmetilvenlafaxina.
WO2008035369A2 (en) *	2006-06-30	2008-03-27	Alembic Limited	Novel form of o-desmethyl venlafaxine
US20090069601A1 (en) *	2006-07-26	2009-03-12	Valerie Niddam-Hildesheim	Processes for the synthesis of O-desmethylvenlafaxine
US20080221356A1 (en) *	2006-07-26	2008-09-11	Valerie Niddam-Hildesheim	Processes for the synthesis of O-desmethylvenlafaxine
US20090062572A1 (en) *	2006-07-26	2009-03-05	Valerie Niddam-Hildesheim	Processes for the synthesis of O-desmethylvenlafaxine
WO2008013995A2 (en) *	2006-07-26	2008-01-31	Teva Pharmaceutical Industries Ltd.	Tridesmethylvenlafaxine and processes for the synthesis of o-desmethylvenlafaxine
WO2008013993A2 (en) *	2006-07-26	2008-01-31	Teva Pharmaceutical Industries Ltd.	Processes for the synthesis of o-desmethylvenlafaxine
WO2008013994A2 (en)	2006-07-26	2008-01-31	Teva Pharmaceutical Industries Ltd.	Processes for the synthesis of o-desmethylvenlafaxine
US20090137846A1 (en) *	2006-07-26	2009-05-28	Valerie Niddam-Hildesheim	Processes for the synthesis of O-Desmethylvenlafaxine
EP2061750A2 (en) *	2006-08-04	2009-05-27	Medichem, S.A.	Improved process for synthesizing desvenlafaxine free base and salts or solvates thereof
EP2114862A1 (en) *	2007-01-31	2009-11-11	Merck Generics (UK) Limited	Process for the preparation of o-desmethyl venlafaxine
IN2009DN05509A (es) *	2007-03-14	2010-04-30	Teva Pharma
WO2009009665A2 (en) *	2007-07-12	2009-01-15	Dr. Reddy's Laboratories, Ltd.	O-desmethylvenlafaxine
WO2009010990A2 (en) *	2007-07-16	2009-01-22	Matrix Laboratories Limited	Process for the preparation of o-desmethylvenlafaxine succinate polymorphic forms
WO2009034434A2 (en) *	2007-09-10	2009-03-19	Cadila Pharmaceuticals Limited	An improved process for the preparation of o-desmethylvenlafaxine
AU2008315740A1 (en)	2007-10-26	2009-04-30	Generics [Uk] Limited	Process for preparing O-desmethylvenlafaxine
WO2009070311A2 (en) *	2007-11-26	2009-06-04	Teva Pharmaceutical Industries Ltd.	Crystal forms of o-desmethylvenlafaxine fumarate
WO2009084038A2 (en) *	2007-12-28	2009-07-09	Ind-Swift Laboratories Limited	Improved process for the preparation of 0-desmethyl-venlafaxine
WO2009151494A1 (en) *	2008-03-06	2009-12-17	Teva Pharmaceutical Industries Ltd.	Processes for the preparation of o-desmethylvenlafaxine, free from its dimer impurities
EP2119695A1 (en)	2008-05-16	2009-11-18	Krka	Preparation of O-desmethylvenlafaxine salts
EP2119696A1 (en)	2008-05-16	2009-11-18	Krka	Preparation of O-desmethylvenlafaxine salts
CA2720538A1 (en) *	2008-06-16	2010-01-21	Teva Pharmaceutical Industries Ltd.	Solid states of o-desmethylvenlafaxine salts
US20100016638A1 (en) *	2008-07-21	2010-01-21	Zdenko Hamersak	Method for preparation of o-desmethylvenlafaxine using polythiolates
CN102164886A (zh) *	2008-07-30	2011-08-24	基因里克斯(英国)有限公司	用于制备o-去甲文拉法辛的方法
CZ301503B6 (cs)	2008-11-27	2010-03-24	Zentiva, A. S.	Zpusob prípravy desvenlafaxinu a jeho solí
CZ301820B6 (cs)	2009-02-06	2010-06-30	Zentiva, K.S.	Nové soli desvenlafaxinu a zpusob jejich prípravy
CZ2009454A3 (cs)	2009-07-15	2010-11-10	Zentiva, K. S.	Zpusob prípravy desvenlafaxinu a jeho solí
WO2011007136A2 (en)	2009-07-16	2011-01-20	Cipla Limited	Process for the preparation of o-desmethyl venlafaxine and intermediate for use therein
US20110098506A1 (en) *	2009-10-26	2011-04-28	Intas Pharmaceuticals Limited	Method of preparing o-desmethylvenlafaxine
US20110184067A1 (en) *	2010-01-25	2011-07-28	Intas Pharmaceuticals Ltd.	O-desmethylvenlafaxine succinate polymorph & process for preparing thereof
WO2011121452A2 (en)	2010-03-29	2011-10-06	Pliva Hrvatska D.O.O.	Crystal forms of o-desmethylvenlafaxine fumarate
CZ303249B6 (cs)	2010-04-06	2012-06-20	Zentiva, K.S.	Zpusob výroby 4-(2-(substituovaných)-1-(1-hydroxycyklohexyl)ethyl)fenolu O-demethylací jejich methyletheru pomocí nepáchnoucích aromatických thiolu
EP2394976A1 (en)	2010-06-11	2011-12-14	LEK Pharmaceuticals d.d.	Process for demethylating aromatic methyl ethers using 3-mercaptopropionic acid
EP3580198B1 (en)	2017-02-09	2023-08-09	R L Finechem Private Limited	A process for preparation of1-[2-(dimethylamino)-1-(4-hydroxyphenyl) ethyl]-cyclohexanol and salts thereof
CN109232189B (zh) *	2018-09-25	2021-10-08	杭州盛弗泰新材料科技有限公司	一种高纯度1-羟基芘的制备方法
CN109665966A (zh) *	2018-11-01	2019-04-23	山东蒲济医药科技有限公司	一种琥珀酸去甲文拉法辛化合物的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2741009A1 (de) *	1976-09-22	1978-03-23	Sandoz Ag	4-styryl-4-indolinol-derivate, ihre verwendung und herstellung
US4535186A (en)	1983-04-19	1985-08-13	American Home Products Corporation	2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
CA1227304A (en) *	1984-08-01	1987-09-29	Raymond C. Francis	Delignification of pulp
GB8902209D0 (en)	1989-02-01	1989-03-22	Wyeth John And Brother Limited	Preparation of cyclohexanol derivatives and novel thioamide intermediates
US6197828B1 (en) *	1998-12-01	2001-03-06	Sepracor, Inc.	Derivatives of (+)-venlafaxine and methods of preparing and using the same
US6342533B1 (en) *	1998-12-01	2002-01-29	Sepracor, Inc.	Derivatives of (−)-venlafaxine and methods of preparing and using the same
DE60039132D1 (de)	1999-04-06	2008-07-17	Sepracor Inc	O-Desmethylvenlafaxin-Succinat
WO2000076955A1 (en)	1999-06-15	2000-12-21	American Home Products Corporation	Enantiomers of o-desmethyl venlafaxine
JP2004504026A (ja)	2000-07-18	2004-02-12	バイエル　アクチェンゲゼルシャフト	ヒトｄｅｓｃ１様セリンプロテアーゼの調節
EP1864967A1 (en) *	2001-02-12	2007-12-12	Wyeth	Method for preparing O-desmethyl-venlafaxine
UA80543C2 (en) *	2001-12-04	2007-10-10	Wyeth Corp	Method for the preparation of o-desmethylvenlafaxine

2002
- 2002-03-12 UA UA20040705306A patent/UA80543C2/uk unknown
- 2002-11-26 US US10/304,871 patent/US6689912B2/en not_active Expired - Fee Related
- 2002-11-27 TW TW091134427A patent/TWI260982B/zh not_active IP Right Cessation
- 2002-12-03 KR KR1020047008512A patent/KR100939650B1/ko not_active Expired - Fee Related
- 2002-12-03 IL IL16225302A patent/IL162253A0/xx active IP Right Grant
- 2002-12-03 JP JP2003549297A patent/JP4342312B2/ja not_active Expired - Fee Related
- 2002-12-03 HU HU0402269A patent/HUP0402269A3/hu active IP Right Revival
- 2002-12-03 AT AT02804479T patent/ATE403641T1/de not_active IP Right Cessation
- 2002-12-03 PL PL02369299A patent/PL369299A1/xx unknown
- 2002-12-03 SI SI200230743T patent/SI1451143T1/sl unknown
- 2002-12-03 CN CNB028242386A patent/CN1319934C/zh not_active Expired - Fee Related
- 2002-12-03 CA CA2466779A patent/CA2466779C/en not_active Expired - Lifetime
- 2002-12-03 DK DK02804479T patent/DK1451143T3/da active
- 2002-12-03 PT PT02804479T patent/PT1451143E/pt unknown
- 2002-12-03 DE DE60228118T patent/DE60228118D1/de not_active Expired - Lifetime
- 2002-12-03 NZ NZ533316A patent/NZ533316A/en unknown
- 2002-12-03 RU RU2004120284/04A patent/RU2317286C2/ru not_active IP Right Cessation
- 2002-12-03 ES ES02804479T patent/ES2311647T4/es not_active Expired - Lifetime
- 2002-12-03 BR BR0214701-7A patent/BR0214701A/pt not_active Application Discontinuation
- 2002-12-03 AR ARP020104669A patent/AR037622A1/es unknown
- 2002-12-03 EP EP02804479A patent/EP1451143B9/en not_active Expired - Lifetime
- 2002-12-03 MX MXPA04005309A patent/MXPA04005309A/es active IP Right Grant
- 2002-12-03 WO PCT/US2002/038403 patent/WO2003048104A1/en not_active Ceased
- 2002-12-03 AU AU2002357049A patent/AU2002357049B2/en not_active Ceased
2003
- 2003-12-31 US US10/750,196 patent/US20040158101A1/en not_active Abandoned
2004
- 2004-05-31 IL IL162253A patent/IL162253A/en not_active IP Right Cessation
- 2004-06-01 CO CO04050957A patent/CO5580816A2/es active IP Right Grant
- 2004-06-04 EC EC2004005135A patent/ECSP045135A/es unknown
- 2004-06-25 NO NO20042680A patent/NO20042680L/no not_active Application Discontinuation
- 2004-07-01 ZA ZA2004/05250A patent/ZA200405250B/en unknown
2007
- 2007-06-01 US US11/756,772 patent/US7435854B2/en not_active Expired - Fee Related
2008
- 2008-09-11 IL IL194034A patent/IL194034A/en not_active IP Right Cessation
- 2008-09-11 US US12/208,990 patent/US20090018365A1/en not_active Abandoned

Also Published As

Publication number	Publication date
RU2317286C2 (ru)	2008-02-20
DK1451143T3 (da)	2008-11-10
US20070225525A1 (en)	2007-09-27
ES2311647T4 (es)	2009-11-10
DE60228118D1 (de)	2008-09-18
AR037622A1 (es)	2004-11-17
PT1451143E (pt)	2008-10-21
IL162253A (en)	2009-02-11
ATE403641T1 (de)	2008-08-15
US7435854B2 (en)	2008-10-14
NO20042680L (no)	2004-06-25
HUP0402269A3 (en)	2010-06-28
EP1451143A1 (en)	2004-09-01
JP4342312B2 (ja)	2009-10-14
HK1065778A1 (en)	2005-03-04
WO2003048104A1 (en)	2003-06-12
ZA200405250B (en)	2005-12-28
CA2466779C (en)	2013-11-19
US20040158101A1 (en)	2004-08-12
US20030105358A1 (en)	2003-06-05
AU2002357049B2 (en)	2009-07-16
KR20050044671A (ko)	2005-05-12
US6689912B2 (en)	2004-02-10
CO5580816A2 (es)	2005-11-30
CA2466779A1 (en)	2003-06-12
SI1451143T1 (sl)	2008-12-31
IL162253A0 (en)	2005-11-20
CN1319934C (zh)	2007-06-06
AU2002357049A1 (en)	2003-06-17
EP1451143B1 (en)	2008-08-06
IL194034A (en)	2010-12-30
BR0214701A (pt)	2004-08-31
EP1451143B9 (en)	2009-08-12
ES2311647T3 (es)	2009-02-16
MXPA04005309A (es)	2004-09-13
RU2004120284A (ru)	2005-04-10
HUP0402269A2 (hu)	2005-02-28
US20090018365A1 (en)	2009-01-15
KR100939650B1 (ko)	2010-02-05
NZ533316A (en)	2005-12-23
TW200301102A (en)	2003-07-01
PL369299A1 (en)	2005-04-18
TWI260982B (en)	2006-09-01
ECSP045135A (es)	2004-07-23
CN1625546A (zh)	2005-06-08
JP2005511681A (ja)	2005-04-28

Publication	Publication Date	Title
UA80543C2 (en)	2007-10-10	Method for the preparation of o-desmethylvenlafaxine
CN1239477C (zh)	2006-02-01	酚类的磺化
CN104086578A (zh)	2014-10-08	一种含糖酰胺基的三硅氧烷及制法
US3660460A (en)	1972-05-02	Process for preparing n n-bis-cyanoethylated derivatives of aliphatic primary amine branched at the alpha-position
TWI243823B (en)	2005-11-21	Phosphonium salts and processes for production of and uses for the same, and phosphines deriving the same and processes for production of the phosphines
CN114845987B (zh)	2024-06-11	用于合成双尾三胺的方法
HK1065778B (en)	2009-03-06	Methods for preparing o-desmethylvenlafaxine
JP2002371088A (ja)	2002-12-26	スルホン酸アミン塩およびその製造方法
CN106132973B (zh)	2018-10-16	纯化的亚磷酰二胺的制备
KR100601133B1 (ko)	2006-07-19	엔,엔,엔-트리스(3-알킬옥시-2-히드록시프로필)아민화합물의 효율적 제조방법
JP3530925B2 (ja)	2004-05-24	オキソエステル化合物の製造方法
JPS5946255A (ja)	1984-03-15	２−アルコキシメチレン−３，３−ジアルコキシプロパンニトリル類の製法
CN104072562A (zh)	2014-10-01	一种乙氧基改性的含糖酰胺基的四硅氧烷及制法
JP2003089664A (ja)	2003-03-28	含フッ素パラシクロファンの製法
JPH06211773A (ja)	1994-08-02	ヒドロキシスルホベタインの製造方法
JPH0676362B2 (ja)	1994-09-28	芳香族アルドオキシムの製法
JP2005047836A (ja)	2005-02-24	１−アルキル−３−ピペリジンエステル類の製造方法
PL148858B1 (en)	1989-12-30	Method of obtaining 1-aminoalkanophosphonic esters in particular in the form of hydrochlorides
JPWO1995010502A1 (ja)	1996-02-27	３−置換−２，４，５−トリフルオロ安息香酸の製造方法および４−アミノ−３，５，６−トリフルオロフタル酸
JPS62132858A (ja)	1987-06-16	２，２，６，６−テトラメチル−４−オキソピペリジンの製造方法