UA91281C2 - Способ получения рекомбинантного инсулина человека - Google Patents
Способ получения рекомбинантного инсулина человекаInfo
- Publication number
- UA91281C2 UA91281C2 UAA200813678A UAA200813678A UA91281C2 UA 91281 C2 UA91281 C2 UA 91281C2 UA A200813678 A UAA200813678 A UA A200813678A UA A200813678 A UAA200813678 A UA A200813678A UA 91281 C2 UA91281 C2 UA 91281C2
- Authority
- UA
- Ukraine
- Prior art keywords
- human insulin
- sequence
- producing
- coding
- recombinant human
- Prior art date
Links
- 101000976075 Homo sapiens Insulin Proteins 0.000 title abstract 4
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000013612 plasmid Substances 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108010076181 Proinsulin Proteins 0.000 abstract 2
- 238000002955 isolation Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000007515 enzymatic degradation Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAA200813678A UA91281C2 (ru) | 2008-11-26 | 2008-11-26 | Способ получения рекомбинантного инсулина человека |
| EP09829420A EP2374888A4 (en) | 2008-11-26 | 2009-06-16 | PROCESS FOR PRODUCING RECOMBINANT HUMAN INSULIN |
| EA201100781A EA201100781A1 (ru) | 2008-11-26 | 2009-06-16 | Способ получения рекомбинантного инсулина человека |
| PCT/UA2009/000025 WO2010062279A1 (ru) | 2008-11-26 | 2009-06-16 | Способ получения рекомбинантного инсулина человека |
| CN2009801545154A CN102282260A (zh) | 2008-11-26 | 2009-06-16 | 用于制备人重组胰岛素的方法 |
| CA2746984A CA2746984A1 (en) | 2008-11-26 | 2009-06-16 | Method for preparing of human recombinant insulin |
| BRPI0920482-2A BRPI0920482A2 (pt) | 2008-11-26 | 2009-06-16 | método para produção de insulina recombinante humana |
| US13/116,822 US20120058513A1 (en) | 2008-11-26 | 2011-05-26 | Method for producing human recombinant insulin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| UAA200813678A UA91281C2 (ru) | 2008-11-26 | 2008-11-26 | Способ получения рекомбинантного инсулина человека |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA91281C2 true UA91281C2 (ru) | 2010-07-12 |
Family
ID=42225939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200813678A UA91281C2 (ru) | 2008-11-26 | 2008-11-26 | Способ получения рекомбинантного инсулина человека |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20120058513A1 (ru) |
| EP (1) | EP2374888A4 (ru) |
| CN (1) | CN102282260A (ru) |
| BR (1) | BRPI0920482A2 (ru) |
| CA (1) | CA2746984A1 (ru) |
| EA (1) | EA201100781A1 (ru) |
| UA (1) | UA91281C2 (ru) |
| WO (1) | WO2010062279A1 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2447149C1 (ru) * | 2011-03-24 | 2012-04-10 | Винсорт Менеджемент Инк | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pMSIN4, КОДИРУЮЩАЯ ГИБРИДНЫЙ ПОЛИПЕПТИД - ПРЕДШЕСТВЕННИК ИНСУЛИНА ЧЕЛОВЕКА, ШТАММ BL21(DE3)/pMSIN4-ПРОДУЦЕНТ РЕКОМБИНАНТНОГО ИНСУЛИНА ЧЕЛОВЕКА, СПОСОБ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИНСУЛИНА ЧЕЛОВЕКА |
| PL2739646T3 (pl) * | 2011-05-10 | 2018-05-30 | Stefan Hermann | Kompleksowy układ buforowy do renaturacji ludzkiej proinsuliny lub pochodnych proinsuliny |
| US10421795B2 (en) * | 2012-12-17 | 2019-09-24 | Merck Sharp & Dohme Corp. | Process for purifying insulin and analogues thereof |
| BR112015031277A2 (pt) | 2013-06-14 | 2017-09-19 | Harvard College | Moduladores do receptor de insulina de polipeptídeos estabilizados, análogos de insulina, composições farmacêuticas compreendendo os referidos polipeptídeos e métodos de preparação e usos dos mesmos |
| US20150165341A1 (en) * | 2013-10-30 | 2015-06-18 | NorthStar Medical Radionuclides LLC | Separator cartridge for radionuclide |
| CN103694339B (zh) * | 2013-12-04 | 2017-10-13 | 珠海联邦制药股份有限公司 | 一种甘精胰岛素前体的复性方法 |
| WO2016144658A1 (en) * | 2015-03-10 | 2016-09-15 | Merck Sharp & Dohme Corp. | Process for preparing recombinant insulin using microfiltration |
| EP3341405A4 (en) * | 2015-09-24 | 2019-05-01 | Hanmi Pharm. Co., Ltd. | PROCESS FOR INSULIN PRODUCTION |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4405179A1 (de) * | 1994-02-18 | 1995-08-24 | Hoechst Ag | Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken |
| KR100253916B1 (ko) * | 1997-12-29 | 2000-05-01 | 김충환 | 사람 인슐린 전구체의 제조방법 |
| EP1563075A4 (en) * | 2002-11-12 | 2006-09-06 | Ckd Bio Corp | HUMANINSULIN EXPRESSIVE PLASMIDE AND METHOD FOR THE PRODUCTION OF HUMANINSULIN THEREWITH |
| UA76661C2 (en) | 2005-04-06 | 2006-08-15 | Omakooe Ltd Liability Company | A method for producing recombinant humanæs insulin |
-
2008
- 2008-11-26 UA UAA200813678A patent/UA91281C2/ru unknown
-
2009
- 2009-06-16 WO PCT/UA2009/000025 patent/WO2010062279A1/ru not_active Ceased
- 2009-06-16 CN CN2009801545154A patent/CN102282260A/zh active Pending
- 2009-06-16 BR BRPI0920482-2A patent/BRPI0920482A2/pt not_active IP Right Cessation
- 2009-06-16 EA EA201100781A patent/EA201100781A1/ru unknown
- 2009-06-16 CA CA2746984A patent/CA2746984A1/en not_active Abandoned
- 2009-06-16 EP EP09829420A patent/EP2374888A4/en not_active Withdrawn
-
2011
- 2011-05-26 US US13/116,822 patent/US20120058513A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2374888A4 (en) | 2012-06-06 |
| EP2374888A1 (en) | 2011-10-12 |
| EA201100781A1 (ru) | 2012-01-30 |
| WO2010062279A1 (ru) | 2010-06-03 |
| BRPI0920482A2 (pt) | 2019-09-24 |
| US20120058513A1 (en) | 2012-03-08 |
| CN102282260A (zh) | 2011-12-14 |
| CA2746984A1 (en) | 2010-06-03 |
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