UA86350C2 - Normal;heading 1;heading 2;MAMMALIAN CYTOKINE-LIKE POLYPEPTIDE-10 - Google Patents

Normal;heading 1;heading 2;MAMMALIAN CYTOKINE-LIKE POLYPEPTIDE-10

Info

Publication number
UA86350C2
UA86350C2 UAA200500986A UA2005000986A UA86350C2 UA 86350 C2 UA86350 C2 UA 86350C2 UA A200500986 A UAA200500986 A UA A200500986A UA 2005000986 A UA2005000986 A UA 2005000986A UA 86350 C2 UA86350 C2 UA 86350C2
Authority
UA
Ukraine
Prior art keywords
polypeptide
heading
zcyto10
antibody
expression vector
Prior art date
Application number
UAA200500986A
Other languages
English (en)
Ukrainian (uk)
Inventor
Деррел К. Конклин
Бетти А. Хелдмен
Анжелика Гросман
Original Assignee
Займодженетикс, Инк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Займодженетикс, Инк filed Critical Займодженетикс, Инк
Publication of UA86350C2 publication Critical patent/UA86350C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Environmental Sciences (AREA)
  • Dermatology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Animal Husbandry (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)

Abstract

Изобретение относится к цитокиноподобным полипептидам млекопитающих Zcyto10 и их применению для изготовления лекарства для усиления заживления ран, для борьбы с микробными или вирусными инфекциями, для предупреждения и лечения тромбоцитопении, обусловленной химиотерапией или радиационной терапией у больных раком. Заявлен экспресионный вектор, который включает цитокиноподобный полипептид млекопитающих Zcyto10, культивированную эвкариотную или прокариотную клетку, в которую введен данный вектор, антитела, которые специфично связывают упомянутый полипептид, и антиидиотипические антитела, которые связывают антитела.
UAA200500986A 1997-11-26 1998-11-25 Normal;heading 1;heading 2;MAMMALIAN CYTOKINE-LIKE POLYPEPTIDE-10 UA86350C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97915697A 1997-11-26 1997-11-26

Publications (1)

Publication Number Publication Date
UA86350C2 true UA86350C2 (en) 2009-04-27

Family

ID=25526742

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA200500986A UA86350C2 (en) 1997-11-26 1998-11-25 Normal;heading 1;heading 2;MAMMALIAN CYTOKINE-LIKE POLYPEPTIDE-10
UA2000063693A UA73275C2 (en) 1997-11-26 1998-11-25 A mammalian cytokine-like polypeptide

Family Applications After (1)

Application Number Title Priority Date Filing Date
UA2000063693A UA73275C2 (en) 1997-11-26 1998-11-25 A mammalian cytokine-like polypeptide

Country Status (20)

Country Link
EP (3) EP1424393A3 (ru)
JP (2) JP5191619B2 (ru)
KR (1) KR100574387B1 (ru)
CN (2) CN1618969A (ru)
AT (1) ATE269902T1 (ru)
AU (1) AU739420B2 (ru)
BR (1) BR9814904A (ru)
CA (1) CA2312000C (ru)
CZ (1) CZ300849B6 (ru)
DE (1) DE69824755T2 (ru)
DK (1) DK1032671T3 (ru)
EA (2) EA005581B1 (ru)
ES (1) ES2218872T3 (ru)
HU (1) HU227703B1 (ru)
IL (2) IL136076A0 (ru)
NO (2) NO326561B1 (ru)
NZ (1) NZ504751A (ru)
PL (2) PL195304B1 (ru)
UA (2) UA86350C2 (ru)
WO (1) WO1999027103A1 (ru)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945511A (en) * 1997-02-20 1999-08-31 Zymogenetics, Inc. Class II cytokine receptor
EP2295079A3 (en) * 1999-12-23 2011-03-23 ZymoGenetics, L.L.C. Method for treating inflammation
US6610286B2 (en) 1999-12-23 2003-08-26 Zymogenetics, Inc. Method for treating inflammation using soluble receptors to interleukin-20
DE60045139D1 (de) 1999-12-23 2010-12-02 Zymogenetics Inc Löslicher Interleukin-20-Rezeptor
EP2177616B1 (en) 2000-08-08 2012-02-29 ZymoGenetics, Inc. Soluble zcytor 11 cytokine receptors
EP1803733B1 (en) 2000-09-15 2010-03-10 ZymoGenetics, Inc. Polypeptides comprising the extracellular domains of IL-20RA and/or IL-20RB
WO2002034917A2 (en) * 2000-10-20 2002-05-02 Zymogenetics, Inc. Secreted alpha-helical cytokine-like protein zlmda24
EP1390060A2 (en) * 2001-01-26 2004-02-25 Eli Lilly And Company Use of lp82 to treat body weight disorders
CA2433933A1 (en) * 2001-02-28 2002-09-12 Eli Lilly And Company Use of lp82 to treat hematopoietic disorders
WO2003035096A1 (en) * 2001-10-22 2003-05-01 Eli Lilly And Company Soluble proteins that inhibit cytokine signal transduction pathways
IL161978A0 (en) 2001-12-17 2005-11-20 Zymogenetics Inc Method for treating cervical cancer
EP1606317B1 (en) 2003-03-24 2010-07-28 ZymoGenetics, Inc. Anti-il-22ra antibodies and binding partners and methods of using in inflammation
JP2007501813A (ja) * 2003-08-08 2007-02-01 ノボ　ノルディスク　アクティーゼルスカブ 新生血管形成と関連した症状を治療および診断するためのインターロイキン−２０
EP2143733A1 (en) 2003-11-21 2010-01-13 ZymoGenetics, Inc. ANTI-IL-20 antibodies and binding partners and methods of using in inflammation
WO2005059127A1 (en) 2003-12-19 2005-06-30 Novo Nordisk A/S Processing of peptides and proteins
ES2642214T3 (es) 2004-01-21 2017-11-15 Novo Nordisk Health Care Ag Conjugación de péptidos mediante transglutaminasa
ATE517914T1 (de) 2004-03-08 2011-08-15 Zymogenetics Inc Dimere fusionsproteine und materialien und verfahren zu deren herstellung
EA015706B1 (ru) 2004-10-22 2011-10-31 Займоджинетикс, Инк. Моноклональное антитело или его фрагмент, связывающиеся с полипептидом il-22ra, гуманизированное антитело, полученное из указанного антитела, гибридомы, продуцирующие антитело, и применение указанного антитела
EP2192132A3 (en) 2005-02-08 2010-08-18 ZymoGenetics, Inc. Anti-IL-20, anti-IL22 and anti-IL-22RA antibodies and binding partners and methods of using in inflammation
EP2636757B1 (en) 2008-05-27 2016-11-23 Dako Denmark A/S Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers
RU2011101969A (ru) 2008-06-30 2012-08-10 Ново Нордиск А/С (DK) Антитела к человеческому интерлейкину-20
EP2340039B1 (en) * 2008-10-07 2015-11-25 National Cheng Kung University Use of il-20 antagonists for treating osteoporosis
US9303287B2 (en) 2009-02-26 2016-04-05 Dako Denmark A/S Compositions and methods for RNA hybridization applications
US8454956B2 (en) 2009-08-31 2013-06-04 National Cheng Kung University Methods for treating rheumatoid arthritis and osteoporosis with anti-IL-20 antibodies
WO2013046033A1 (en) 2011-09-30 2013-04-04 Dako Denmark A/S Hybridization compositions and methods using formamide
US11118226B2 (en) 2011-10-21 2021-09-14 Agilent Technologies, Inc. Hybridization compositions and methods
CA2864523C (en) * 2012-03-05 2019-02-05 Seegene, Inc. Detection of nucleotide variation on target nucleic acid sequence by pto cleavage and extension assay
WO2013164440A1 (en) 2012-05-03 2013-11-07 Novo Nordisk A/S Methods related to treatment of inflammatory diseases and disorders
US9221904B2 (en) 2012-07-19 2015-12-29 National Cheng Kung University Treatment of osteoarthritis using IL-20 antagonists
US8852588B2 (en) 2012-08-07 2014-10-07 National Cheng Kung University Treating allergic airway disorders using anti-IL-20 receptor antibodies
US8603470B1 (en) 2012-08-07 2013-12-10 National Cheng Kung University Use of IL-20 antagonists for treating liver diseases
WO2017202813A1 (en) 2016-05-24 2017-11-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of pulmonary bacterial infections
EP3615570A4 (en) 2017-04-25 2021-02-24 LBL Biotechnology Inc. USE OF IL-20 ANTAGONISTS FOR TREATMENT OF EYE DISEASES
CN114829372A (zh) * 2019-10-10 2022-07-29 纽约州立大学研究基金会 镇痛和麻醉的肽及其他试剂
CN113248567B (zh) * 2021-02-10 2023-02-03 渤海大学 一种苦味受体阻滞肽及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001500369A (ja) * 1996-08-30 2001-01-16 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド インターロイキン―１９
EP2295079A3 (en) * 1999-12-23 2011-03-23 ZymoGenetics, L.L.C. Method for treating inflammation

Also Published As

Publication number Publication date
AU1607799A (en) 1999-06-15
NO329731B1 (no) 2010-12-13
EA005581B1 (ru) 2005-04-28
KR20010032490A (ko) 2001-04-25
PL198687B1 (pl) 2008-07-31
EP1719780A3 (en) 2006-12-20
HUP0100436A3 (en) 2003-08-28
CZ20001910A3 (cs) 2000-11-15
CA2312000C (en) 2013-03-26
CZ300849B6 (cs) 2009-08-26
WO1999027103A1 (en) 1999-06-03
NO326561B1 (no) 2009-01-12
HUP0100436A2 (hu) 2001-06-28
ATE269902T1 (de) 2004-07-15
EA010741B1 (ru) 2008-10-30
ES2218872T3 (es) 2004-11-16
CA2312000A1 (en) 1999-06-03
NO20002698D0 (no) 2000-05-26
BR9814904A (pt) 2000-10-03
JP2001524313A (ja) 2001-12-04
HU227703B1 (en) 2011-12-28
CN1247780C (zh) 2006-03-29
IL136076A (en) 2007-12-03
PL340755A1 (en) 2001-02-26
EP1032671B1 (en) 2004-06-23
CN1282372A (zh) 2001-01-31
JP5191619B2 (ja) 2013-05-08
PL195304B1 (pl) 2007-08-31
EP1424393A3 (en) 2004-06-09
DE69824755T2 (de) 2005-08-04
EA200000565A1 (ru) 2000-12-25
JP2010187698A (ja) 2010-09-02
KR100574387B1 (ko) 2006-04-27
NO20002698L (no) 2000-07-20
DK1032671T3 (da) 2004-10-11
EA200401501A1 (ru) 2006-02-24
EP1719780A2 (en) 2006-11-08
AU739420B2 (en) 2001-10-11
CN1618969A (zh) 2005-05-25
DE69824755D1 (de) 2004-07-29
JP5331054B2 (ja) 2013-10-30
NO20074516L (no) 2000-07-20
NZ504751A (en) 2001-10-26
EP1032671A1 (en) 2000-09-06
EP1424393A2 (en) 2004-06-02
IL136076A0 (en) 2001-05-20
UA73275C2 (en) 2005-07-15

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