UA97036C2 - Cyclopropyl amine derivatives - Google Patents
Cyclopropyl amine derivativesInfo
- Publication number
- UA97036C2 UA97036C2 UAA201008762A UAA201008762A UA97036C2 UA 97036 C2 UA97036 C2 UA 97036C2 UA A201008762 A UAA201008762 A UA A201008762A UA A201008762 A UAA201008762 A UA A201008762A UA 97036 C2 UA97036 C2 UA 97036C2
- Authority
- UA
- Ukraine
- Prior art keywords
- amine derivatives
- cyclopropyl amine
- compounds
- histamine
- formula
- Prior art date
Links
- HTJDQJBWANPRPF-UHFFFAOYSA-N Cyclopropylamine Chemical class NC1CC1 HTJDQJBWANPRPF-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003446 ligand Substances 0.000 abstract 2
- 230000001668 ameliorated effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/12—Oxygen or sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Organic Chemistry (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
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- Neurology (AREA)
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- Biomedical Technology (AREA)
- Diabetes (AREA)
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Abstract
(I).Соединения формулы (I), где R, R, R, R, R, Rи Rопределены в описании, можно применять для лечения патологических состояний или расстройств, которые предупреждаются или облегчаются лигандами гистаминового рецептора типа 3.Описаны также фармацевтические композиции, которые содержат лиганды гистаминового рецептора типа 3, применение таких соединений и композиций и способ получения соединений, которые обозначают формулой (I).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/956,816 US9108948B2 (en) | 2006-06-23 | 2007-12-14 | Cyclopropyl amine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA97036C2 true UA97036C2 (en) | 2011-12-26 |
Family
ID=40589783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201008762A UA97036C2 (en) | 2007-12-14 | 2008-05-12 | Cyclopropyl amine derivatives |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US9108948B2 (ru) |
| EP (1) | EP2231631A1 (ru) |
| JP (1) | JP5649975B2 (ru) |
| KR (1) | KR20100095011A (ru) |
| CN (2) | CN101952267A (ru) |
| AR (1) | AR069691A1 (ru) |
| AU (1) | AU2008338748B2 (ru) |
| BR (1) | BRPI0821258A2 (ru) |
| CA (1) | CA2709081C (ru) |
| CO (1) | CO6290643A2 (ru) |
| CR (1) | CR11500A (ru) |
| DO (1) | DOP2010000181A (ru) |
| EC (1) | ECSP10010253A (ru) |
| GT (1) | GT201000170A (ru) |
| IL (1) | IL206254A0 (ru) |
| MX (1) | MX2010006535A (ru) |
| NZ (2) | NZ601644A (ru) |
| PA (1) | PA8807301A1 (ru) |
| PE (1) | PE20091428A1 (ru) |
| RU (1) | RU2010129078A (ru) |
| UA (1) | UA97036C2 (ru) |
| WO (1) | WO2009079225A1 (ru) |
| ZA (1) | ZA201004655B (ru) |
Families Citing this family (14)
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| US20110245267A1 (en) | 2008-12-19 | 2011-10-06 | Schering Plough Corporation | Piperidine and piperazine derivatives and methods of use thereof |
| WO2010080757A2 (en) | 2009-01-07 | 2010-07-15 | Astrazeneca Ab | Combinations with an alpha-4beta-2 nicotinic agonist |
| TW201039825A (en) * | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
| US20100227876A1 (en) * | 2009-03-06 | 2010-09-09 | Rechfensen Llp | Methods of Reducing Side Effects of Analgesics |
| US9186353B2 (en) * | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| AR079851A1 (es) | 2010-01-08 | 2012-02-22 | Takeda Pharmaceutical | Derivados de benzazepina para tratamiento de desordenes en el sistema nervioso central |
| WO2011083315A1 (en) | 2010-01-08 | 2011-07-14 | Takeda Pharmaceutical Company Limited | Compounds and their use |
| WO2011083316A1 (en) | 2010-01-08 | 2011-07-14 | Takeda Pharmaceutical Company Limited | Benzazepine derivatives for the treatment of central nervous system disorders |
| WO2012037258A1 (en) * | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
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2007
- 2007-12-14 US US11/956,816 patent/US9108948B2/en not_active Expired - Fee Related
-
2008
- 2008-05-12 UA UAA201008762A patent/UA97036C2/ru unknown
- 2008-12-05 KR KR1020107015538A patent/KR20100095011A/ko not_active Withdrawn
- 2008-12-05 CN CN2008801268829A patent/CN101952267A/zh active Pending
- 2008-12-05 AU AU2008338748A patent/AU2008338748B2/en not_active Ceased
- 2008-12-05 CA CA2709081A patent/CA2709081C/en not_active Expired - Fee Related
- 2008-12-05 MX MX2010006535A patent/MX2010006535A/es active IP Right Grant
- 2008-12-05 BR BRPI0821258-9A patent/BRPI0821258A2/pt not_active IP Right Cessation
- 2008-12-05 EP EP08861197A patent/EP2231631A1/en not_active Withdrawn
- 2008-12-05 CN CN201310400583.2A patent/CN103483234A/zh active Pending
- 2008-12-05 JP JP2010538064A patent/JP5649975B2/ja not_active Expired - Fee Related
- 2008-12-05 NZ NZ601644A patent/NZ601644A/xx not_active IP Right Cessation
- 2008-12-05 WO PCT/US2008/085622 patent/WO2009079225A1/en not_active Ceased
- 2008-12-05 NZ NZ617334A patent/NZ617334A/en not_active IP Right Cessation
- 2008-12-05 RU RU2010129078/04A patent/RU2010129078A/ru not_active Application Discontinuation
- 2008-12-11 PA PA20088807301A patent/PA8807301A1/es unknown
- 2008-12-11 PE PE2008002048A patent/PE20091428A1/es not_active Application Discontinuation
- 2008-12-12 AR ARP080105430A patent/AR069691A1/es unknown
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2010
- 2010-06-08 IL IL206254A patent/IL206254A0/en unknown
- 2010-06-11 GT GT201000170A patent/GT201000170A/es unknown
- 2010-06-11 CO CO10070735A patent/CO6290643A2/es not_active Application Discontinuation
- 2010-06-14 EC EC2010010253A patent/ECSP10010253A/es unknown
- 2010-06-14 CR CR11500A patent/CR11500A/es not_active Application Discontinuation
- 2010-06-14 DO DO2010000181A patent/DOP2010000181A/es unknown
- 2010-07-01 ZA ZA2010/04655A patent/ZA201004655B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ601644A (en) | 2013-11-29 |
| CO6290643A2 (es) | 2011-06-20 |
| IL206254A0 (en) | 2010-12-30 |
| PE20091428A1 (es) | 2009-10-24 |
| GT201000170A (es) | 2012-04-03 |
| PA8807301A1 (es) | 2009-07-23 |
| CA2709081A1 (en) | 2009-06-25 |
| US9108948B2 (en) | 2015-08-18 |
| KR20100095011A (ko) | 2010-08-27 |
| CR11500A (es) | 2010-10-11 |
| US20080242653A1 (en) | 2008-10-02 |
| RU2010129078A (ru) | 2012-01-20 |
| CN103483234A (zh) | 2014-01-01 |
| BRPI0821258A2 (pt) | 2015-06-16 |
| NZ617334A (en) | 2015-10-30 |
| AU2008338748B2 (en) | 2013-05-16 |
| DOP2010000181A (es) | 2010-06-30 |
| AR069691A1 (es) | 2010-02-10 |
| WO2009079225A1 (en) | 2009-06-25 |
| JP5649975B2 (ja) | 2015-01-07 |
| ECSP10010253A (es) | 2010-07-30 |
| AU2008338748A1 (en) | 2009-06-25 |
| EP2231631A1 (en) | 2010-09-29 |
| MX2010006535A (es) | 2010-08-31 |
| JP2011506456A (ja) | 2011-03-03 |
| ZA201004655B (en) | 2011-03-30 |
| CN101952267A (zh) | 2011-01-19 |
| CA2709081C (en) | 2016-03-22 |
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