US20130102832A1 - Brachytherapy devices and related methods having microencapsulated brachytherapy materials - Google Patents

Brachytherapy devices and related methods having microencapsulated brachytherapy materials Download PDF

Info

Publication number
US20130102832A1
US20130102832A1 US13/594,214 US201213594214A US2013102832A1 US 20130102832 A1 US20130102832 A1 US 20130102832A1 US 201213594214 A US201213594214 A US 201213594214A US 2013102832 A1 US2013102832 A1 US 2013102832A1
Authority
US
United States
Prior art keywords
microspheres
microcapsule
bioabsorbable
support
radioactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US13/594,214
Other languages
English (en)
Inventor
Seth A. Hoedl
Bruce Kitzman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Civatech Oncology
Original Assignee
Civatech Oncology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Civatech Oncology filed Critical Civatech Oncology
Priority to US13/594,214 priority Critical patent/US20130102832A1/en
Publication of US20130102832A1 publication Critical patent/US20130102832A1/en
Assigned to CIVATECH ONCOLOGY reassignment CIVATECH ONCOLOGY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HOEDL, SETH A., KITZMAN, BRUCE
Priority to US15/657,898 priority patent/US10646724B2/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor
    • A61N2005/1023—Means for creating a row of seeds, e.g. spacers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor
    • A61N2005/1024—Seeds

Definitions

  • the present invention relates to brachytherapy, and more particularly, to brachytherapy devices having microencapsulated radioactive materials.
  • Low-dose rate brachytherapy may provide a viable alternative to external beam radiation and high-dose rate brachytherapy. Although low-dose brachytherapy is most often used for prostate cancer, low-dose brachytherapy is being considered increasingly with respect to other cancers, such as breast cancer.
  • a brachytherapy device includes a bioabsorbable support and a plurality of microcapsules on the support.
  • Each of the plurality of microcapsules includes a plurality of microspheres and a bioabsorbable microcapsule wall that encloses the plurality of microspheres.
  • the plurality of microspheres includes radiation-emitting microspheres comprising a radioactive material, radio-opaque microspheres comprising a radio-opaque material or a combination thereof.
  • the plurality of microspheres have a diameter of about 1 to 20 microns.
  • the plurality of microspheres may be sized and configured so as to be subject to phagocytosis by macrophages in a subject after bioabsorption of the bioabsorbable support and the bioabsorbable microcapsule wall.
  • the bioabsorbable support and the microcapsule wall have a decay time that is greater than about two and a half times a half life of the radioactive material.
  • Some of the plurality of microspheres may include a radioactive core and an outer wall.
  • the radioactive core may include a radioactive material and a biocompatible polymer and/or ceramic.
  • the radioactive core may include a porous material and a radio-isotope deposited therein.
  • the outer wall may include glass or acrylic.
  • the microcapsule wall includes a poly-lactide, poly-glycolide, polycaprolactone, poly-trimethylene-carbonate, polyanhdride, co-polymers formed thereof, and/or combinations thereof
  • the bioabsorbable support includes a poly-lactide, poly-glycolide, polycaprolactone, poly-trimethylene-carbonate, polyanhdride, co-polymers formed thereof, and/or combinations thereof
  • the bioabsorbable support is configured to seal the microcapsules therein after implantation.
  • a size and/or thickness of the bioabsorbable support and/or microcapsule walls is configured to release the microspheres after a predetermined time.
  • the predetermined time may be greater than two and a half times a half life of the radioactive material.
  • the predetermined time may be about three months.
  • the bioabsorbable support comprises a seed casing that is configured to seal the plurality of microcapsules therein prior to bioabsorption of the support.
  • the bioabsorbable support comprises a substantially linear support having a plurality of wells therein that is configured to seal the plurality of microcapsules in respective ones of the plurality of wells prior to bioabsorption of the support.
  • the bioabsorbable support comprises a substantially planar support that is configured to seal the plurality of microcapsules therein prior to bioabsorption of the support.
  • a microcapsule includes a microcapsule outer wall, and a plurality of microspheres enclosed by the microcapsule outer wall, wherein the plurality of microspheres comprises radiation-emitting microspheres comprising a radioactive material, radio-opaque microspheres comprising a radio-opaque material or a combination thereof.
  • the plurality of microspheres have a diameter of about 1 to 20 microns.
  • the plurality of microspheres may be sized and configured so as to be subject to phagocytosis by macrophages in a subject after bioabsorption of the bioabsorbable support and the bioabsorbable microcapsule wall.
  • some of the plurality of microspheres comprises a radioactive core and an outer wall.
  • the radioactive core may include a radioactive material and a biocompatible polymer and/or ceramic.
  • the radioactive core may include a porous material and a radio-isotope deposited therein.
  • the outer wall may include glass or acrylic.
  • the microcapsule wall may include a poly-lactide, poly-glycolide, polycaprolactone, poly-trimethylene-carbonate, polyanhdride, co-polymers formed thereof, and/or combinations thereof.
  • FIG. 1 is a cross-sectional schematic diagram of a low-dose-rate (LDR) brachytherapy device according to some embodiments of the present invention.
  • LDR low-dose-rate
  • FIG. 2 is a cross-sectional schematic diagram of a bioabsorbable microcapsule including radioactive microspheres according to some embodiments of the present invention.
  • FIG. 3 is a cross-sectional schematic diagram of a bioabsorbable microcapsule including radio-opaque microspheres according to some embodiments of the present invention.
  • FIG. 4 is a cross-sectional schematic diagram of a bioabsorbable microcapsule including radioactive microspheres and radio-opaque microspheres according to some embodiments of the present invention.
  • FIG. 5 is a cross-sectional schematic diagram of a radioactive microsphere according to some embodiments of the present invention.
  • FIG. 6 is a cross-sectional schematic diagram of a radio-opaque microsphere according to some embodiments of the present invention.
  • FIG. 7 is a cross-sectional schematic diagram of a brachytherapy seed having a radioactive core comprising microcapsules according to some embodiments of the present invention.
  • FIG. 8 is a cross-sectional schematic diagram of a generally linear brachytherapy device having a radioactive core comprising microcapsules according to some embodiments of the present invention.
  • FIG. 9 is a top view schematic diagram of a generally planar brachytherapy device having a radioactive core comprising microcapsules according to some embodiments of the present invention.
  • FIG. 10 is a cross-sectional side view of the brachytherapy device of FIG. 9 .
  • phrases such as “between X and Y” and “between about X and Y” should be interpreted to include X and Y.
  • phrases such as “between about X and Y” mean “between about X and about Y.”
  • phrases such as “from about X to Y” mean “from about X to about Y.”
  • spatially relative terms such as “under,” “below,” “lower,” “over,” “upper” and the like, may be used herein for ease of description to describe one element or feature's relationship to another element(s) or feature(s) as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is inverted, elements described as “under” or “beneath” other elements or features would then be oriented “over” the other elements or features.
  • the exemplary term “under” can encompass both an orientation of “over” and “under.”
  • the device may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.
  • the terms “upwardly,” “downwardly,” “vertical,” “horizontal” and the like are used herein for the purpose of explanation only unless specifically indicated otherwise.
  • Biocompatible refers to a material and any metabolites or degradation products thereof that are generally non-toxic to the recipient and do not cause any significant adverse effects to the subject.
  • the criteria for defining significant adverse effects may be based on criteria used by regulatory agencies such as the U.S. Food and Drug Administration.
  • Biodegradable or “bioabsorbable” refers to a material that will degrade or erode under physiologic conditions to smaller units or chemical species that are capable of being metabolized, eliminated, absorbed or excreted by the subject.
  • embodiments are described herein as relating to breast cancer and implantation in breast tissue, it should be understood that other types of cancer may be treated using the methods and devices described herein, including lung cancer, bladder cancer, colon cancer, kidney or renal cancer, pancreatic cancer, prostate cancer thyroid cancer, head and neck cancers and soft tissue sarcomas.
  • FIGS. 1-10 Embodiments according to the present invention will now be described with respect to FIGS. 1-10 .
  • FIG. 1 An exemplary device 10 in which a substrate or scaffold support 20 includes a plurality of wells 22 is shown in FIG. 1 .
  • the wells 22 may include either a radioactive material 30 or a radio-opaque marker material 40 or a combination thereof As illustrated in FIGS. 2-3 , the radioactive material 30 may be provided by a plurality of radiation treatment microcapsules 50 ( FIG. 2 ) and the radio-opaque marker material 40 may be provided by a plurality of radio-opaque microcapsules 50 ( FIG. 3 ).
  • the radiation treatment microcapsules 50 include a bioabsorbable microcapsule body or wall 52 that has radioactive microspheres 54 embedded therein.
  • the radio-opaque microcapsules 60 include a bioabsorbable microcapsule body or wall 62 that has radio-opaque microspheres 64 embedded therein.
  • the device 10 of FIG. 1 is illustrated with respect to wells 22 that include either a radioactive material 30 or a radio-opaque marker material 40 , it should be understood that the wells 22 may include both radiation treatment microcapsules 50 and radio-opaque microcapsules 60 .
  • a microcapsule 70 is shown that includes both radioactive microspheres 54 and radio-opaque microspheres 64 . Therefore, microcapsules according to some embodiments may include either radioactive or radio-opaque microspheres or a combination thereof
  • LDR brachytherapy devices may addresses concerns such as future imaging (e.g., mammography) and cosmetic concerns of LDR brachytherapy, including the potential toxicity of the radio-isotope or its decay products to healthy tissue as they are released from the bioabsorbable device.
  • the microcapsules 50 , 60 , 70 ( FIGS. 2-4 ) and various components of the support 20 ( FIG. 1 ) may be biocompatible and biodegradable and/or bioabsorbable; however, the radioactive microspheres 54 and radio-opaque microspheres 64 may be biocompatible, but not biodegradable or bioabsorbable.
  • the biodegradable/bioabsorbable components of the device 10 may be selected such that they degrade or absorb into the body after a substantial amount of radioactive decay has occurred.
  • the microspheres 54 , 64 disperse within the body.
  • the radioactive microspheres 54 and the biodegradable components of the device 10 may be selected so that the time that the biodegradable/bioabsorbable components take to degrade and release the radioactive microspheres 54 is sufficient to allow significant decay of the radioactive material in the microspheres 54 .
  • the biodegradable components of the device 10 permit the radioactive microspheres 54 to be fixed in a desired location during radiation treatment, but once the radioactive material has decayed such that its therapeutic value is decreased and its potential to deliver radiation to healthy tissue is reduced, the biodegradable components of the device 10 degrade and/or are absorbed into the body and the microspheres 54 , 64 are released.
  • devices described herein will not directly expose a patient to the radioactive components after it is bioabsorbed or biodegraded.
  • the microspheres 54 , 64 may include a respective microsphere core 54 A, 64 A and an outer microsphere wall 54 B, 64 B.
  • the walls 54 B, 64 B may be biocompatible and may provide a barrier between the respective cores 54 A, 64 A and tissue in the body.
  • the size of the microspheres 54 , 64 is selected so that macrophages in the patient's body can engulf the microspheres in the process of phagocytosis.
  • LDR brachytherapy devices having any suitable shape and configuration, including conventional brachytherapy seed shapes, planar sheets, uni-directional devices having a radiation shielding material and the like.
  • LDR brachytherapy devices that may be suitable for use with the microcapsules described herein, for example, with respect to FIGS. 2-4 may be found, e.g., in U.S. Pat. No. 7,686,756 and U.S. Publication No. 20090275793, the disclosures of which are hereby incorporated by reference in their entirety. For example, as shown in FIG.
  • a brachytherapy device 110 includes a sealed housing or casing 112 and a radioactive material 114 .
  • the radioactive material 114 may include one or more of the microcapsules 50 , 60 , 70 .
  • the sealed casing 112 may be a biocompatible and/or bioabsorbable material. According to some embodiments, the type of bioabsorbable material in the casing 112 may be evaluated to ensure that the radioactive material 114 is sealed for a sufficient period of time, such as until the radioactive material 114 decays to a safe level, such as less than 10%, less than 5% or even less than 1% of the original radioactivity.
  • a device 120 includes a plurality of globules of radioactive material 122 encapsulated in a sealed casing 124 .
  • the radioactive material 122 may include one or more of the microcapsules 50 , 60 , 70 .
  • the linear device 20 may be suitable for implantation, e.g., in breast or prostate tissue.
  • a planar device 130 includes a radioactive material 132 in a planar sealed casing 134 .
  • the radioactive material 132 may include one or more of the microcapsules 50 , 60 , 70 .
  • the sealed casing 134 may include two planar members 134 A and 134 B with the radioactive material 132 positioned therebetween.
  • Any suitable bioabsorbable or biodegradable material may be used, such as copolymers and homopolymers of glycolic acid (GA) and L-lactic acid (LA) or combinations thereof, including copolymers having a blend of these two base materials (e.g., Vicyrl (Polyglactin 910), for instance, is formed with a 90:10 GA-to-LA blend).
  • a blend of 18:82 GA-to-LA blend to achieve longer-term stability in the body.
  • Atrisorb® Zila, Inc., Fort Collins, Colo., USA
  • Resolute W. L. Gore and Associates, Inc., Neward, Del., USA
  • Lactosorb® Biomet Microfixation, Jacksonville, Fla., USA
  • palladium-103 may be used in the radioactive microspheres 54 of the microcapsules 50 and 70 ; however, any suitable radioactive material may be used, including palladium-103, iodine-125, cesium-131 and phosphorus-32. Although palladium-103 and its daughter isotope rhodium are both in their elemental forms harmless, both palladium chloride and rhodium trichloride are toxic with intravenous rat LD50s of 3 mg/kg and 215 mg/kg respectively. Typically, palladium-103 is supplied in the chloride form. Thus, a bioabsorbable device that liberates the radio-isotope directly into the patient would likely face significant regulatory hurdles to ensure its long term safety. According to some embodiments, the outer surface of the microspheres is made of a leak-tight biocompatible material, such as glass or acrylic that may reduce or prevent chemical contact with the patient after bioabsorption of the microcapsule.
  • a leak-tight biocompatible material such as glass
  • the flexible scaffold or support 20 of FIG. 1 has an outer diameter of about 0.8 mm and a length of up to 60 mm, and may be molded out of a flexible, bioabsorbable material, such as a poly-lactide/poly-glycolide co-polymer. These dimensions may be used so that the device may be applied with an 18 gauge brachytherapy needle. However, other suitable sizes may be used. Generally regularly spaced wells 22 in this support 20 contain radioactive and/or radio-opaque material.
  • the radioactive material may be palladium-103, and the radio-opaque material could be a gold, iodine, or barium, including compounds and combinations thereof Both the radioactive and radio-opaque materials are each contained within biocompatible microspheres as described herein.
  • the microspheres 54 , 64 may have diameters between 1 and 20 microns. As illustrated in FIGS. 5-6 , the microspheres 54 , 64 may include a respective microsphere core 54 A, 64 A and an outer microsphere wall 54 B, 64 B.
  • the outer microsphere walls 54 B, 64 B may be formed, e,g., of a leak-tight material such as glass or an acrylic, such as polymethylmethacrylate (PMMA).
  • the radioactive core 54 A may be formed of a radioactive material, such as palladium-103, alone or infused in a porous base (e.g., a porous polymer or glass material) or mixed with a polymer.
  • the radio-opaque core 64 A may be formed of any suitable radio-opaque material, such as gold, iodine or barium, including compounds and combinations thereof.
  • the microspheres 54 , 64 are illustrated in FIGS. 5-6 as having respective microsphere cores 54 A, 64 A and outer walls 54 B, 64 B, it should be understood that any suitable configuration may be used.
  • the outer walls 54 B, 64 B are omitted and the microspheres may be formed of a generally homogeneous material, such as a radioactive material alone, infused in a porous base, or mixed with another material, such as a polymer.
  • these microspheres 54 , 64 may in turn be contained in the bioabsorbable microcapsules 50 , 60 , 70 , which may have a diameter of approximately 100 microns or more. These microcapsules may in turn be sealed into the wells 22 in the support 20 with a bioabsorbable material or well sealant.
  • the bioabsorption of devices may proceed as follows. After three months (e.g., five half-lives of the palladium-103), a device using palladium-103 would have delivered 97% of the radiation dose. At that time, the bioabsorbable materials, e.g., including the scaffold support, the well sealant, and the microcapsule wall and other bioabsorbable materials, may begin to significantly decay in the patient's body. In some embodiments, the size and/or thickness of the scaffold support and other bioabsorbable materials may be selected so as to approximate a predetermined decay time, such as a decay time that is greater than two and a half times the half life of the radioactive material or five times or greater than the half life of the radioactive material. The decay process may liberate the microspheres 54 , 64 .
  • a predetermined decay time such as a decay time that is greater than two and a half times the half life of the radioactive material or five times or greater than the half life of the radioactive material.
  • the size of these microspheres 54 , 64 may be chosen so as to increase dispersement of the microspheres 54 , 64 upon release.
  • macrophages in the patient's body may engulf the microspheres in the process of phagocytosis.
  • Phagocytosis is the cellular process of engulfing solid particles by the cell membrane to form an internal phagosome by phagocytes and protists.
  • phagocytosis is a mechanism used to remove pathogens and cell debris. Bacteria, dead tissue cells, and small mineral particles are all examples of objects that may be phagocytosed.
  • the microspheres 54 , 64 may be about 1-20 microns, which may be a suitable size to be subject to phagocytosis.
  • the microspheres 54 , 64 may be sufficiently large so that the macrophages cannot transport the microspheres to the patient's lymph nodes where they may collect and appear confusingly similar to a cancer occurrence or recurrence with a CT or fluoroscopy scan. Instead, due to the size of the microsphere, the macrophages may disperse, but then fix in place, the microspheres 54 , 64 .
  • the walls 54 A, 64 A of these microspheres 54 , 64 may permanently contain both the decay products of the radioactive material core 54 A and the radio-opaque material core 64 A, respectively, for example, with a suitable material such as glass or acrylic, which may reduce or prevent direct contact with body tissue.
  • a suitable material such as glass or acrylic, which may reduce or prevent direct contact with body tissue.
  • the walls 54 A, 64 A may be omitted.
  • the device may no longer be felt as a permanent implant by the patient and it may be appear to dissolve on a CT scan or other imaging scan because the radio-opaque markers in the microspheres 64 will have dispersed such that their visibility is reduced or eliminated. Exposure of healthy tissue to the potentially toxic components of the radioactive materials in the microspheres 54 may also be reduced or eliminated because sufficient radiation decay occurs prior to the release of the microspheres 54 , 64 outside of the desired treatment area.
  • a CT or MRI scan of the diseased tissue such as a breast following a lumpectomy
  • health professionals such as medical physicists in consultation with radiation oncologists, may plan the placement and location of the devices described herein so that a dose is delivered to the diseased tissue while sparing the adjacent healthy tissue.
  • the number and lengths of the devices may be determined for the desired or optimal treatment plan, and therefore, devices according to some embodiments may be customizable for each patient. For example, for breast cancer, it is anticipated that between five to ten linear or string-shaped scaffold devices with lengths between about 1 and 6 cm may be needed to treat a malignancy.
  • the devices according to embodiments of the present invention may be applied in an outpatient setting with minimal anesthesia and the patient may likely leave the hospital the same day.
  • a follow-up CT scan after implantation may be used to confirm device placement and perform quality control.
  • a low-dose rate (LDR) brachytherapy device may reduce or minimize some of the practical problems with permanent seed implants with cancers such as breast cancer while maintaining the LDR technique's efficacy, lower side effect profile, and high convenience when compared to high dose brachytherapy or radiation beam treatment.
  • a device of sufficient size to deliver a uniform or substantially uniform radiation dose and stay fixed in place in tissue, such as breast tissue may have reduced dosimetry uncertainties than traditional seeds.
  • Devices according to some embodiments may be made of flexible polymers and may be more comfortable for the patient than traditional seeds when implanted in soft tissue, such as breast tissue.
  • a bioabsorbable device may reduce the concerns about subsequent mammograms, and cosmetic concerns about permanent implants in soft tissue, such as breast tissue.
  • devices according to the present invention may be customized for each individual patient.
  • a bioabsorbable or biodegradable support or scaffold (such as the support 20 in FIG. 1 , the casing 124 in FIG. 8 , and the casing 134 in FIGS. 9-10 ) is fabricated from a bioabsorbable material such as a poly-lactide, poly-glycolide, polycaprolactone, poly-trimethylene-carbonate, polyanhdride, co-polymers formed thereof, combinations thereof, or any other suitable bioabsorbable or biodegradable material.
  • a bioabsorbable material such as a poly-lactide, poly-glycolide, polycaprolactone, poly-trimethylene-carbonate, polyanhdride, co-polymers formed thereof, combinations thereof, or any other suitable bioabsorbable or biodegradable material.
  • the bioabsorbable material may be chosen so that it has a decay time in the human body that is long enough to allow sufficient decay of the radioisotope, e.g., longer than at least two half-lives of the radioisotope.
  • the support can be formed by either injection molding, solvent casting, laser or mechanical machining or any other suitable method.
  • the microspheres containing a therapeutic radioisotope can be fabricated in a variety of ways.
  • the radioisotope is mixed with a biocompatible polymer, such as PMMA.
  • the mixture may be achieved by dissolving both the radioisotope and the polymer in an appropriate solvent, or may be achieved by mixing the radioisotope into the polymer when the polymer is heated into a molten state.
  • the radioisotope/polymer mixture may then be fabricated into microspheres through a variety of techniques (see, e.g., U.S. Patent Publication No. 2012/0121510) including solvent evaporation (see, e.g., U.S. Pat. Nos. 5,407,609; 5,650,173 and 5,654,008), phase inversion (see U.S. Pat. No. 6,235,224), or spraying methods (see U.S. Pat. No. 5,667,806), or other suitable techniques.
  • the radioisotope may be mixed with a biocompatible ceramic, such as SchottTM 8625 glass, available from Schott, North America, Inc., Elmsford, N.Y., U.S.A.), in the molten phase.
  • a biocompatible ceramic such as SchottTM 8625 glass, available from Schott, North America, Inc., Elmsford, N.Y., U.S.A.
  • the glass/radioisotope mixture may then be formed into microspheres through various techniques including spraying methods (see U.S. Pat. No. 3,279,905).
  • the biocompatible polymer or biocompatible ceramic microspheres may be further processed to the appropriate size, e.g., through a mechanical milling action (see U.S. Pat. No. 5,011,677).
  • the microspheres may include three components: a porous inner core, the radioisotope, and a biocompatible shell.
  • the porous inner core may be made of a porous polymer, such as polyethylene (see U.S. Pat. No. 3,865,674), a porous glass (see U.S. Pat. No. 3,513,106) or other suitable porous material.
  • the porous material may be mechanically milled to the appropriate size.
  • the radioisotope may be deposited as a liquid into the porous cores through a precision deposition process (See U.S. Pat. No. 7,686,756).
  • the radioisotope could be converted from a soluble form into an insoluble form by various techniques, including exposing the soluble form to a plasma, by chemical precipitation and/or by exposing the soluble form to heat.
  • Methods and devices for forming non-soluble radioactive materials are disclosed in U.S. patent application Ser. No. 12/434,131, filed May 1, 2009 and published as U.S. Publication No. 2009/0275793 on Nov. 5, 2009, the disclosure of which is incorporated herein by reference in its entirety.
  • the core and radioisotope may be encapsulated in a biocompatible material using a spray-drying process, interfacial polymerization process (see U.S. Pat. No. 5,277,979) a pan-coating process or any other suitable method.
  • the microspheres containing a radio-opaque material may be fabricated as described above with respect to the microspheres that contain a therapeutic radioisotope except that a radio-opaque material, such as a gold or barium containing compound, replaces the radioisotope.
  • microcapsules containing the microspheres may be fabricated, for example, by mixing the microspheres with a bioabsorbable material, such as poly-lactide, poly-glycolide, polycaprolactone, poly-trimethylene-carbonate or co-polymers formed thereof with a suitable solvent that does not dissolve the material or shell wall of the microspheres.
  • a bioabsorbable material such as poly-lactide, poly-glycolide, polycaprolactone, poly-trimethylene-carbonate or co-polymers formed thereof with a suitable solvent that does not dissolve the material or shell wall of the microspheres.
  • the bioabsorbable shell may have a decay time in the human body that is sufficiently long to encase the radioisotope during its therapeutically useful lifetime and to release the radioisotope after significant decay has occurred, e.g., longer than at least two half-lives of the therapeutic radioisotope or more.
  • This mixture may then be formed into microcapsules of specific size through any of the methods discussed above.
  • the microcapsules are suspended in an emulsion containing a bioabsorbable material dissolved in an appropriate solvent such as toluene or xylene.
  • the emulsion is then deposited in appropriate wells or otherwise affixed or embedded in the bioabsorbable or biodegradable scaffold or support.
  • An emulsion containing the radioactive microcapsules may be deposited in some wells, the emulsion containing the radio-opaque microcapsules may be deposited in other wells or the radioactive microcapsules and radio-opaque microcapsules may be combined in a single emulsion.
  • the solvent may then be allowed to evaporate leaving the microcapsules secured into the scaffold.
  • the microcapsules may be mixed into a bioabsorbable or biodegradable material that is heated into a liquid state.
  • the mixture containing radioactive microcapsules may be deposited in some wells, and the mixture containing radio-opaque microcapsules would be deposited in other wells, or a single mixture including both radioactive and radio-opaque microcapsules may be deposited.
  • the heated mixture may be allowed to cool, thereby securing the microcapsules into the scaffold or support.
  • brachytherapy devices may be treated using the methods and devices described herein, including bladder cancer, colon cancer, kidney or renal cancer, pancreatic cancer, prostate cancer thyroid cancer, head and neck cancers and soft tissue sarcomas.
  • shielding materials may be strategically placed in brachytherapy devices described herein to provide generally uni-directional radiation and to protect healthy tissue adjacent cancer tissue.
  • chemotherapy drugs or other therapeutic agents may be incorporated into the brachytherapy device and delivered to the tissue, e.g., when a portion of the device is bioabsorbed by the body.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
US13/594,214 2011-08-25 2012-08-24 Brachytherapy devices and related methods having microencapsulated brachytherapy materials Abandoned US20130102832A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13/594,214 US20130102832A1 (en) 2011-08-25 2012-08-24 Brachytherapy devices and related methods having microencapsulated brachytherapy materials
US15/657,898 US10646724B2 (en) 2011-08-25 2017-07-24 Brachytherapy devices and related methods having microencapsulated brachytherapy materials

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161527391P 2011-08-25 2011-08-25
US13/594,214 US20130102832A1 (en) 2011-08-25 2012-08-24 Brachytherapy devices and related methods having microencapsulated brachytherapy materials

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US15/657,898 Continuation US10646724B2 (en) 2011-08-25 2017-07-24 Brachytherapy devices and related methods having microencapsulated brachytherapy materials

Publications (1)

Publication Number Publication Date
US20130102832A1 true US20130102832A1 (en) 2013-04-25

Family

ID=47746914

Family Applications (2)

Application Number Title Priority Date Filing Date
US13/594,214 Abandoned US20130102832A1 (en) 2011-08-25 2012-08-24 Brachytherapy devices and related methods having microencapsulated brachytherapy materials
US15/657,898 Active US10646724B2 (en) 2011-08-25 2017-07-24 Brachytherapy devices and related methods having microencapsulated brachytherapy materials

Family Applications After (1)

Application Number Title Priority Date Filing Date
US15/657,898 Active US10646724B2 (en) 2011-08-25 2017-07-24 Brachytherapy devices and related methods having microencapsulated brachytherapy materials

Country Status (4)

Country Link
US (2) US20130102832A1 (de)
EP (1) EP2747839A4 (de)
CA (1) CA2882862C (de)
WO (1) WO2013029024A1 (de)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10981018B2 (en) 2019-02-14 2021-04-20 Gt Medical Technologies, Inc. Radioactive seed loading apparatus
US11278736B2 (en) 2013-03-15 2022-03-22 Gt Medical Technologies, Inc. Dosimetrically customizable brachytherapy carriers and methods thereof in the treatment of tumors
US11383093B1 (en) 2019-12-06 2022-07-12 Hoseon LEE Radiation release capsule
US20220233881A1 (en) * 2019-06-27 2022-07-28 Nucletron Operations B.V. Brachytherapy source assembly
US11413473B2 (en) 2011-04-28 2022-08-16 Gt Medical Technologies, Inc. Customizable radioactive carriers and loading system
US11673002B2 (en) 2016-11-29 2023-06-13 Gt Medical Technologies, Inc. Transparent loading apparatus
US11679275B1 (en) 2015-02-06 2023-06-20 Gt Medical Technologies, Inc. Radioactive implant planning system and placement guide system
US11794033B2 (en) 2017-08-15 2023-10-24 Westinghouse Electric Company Llc Surgically positioned neutron flux activated high energy therapeutic charged particle generation system
US12053644B2 (en) 2021-12-30 2024-08-06 Gt Medical Technologies, Inc. Radiation shielding apparatus for implantable radioactive seeds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020055667A1 (en) * 1998-07-28 2002-05-09 William Mavity Absorbable brachytherapy and chemotherapy delivery devices and methods
US20100261946A1 (en) * 2000-11-16 2010-10-14 Microspherix Llc Flexible and/or elastic brachytherapy seed or strand
US20110118532A1 (en) * 2000-11-16 2011-05-19 Microspherix Llc Brachytherapy seed

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4702228A (en) * 1985-01-24 1987-10-27 Theragenics Corporation X-ray-emitting interstitial implants
US5342283A (en) * 1990-08-13 1994-08-30 Good Roger R Endocurietherapy
US5405309A (en) * 1993-04-28 1995-04-11 Theragenics Corporation X-ray emitting interstitial implants
US6527693B2 (en) * 2001-01-30 2003-03-04 Implant Sciences Corporation Methods and implants for providing radiation to a patient
US7927368B2 (en) * 2002-03-25 2011-04-19 Kieran Murphy Llc Device viewable under an imaging beam
US9265866B2 (en) * 2006-08-01 2016-02-23 Abbott Cardiovascular Systems Inc. Composite polymeric and metallic stent with radiopacity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020055667A1 (en) * 1998-07-28 2002-05-09 William Mavity Absorbable brachytherapy and chemotherapy delivery devices and methods
US20100261946A1 (en) * 2000-11-16 2010-10-14 Microspherix Llc Flexible and/or elastic brachytherapy seed or strand
US20110118532A1 (en) * 2000-11-16 2011-05-19 Microspherix Llc Brachytherapy seed

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11413473B2 (en) 2011-04-28 2022-08-16 Gt Medical Technologies, Inc. Customizable radioactive carriers and loading system
US12478800B2 (en) 2011-04-28 2025-11-25 Gt Medical Technologies, Inc. Customizable radioactive carriers and loading system
US11278736B2 (en) 2013-03-15 2022-03-22 Gt Medical Technologies, Inc. Dosimetrically customizable brachytherapy carriers and methods thereof in the treatment of tumors
US11679275B1 (en) 2015-02-06 2023-06-20 Gt Medical Technologies, Inc. Radioactive implant planning system and placement guide system
US11673002B2 (en) 2016-11-29 2023-06-13 Gt Medical Technologies, Inc. Transparent loading apparatus
US11794033B2 (en) 2017-08-15 2023-10-24 Westinghouse Electric Company Llc Surgically positioned neutron flux activated high energy therapeutic charged particle generation system
US10981018B2 (en) 2019-02-14 2021-04-20 Gt Medical Technologies, Inc. Radioactive seed loading apparatus
US20220233881A1 (en) * 2019-06-27 2022-07-28 Nucletron Operations B.V. Brachytherapy source assembly
US12594436B2 (en) * 2019-06-27 2026-04-07 Nucletron Operations B.V. Brachytherapy source assembly
US11383093B1 (en) 2019-12-06 2022-07-12 Hoseon LEE Radiation release capsule
US12053644B2 (en) 2021-12-30 2024-08-06 Gt Medical Technologies, Inc. Radiation shielding apparatus for implantable radioactive seeds

Also Published As

Publication number Publication date
CA2882862A1 (en) 2013-02-28
CA2882862C (en) 2021-01-19
US20190038915A1 (en) 2019-02-07
EP2747839A4 (de) 2015-05-27
WO2013029024A1 (en) 2013-02-28
EP2747839A1 (de) 2014-07-02
US10646724B2 (en) 2020-05-12

Similar Documents

Publication Publication Date Title
US10646724B2 (en) Brachytherapy devices and related methods having microencapsulated brachytherapy materials
US9289625B2 (en) Brachytherapy seed with fast dissolving matrix for optimal delivery of radionuclides to cancer tissue
US6986880B2 (en) Polymeric-matrix brachytherapy sources
US4702228A (en) X-ray-emitting interstitial implants
US6527693B2 (en) Methods and implants for providing radiation to a patient
US8827884B2 (en) Oncology therapies employing radioactive seeds
CN116615264A (zh) 具有增强的β治疗的扩散性α发射体放射疗法
WO1997019706A9 (en) Radioisotope dispersed in a matrix for brachytherapy
US20080004483A1 (en) Biodegradable seed placement device and method
US7530941B2 (en) X-ray and gamma ray emitting temporary high dose rate brachytherapy source
US20100056843A1 (en) Brachytherapy Seed With Fast Dissolving Matrix for Optimal Delivery of Radionuclides To Cancer Tissue
Goldson et al. Intraoperative radiotherapy for intracranial malignancies: a pilot study
PL241256B1 (pl) Radioaktywny implant i jego zastosowanie
CA2010038A1 (en) Low energy radiation source and devices
Sutton Liver cancer and selective internal radiation therapy
HK1162305A (en) Brachytherapy seed with fast dissolving matrix for optimal delivery of radionuclides to cancer tissue
BRPI0805778B1 (pt) Dispositivo para braquiterapia ocular e método

Legal Events

Date Code Title Description
AS Assignment

Owner name: CIVATECH ONCOLOGY, NORTH CAROLINA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HOEDL, SETH A.;KITZMAN, BRUCE;SIGNING DATES FROM 20121213 TO 20130104;REEL/FRAME:035576/0704

STCB Information on status: application discontinuation

Free format text: ABANDONED -- AFTER EXAMINER'S ANSWER OR BOARD OF APPEALS DECISION