UA81908C2 - Рекомбинантный химерный белок - антагонист anth1 - Google Patents
Рекомбинантный химерный белок - антагонист anth1 Download PDFInfo
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- UA81908C2 UA81908C2 UA20041210147A UA20041210147A UA81908C2 UA 81908 C2 UA81908 C2 UA 81908C2 UA 20041210147 A UA20041210147 A UA 20041210147A UA 20041210147 A UA20041210147 A UA 20041210147A UA 81908 C2 UA81908 C2 UA 81908C2
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- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
Abstract
Рекомбинантный химерный антагонист, в состав которого входит фрагмент цитокина, который кодирует 60 аминокислот N-концевого участка человеческого интерлейкина-2 (IL-2), слитый с N-концом внеклеточного участка альфа-субъединицы рецептора гамма-интерферона через соединительный пептид. Этот белок in vitro стимулирует рост Т-клеток, подавляет рост-стимулирующую активность IL-2 в отношении Т-клеток, подавляет индукцию HLA-DRи подавляет антипролиферативную активность. Это изобретение может применяться в медицине для лечения таких патологий, как, например, аутоиммунных заболеваний, отторжения трансплантатов, хронических воспалений, сепсиса, ишемии, синдрома реперфузии и атеросклероза.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20020095A CU23229A1 (es) | 2002-05-10 | 2002-05-10 | ANTAGONISTA QUIMéRICO ANTH1 |
| PCT/CU2003/000006 WO2003095488A1 (es) | 2002-05-10 | 2003-05-08 | Antagonista quimérico anth1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA81908C2 true UA81908C2 (ru) | 2008-02-25 |
Family
ID=40091620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20041210147A UA81908C2 (ru) | 2002-05-10 | 2003-08-05 | Рекомбинантный химерный белок - антагонист anth1 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7429384B2 (ru) |
| EP (1) | EP1550672B1 (ru) |
| JP (1) | JP4275065B2 (ru) |
| KR (1) | KR20040108786A (ru) |
| CN (1) | CN100384873C (ru) |
| AR (1) | AR039973A1 (ru) |
| AT (1) | ATE439379T1 (ru) |
| AU (1) | AU2003223832B2 (ru) |
| BR (1) | BR0304827A (ru) |
| CA (1) | CA2485439A1 (ru) |
| CU (1) | CU23229A1 (ru) |
| DE (1) | DE60328807D1 (ru) |
| MX (1) | MXPA04011143A (ru) |
| RU (1) | RU2322455C2 (ru) |
| UA (1) | UA81908C2 (ru) |
| WO (1) | WO2003095488A1 (ru) |
| ZA (1) | ZA200409073B (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2274416B1 (en) | 2008-04-09 | 2017-01-18 | Cornell University | Commensal bacteria as signal mediators within a mammalian host |
| CN103429742A (zh) | 2010-10-15 | 2013-12-04 | 康奈尔大学 | 用于治疗内分泌、胃肠或自体免疫性疾病的组合物和方法 |
| CA2913205C (en) * | 2013-05-08 | 2023-01-03 | Gr Intellectual Reserve, Llc | Methods and treatment for certain demyelination and dysmyelination-based disorders and/or promoting remyelination |
| CN107266586A (zh) * | 2017-08-09 | 2017-10-20 | 安徽九川生物科技有限公司 | 一种重组猪长效干扰素γ及制备此长效干扰素γ的融合蛋白及其制备方法 |
| CA3086486A1 (en) | 2018-09-17 | 2020-03-26 | Gi Innovation, Inc. | Fusion protein comprising il-2 protein and cd80 protein, and use thereof |
| IL314996A (en) | 2019-01-24 | 2024-10-01 | Univ Central Florida Res Found Inc | Compositions and methods for stimulating natural killer cells |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0393502T3 (da) | 1989-04-19 | 1996-03-04 | Hoffmann La Roche | Opløselige interferon-gamma-receptorer og fremgangsmåder til fremstilling heraf |
| US5073627A (en) * | 1989-08-22 | 1991-12-17 | Immunex Corporation | Fusion proteins comprising GM-CSF and IL-3 |
| CA2114168A1 (en) * | 1993-03-05 | 1994-09-06 | Zlatko Dembic | Chimeric human interferon-gamma-receptor/immunoglobulin polypeptides |
| EP0689451A4 (en) * | 1993-03-19 | 1997-08-20 | Immunex Corp | PHARMACEUTICAL COMPOSITIONS COMPRISING A LIGAND COMPLEXED WITH A SOLUBLE RECEPTOR |
| EP0621338A3 (en) * | 1993-04-21 | 1997-10-29 | Ajinomoto Kk | The interleukin-2 response blocking immunosuppressor. |
-
2002
- 2002-05-10 CU CU20020095A patent/CU23229A1/es unknown
-
2003
- 2003-05-07 AR ARP030101604A patent/AR039973A1/es active IP Right Grant
- 2003-05-08 AT AT03720120T patent/ATE439379T1/de not_active IP Right Cessation
- 2003-05-08 CA CA002485439A patent/CA2485439A1/en not_active Abandoned
- 2003-05-08 BR BR0304827-6A patent/BR0304827A/pt not_active IP Right Cessation
- 2003-05-08 RU RU2004136170/13A patent/RU2322455C2/ru active
- 2003-05-08 KR KR10-2004-7017991A patent/KR20040108786A/ko not_active Ceased
- 2003-05-08 CN CNB038141264A patent/CN100384873C/zh not_active Expired - Fee Related
- 2003-05-08 AU AU2003223832A patent/AU2003223832B2/en not_active Ceased
- 2003-05-08 DE DE60328807T patent/DE60328807D1/de not_active Expired - Fee Related
- 2003-05-08 WO PCT/CU2003/000006 patent/WO2003095488A1/es not_active Ceased
- 2003-05-08 EP EP03720120A patent/EP1550672B1/en not_active Expired - Lifetime
- 2003-05-08 MX MXPA04011143A patent/MXPA04011143A/es active IP Right Grant
- 2003-05-08 JP JP2004503502A patent/JP4275065B2/ja not_active Expired - Fee Related
- 2003-05-08 US US10/513,931 patent/US7429384B2/en not_active Expired - Fee Related
- 2003-08-05 UA UA20041210147A patent/UA81908C2/ru unknown
-
2004
- 2004-11-09 ZA ZA200409073A patent/ZA200409073B/en unknown
-
2007
- 2007-01-22 US US11/656,301 patent/US20070160575A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP4275065B2 (ja) | 2009-06-10 |
| BR0304827A (pt) | 2004-08-17 |
| JP2006506958A (ja) | 2006-03-02 |
| WO2003095488A1 (es) | 2003-11-20 |
| CN1662555A (zh) | 2005-08-31 |
| CN100384873C (zh) | 2008-04-30 |
| US20060073115A1 (en) | 2006-04-06 |
| KR20040108786A (ko) | 2004-12-24 |
| AR039973A1 (es) | 2005-03-09 |
| MXPA04011143A (es) | 2005-01-25 |
| US7429384B2 (en) | 2008-09-30 |
| CA2485439A1 (en) | 2003-11-20 |
| EP1550672B1 (en) | 2009-08-12 |
| RU2004136170A (ru) | 2005-05-27 |
| ZA200409073B (en) | 2005-05-09 |
| RU2322455C2 (ru) | 2008-04-20 |
| CU23229A1 (es) | 2007-09-26 |
| AU2003223832B2 (en) | 2009-02-19 |
| US20070160575A1 (en) | 2007-07-12 |
| EP1550672A1 (en) | 2005-07-06 |
| ATE439379T1 (de) | 2009-08-15 |
| DE60328807D1 (de) | 2009-09-24 |
| AU2003223832A1 (en) | 2003-11-11 |
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