BRPI0511072A - derivados de alquinila como moduladores dos receptores de glutamato metabotróbico - Google Patents

derivados de alquinila como moduladores dos receptores de glutamato metabotróbico

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Publication number
BRPI0511072A
BRPI0511072A BRPI0511072-6A BRPI0511072A BRPI0511072A BR PI0511072 A BRPI0511072 A BR PI0511072A BR PI0511072 A BRPI0511072 A BR PI0511072A BR PI0511072 A BRPI0511072 A BR PI0511072A
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BR
Brazil
Prior art keywords
metabotropic glutamate
glutamate receptor
receptor modulators
alkynyl derivatives
modulators
Prior art date
Application number
BRPI0511072-6A
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English (en)
Inventor
Anne-Sophie Bessis
Christelle Bolea
Beatrice Bonnet
Mark Epping-Jordan
Nicholas Poirier
Sonia-Maria Poli
Jean-Philippe Rocher
Yves Thollon
Original Assignee
Addex Pharmaceuticals Sa
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Publication date
Application filed by Addex Pharmaceuticals Sa filed Critical Addex Pharmaceuticals Sa
Publication of BRPI0511072A publication Critical patent/BRPI0511072A/pt
Publication of BRPI0511072B1 publication Critical patent/BRPI0511072B1/pt
Publication of BRPI0511072B8 publication Critical patent/BRPI0511072B8/pt

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Abstract

DERIVADOS DE ALQUINILA COMO MODULADORES DOS RECEPTORES DE GLUTAMATO METABOTRóBICO.A presente invenção refere-se a novos compostos de fórmula (I) em que W, n, X e W<39> são definidos na descrição; os compostos da invenção são moduladores dos receptores de glutamato metabotrópico - subtipo 5 ("mGIuR5") que são úteis para o tratamento de distúrbios do sistema nervoso central assim como outros distúrbios modulados pelos receptores de m-GIuR5.
BRPI0511072A 2004-06-17 2005-06-17 compostos derivados de alquinila como moduladores dos receptores de glutamato metabotróbico, seus usos e suas composições farmacêuticas BRPI0511072B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0413605.7A GB0413605D0 (en) 2004-06-17 2004-06-17 Novel compounds
PCT/IB2005/002390 WO2005123703A2 (en) 2004-06-17 2005-06-17 Alkynyl derivatives as modulators of metabotropic glutamate receptors

Publications (3)

Publication Number Publication Date
BRPI0511072A true BRPI0511072A (pt) 2007-11-27
BRPI0511072B1 BRPI0511072B1 (pt) 2019-08-27
BRPI0511072B8 BRPI0511072B8 (pt) 2021-05-25

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BRPI0511072A BRPI0511072B8 (pt) 2004-06-17 2005-06-17 compostos derivados de alquinila como moduladores dos receptores de glutamato metabotróbico, seus usos e suas composições farmacêuticas

Country Status (23)

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US (3) US8101637B2 (pt)
EP (2) EP2426115A3 (pt)
JP (2) JP5053840B2 (pt)
KR (1) KR101200175B1 (pt)
CN (2) CN102993084B (pt)
AU (1) AU2005254808B2 (pt)
BR (1) BRPI0511072B8 (pt)
CA (1) CA2570987C (pt)
CY (1) CY1114582T1 (pt)
DK (1) DK1765795T3 (pt)
EA (2) EA012206B1 (pt)
ES (1) ES2404034T3 (pt)
GB (1) GB0413605D0 (pt)
IL (1) IL179692A (pt)
MX (1) MXPA06014721A (pt)
NO (1) NO339660B1 (pt)
NZ (1) NZ551664A (pt)
PL (1) PL1765795T3 (pt)
PT (1) PT1765795E (pt)
SI (1) SI1765795T1 (pt)
UA (1) UA87856C2 (pt)
WO (1) WO2005123703A2 (pt)
ZA (1) ZA200610023B (pt)

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GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
GB2431173B (en) * 2005-09-15 2010-01-13 Alexium Ltd Method for attachment of silicon-containing compounds to a surface
US8815351B2 (en) * 2005-09-15 2014-08-26 The United States Of America As Represented By The Secretary Of The Air Force Method for attachment of silicon-containing compounds to a surface and for synthesis of hypervalent silicon-compounds
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
MX2008012617A (es) * 2006-03-31 2008-10-10 Novartis Ag Compuestos organicos.
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TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
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