UA86082C2 - Производные 4-арилморфолин-3-она, способ их получения и их применение в терапии - Google Patents

Производные 4-арилморфолин-3-она, способ их получения и их применение в терапии

Info

Publication number
UA86082C2
UA86082C2 UAA200701878A UAA200701878A UA86082C2 UA 86082 C2 UA86082 C2 UA 86082C2 UA A200701878 A UAA200701878 A UA A200701878A UA A200701878 A UAA200701878 A UA A200701878A UA 86082 C2 UA86082 C2 UA 86082C2
Authority
UA
Ukraine
Prior art keywords
derivatives
therapeutic use
unsubstituted
arylmorpholin
preparation
Prior art date
Application number
UAA200701878A
Other languages
English (en)
Ukrainian (uk)
Inventor
Ксавье Эмон-Альт
Винченцо Проиетто
Original Assignee
Санофи-Авентис
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи-Авентис filed Critical Санофи-Авентис
Publication of UA86082C2 publication Critical patent/UA86082C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Объектом изобретения являются соединения формулы (І), в которой: Аr означает фенил, моно- или двузамещенный;Rозначает фенил, незамещенный или замещенный;Rозначает: пиридил; фенил, незамещенный или замещенный; бензил, незамещенный или замещенный по фенилу;кроме того, Rможет означать гетероциклический радикал;Rимеет разные значения.Способ получения и применение в терапии.(І)
UAA200701878A 2004-07-23 2005-07-20 Производные 4-арилморфолин-3-она, способ их получения и их применение в терапии UA86082C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0408222A FR2873373B1 (fr) 2004-07-23 2004-07-23 Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
UA86082C2 true UA86082C2 (ru) 2009-03-25

Family

ID=34951659

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200701878A UA86082C2 (ru) 2004-07-23 2005-07-20 Производные 4-арилморфолин-3-она, способ их получения и их применение в терапии

Country Status (29)

Country Link
US (1) US7521449B2 (ru)
EP (1) EP1773823B1 (ru)
JP (1) JP4812759B2 (ru)
KR (1) KR20070034066A (ru)
CN (1) CN101006084B (ru)
AR (1) AR050262A1 (ru)
AU (1) AU2005276352A1 (ru)
BR (1) BRPI0513581A (ru)
CA (1) CA2573446A1 (ru)
CR (1) CR8843A (ru)
EA (1) EA011035B1 (ru)
EC (1) ECSP077181A (ru)
FR (1) FR2873373B1 (ru)
GT (1) GT200500196A (ru)
HN (1) HN2005000380A (ru)
IL (1) IL180484A0 (ru)
MA (1) MA28741B1 (ru)
MX (1) MX2007000814A (ru)
MY (1) MY142757A (ru)
NO (1) NO20071020L (ru)
PA (1) PA8640101A1 (ru)
PE (1) PE20060553A1 (ru)
SV (1) SV2006002176A (ru)
TN (1) TNSN06438A1 (ru)
TW (1) TW200603800A (ru)
UA (1) UA86082C2 (ru)
UY (1) UY29022A1 (ru)
WO (1) WO2006021654A1 (ru)
ZA (1) ZA200700603B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2912058A1 (fr) * 2007-02-07 2008-08-08 Sanofi Aventis Sa Utilisation d'un compose antagoniste des recepteurs nk2 de la neurokinine a pour la preparation de medicaments utiles pour la prevention et le traitement des dysfonctions sexuelles
EP3915560A1 (en) 2014-06-25 2021-12-01 Emory University Methods of managing conditioned fear with neurokinin receptor antagonists

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2751654B1 (fr) * 1996-07-26 1998-10-23 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2729954B1 (fr) * 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2738819B1 (fr) * 1995-09-14 1997-12-05 Sanofi Sa Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant
HU224225B1 (hu) * 1995-12-01 2005-06-28 Sankyo Co. Ltd. Tachikinin receptor antagonista hatású heterociklusos vegyületek, ezek előállítási eljárása és alkalmazásuk gyógyszerkészítmények előállítására
GB9601680D0 (en) * 1996-01-27 1996-03-27 Pfizer Ltd Therapeutic agents
KR100610538B1 (ko) * 1997-12-04 2006-08-09 상꾜 가부시키가이샤 지환식 아실화 복소환 유도체
JPH11240880A (ja) * 1997-12-04 1999-09-07 Sankyo Co Ltd 脂環式アシル化複素環誘導体
GB9812037D0 (en) * 1998-06-04 1998-07-29 Pfizer Ltd Piperidones
FR2789390B3 (fr) * 1999-02-10 2001-03-09 Sanofi Sa Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant
FR2791346B3 (fr) * 1999-03-25 2001-04-27 Sanofi Sa Nouveaux derives de morpholine, procede pour leur preparation et compositions pharmaceutiques les contenant
CN1434805A (zh) * 1999-12-17 2003-08-06 先灵公司 选择性神经激肽拮抗剂
FR2824828B1 (fr) * 2001-05-21 2005-05-20 Sanofi Synthelabo Nouveaux derives de piperidinecarboxamide, un procede pour leur preparation et les compositions pharmaceutiques les contenant
GB0130261D0 (en) * 2001-12-18 2002-02-06 Pfizer Ltd Lactams as tachykinin antagonists

Also Published As

Publication number Publication date
MY142757A (en) 2010-12-31
EA200700098A1 (ru) 2007-06-29
CN101006084A (zh) 2007-07-25
MA28741B1 (fr) 2007-07-02
SV2006002176A (es) 2006-01-13
PE20060553A1 (es) 2006-07-04
AR050262A1 (es) 2006-10-11
EP1773823A1 (fr) 2007-04-18
JP2008507497A (ja) 2008-03-13
EP1773823B1 (fr) 2013-08-21
FR2873373B1 (fr) 2006-09-08
IL180484A0 (en) 2007-06-03
NO20071020L (no) 2007-02-22
EA011035B1 (ru) 2008-12-30
BRPI0513581A (pt) 2008-05-13
TW200603800A (en) 2006-02-01
PA8640101A1 (es) 2006-03-24
ZA200700603B (en) 2008-10-29
CN101006084B (zh) 2010-09-08
WO2006021654A8 (fr) 2007-05-24
AU2005276352A1 (en) 2006-03-02
HN2005000380A (es) 2009-05-14
FR2873373A1 (fr) 2006-01-27
US7521449B2 (en) 2009-04-21
ECSP077181A (es) 2007-02-28
HK1107340A1 (en) 2008-04-03
MX2007000814A (es) 2007-04-02
US20070142349A1 (en) 2007-06-21
TNSN06438A1 (fr) 2008-02-22
JP4812759B2 (ja) 2011-11-09
CR8843A (es) 2007-08-28
GT200500196A (es) 2006-03-02
KR20070034066A (ko) 2007-03-27
UY29022A1 (es) 2006-02-24
CA2573446A1 (fr) 2006-03-02
WO2006021654A1 (fr) 2006-03-02

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