UA96150C2 - Производные бензоазепиноксиуксусной кислоты и их применение как агонистов дельта-ppar для повышения hdl-c и снижения ldl-c и холестерина - Google Patents

Производные бензоазепиноксиуксусной кислоты и их применение как агонистов дельта-ppar для повышения hdl-c и снижения ldl-c и холестерина

Info

Publication number: UA96150C2
Authority: UA; Ukraine
Prior art keywords: hdl; ppar; benzoazepin; oxy; increase
Prior art date: 2006-04-18

Application number

UAA200813306A

Other languages

English (en)

Ukrainian (uk)

Inventor

Ко Гее-Хун

Янь Чжан

Лань Шень

Сунфен Лу

Кит Т. Демарест

Патрисия Пелтон

Original Assignee

Янссен Фармацевтика Н.В.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-04-18

Filing date

2007-04-17

Publication date

2011-10-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38610435&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA96150(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-04-17 Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.

2011-10-10 Publication of UA96150C2 publication Critical patent/UA96150C2/ru

Links

239000000556 agonist Substances 0.000 title abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title 2
XWRCWBNSNDDBQB-UHFFFAOYSA-N 2-(1h-1-benzazepin-2-yloxy)acetic acid Chemical class N1C(OCC(=O)O)=CC=CC2=CC=CC=C21 XWRCWBNSNDDBQB-UHFFFAOYSA-N 0.000 title 1
235000012000 cholesterol Nutrition 0.000 title 1
208000035150 Hypercholesterolemia Diseases 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
208000035475 disorder Diseases 0.000 abstract 2
201000001320 Atherosclerosis Diseases 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
208000002177 Cataract Diseases 0.000 abstract 1
208000032928 Dyslipidaemia Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
206010068961 Hypo HDL cholesterolaemia Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 abstract 1
108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 abstract 1
208000017442 Retinal disease Diseases 0.000 abstract 1
206010038923 Retinopathy Diseases 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
206010060755 Type V hyperlipidaemia Diseases 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
230000019439 energy homeostasis Effects 0.000 abstract 1
208000006575 hypertriglyceridemia Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
208000028867 ischemia Diseases 0.000 abstract 1
208000017169 kidney disease Diseases 0.000 abstract 1
230000037356 lipid metabolism Effects 0.000 abstract 1
201000001119 neuropathy Diseases 0.000 abstract 1
230000007823 neuropathy Effects 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
208000033808 peripheral neuropathy Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
201000010065 polycystic ovary syndrome Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
- C07D233/08—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms
- C07D233/12—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D233/16—Radicals substituted by nitrogen atoms
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Reproductive Health (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Child & Adolescent Psychology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

UAA200813306A 2006-04-18 2007-04-17 Производные бензоазепиноксиуксусной кислоты и их применение как агонистов дельта-ppar для повышения hdl-c и снижения ldl-c и холестерина UA96150C2 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US79300106P	2006-04-18	2006-04-18

Publications (1)

Publication Number	Publication Date
UA96150C2 true UA96150C2 (ru)	2011-10-10

Family

ID=38610435

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UAA200813306A UA96150C2 (ru)	2006-04-18	2007-04-17	Производные бензоазепиноксиуксусной кислоты и их применение как агонистов дельта-ppar для повышения hdl-c и снижения ldl-c и холестерина

Country Status (29)

Country	Link
US (2)	US7678786B2 (ru)
EP (1)	EP2010289B1 (ru)
JP (1)	JP5232771B2 (ru)
KR (1)	KR101472370B1 (ru)
CN (1)	CN101479008B (ru)
AR (1)	AR060489A1 (ru)
AT (1)	ATE535282T1 (ru)
AU (1)	AU2007237928B2 (ru)
BR (1)	BRPI0711695A2 (ru)
CA (1)	CA2649700C (ru)
CO (1)	CO6160296A2 (ru)
CR (1)	CR10447A (ru)
EA (1)	EA016583B1 (ru)
EC (1)	ECSP088841A (ru)
ES (1)	ES2375754T3 (ru)
GT (1)	GT200800226A (ru)
HN (1)	HN2008001559A (ru)
IL (1)	IL194850A (ru)
JO (1)	JO3444B1 (ru)
MX (1)	MX2008013534A (ru)
MY (1)	MY144637A (ru)
NO (1)	NO344334B1 (ru)
NZ (1)	NZ571998A (ru)
PE (1)	PE20080188A1 (ru)
TW (1)	TWI404712B (ru)
UA (1)	UA96150C2 (ru)
UY (1)	UY30288A1 (ru)
WO (1)	WO2007121432A2 (ru)
ZA (1)	ZA200809790B (ru)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
ES2590604T3 (es) *	2008-01-04	2016-11-22	Schabar Research Associates Llc	Composición que comprende un analgésico y un antihistamínico
WO2009097995A1 (de) *	2008-02-07	2009-08-13	Sanofi-Aventis	Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
JP5566288B2 (ja)	2008-05-30	2014-08-06	武田薬品工業株式会社	複素環化合物
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US9051290B2 (en)	2010-04-28	2015-06-09	Leo Pharma A/S	Biaryl phosphodiesterase inhibitors
EP2582709B1 (de)	2010-06-18	2018-01-24	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
JP5996532B2 (ja)	2010-07-15	2016-09-21	バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒＩｎｔｅｌｌｅｃｔｕａｌＰｒｏｐｅｒｔｙＧｍｂＨ	有害生物防除剤としての新規複素環式化合物
EP2612669A4 (en)	2010-08-31	2014-05-14	Snu R&Db Foundation	USING THE FÖTAL REPROGRAMMING OF A PPAR AGONIST
EP2683699B1 (de)	2011-03-08	2015-06-24	Sanofi	Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828994B2 (en)	2011-03-08	2014-09-09	Sanofi	Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120056A1 (de)	2011-03-08	2012-09-13	Sanofi	Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683704B1 (de)	2011-03-08	2014-12-17	Sanofi	Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2766349B1 (de)	2011-03-08	2016-06-01	Sanofi	Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
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WO2021097034A1 (en) *	2019-11-14	2021-05-20	Cymabay Therapeutics, Inc.	Seladelpar for use in the treatment of intestinal barrier dysfunction and associated diseases
US11324727B2 (en)	2020-07-15	2022-05-10	Schabar Research Associates, Llc	Unit oral dose compositions composed of naproxen sodium and famotidine for the treatment of acute pain and the reduction of the severity of heartburn and/or the risk of heartburn
KR20230051164A (ko)	2020-07-15	2023-04-17	샤바르 리서치 어소시에이츠 엘엘씨	급성 통증의 치료 및 속쓰림의 중증도 및/또는 위험의 감소를 위한 이부프로펜 및 파모티딘으로 구성된 단위 경구 투여 조성물
US12514846B2 (en)	2020-07-15	2026-01-06	Schabar Research Associates Llc	Unit oral dose compositions composed of ibuprofen or a pharmaceutically acceptable salt thereof and famotidine or a pharmaceutically acceptable salt thereof for the treatment of acute pain and the reduction of the severity and/or risk of heartburn and/or upset stomach

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2460689C3 (de)	1974-12-20	1980-06-26	Klinge Pharma Gmbh & Co, 8000 Muenchen	13-disubstituierte Propanol-(2)-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US4125732A (en)	1977-05-06	1978-11-14	American Cyanamid Company	2-Aryloxy-2-(phenoxyalkoxy)phenyl acetic acid and esters
DE3026924A1 (de)	1980-07-16	1982-02-18	Klinge Pharma GmbH & Co, 8000 München	1,3-diphenoxypropan-2-ol-derivate sowie verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3028776A1 (de)	1980-07-29	1982-02-25	Klinge Pharma GmbH & Co, 8000 München	Neue 1,3-diphenoxypropan-2-on-derivate sowie verfahren zu ihrer herstellung und diese enthaltende arzneimittel
EP0056172B1 (en)	1981-01-09	1985-04-03	FISONS plc	Phenoxy- and thiophenoxy compounds, methods for their preparation and pharmaceutical formulations containing them
JPS58177934A (ja)	1982-04-13	1983-10-18	Takeda Chem Ind Ltd	ベンゾキノン誘導体
ATE22072T1 (de)	1982-09-30	1986-09-15	Merck Frosst Canada Inc	Leukotrienantagonisten, deren herstellung und diese enthaltende zusammensetzungen.
US4820867A (en) *	1983-04-21	1989-04-11	Merck Frosst Canada, Inc.	Phenoxypropoxy halophenylacetic acids as leukotriene antagonists
US4513006A (en)	1983-09-26	1985-04-23	Mcneil Lab., Inc.	Anticonvulsant sulfamate derivatives
JPS61268651A (ja)	1985-05-23	1986-11-28	Takeda Chem Ind Ltd	フエニル酢酸誘導体およびその製造法
EP0204349A3 (de) *	1985-06-01	1990-01-03	Dr. Karl Thomae GmbH	Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
JPH0714910B2 (ja)	1988-12-13	1995-02-22	塩野義製薬株式会社	安定な結晶性の塩およびそれを含有するトロンボキサン受容体拮抗剤
US5487008A (en)	1990-04-20	1996-01-23	The Regents Of The University Of Michigan	Method and system for detecting the misfire of a reciprocating internal combustion engine in frequency domain
CA2092152A1 (en)	1992-03-23	1993-09-24	Azuma Igarashi	Phenoxyacetic acid compounds and medical preparations containing them
US5726165A (en)	1994-07-29	1998-03-10	Smithkline Beecham P.L.C.	Derivatives of 4-(2-aminoethyl)phenoxymethyl-phosphonic and -phosphinic acid and pharmaceutical and veterinary uses therefor
AU721452B2 (en)	1996-02-02	2000-07-06	Merck & Co., Inc.	Antidiabetic agents
ATE293963T1 (de)	1996-02-02	2005-05-15	Merck & Co Inc	Verfahren zur behandlung von diabetes und verwandter krankheitszustände.
JP3268242B2 (ja)	1996-11-14	2002-03-25	三共株式会社	縮合複素環化合物を含有する医薬
CA2295930C (en)	1997-07-24	2010-12-14	Yamanouchi Pharmaceutical Co., Ltd.	Pharmaceutical compositions having cholesterol-lowering effect
GB9914977D0 (en)	1999-06-25	1999-08-25	Glaxo Group Ltd	Chemical compounds
GB0031107D0 (en) *	2000-12-20	2001-01-31	Glaxo Group Ltd	Chemical compounds
CZ20033309A3 (cs)	2001-06-07	2004-05-12	Eliálillyáandácompany	Modulátory receptorů aktivovaných peroxizomálními proliferátory }PPARB
RU2004105956A (ru)	2001-07-30	2005-03-27	Ново Нордиск А/С (DK)	Новые производные винилкарбоновых кислот и их применение в качестве антидиабетических средств и т.п.
BRPI0211844B8 (pt) *	2001-08-10	2021-05-25	Nippon Chemiphar Co	composto de ácido fenóxi-acético ou um de seus sais farmaceuticamente aceitáveis, e, composição farmacêutica
ATE323674T1 (de) *	2001-08-29	2006-05-15	Warner Lambert Co	Orale antidiabetische wirkstoffe
PT1445258E (pt) *	2001-10-12	2009-07-02	Nippon Chemiphar Co	Activador para o receptor delta activado por proliferador de peroxissoma
ITRM20020014A1 (it)	2002-01-15	2003-07-15	Sigma Tau Ind Farmaceuti	Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del
EP1480957A1 (en)	2002-03-01	2004-12-01	Smithkline Beecham Corporation	Hppars activators
US6875780B2 (en)	2002-04-05	2005-04-05	Warner-Lambert Company	Compounds that modulate PPAR activity and methods for their preparation
GB0214149D0 (en)	2002-06-19	2002-07-31	Glaxo Group Ltd	Chemical compounds
BR0314335A (pt) *	2002-09-05	2005-07-26	Novo Nordisk As	Composto, uso do mesmo, composição farmacêutica, e métodos para o tratamento e/ou prevenção de condições mediadas por receptores nucleares, e de diabetes de tipo i, diabetes de tipo ii, tolerância prejudicada à glicose, resistência à insulina ou obesidade
DE60332860D1 (de)	2002-10-28	2010-07-15	High Point Pharmaceuticals Llc	Neue verbindungen, die sich f r die behandlung von durch ppar vermittelten krankheiten eignen
DE60333211D1 (de)	2002-10-28	2010-08-12	High Point Pharmaceuticals Llc	Neue verbindungen und deren verwendung als ppar-modulatoren
AU2003296405A1 (en) *	2003-01-06	2004-08-10	Eli Lilly And Company	Fused heterocyclic derivatives as ppar modulators
US7528160B2 (en) *	2003-01-06	2009-05-05	Eli Lilly And Company	Fused heterocyclic derivatives as PPAR modulators
DK1594955T3 (da)	2003-02-14	2012-06-25	Biogen Idec Inc	Ekspressionskassette og vektor til transient eller stabil ekspression af eksogene molekyler
PA8594401A1 (es) *	2003-02-21	2004-09-16	Pfizer	Acidos carboxilicos de heteroarilo condensado como agonista del ppar
US7244763B2 (en) *	2003-04-17	2007-07-17	Warner Lambert Company Llc	Compounds that modulate PPAR activity and methods of preparation
US6987118B2 (en) *	2003-05-21	2006-01-17	Pfizer Inc.	Tetrahydroisoquinoline derivatives as PPAR-alpha activators
EP1660428A1 (en) *	2003-08-20	2006-05-31	Eli Lilly And Company	Ppar modulators
WO2005042478A2 (en) *	2003-09-19	2005-05-12	Janssen Pharmaceutica, N.V.	4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
DE602004028500D1 (de)	2003-09-19	2010-09-16	Janssen Pharmaceutica Nv	4-((phenoxyalkyl)thio)-phenoxyessigsäuren und analoga
JP2007527416A (ja) *	2003-10-31	2007-09-27	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ペルオキシソーム増殖因子活性化受容体（ｐｐａｒ）二重作動薬として有用なフェノキシ酢酸誘導体
WO2005060958A1 (en) *	2003-12-19	2005-07-07	Kalypsys, Inc.	(5- (2-phenyl)-thiazol-5-ylmethoxy)-indol-1-yl) -acetic acid derivatives and related compounds as modulators of the human ppar-delta receptor for the treatment of metabolic disorders such as type 2 diabetes
ATE461932T1 (de)	2004-04-21	2010-04-15	Schering Corp	Pyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidine als antagonisten des adenosin-a2a-rezeptors
WO2005115384A2 (en) *	2004-05-25	2005-12-08	Metabolex, Inc.	Bicyclic, substituted triazoles as modulators of ppar and methods of their preparation
BRPI0512951A (pt)	2004-07-01	2008-04-15	Hoffmann La Roche	compostos, processo para sua fabricação, composições farmacêuticas contendo os mesmos, uso e método para tratamento e/ou prevenção de doenças que são moduladas pelos agonistas de ppar(delta) e/ou ppar(alpha)
EP1794159B1 (en) *	2004-09-11	2012-08-01	Sanofi-Aventis Deutschland GmbH	7-azaindoles and their use as ppar agonists
PE20060664A1 (es)	2004-09-15	2006-08-04	Novartis Ag	Amidas biciclicas como inhibidores de cinasa
MY147518A (en) *	2004-09-15	2012-12-31	Janssen Pharmaceutica Nv	4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
MY145712A (en)	2004-09-15	2012-03-30	Janssen Pharmaceutica Nv	4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
JO3006B1 (ar) *	2005-09-14	2016-09-05	Janssen Pharmaceutica Nv	املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك
US20090012097A1 (en) *	2006-01-30	2009-01-08	Irm Llc	Polycyclic 1,2,3,4-Tetrahydro-Isoquinoline Derivatives and Compositions Comprising Them As Ppar Modulators
GB0618963D0 (en)	2006-09-26	2006-11-08	Ucl Business Plc	Formulations and composites with reactive fillers

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Publication number	Publication date
CA2649700A1 (en)	2007-10-25
AU2007237928A1 (en)	2007-10-25
KR101472370B1 (ko)	2014-12-15
MX2008013534A (es)	2008-10-29
ECSP088841A (es)	2008-11-27
NO20084847L (no)	2008-12-16
US8633184B2 (en)	2014-01-21
WO2007121432A2 (en)	2007-10-25
EA200870445A1 (ru)	2009-04-28
KR20080109933A (ko)	2008-12-17
MY144637A (en)	2011-10-14
CN101479008A (zh)	2009-07-08
CN101479008B (zh)	2013-07-17
IL194850A (en)	2013-04-30
EA016583B1 (ru)	2012-06-29
UY30288A1 (es)	2007-08-31
TW200813003A (en)	2008-03-16
TWI404712B (zh)	2013-08-11
AU2007237928B2 (en)	2011-11-17
EP2010289A4 (en)	2010-05-26
US7678786B2 (en)	2010-03-16
BRPI0711695A2 (pt)	2011-12-06
US20070244094A1 (en)	2007-10-18
HK1124797A1 (en)	2009-07-24
NZ571998A (en)	2011-08-26
ZA200809790B (en)	2009-12-30
NO344334B1 (no)	2019-11-04
CO6160296A2 (es)	2010-05-20
JO3444B1 (ar)	2019-10-20
CR10447A (es)	2009-02-23
WO2007121432A3 (en)	2008-10-30
HN2008001559A (es)	2012-01-17
ATE535282T1 (de)	2011-12-15
IL194850A0 (en)	2009-08-03
US20100120748A1 (en)	2010-05-13
PE20080188A1 (es)	2008-03-10
AR060489A1 (es)	2008-06-18
EP2010289A2 (en)	2009-01-07
GT200800226A (es)	2009-03-13
JP2009534402A (ja)	2009-09-24
EP2010289B1 (en)	2011-11-30
JP5232771B2 (ja)	2013-07-10
ES2375754T3 (es)	2012-03-06
CA2649700C (en)	2015-04-14

Publication	Publication Date	Title
MY144637A (en)	2011-10-14	Benzoazepin-oxy-acetic acid derivatives as ppar-delta agonists used for the increase of hdl-c, lower ldl-c and lower cholesterol
NZ606827A (en)	2015-02-27	Agonists of gpr40
CL2007001971A1 (es)	2008-01-25	Ester isopropilico del acido 4-[5-metoxi-6-(2-metil-6-[1,2,4]triazol-1-il-piridin-3-ilamino)-pirimidin-4-iloxi]-piperidin-1-carboxilico, agonista del receptor rup3, modulador del metabolismo de glucosa; composicion farmaceutica; y uso para tratar trastornos metabolicos, como diabetes, hiperlipidemia, hiperglicemia, obesidad
MX2015001500A (es)	2015-04-08	Compuestos antidiabeticos triciclicos.
NZ631569A (en)	2016-10-28	Phenyl alkanoic acid derivatives as gpr agonists
FR2957599B1 (fr)	2014-01-10	Procede de depolymerisation de biomasse lignocellulosique
EA023861B3 (ru)	2016-09-30	Производные пирролидин карбоновой кислоты как агонисты сопряженного с g-белком рецептора 43 (gpr43), фармацевтическая композиция и методы их использования при лечении метаболических нарушений
AU2015263620A8 (en)	2017-02-02	Antidiabetic tricyclic compounds
NO20080058L (no)	2008-04-18	Pyridazinonderivativer som tyroidhormon reseptoragonister
SI2021337T1 (sl)	2010-05-31	Inhibitorji beta hidroksisteroidne dehidrogenaze
WO2005115383A3 (en)	2006-08-17	Substituted triazoles as modulators of ppar and methods of their preparation
MY148079A (en)	2013-02-28	Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CL2007001873A1 (es)	2008-01-04	Acido((3s))-6-((¨2,6-dimetil-4-(3-(metilsulfonil)-propoxi)bifenil-3-il)metoxi-2,3-dihidro-1-benzofuran-3-il)acetico o una sal del mismo
CL2007001972A1 (es)	2008-04-04	Ester isopropilico del acido 4-[6-(6-metanosulfonil-2-metilpiridin-3-ilamino)-5-metilpirimidin-4-iloxi]piperidin-1-carboxilico, moduladores del metabolismo; composicion farmaceutica; y su uso para tratar trastornos metabolicos.
WO2014059232A3 (en)	2015-07-16	Substituted spiropiperidinyl compounds useful as gpr120 agonists
TW200732313A (en)	2007-09-01	Oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators
NZ588612A (en)	2012-08-31	Benzothiophen derivatives as activators of peroxisome proliferator activated receptor (PPAR)
DK1470102T3 (da)	2011-06-20	Substituerede methylenamidderivater som modulatorer af proteintyrosinphosphataser (PTPS)
CN103011675A (zh)	2013-04-03	一种水性减水型砂浆增粘剂及其制备方法与应用
IN2014DN09941A (ru)	2015-08-14
AU2017297550A8 (en)	2019-03-14	Pyrrolidine derivative serving as PPAR agonist
WO2008152094A3 (en)	2009-04-23	Substituted acetamides as modulators of the ep2 receptor
WO2007041076A3 (en)	2007-06-07	1,2,3,5-tetrahydro-cyclopental[c]quinolin-4-one derivatives as rxr agonists for the treatment of dyslipidemia, hypercholesterolemia and diabetes
WO2005115384A3 (en)	2005-12-29	Bicyclic, substituted triazoles as modulators of ppar and methods of their preparation
WO2007146768A3 (en)	2008-02-21	Compounds for the treatment of metabolic disorders