UA93226C2 - (4r)-1'-[(2e)-3-(3,4-dichlorophenyl)prop-2-ene-1-yl]-2h,5h-spiro[imidazolidine-4,3'-indole]-2,2',5(1'h)-trione and use thereof - Google Patents

(4r)-1'-[(2e)-3-(3,4-dichlorophenyl)prop-2-ene-1-yl]-2h,5h-spiro[imidazolidine-4,3'-indole]-2,2',5(1'h)-trione and use thereof

Info

Publication number: UA93226C2
Authority: UA; Ukraine
Prior art keywords: trione; imidazolidine; dichlorophenyl; spiro; ene
Prior art date: 2006-02-07

Application number

UAA200809311A

Other languages

English (en)

Inventor

Кармен Лунг

Мирослав Томашевски

Саймон By

Original Assignee

Астразенека Аб

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-02-07

Filing date

2007-06-02

Publication date

2011-01-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38345567&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA93226(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-06-02 Application filed by Астразенека Аб filed Critical Астразенека Аб

2011-01-25 Publication of UA93226C2 publication Critical patent/UA93226C2/ru

Links

DHFXVPUHKMWKRT-GNAXCBTBSA-N (5r)-1'-[(e)-3-(3,4-dichlorophenyl)prop-2-enyl]spiro[imidazolidine-5,3'-indole]-2,2',4-trione Chemical compound C1=C(Cl)C(Cl)=CC=C1\C=C\CN1C2=CC=CC=C2[C@@]2(C(NC(=O)N2)=O)C1=O DHFXVPUHKMWKRT-GNAXCBTBSA-N 0.000 title 1
HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Chemical group C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
150000003839 salts Chemical group 0.000 abstract 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Child & Adolescent Psychology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Epidemiology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

UAA200809311A 2006-02-07 2007-06-02 (4r)-1'-[(2e)-3-(3,4-dichlorophenyl)prop-2-ene-1-yl]-2h,5h-spiro[imidazolidine-4,3'-indole]-2,2',5(1'h)-trione and use thereof UA93226C2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US77111906P	2006-02-07	2006-02-07

Publications (1)

Publication Number	Publication Date
UA93226C2 true UA93226C2 (en)	2011-01-25

Family

ID=38345567

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAA200809311A UA93226C2 (en)	2006-02-07	2007-06-02	(4r)-1'-[(2e)-3-(3,4-dichlorophenyl)prop-2-ene-1-yl]-2h,5h-spiro[imidazolidine-4,3'-indole]-2,2',5(1'h)-trione and use thereof

Country Status (21)

Country	Link
US (2)	US20070185179A1 (ru)
EP (1)	EP2013215A4 (ru)
JP (1)	JP2009526043A (ru)
KR (1)	KR20080094906A (ru)
CN (1)	CN101415711A (ru)
AR (1)	AR059265A1 (ru)
AU (1)	AU2007212786B2 (ru)
BR (1)	BRPI0707423A2 (ru)
CA (1)	CA2641632A1 (ru)
CL (1)	CL2009000523A1 (ru)
IL (1)	IL192890A0 (ru)
NO (1)	NO20083547L (ru)
NZ (1)	NZ571070A (ru)
RU (1)	RU2421457C2 (ru)
SA (1)	SA07280027B1 (ru)
SG (1)	SG169387A1 (ru)
TW (1)	TW200801011A (ru)
UA (1)	UA93226C2 (ru)
UY (1)	UY30132A1 (ru)
WO (1)	WO2007091947A2 (ru)
ZA (1)	ZA200806407B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8921576B2 (en)	2011-10-19	2014-12-30	Kowa Company, Ltd.	Spiroindoline compound, and medicinal agent comprising same
TWI586668B (zh) *	2012-09-06	2017-06-11	第一三共股份有限公司	二螺吡咯啶衍生物之結晶
CN108409746B (zh) *	2018-05-15	2021-08-24	中山大学	一种含吡咯或吲哚并氮杂环烷结构的手性氧代螺环吲哚类化合物及其消旋体和制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU532110B2 (en) *	1979-11-13	1983-09-15	Ici Ltd.	Spiro(imidazolidine-4,3:-indoline)-2,2:5-trione derivatives
ZA806623B (en) *	1979-11-13	1981-12-30	Ici Ltd	Substituted indoline-2-one derivatives
IE52879B1 (en) *	1981-05-12	1988-03-30	Ici Plc	Pharmaceutical spiro-hydantoin derivatives
GB8331194D0 (en)	1982-12-20	1983-12-29	Ici Plc	Chemical process
US4611062A (en) *	1984-03-26	1986-09-09	Imperial Chemical Industries Plc	Process for resolving certain spiro compounds
WO1992007830A2 (en)	1990-10-29	1992-05-14	Pfizer Inc.	Oxindole peptide antagonists
NZ516452A (en) *	1999-07-21	2004-06-25	Astrazeneca Ab	Spirooxindole Derivatives
US7248802B2 (en)	2002-11-27	2007-07-24	Nokia Corporation	Distribution of a synchronization signal in an optical communication system
TW200508197A (en)	2003-03-31	2005-03-01	Ucb Sa	Indolone-acetamide derivatives, processes for preparing them and their uses
SE0301446D0 (sv) *	2003-05-16	2003-05-16	Astrazeneca Ab	New Compounds
MXPA05013434A (es)	2003-06-12	2006-03-17	Astellas Pharma Inc	Derivados de benzamida o sal del mismo.
GB0326633D0 (en) *	2003-11-14	2003-12-17	Merck Sharp & Dohme	Therapeutic agents
US7879866B2 (en)	2004-07-19	2011-02-01	Dorte Xenia Gram	Inhibition of the activity of the capsaicin receptor in the treatment of obesity or obesity-related diseases and disorders
CN101415713A (zh)	2006-02-07	2009-04-22	阿斯利康(瑞典)有限公司	用于治疗香草素受体1相关病症的新螺[咪唑烷-4,3’-吲哚]-2,2’,5(1’h)-三酮

2007
- 2007-01-31 TW TW096103591A patent/TW200801011A/zh unknown
- 2007-01-31 AR ARP070100412A patent/AR059265A1/es not_active Application Discontinuation
- 2007-02-05 US US11/671,153 patent/US20070185179A1/en not_active Abandoned
- 2007-02-06 SA SA07280027A patent/SA07280027B1/ar unknown
- 2007-02-06 CN CNA2007800125819A patent/CN101415711A/zh active Pending
- 2007-02-06 JP JP2008554186A patent/JP2009526043A/ja active Pending
- 2007-02-06 EP EP07709323A patent/EP2013215A4/en not_active Withdrawn
- 2007-02-06 RU RU2008131905/04A patent/RU2421457C2/ru not_active IP Right Cessation
- 2007-02-06 NZ NZ571070A patent/NZ571070A/en unknown
- 2007-02-06 UY UY30132A patent/UY30132A1/es not_active Application Discontinuation
- 2007-02-06 KR KR1020087019272A patent/KR20080094906A/ko not_active Withdrawn
- 2007-02-06 AU AU2007212786A patent/AU2007212786B2/en not_active Ceased
- 2007-02-06 WO PCT/SE2007/000107 patent/WO2007091947A2/en not_active Ceased
- 2007-02-06 SG SG201100854-7A patent/SG169387A1/en unknown
- 2007-02-06 CA CA002641632A patent/CA2641632A1/en not_active Abandoned
- 2007-02-06 BR BRPI0707423-9A patent/BRPI0707423A2/pt not_active IP Right Cessation
- 2007-06-02 UA UAA200809311A patent/UA93226C2/ru unknown
2008
- 2008-07-17 IL IL192890A patent/IL192890A0/en unknown
- 2008-07-23 ZA ZA200806407A patent/ZA200806407B/xx unknown
- 2008-08-14 NO NO20083547A patent/NO20083547L/no not_active Application Discontinuation
- 2008-11-20 US US12/274,837 patent/US7868181B2/en not_active Expired - Fee Related
2009
- 2009-03-05 CL CL2009000523A patent/CL2009000523A1/es unknown

Also Published As

Publication number	Publication date
NO20083547L (no)	2008-11-05
AU2007212786B2 (en)	2011-06-02
WO2007091947A2 (en)	2007-08-16
SA07280027B1 (ar)	2010-11-22
UY30132A1 (es)	2009-07-17
ZA200806407B (en)	2009-04-29
JP2009526043A (ja)	2009-07-16
AU2007212786A1 (en)	2007-08-16
EP2013215A4 (en)	2010-09-08
US20070185179A1 (en)	2007-08-09
AR059265A1 (es)	2008-03-19
NZ571070A (en)	2011-07-29
WO2007091947A3 (en)	2007-10-04
CL2009000523A1 (es)	2009-07-17
WO2007091947A8 (en)	2008-08-07
CN101415711A (zh)	2009-04-22
KR20080094906A (ko)	2008-10-27
US7868181B2 (en)	2011-01-11
US20090137650A1 (en)	2009-05-28
TW200801011A (en)	2008-01-01
EP2013215A2 (en)	2009-01-14
BRPI0707423A2 (pt)	2011-05-03
SG169387A1 (en)	2011-03-30
RU2421457C2 (ru)	2011-06-20
RU2008131905A (ru)	2010-03-20
CA2641632A1 (en)	2007-08-16
AU2007212786A8 (en)	2010-05-06
IL192890A0 (en)	2009-02-11

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MX2009004096A (es)	2009-06-16	Metabolitos de talarozol.
WO2008062905A3 (en)	2008-12-04	Heteromonocyclic compound and use thereof
TW200738672A (en)	2007-10-16	Intermediated for the preparation of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
WO2002062766A3 (en)	2002-10-03	Melanocortin-4 receptor binding compounds and methods of use thereof
IL164511A0 (en)	2005-12-18	Heterocyclic compounds
WO2009027393A3 (en)	2009-09-24	Pyrazole compounds for controlling invertebrate pests
MX2007003108A (es)	2007-05-24	Compuestos imidazo-3-il-amina sustituidos y biciclicos.
MX2007006397A (es)	2007-06-22	Derivados de tetrahidropirano.
WO2005060972A3 (en)	2005-10-20	Pyrrolo [2,3-d] pyrimidine compounds for treating transplant rejection
EP2078721A3 (en)	2009-07-22	Thieno-pyrimidime compounds having fungicidal activity
UA93043C2 (ru)	2011-01-10	ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ ДЛЯ ПОЛУЧЕНИЯ ТРАНС-5-ХЛОР-2-МЕТИЛ-2,3,3А,12В-ТЕТРАГИДРО-1Н-ДИБЕНЗ[2,3:6,7]ОКСЕПИНО[4,5-с]ПИРОЛА
WO2009018065A3 (en)	2009-05-07	Novel glucokinase activators and methods of using same
MX2007005611A (es)	2007-07-11	Compuestos de imidazo[1,2-a]piridina, composiciones, usos y metodos relacionados.
AU2003218110A1 (en)	2003-09-29	C3-cyano epothilone derivatives
WO2006030977A3 (en)	2006-07-13	Imidazole derivatives as large conductance calcium-activated k channel openers
UA93226C2 (en)	2011-01-25	(4r)-1'-[(2e)-3-(3,4-dichlorophenyl)prop-2-ene-1-yl]-2h,5h-spiro[imidazolidine-4,3'-indole]-2,2',5(1'h)-trione and use thereof
WO2005077922A3 (en)	2006-01-26	Process for the preparation of substituted triazole compounds
TW200626600A (en)	2006-08-01	Octahydropyrrolo[3, 4-c]pyrrole derivatives
WO2005115984A3 (en)	2006-03-02	Large conductance calcium-activitated k channel opener
WO2006035244A8 (en)	2007-05-18	Ecteinascidin compounds as anti -inflammatory agents
CA2562251A1 (en)	2005-10-20	Pyrazolo'4,3-d pyrimidines
WO2006088903A3 (en)	2007-05-10	Pyrazole compounds
WO2001000185A3 (en)	2002-04-11	1,4-denzothiazepines to treat obesity related disorders
WO2006133928A3 (en)	2007-11-15	Use of phenylsemicarbazones for seed treatment
AU2003224115A1 (en)	2003-11-17	A process for the preparation of clopidogrel