US20040143207A1 - Apparatus usable in haemofiltration treatment - Google Patents

Apparatus usable in haemofiltration treatment Download PDF

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Publication number
US20040143207A1
US20040143207A1 US10/699,098 US69909803A US2004143207A1 US 20040143207 A1 US20040143207 A1 US 20040143207A1 US 69909803 A US69909803 A US 69909803A US 2004143207 A1 US2004143207 A1 US 2004143207A1
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Prior art keywords
blood
patient
pump
oxygenating device
oxygenating
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Abandoned
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US10/699,098
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English (en)
Inventor
Florenziano Torre
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Freeview Ventures LLC
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Freeview Ventures LLC
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Application filed by Freeview Ventures LLC filed Critical Freeview Ventures LLC
Assigned to FREEVIEW VENTURES LLC reassignment FREEVIEW VENTURES LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DELLA TORRE, FLORENZIANO
Publication of US20040143207A1 publication Critical patent/US20040143207A1/en
Priority to US12/043,696 priority Critical patent/US7942842B2/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698—Blood oxygenators with or without heat-exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342—Adding solutions to the blood, e.g. substitution solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3626—Gas bubble detectors

Definitions

  • the present invention relates to an apparatus usable in CRRT (Continuous Renal Replacement Therapy) treatment.
  • CRRT Continuous Renal Replacement Therapy
  • haemodialysis haemofiltration
  • ultrafiltration all of which provide for removing waste products from the patient. That is, the patient's blood is fed through filters or membranes to eliminate the waste substances in it, and is then fed back to the patient.
  • CAVH Continuous ArterioVenous Haemofiltration
  • CVVH Continuous VenoVenous Haemofiltration
  • CRRT CRRT
  • a CRRT machine comprises a central unit connected at the input and output to the patient, e.g. by means of one or more catheters inserted inside corresponding blood vessels, to continuously withdraw the blood for treatment and feed back the treated blood.
  • the central unit of a CRRT machine normally comprises a blood pump, blood heating and processing means, such as, heparin adding means, means for feeding refill liquid into the blood, and a haemofilter.
  • the blood withdrawn continuously from the patient is thus pumped by the blood pump along the machine circuit, heparin and appropriately heated refill liquid is added, and the blood is then filtered before being fed back to the patient.
  • the advantages of the apparatus according to the present invention substantially lie in greatly improving “decapneisation”, i.e. in greatly reducing the CO 2 values of the blood.
  • reducing FiO 2 from 100 to 70% has been found to increase O 2 saturation of the patient from 92 to 100%. This is extremely important, in that the poor capacity of the lung to exchange O 2 constitutes a serious complication in many patients.
  • Another advantage lies in the principle of the present invention being applicable to existing machines, which can be altered to achieve more complete, more effective performance.
  • the characteristics of an apparatus in accordance with the invention remain unchanged with very little maintenance.
  • FIG. 1 shows, schematically and not to scale, one possible embodiment of a CRRT apparatus in accordance with the present invention.
  • Number 1 in FIG. 1 indicates as a whole a CRRT apparatus in accordance with the present invention.
  • Apparatus 1 is connected at the input to a patient P by a first conduit 9 , which may be defined, for example, by a Horizon Medical Product DLC600 KC 11.5 Fr or DLC 800 KC femoral catheter.
  • a first conduit 9 which may be defined, for example, by a Horizon Medical Product DLC600 KC 11.5 Fr or DLC 800 KC femoral catheter.
  • Other means may, of course be used to connect the apparatus to the patient, and data relative to other component parts described herein is also provided purely by way of non-limiting examples.
  • Catheter 9 is connected to a conduit 90 , which is fitted with and acted on downstream by a blood pump 3 ; a gauge 20 is also provided to measure the intake arterial pressure of the patient.
  • the successive portions of the path along which the blood flows are defined by conduit portions 91 , 92 , 93 , 94 and 95 .
  • Pump 3 pumps the blood downstream (in the direction shown by the arrows) to a connecting member 4 , after first adding heparin by means of a conduit 50 connected to conduit 91 and to a heparin tank (syringe) 5 .
  • a conduit 60 is connected to the input of connecting member 4 to supply, by means of a pump 61 , a refill liquid or infusion contained in a tank 6 and heated by heating means 62 .
  • a gauge 40 is provided at connecting member 4 to measure the pressure at that point along the path.
  • conduit portion 92 Downstream from connecting member 4 , conduit portion 92 is connected to an oxygenating device 7 or “decapneisator”, which may be a Jostra Polystan mycro or Jostra Safe mycro neonatal type, and which is connected by a conduit 77 to an oxygen tank 78 , and is fitted inside with an oxygenating membrane 71 .
  • Oxygenating device 7 provides for supplying oxygen to eliminate CO 2 from the blood; for which purpose, CO 2 is eliminated through an outlet 70 of device 7 and sent to measuring means not shown.
  • conduit portion 93 Downstream from “decapneisator” 7 , conduit portion 93 is connected to a blood filter or haemofilter 8 having an output connected to a conduit 80 for discharging ultrafiltrate into a collecting tank 81 .
  • Conduit 80 is fitted with control means 82 , which may be defined, for example, by a detector for detecting blood loss in the ultrafiltrate, and which acts directly on conduit 80 .
  • Blood filter 8 may be a currently marketed type, such as a MEDICA company MEDISULFONE D200 haemofilter.
  • Apparatus 1 according to the present invention advantageously does not employ an ultrafiltrate pump, in that, using oxygenating device 7 , ultrafiltration takes place naturally, in a more physiologically correct manner.
  • conduit portion 94 Downstream from filter 8 , conduit portion 94 is connected to a member 49 defined by a venous vessel and having a gauge 48 for measuring the pressure of the return blood to the patient.
  • conduit portion 95 Downstream from member 49 , conduit portion 95 —which is fitted with an air detector 47 to prevent emboli (e.g. a UABD ultrasonic air bubble detector)—is connected to a return catheter 9 ′ for feeding the blood back to patient P.
  • emboli e.g. a UABD ultrasonic air bubble detector
  • an apparatus in accordance with the present invention comprises a CRRT machine, and an oxygenating device or “decapneisator”.
  • the CRRT machine may be an Equasmart Medica equipped with appropriate connecting tubes, catheters, connections, etc.
  • the apparatus is advantageous in all cases in which the oxygen concentration of the blood requires supplementing, and especially in eliminating CO 2 in patients in which correct substitute respiration therapy is difficult to apply.
  • the apparatus is connected to the patient undergoing CVVH treatment, and a patient weight loss is set as required. For example, a total weight loss of 2400 g and an hourly loss of 100 g may be programmed. These two parameters determine a treatment time of 24 hours. Administration of an anticoagulant equal to 1.5 times the blood coagulation time may be set; in which case, a pump flow rate (QB) of 280-300 ml/min and an oxygen flow rate (QO 2 ) of 500 ml/min will be programmed.
  • QB pump flow rate
  • QO 2 oxygen flow rate
  • the patient is connected to a CRRT machine, using an oxygenating device located and acting upstream from the blood filter and downstream from the blood pump.
  • This location of the oxygenating device is particularly important. In fact, it means the oxygenating membranes of the oxygenating device operate without the intake (negative) pressure along the portion upstream from the blood pump, and also without the blood concentration characteristic of the venous portion, which could eventually impair their efficiency.
  • a weight loss i.e. the quantity of liquid to be drained
  • An anticoagulant infusion in line with standard CRRT protocols will therefore be provided, with a blood flow rate (QB) of over 300 ml/min, and an oxygen flow rate (QO 2 ) higher than QB. It is important to continuously monitor both coagulation time, which must be kept constantly at one and a half times normal, and oxygen saturation, haematocrit, blood volume values, etc.
  • a CRITE-LINE or similar apparatus may be used.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)
  • Amplifiers (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Registering, Tensioning, Guiding Webs, And Rollers Therefor (AREA)
US10/699,098 2002-10-31 2003-10-30 Apparatus usable in haemofiltration treatment Abandoned US20040143207A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/043,696 US7942842B2 (en) 2002-10-31 2008-03-06 Apparatus and method for the treatment of blood

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000208A ITFI20020208A1 (it) 2002-10-31 2002-10-31 Apparecchiatura utilizzabile in trattamenti di emofiltrazione.
ITFI2002A000208 2002-10-31

Related Child Applications (1)

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US12/043,696 Continuation US7942842B2 (en) 2002-10-31 2008-03-06 Apparatus and method for the treatment of blood

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US20040143207A1 true US20040143207A1 (en) 2004-07-22

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ID=32088997

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US10/699,098 Abandoned US20040143207A1 (en) 2002-10-31 2003-10-30 Apparatus usable in haemofiltration treatment
US12/043,696 Expired - Lifetime US7942842B2 (en) 2002-10-31 2008-03-06 Apparatus and method for the treatment of blood

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US12/043,696 Expired - Lifetime US7942842B2 (en) 2002-10-31 2008-03-06 Apparatus and method for the treatment of blood

Country Status (6)

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US (2) US20040143207A1 (de)
EP (1) EP1415673B2 (de)
AT (1) ATE457757T2 (de)
DE (1) DE60331281D1 (de)
ES (1) ES2341324T5 (de)
IT (1) ITFI20020208A1 (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080243045A1 (en) * 2003-10-03 2008-10-02 Medical Service S.R.L Apparatus and method for the treatment of blood
EP2606921A1 (de) 2011-12-21 2013-06-26 Infomed SA Vorrichtung zur Blutreinigung durch extrakorporale Zirkulation
CN117202946A (zh) * 2021-04-13 2023-12-08 B·布莱恩·阿维图姆股份公司 用于有机流体的血液二氧化碳去除的体外回路

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITFI20030256A1 (it) * 2003-10-09 2005-04-10 Angela Caramuta Dispositivo per l'eliminazione dell'anidride carbonica
WO2005107928A2 (en) 2004-04-27 2005-11-17 Vital Therapies, Inc. Metabolic detoxification system and method
EP2238995A1 (de) * 2009-04-09 2010-10-13 Gazzano, Michele System zur Behandlung von Blut
ITBO20120197A1 (it) * 2012-04-12 2013-10-13 Medical Service S R L Apparecchiatura utilizzabile in procedure di ventilazione meccanica o assistita
CN104971391A (zh) * 2015-06-19 2015-10-14 南方医科大学珠江医院 新型组合型肝肾支持系统crrt模式管路
ITUB20159389A1 (it) * 2015-12-18 2017-06-18 Eurosets Srl Apparecchiatura per la decapneizzazione del sangue
ITUB20159161A1 (it) * 2015-12-18 2017-06-18 Eurosets Srl Apparecchiatura per la decapneizzazione del sangue
IT201700038389A1 (it) * 2017-04-07 2018-10-07 In10Sivecare S R L Apparecchiatura per il trattamento extracorporeo del sangue

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4828543A (en) * 1986-04-03 1989-05-09 Weiss Paul I Extracorporeal circulation apparatus
US5858238A (en) * 1996-03-08 1999-01-12 Baxter Research Medical, Inc. Salvage of autologous blood via selective membrane/sorption technologies
US20020077581A1 (en) * 2000-12-19 2002-06-20 Alan Davidner Simplified cerebral retroperfusion apparatus and method
US6561997B1 (en) * 1999-04-23 2003-05-13 The Regents Of The University Of Michigan Extracorporeal fluid circuit and related methods
US6626857B1 (en) * 1998-11-19 2003-09-30 Tomio Ohta Extracorporeal circulation device and method for isolation temperature control method

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US4666425A (en) * 1985-12-17 1987-05-19 The Dis Corporation Device for perfusing an animal head
DE4113185C1 (en) * 1991-04-23 1992-07-23 Fresenius Ag, 6380 Bad Homburg, De Extracorporeal blood gas exchanger - has gas exchanger with blood inlet and outlet lines coupled by ultra-filtrate discharge device
US5211849B1 (en) * 1991-10-11 1997-05-27 Childrens Hosp Medical Center Hemofiltration system and method
US5368555A (en) * 1992-12-29 1994-11-29 Hepatix, Inc. Organ support system
US6193681B1 (en) * 1998-09-14 2001-02-27 American Immuno Tech, Llc. Septicemia prevention and treatment system
DE19858950A1 (de) * 1998-12-09 2000-06-29 Robby Knueppel Vorrichtung zum extrakorporalen Stoff- und Gasaustausch von Blut
JP2001178817A (ja) * 1999-12-24 2001-07-03 Terumo Corp 人工腎臓用装置およびこれを用いた品質評価装置ならびに流体回路
CN100346869C (zh) * 2001-02-07 2007-11-07 尼弗茹斯公司 用于血液透析过滤供应组件的方法和装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4828543A (en) * 1986-04-03 1989-05-09 Weiss Paul I Extracorporeal circulation apparatus
US5858238A (en) * 1996-03-08 1999-01-12 Baxter Research Medical, Inc. Salvage of autologous blood via selective membrane/sorption technologies
US6626857B1 (en) * 1998-11-19 2003-09-30 Tomio Ohta Extracorporeal circulation device and method for isolation temperature control method
US6561997B1 (en) * 1999-04-23 2003-05-13 The Regents Of The University Of Michigan Extracorporeal fluid circuit and related methods
US20020077581A1 (en) * 2000-12-19 2002-06-20 Alan Davidner Simplified cerebral retroperfusion apparatus and method

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080243045A1 (en) * 2003-10-03 2008-10-02 Medical Service S.R.L Apparatus and method for the treatment of blood
US8070952B2 (en) 2003-10-03 2011-12-06 Medical Service S.R.L. Apparatus and method for the treatment of blood
EP2606921A1 (de) 2011-12-21 2013-06-26 Infomed SA Vorrichtung zur Blutreinigung durch extrakorporale Zirkulation
CN117202946A (zh) * 2021-04-13 2023-12-08 B·布莱恩·阿维图姆股份公司 用于有机流体的血液二氧化碳去除的体外回路

Also Published As

Publication number Publication date
ES2341324T5 (es) 2018-10-24
EP1415673A1 (de) 2004-05-06
ES2341324T3 (es) 2010-06-18
US7942842B2 (en) 2011-05-17
US20080154171A1 (en) 2008-06-26
EP1415673B2 (de) 2018-06-20
EP1415673B1 (de) 2010-02-17
ITFI20020208A1 (it) 2004-05-01
DE60331281D1 (de) 2010-04-01
ATE457757T2 (de) 2010-03-15

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Owner name: FREEVIEW VENTURES LLC, TEXAS

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:DELLA TORRE, FLORENZIANO;REEL/FRAME:015176/0502

Effective date: 20040219

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION