ECSP077181A - Derivados de la 4-arilmorfolin-3-ona, su preparación y su aplicación en terapéutica - Google Patents

Derivados de la 4-arilmorfolin-3-ona, su preparación y su aplicación en terapéutica

Info

Publication number
ECSP077181A
ECSP077181A EC2007007181A ECSP077181A ECSP077181A EC SP077181 A ECSP077181 A EC SP077181A EC 2007007181 A EC2007007181 A EC 2007007181A EC SP077181 A ECSP077181 A EC SP077181A EC SP077181 A ECSP077181 A EC SP077181A
Authority
EC
Ecuador
Prior art keywords
therapeutics
preparation
application
arilmorfolin
ona
Prior art date
Application number
EC2007007181A
Other languages
English (en)
Inventor
Xavier Emonds-Alt
Vincenzo Proietto
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of ECSP077181A publication Critical patent/ECSP077181A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La invención tiene por objeto compuestos que responden a la fórmula (I) en la que Ar representa un fenilo mono-o disustituido; R1 representa un fenilo no sustituido o sustituido; R2 representa un piridilo; un fenilo no sustituido o sustituido, un bencilo no sustituido o sustituido sobre el fenilo; R2 puede además representar un radical heterocíclico; R3 representa diferentes valores. Procedimiento de preparación y aplicación en terapéutica.
EC2007007181A 2004-07-23 2007-01-17 Derivados de la 4-arilmorfolin-3-ona, su preparación y su aplicación en terapéutica ECSP077181A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0408222A FR2873373B1 (fr) 2004-07-23 2004-07-23 Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique
PCT/FR2005/001852 WO2006021654A1 (fr) 2004-07-23 2005-07-20 Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ECSP077181A true ECSP077181A (es) 2007-02-28

Family

ID=34951659

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2007007181A ECSP077181A (es) 2004-07-23 2007-01-17 Derivados de la 4-arilmorfolin-3-ona, su preparación y su aplicación en terapéutica

Country Status (29)

Country Link
US (1) US7521449B2 (es)
EP (1) EP1773823B1 (es)
JP (1) JP4812759B2 (es)
KR (1) KR20070034066A (es)
CN (1) CN101006084B (es)
AR (1) AR050262A1 (es)
AU (1) AU2005276352A1 (es)
BR (1) BRPI0513581A (es)
CA (1) CA2573446A1 (es)
CR (1) CR8843A (es)
EA (1) EA011035B1 (es)
EC (1) ECSP077181A (es)
FR (1) FR2873373B1 (es)
GT (1) GT200500196A (es)
HN (1) HN2005000380A (es)
IL (1) IL180484A0 (es)
MA (1) MA28741B1 (es)
MX (1) MX2007000814A (es)
MY (1) MY142757A (es)
NO (1) NO20071020L (es)
PA (1) PA8640101A1 (es)
PE (1) PE20060553A1 (es)
SV (1) SV2006002176A (es)
TN (1) TNSN06438A1 (es)
TW (1) TW200603800A (es)
UA (1) UA86082C2 (es)
UY (1) UY29022A1 (es)
WO (1) WO2006021654A1 (es)
ZA (1) ZA200700603B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2912058A1 (fr) * 2007-02-07 2008-08-08 Sanofi Aventis Sa Utilisation d'un compose antagoniste des recepteurs nk2 de la neurokinine a pour la preparation de medicaments utiles pour la prevention et le traitement des dysfonctions sexuelles
US10314835B2 (en) 2014-06-25 2019-06-11 Emory University Methods of managing conditioned fear with neurokinin receptor antagonists

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2729954B1 (fr) * 1995-01-30 1997-08-01 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2751654B1 (fr) * 1996-07-26 1998-10-23 Sanofi Sa Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2738819B1 (fr) * 1995-09-14 1997-12-05 Sanofi Sa Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant
RU2135494C1 (ru) * 1995-12-01 1999-08-27 Санкио Компани Лимитед Гетероциклические соединения и композиция на их основе, проявляющая антагонистическое действие в отношении рецепторов тахикинина
GB9601680D0 (en) * 1996-01-27 1996-03-27 Pfizer Ltd Therapeutic agents
JPH11240880A (ja) * 1997-12-04 1999-09-07 Sankyo Co Ltd 脂環式アシル化複素環誘導体
ES2243012T3 (es) * 1997-12-04 2005-11-16 Sankyo Company Limited Derivados heterociclicos aliciclicos acilados.
GB9812037D0 (en) * 1998-06-04 1998-07-29 Pfizer Ltd Piperidones
FR2789390B3 (fr) * 1999-02-10 2001-03-09 Sanofi Sa Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant
FR2791346B3 (fr) * 1999-03-25 2001-04-27 Sanofi Sa Nouveaux derives de morpholine, procede pour leur preparation et compositions pharmaceutiques les contenant
JP2003522739A (ja) * 1999-12-17 2003-07-29 シェーリング コーポレイション 選択的ニューロキニンアンタゴニスト
FR2824828B1 (fr) * 2001-05-21 2005-05-20 Sanofi Synthelabo Nouveaux derives de piperidinecarboxamide, un procede pour leur preparation et les compositions pharmaceutiques les contenant
GB0130261D0 (en) * 2001-12-18 2002-02-06 Pfizer Ltd Lactams as tachykinin antagonists

Also Published As

Publication number Publication date
EP1773823B1 (fr) 2013-08-21
FR2873373B1 (fr) 2006-09-08
EA200700098A1 (ru) 2007-06-29
NO20071020L (no) 2007-02-22
TW200603800A (en) 2006-02-01
CA2573446A1 (fr) 2006-03-02
HK1107340A1 (en) 2008-04-03
MY142757A (en) 2010-12-31
EP1773823A1 (fr) 2007-04-18
TNSN06438A1 (fr) 2008-02-22
CN101006084B (zh) 2010-09-08
JP4812759B2 (ja) 2011-11-09
UY29022A1 (es) 2006-02-24
US20070142349A1 (en) 2007-06-21
GT200500196A (es) 2006-03-02
MA28741B1 (fr) 2007-07-02
US7521449B2 (en) 2009-04-21
CR8843A (es) 2007-08-28
PE20060553A1 (es) 2006-07-04
HN2005000380A (es) 2009-05-14
AR050262A1 (es) 2006-10-11
KR20070034066A (ko) 2007-03-27
SV2006002176A (es) 2006-01-13
BRPI0513581A (pt) 2008-05-13
JP2008507497A (ja) 2008-03-13
FR2873373A1 (fr) 2006-01-27
MX2007000814A (es) 2007-04-02
PA8640101A1 (es) 2006-03-24
CN101006084A (zh) 2007-07-25
IL180484A0 (en) 2007-06-03
WO2006021654A8 (fr) 2007-05-24
WO2006021654A1 (fr) 2006-03-02
EA011035B1 (ru) 2008-12-30
AU2005276352A1 (en) 2006-03-02
ZA200700603B (en) 2008-10-29
UA86082C2 (ru) 2009-03-25

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