UA81468C2 - Heteroarylcarbamoylbenzene derivatives - Google Patents

Heteroarylcarbamoylbenzene derivatives

Info

Publication number: UA81468C2
Authority: UA; Ukraine
Prior art keywords: formula; ring; iii; compound; nitrogen atom
Prior art date: 2003-02-26

Application number

UAA200509024A

Other languages

English (en)

Original Assignee

Banyu Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-02-26

Filing date

2004-02-26

Publication date

2008-01-10

2004-02-26 Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd

2008-01-10 Publication of UA81468C2 publication Critical patent/UA81468C2/xx

Links

150000001875 compounds Chemical class 0.000 abstract 3
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000000126 substance Substances 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
102000030595 Glucokinase Human genes 0.000 abstract 1
108010021582 Glucokinase Proteins 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000003368 amide group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Obesity (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

UAA200509024A 2003-02-26 2004-02-26 Heteroarylcarbamoylbenzene derivatives UA81468C2 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2003049466		2003-02-26
JP2003400882		2003-11-28
JP2004031298		2004-02-06
PCT/JP2004/002284 WO2004076420A1 (fr)	2003-02-26	2004-02-26	Derives d'heteroarylcarbamoylbenzene

Publications (1)

Publication Number	Publication Date
UA81468C2 true UA81468C2 (en)	2008-01-10

Family

ID=32931126

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAA200509024A UA81468C2 (en)	2003-02-26	2004-02-26	Heteroarylcarbamoylbenzene derivatives

Country Status (16)

Country	Link
US (2)	US7432287B2 (fr)
EP (1)	EP1600442B1 (fr)
JP (1)	JP4432901B2 (fr)
KR (1)	KR20050105488A (fr)
CN (1)	CN101712657A (fr)
AU (1)	AU2004215514B2 (fr)
BR (1)	BRPI0407810A (fr)
CA (1)	CA2516407C (fr)
EC (1)	ECSP055987A (fr)
MA (1)	MA27660A1 (fr)
MX (1)	MXPA05009059A (fr)
NO (1)	NO20054425L (fr)
NZ (1)	NZ541824A (fr)
RU (1)	RU2330030C2 (fr)
UA (1)	UA81468C2 (fr)
WO (1)	WO2004076420A1 (fr)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0102299D0 (sv)	2001-06-26	2001-06-26	Astrazeneca Ab	Compounds
SE0102764D0 (sv) *	2001-08-17	2001-08-17	Astrazeneca Ab	Compounds
PL375021A1 (en)	2002-10-03	2005-11-14	Novartis Ag	Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes
GB0226931D0 (en)	2002-11-19	2002-12-24	Astrazeneca Ab	Chemical compounds
GB0226930D0 (en)	2002-11-19	2002-12-24	Astrazeneca Ab	Chemical compounds
BRPI0407283A (pt)	2003-02-13	2006-01-31	Banyu Pharma Co Ltd	Composto, composição farmacêutica, e, agente ativador de glucoquinase, agentes terapêuticos e/ou agentes preventivos para diabetes melito e obesidade
GB0325402D0 (en) *	2003-10-31	2003-12-03	Astrazeneca Ab	Compounds
GB0327761D0 (en) *	2003-11-29	2003-12-31	Astrazeneca Ab	Compounds
US7728025B2 (en) *	2003-12-29	2010-06-01	Banyu Pharmaceutical Co., Ltd.	2-heteroaryl-substituted benzimidazole derivative
JP2007523905A (ja) *	2004-02-18	2007-08-23	アストラゼネカアクチボラグ	化合物
EP2048137A1 (fr) *	2004-02-18	2009-04-15	AstraZeneca AB	Dérivés de la benzamide et leur utilisation comme activateurs de la glucokinase.
PT1735322E (pt)	2004-04-02	2012-01-12	Novartis Ag	Derivados de sulfonamido-tiazolopiridina como activadores de glucoquinase úteis para o tratamento de diabetes de tipo 2
US7781451B2 (en)	2004-04-02	2010-08-24	Novartis Ag	Thiazolopyridine derivatives, pharmaceut ical conditions containing them and methods of treating glucokinase mediated conditions
TW200600086A (en)	2004-06-05	2006-01-01	Astrazeneca Ab	Chemical compound
GB0423042D0 (en) *	2004-10-16	2004-11-17	Astrazeneca Ab	Chemical process
BRPI0516595A (pt) *	2004-10-16	2008-09-23	Astrazeneca Ab	processo para fabricar um composto, e, composto
GB0423043D0 (en) *	2004-10-16	2004-11-17	Astrazeneca Ab	Compounds
GB0423044D0 (en) *	2004-10-16	2004-11-17	Astrazeneca Ab	Compounds
ES2476840T3 (es) *	2005-03-04	2014-07-15	F. Hoffmann-La Roche Ag	Derivados de piridina-2-carboxamida como antagonistas de MGLUR5
EP1891069A1 (fr) *	2005-05-24	2008-02-27	AstraZeneca AB	Derives d'imidazol[4,5b]pyridine/pyrazine et purine substitues en 2-phenyl en tant que modulateurs de la glucokinase
TW200714597A (en)	2005-05-27	2007-04-16	Astrazeneca Ab	Chemical compounds
RU2415141C2 (ru) *	2005-07-09	2011-03-27	Астразенека Аб	Производные гетероарилбензамида для применения в качестве активаторов glk в лечении диабета
KR20110084339A (ko)	2005-07-09	2011-07-21	아스트라제네카 아베	당뇨병 치료에 있어 ｇｌｋ 활성화제로서 사용하기 위한 헤테로아릴 벤즈아미드 유도체
US20110053910A1 (en) *	2005-07-09	2011-03-03	Mckerrecher Darren	2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes
GB0514173D0 (en) *	2005-07-09	2005-08-17	Astrazeneca Ab	Chemical compounds
WO2007017649A1 (fr) *	2005-08-09	2007-02-15	Astrazeneca Ab	Dérivés hétéroarylcarbamoylbenzène pour traiter le diabète
US9202182B2 (en) *	2005-08-11	2015-12-01	International Business Machines Corporation	Method and system for analyzing business architecture
JP2007063225A (ja)	2005-09-01	2007-03-15	Takeda Chem Ind Ltd	イミダゾピリジン化合物
EP1928874A1 (fr) *	2005-09-16	2008-06-11	AstraZeneca AB	Composés hétérobicycliques utilisés comme activateurs de la glucokinase
GT200600429A (es)	2005-09-30	2007-04-30		Compuestos organicos
JP4990783B2 (ja) *	2005-09-30	2012-08-01	Ｍｓｄ株式会社	２−ヘテロアリール置換インドール誘導体
GT200600428A (es)	2005-09-30	2007-05-21		Compuestos organicos
BRPI0616865A2 (pt)	2005-10-05	2011-07-05	Hoffmann La Roche	compostos derivados de naftiridina, processo para preparação dos mesmos, medicamentos e uso dos mesmos
TW200738621A (en)	2005-11-28	2007-10-16	Astrazeneca Ab	Chemical process
EP2001875A2 (fr)	2006-03-08	2008-12-17	Takeda San Diego, Inc.	Activateurs de la glucokinase
PE20080251A1 (es)	2006-05-04	2008-04-25	Boehringer Ingelheim Int	Usos de inhibidores de dpp iv
EP2049518B1 (fr)	2006-05-31	2011-08-31	Takeda San Diego, Inc.	Derives de l'indazole et de l'isoindazole comme agents de l'activation de glucokinase
US7910747B2 (en) *	2006-07-06	2011-03-22	Bristol-Myers Squibb Company	Phosphonate and phosphinate pyrazolylamide glucokinase activators
JP2009544648A (ja) *	2006-07-24	2009-12-17	エフ．ホフマン−ラロシュアーゲー	グルコキナーゼ活性化剤としてのピラゾール類
AR063028A1 (es) *	2006-10-06	2008-12-23	Banyu Pharma Co Ltd	Derivados heterociclicos de piridin-2-carboxamida activadores de glucoquinasas, utiles para el tratamiento de diabetes y obesidad y composiciones farmaceuticas que los contienen.
TW200825063A (en) *	2006-10-23	2008-06-16	Astrazeneca Ab	Chemical compounds
TW200825060A (en) *	2006-10-26	2008-06-16	Astrazeneca Ab	Chemical compounds
CN101563330B (zh) *	2006-10-26	2012-06-27	阿斯利康(瑞典)有限公司	作为葡糖激酶(glk)激活剂的苯甲酰氨基杂环化合物
TW200827346A (en)	2006-11-03	2008-07-01	Astrazeneca Ab	Chemical compounds
JP5419706B2 (ja)	2006-12-20	2014-02-19	タケダカリフォルニアインコーポレイテッド	グルコキナーゼアクチベーター
MX2009006729A (es) *	2006-12-21	2009-08-07	Astrazeneca Ab	Nuevo compuesto cristalino util como activador de glk.
ES2627221T3 (es)	2006-12-28	2017-07-27	Rigel Pharmaceuticals, Inc.	Compuestos de heterocicloalquiloxibenzamida N-sustituidos y métodos de uso
WO2008084872A1 (fr)	2007-01-10	2008-07-17	Mitsubishi Tanabe Pharma Corporation	Dérivé d'hydrazone
TW200836719A (en)	2007-02-12	2008-09-16	Astrazeneca Ab	Chemical compounds
WO2008116107A2 (fr)	2007-03-21	2008-09-25	Takeda San Diego, Inc.	Activateurs de glucokinase
JP2010138073A (ja) *	2007-03-30	2010-06-24	Taisho Pharmaceutical Co Ltd	ピコリン酸アミド化合物
CN101808995A (zh)	2007-07-27	2010-08-18	百时美施贵宝公司	新颖的葡糖激酶激活剂及其使用方法
EP2178852B9 (fr)	2007-08-03	2016-06-22	Romark Laboratories, L.C.	Composés thiazolide à substitution alkylsulfonyle
CA2695583A1 (fr)	2007-08-13	2009-02-19	Metabasis Therapeutics, Inc.	Nouveaux activateurs de glucokinase
AR068540A1 (es) *	2007-09-28	2009-11-18	Merck & Co Inc	Metodos de produccion de un derivado de pirazol-3-il-benzamida.
JP5457358B2 (ja) *	2007-10-09	2014-04-02	メルクパテントゲゼルシャフトミットベシュレンクテルハフツング	グルコキナーゼアクチベーターとしてのｎ−（ピラゾール−３−イル）−ベンズアミド誘導体
KR20100090250A (ko) *	2007-10-09	2010-08-13	메르크 파텐트 게엠베하	글루코키나제 활성체로서 유용한 피리딘 유도체
AU2008321959B2 (en)	2007-11-12	2014-02-13	Msd K.K.	Heteroaryloxy quinazoline derivative
JPWO2009081782A1 (ja) *	2007-12-25	2011-05-06	萬有製薬株式会社	Ｎ−ピラゾール−２−ピリジンカルボキサミド誘導体
CN102015637B (zh) *	2008-02-06	2014-05-21	第一三共株式会社	苯基吡咯衍生物
EP2245025A1 (fr) *	2008-02-27	2010-11-03	Merck Patent GmbH	Dérivés d'hétéroaryl-carboxamides utilisés pour le traitement du diabète
US7741327B2 (en)	2008-04-16	2010-06-22	Hoffmann-La Roche Inc.	Pyrrolidinone glucokinase activators
US8258134B2 (en)	2008-04-16	2012-09-04	Hoffmann-La Roche Inc.	Pyridazinone glucokinase activators
MX2011001333A (es)	2008-08-04	2011-03-15	Astrazeneca Ab	Derivados de pirazolo [3, 4] pirimidin-4-ilo y sus usos para tratar la diabetes y obesidad.
JP2012500181A (ja)	2008-08-15	2012-01-05	Ｍｓｄ株式会社	アセチルピロリジニルインドール誘導体
CA2734981A1 (fr) *	2008-08-29	2010-03-04	Banyu Pharmaceutical Co., Ltd.	Derive d'oxotetrahydrofurann-2-yl-benzimidazole
GEP20135793B (en)	2008-09-11	2013-03-25	Pfizer	Heteroaryls amide derivatives and their use as glucokinase activators
JP5514831B2 (ja)	2008-11-17	2014-06-04	メルク・シャープ・アンド・ドーム・コーポレーション	糖尿病の治療のための置換二環式アミン
UA104742C2 (uk) *	2008-12-19	2014-03-11	Эли Лилли Энд Компани	Похідні арилциклопропілацетаміду, застосовні як активатори глюкокінази
WO2010082601A1 (fr) *	2009-01-16	2010-07-22	第一三共株式会社	Nouveau dérivé de pyrrole 2,5-disubstitué
GB0902406D0 (en)	2009-02-13	2009-04-01	Astrazeneca Ab	Crystalline polymorphic form
GB0902434D0 (en)	2009-02-13	2009-04-01	Astrazeneca Ab	Chemical process
WO2010103437A1 (fr)	2009-03-11	2010-09-16	Pfizer Inc.	Dérivés de benzofuranyle utilisés comme inhibiteurs de la glucokinase
WO2010107610A1 (fr) *	2009-03-17	2010-09-23	Merck Sharp & Dohme Corp.	Méthode de traitement du diabète et des états pathologiques correspondants par thérapie combinatoire et compositions contenant de tels composés
WO2010116176A1 (fr) *	2009-04-09	2010-10-14	Astrazeneca Ab	Dérivé de pyrazolo [4, 5-e] pyrimidine et son utilisation pour traiter le diabète et l'obésité
AR076220A1 (es)	2009-04-09	2011-05-26	Astrazeneca Ab	Derivados de pirazol [4,5 - e] pirimidina
CN105853415A (zh)	2009-05-12	2016-08-17	罗马克实验室有限公司	卤代烷基杂芳基苯甲酰胺化合物
BRPI1014322A2 (pt)	2009-06-26	2015-08-25	Romark Lab Lc	Método para tratar infecção, e para interromper ou evitar a produção de partículas virais infecciosas, combinação, e, composição farmacêutica.
WO2011011506A1 (fr)	2009-07-23	2011-01-27	Schering Corporation	Composés oxazépine spirocyclique en tant qu'inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase
US20110021570A1 (en) *	2009-07-23	2011-01-27	Nancy-Ellen Haynes	Pyridone glucokinase activators
CA2768577A1 (fr)	2009-07-23	2011-01-27	Schering Corporation	Composes d?oxazepine benzofusionnes en tant qu?inhibiteurs de la coenzyme-stearoyle a delta-9 desaturase
EP2459554B1 (fr)	2009-07-31	2013-09-18	Cadila Healthcare Limited	Dérivés de benzamide substitués utiles comme activateurs de la glucokinase (gk)
BR112012016025A2 (pt) *	2009-12-11	2018-11-06	Astellas Pharma Inc.	composto de benzamida
US8222416B2 (en) *	2009-12-14	2012-07-17	Hoffmann-La Roche Inc.	Azaindole glucokinase activators
WO2011095997A1 (fr) *	2010-02-08	2011-08-11	Advinus Therapeutics Private Limited	Composés de benzamide à titre d'activateurs de glucokinase et leur application pharmaceutique
US8178689B2 (en)	2010-06-17	2012-05-15	Hoffman-La Roche Inc.	Tricyclic compounds
WO2011158149A1 (fr) *	2010-06-18	2011-12-22	Pfizer Inc.	Dérivés de 2-(3,5-disubstitutedphenyl)pyrimidin-4(3h)-one
US9000154B2 (en) *	2010-10-19	2015-04-07	Boehringer Ingelheim International Gmbh	Rho kinase inhibitors
CN106349138A (zh) *	2011-06-02	2017-01-25	奇诺因私人有限公司	用于制备前列腺素酰胺的新的方法
CN104230892B (zh) *	2011-11-09	2016-12-07	福建海西新药创制有限公司	一组提高激酶活性的化合物及其应用
CA2870488A1 (fr)	2012-04-16	2013-10-24	Kaneq Pharma Inc.	Derives de phosphonates aromatiques fusionnes utilises comme precurseurs d'inhibiteurs de ptp-1b
IN2014DN09554A (fr)	2012-05-17	2015-07-17	Transtech Pharma Llc
CN109715637B (zh) *	2016-07-22	2022-04-05	百时美施贵宝公司	葡萄糖激酶激活剂及其使用方法
WO2019023651A2 (fr) *	2017-07-28	2019-01-31	Massachusetts Institute Of Technology	Modulateurs du récepteur des androgènes à petite molécule
GB201714777D0 (en)	2017-09-14	2017-11-01	Univ London Queen Mary	Agent
CA3093025A1 (fr)	2018-06-12	2019-12-19	Vtv Therapeutics Llc	Utilisations therapeutiques d'activateurs de glucokinase en combinaison avec de l'insuline ou des analogues d'insuline
US12391658B2 (en)	2020-02-18	2025-08-19	Vtv Therapeutics Llc	Sulfoxide and sulfone glucokinase activators and methods of use thereof
US12479808B2 (en)	2020-06-08	2025-11-25	Vtv Therapeutics Llc	Salts or co-crystals of {2-[3-cyclohexyl-3-(trans-4-propoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid and uses thereof
CN113527146B (zh) *	2021-08-19	2023-04-18	广东药科大学	分子氧促进谐二氟烯烃羟化磺酰酯化反应制备β-羟基-谐二氟磺酰酯类化合物的方法
CN121712503A (zh) *	2023-06-16	2026-03-20	康特克斯生物科技美国公司	稠合二环杂环或杂芳基酰胺化合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU3091392A (en)	1991-12-11	1993-07-19	Sasol Chemicals Europe Limited	Method to produce single cell oil containing gamma-linolenic acid
GB9725298D0 (en) *	1997-11-28	1998-01-28	Zeneca Ltd	Insecticidal thiazole derivatives
US6268387B1 (en) *	1997-12-23	2001-07-31	Warner-Lambert Company	Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis
SE0102300D0 (sv) *	2001-06-26	2001-06-26	Astrazeneca Ab	Compounds
SE0102764D0 (sv)	2001-08-17	2001-08-17	Astrazeneca Ab	Compounds
WO2003080585A1 (fr) *	2002-03-26	2003-10-02	Banyu Pharmaceutical Co., Ltd.	Derive aminobenzamide
GB0327761D0 (en) *	2003-11-29	2003-12-31	Astrazeneca Ab	Compounds
JP2007523905A (ja) *	2004-02-18	2007-08-23	アストラゼネカアクチボラグ	化合物
EP2048137A1 (fr) *	2004-02-18	2009-04-15	AstraZeneca AB	Dérivés de la benzamide et leur utilisation comme activateurs de la glucokinase.

2004
- 2004-02-26 WO PCT/JP2004/002284 patent/WO2004076420A1/fr not_active Ceased
- 2004-02-26 EP EP04714930.7A patent/EP1600442B1/fr not_active Expired - Lifetime
- 2004-02-26 MX MXPA05009059A patent/MXPA05009059A/es active IP Right Grant
- 2004-02-26 CA CA2516407A patent/CA2516407C/fr not_active Expired - Lifetime
- 2004-02-26 US US10/546,962 patent/US7432287B2/en not_active Expired - Lifetime
- 2004-02-26 CN CN200910259049A patent/CN101712657A/zh active Pending
- 2004-02-26 UA UAA200509024A patent/UA81468C2/xx unknown
- 2004-02-26 RU RU2005129729/04A patent/RU2330030C2/ru not_active IP Right Cessation
- 2004-02-26 KR KR1020057015810A patent/KR20050105488A/ko not_active Ceased
- 2004-02-26 NZ NZ541824A patent/NZ541824A/en unknown
- 2004-02-26 JP JP2005502928A patent/JP4432901B2/ja not_active Expired - Lifetime
- 2004-02-26 AU AU2004215514A patent/AU2004215514B2/en not_active Expired
- 2004-02-26 BR BRPI0407810-1A patent/BRPI0407810A/pt not_active Application Discontinuation
2005
- 2005-08-22 MA MA28448A patent/MA27660A1/fr unknown
- 2005-08-26 EC EC2005005987A patent/ECSP055987A/es unknown
- 2005-09-23 NO NO20054425A patent/NO20054425L/no not_active Application Discontinuation
2008
- 2008-09-05 US US12/231,856 patent/US7754743B2/en not_active Expired - Lifetime

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Publication number	Publication date
CA2516407C (fr)	2013-07-09
JPWO2004076420A1 (ja)	2006-06-01
BRPI0407810A (pt)	2006-03-01
NZ541824A (en)	2010-04-30
HK1091204A1 (zh)	2007-01-12
JP4432901B2 (ja)	2010-03-17
CA2516407A1 (fr)	2004-09-10
AU2004215514B2 (en)	2010-03-04
WO2004076420A1 (fr)	2004-09-10
EP1600442A4 (fr)	2006-11-02
US7754743B2 (en)	2010-07-13
KR20050105488A (ko)	2005-11-04
CN101712657A (zh)	2010-05-26
MXPA05009059A (es)	2005-10-19
NO20054425L (no)	2005-09-23
US20060167053A1 (en)	2006-07-27
EP1600442B1 (fr)	2018-01-17
RU2005129729A (ru)	2006-03-20
US7432287B2 (en)	2008-10-07
RU2330030C2 (ru)	2008-07-27
AU2004215514A1 (en)	2004-09-10
EP1600442A1 (fr)	2005-11-30
US20090018056A1 (en)	2009-01-15
MA27660A1 (fr)	2005-12-01
ECSP055987A (es)	2006-01-16

Publication	Publication Date	Title
MXPA05009059A (es)	2005-10-19	Derivados de heteroarilcarbamoilbenceno.
MX2009010024A (es)	2009-10-12	Nuevo compuesto de adenina.
MXPA05008619A (es)	2005-11-04	Derivados novedosos de 2-piridincarboxamida.
TW200736363A (en)	2007-10-01	Material for organic electroluminescent device and organic electroluminescent device
TNSN08372A1 (en)	2009-12-29	Heterocyclic amides for use as pharmaceuticals
PH12012501711A1 (en)	2012-11-12	[5,6] heterocyclic compound
DE602005023343D1 (de)	2010-10-14	Pyrimidinderivate als gpcr-agonisten
MXPA04004037A (es)	2004-07-23	Compuestos novedosos de 1, 2, 4-de triazol.
TNSN07397A1 (en)	2009-03-17	Acetylene derivatives
TW200611907A (en)	2006-04-16	Fused heterocyclic compound
AP1902A (en)	2008-10-15	N-aryl-2-oxazolidinone-5-carboxamides and their derivatives and their use as antibacterials
TN2010000091A1 (en)	2011-09-26	Substituted pyrazole derivative
EP1731523A4 (fr)	2009-08-12	Dérivé de thiazolopyrimidine
MY150269A (en)	2013-12-31	Novel phenylpyrrole derivative
SG162805A1 (en)	2010-07-29	Pyrazine derivatives useful as adenosine receptor antagonists
PE20091842A1 (es)	2009-12-04	Pirrolidinonas como activadores de glucoquinasa
EP1734040A4 (fr)	2007-11-28	Derive de la quinazoline ou de la pyridopyrimidine substituee
MX2009010824A (es)	2009-10-29	Compuesto de hidrazida heterociclica y uso pesticida del mismo.
MX2009012885A (es)	2009-12-10	Nuevo derivado de 1,2,3,4-tetrahidroquinoxalina que tiene, como sustituyente, grupo fenilo que tiene estructura de ester de acido sulfonico o estructura de amida de acido sulfonico introducida en este, y tiene actividad de enlace al receptor de gluco
WO2009057784A1 (fr)	2009-05-07	Composé hétérocyclique
CO6160314A2 (es)	2010-05-20	Compuestos benzoil amino heterociclil como activadores de la glucoquinasa (glk)
TW200745032A (en)	2007-12-16	Novel heterobicyclic derivatives
GB0412769D0 (en)	2004-07-07	Organic compounds
TW200745034A (en)	2007-12-16	New compounds
WO2009018065A3 (fr)	2009-05-07	Nouveaux activateurs de glucokinase et procédés pour les utiliser