UA87991C2 - Substituted indole-o-glucosides - Google Patents

Substituted indole-o-glucosides

Info

Publication number
UA87991C2
UA87991C2 UAA200605346A UAA200605346A UA87991C2 UA 87991 C2 UA87991 C2 UA 87991C2 UA A200605346 A UAA200605346 A UA A200605346A UA A200605346 A UAA200605346 A UA A200605346A UA 87991 C2 UA87991 C2 UA 87991C2
Authority
UA
Ukraine
Prior art keywords
glucosides
substituted indole
indole
substituted
diabetes
Prior art date
Application number
UAA200605346A
Other languages
English (en)
Ukrainian (uk)
Inventor
Мери Пет Биверс
Мона Патель
Филип Рибчински
Мод Урбански
Сяоян Жанг
Original Assignee
Янссен Фармацевтика Н.В.
Танабе Сейяку Ко., Лтд
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В., Танабе Сейяку Ко., Лтд filed Critical Янссен Фармацевтика Н.В.
Publication of UA87991C2 publication Critical patent/UA87991C2/ru

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Данное изобретение касается замещенных индол-о-глюкозидов, композиций, которые их содержат, и способов их использования, например, для лечения диабета и Синдрома X.
UAA200605346A 2003-08-01 2004-07-30 Substituted indole-o-glucosides UA87991C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49152303P 2003-08-01 2003-08-01

Publications (1)

Publication Number Publication Date
UA87991C2 true UA87991C2 (en) 2009-09-10

Family

ID=34115512

Family Applications (5)

Application Number Title Priority Date Filing Date
UAA200605348A UA86042C2 (en) 2003-08-01 2004-07-29 Substituted indazole-o-glucosides
UAA200602256A UA83377C2 (ru) 2003-08-01 2004-07-30 N-гликозид, способ его получения, фармацевтическая композиция и способ лечения
UAA200605347A UA85569C2 (ru) 2003-08-01 2004-07-30 Замещенные конденсированные гетероциклические с-гликозиды
UAA200605346A UA87991C2 (en) 2003-08-01 2004-07-30 Substituted indole-o-glucosides
UAA200605349A UA86599C2 (en) 2003-08-01 2004-07-30 Substituted benzimidazole-, benztriazole- and benzimidazolone-о-glucosides

Family Applications Before (3)

Application Number Title Priority Date Filing Date
UAA200605348A UA86042C2 (en) 2003-08-01 2004-07-29 Substituted indazole-o-glucosides
UAA200602256A UA83377C2 (ru) 2003-08-01 2004-07-30 N-гликозид, способ его получения, фармацевтическая композиция и способ лечения
UAA200605347A UA85569C2 (ru) 2003-08-01 2004-07-30 Замещенные конденсированные гетероциклические с-гликозиды

Family Applications After (1)

Application Number Title Priority Date Filing Date
UAA200605349A UA86599C2 (en) 2003-08-01 2004-07-30 Substituted benzimidazole-, benztriazole- and benzimidazolone-о-glucosides

Country Status (18)

Country Link
US (1) US7521430B2 (ru)
EP (1) EP1654269B1 (ru)
JP (1) JP4717811B2 (ru)
KR (1) KR101101500B1 (ru)
CN (2) CN102060888A (ru)
AU (1) AU2004260760B2 (ru)
BR (1) BRPI0413233A (ru)
CA (1) CA2534022C (ru)
EA (1) EA011025B1 (ru)
ES (1) ES2527053T3 (ru)
IL (1) IL173051A (ru)
MX (1) MXPA06001273A (ru)
NO (1) NO333679B1 (ru)
NZ (1) NZ545305A (ru)
TW (1) TWI377209B (ru)
UA (5) UA86042C2 (ru)
WO (1) WO2005012321A1 (ru)
ZA (2) ZA200601686B (ru)

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BRPI0913129A2 (pt) 2008-05-22 2016-01-05 Bristol Myers Squibb Co método para tratamento de hiperuricemia empregando um inibidor de sglt2 e composição contendo o mesmo
MX2011002166A (es) 2008-08-28 2011-04-07 Pfizer Derivados de dioxa-biciclo[3.2.1]octano-2,3,1-triol.
CN102159561A (zh) * 2008-09-19 2011-08-17 诺瓦提斯公司 糖苷衍生物及其用途
US9056850B2 (en) * 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
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KR101532412B1 (ko) 2009-07-10 2015-06-29 얀센 파마슈티카 엔.브이. 1-(β-Ｄ-글루코피라노실)-4-메틸-3-(5-(4-플루오로페닐)-2-티에닐메틸) 벤젠의 결정화 방법
SG10201500258WA (en) * 2009-10-14 2015-03-30 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of sglt2
NZ599945A (en) 2009-11-02 2014-05-30 Pfizer Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
LT2568988T (lt) 2010-05-11 2016-09-12 Janssen Pharmaceutica, N.V. Farmacinės kompozicijos, apimančios 1-(beta-d-gliukopiranozil)-2-tienilmetilbenzeno darinius kaip sglt inhibitorius
AU2012241897C1 (en) 2011-04-13 2017-05-11 Janssen Pharmaceutica Nv Process for the preparation of compounds useful as inhibitors of SGLT2
TWI542596B (zh) * 2011-05-09 2016-07-21 健生藥品公司 （２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體
EP2963048B1 (en) * 2013-02-26 2020-11-18 Mitsubishi Tanabe Pharma Corporation Method for producing alpha-halo-tetraacyl glucose
CN103896930B (zh) * 2014-04-02 2016-08-17 安徽联创生物医药股份有限公司 卡格列净半水合物药用晶型的制备方法
ES2711804T3 (es) 2014-05-27 2019-05-07 Glenmark Pharmaceuticals Ltd Proceso para preparación de canagliflozina
CN104045673B (zh) * 2014-06-06 2017-01-18 安徽省食品药品检验研究院 双‑三氮唑缀合的假二糖衍生物及其制备方法
CN104478968A (zh) * 2015-01-14 2015-04-01 佛山市赛维斯医药科技有限公司 含噻唑基的o-半乳糖苷衍生物、其制备方法和用途
CN106188022A (zh) * 2015-04-30 2016-12-07 上海医药工业研究院 伊格列净的制备方法
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
MY210547A (en) 2017-11-30 2025-09-30 Idorsia Pharmaceuticals Ltd Combination of a 4-pyrimidinesulfamide derivative with an sglt-2 inhibitor for the treatment of endothelin related diseases
WO2020016335A1 (en) 2018-07-19 2020-01-23 Astrazeneca Ab Methods of treating hfpef employing dapagliflozin and compositions comprising the same
PT4188389T (pt) 2020-07-27 2025-10-07 Astrazeneca Ab Dapagliflozina para utilização em métodos de tratamento de doença renal crónica
AU2021202643B2 (en) 2020-07-27 2023-02-02 Astrazeneca Ab Methods of treating chronic kidney disease with dapagliflozin
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Also Published As

Publication number Publication date
AU2004260760B2 (en) 2009-08-13
UA85569C2 (ru) 2009-02-10
US20070060545A1 (en) 2007-03-15
NO333679B1 (no) 2013-08-05
IL173051A0 (en) 2006-06-11
TWI377209B (en) 2012-11-21
ZA200601686B (en) 2007-05-30
EP1654269A1 (en) 2006-05-10
EA011025B1 (ru) 2008-12-30
UA86042C2 (en) 2009-03-25
KR101101500B1 (ko) 2012-01-03
JP4717811B2 (ja) 2011-07-06
UA83377C2 (ru) 2008-07-10
NO20060219L (no) 2006-04-28
BRPI0413233A (pt) 2006-10-03
CN102060888A (zh) 2011-05-18
IL173051A (en) 2012-06-28
NZ545305A (en) 2008-11-28
ZA200603880B (en) 2010-01-27
AU2004260760A1 (en) 2005-02-10
US7521430B2 (en) 2009-04-21
EA200600348A1 (ru) 2006-08-25
KR20060132539A (ko) 2006-12-21
ES2527053T3 (es) 2015-01-20
CA2534022C (en) 2012-10-02
EP1654269B1 (en) 2014-10-15
TW200510440A (en) 2005-03-16
MXPA06001273A (es) 2006-04-11
WO2005012321A1 (en) 2005-02-10
CA2534022A1 (en) 2005-02-10
JP2007518682A (ja) 2007-07-12
UA86599C2 (en) 2009-05-12
CN1829728A (zh) 2006-09-06

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