UA99459C2 - 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer - Google Patents

9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer

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Publication number
UA99459C2
UA99459C2 UAA200912433A UAA200912433A UA99459C2 UA 99459 C2 UA99459 C2 UA 99459C2 UA A200912433 A UAA200912433 A UA A200912433A UA A200912433 A UAA200912433 A UA A200912433A UA 99459 C2 UA99459 C2 UA 99459C2
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Ukraine
Prior art keywords
amine
cancer
treatment
pyraz0l
imidazo
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Application number
UAA200912433A
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English (en)
Ukrainian (uk)
Inventor
Одри ДЕЙВИС
Стефанос ИОАННИДИС
Мишель Лам
Мей Су
Тао ВАН
Хай-Цзюнь Чжан
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Астразенека Аб
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Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of UA99459C2 publication Critical patent/UA99459C2/ru

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
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    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
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    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
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  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Данное изобретение касается соединений формулы (I):(I),их фармацевтических композиций и их применения.Эти соединения обеспечивают лечение миелопролиферативных нарушений и рака.
UAA200912433A 2007-05-04 2008-02-05 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer UA99459C2 (en)

Applications Claiming Priority (1)

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US91627007P 2007-05-04 2007-05-04

Publications (1)

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UA99459C2 true UA99459C2 (en) 2012-08-27

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US (3) US8486966B2 (ru)
EP (1) EP2152705A1 (ru)
JP (1) JP5415403B2 (ru)
KR (1) KR101563372B1 (ru)
CN (1) CN101679426A (ru)
AR (1) AR066429A1 (ru)
AU (1) AU2008247159B2 (ru)
BR (1) BRPI0811534A2 (ru)
CA (1) CA2684693C (ru)
CL (1) CL2008001297A1 (ru)
CO (1) CO6251294A2 (ru)
EC (1) ECSP099751A (ru)
IL (1) IL201691A0 (ru)
MX (1) MX2009011944A (ru)
MY (1) MY147890A (ru)
NZ (1) NZ581633A (ru)
PE (1) PE20090238A1 (ru)
RU (1) RU2481348C2 (ru)
SA (1) SA08290271B1 (ru)
TW (1) TWI406864B (ru)
UA (1) UA99459C2 (ru)
UY (1) UY31065A1 (ru)
WO (1) WO2008135785A1 (ru)
ZA (1) ZA200907679B (ru)

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