Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
  • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
  • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
  • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
  • C07D213/62—Oxygen or sulfur atoms
  • C07D213/70—Sulfur atoms
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
  • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
  • C07D471/04—Ortho-condensed systems

Definitions

• This invention is concerned with processes for the preparation of 2-(methoxycarbonylamino)-6-(phenylsulfinyl) imidazo [1,2-a] pyridine, which is an active anthelmintic agent.
• the process involves the treatment of a 5-phenylsulfinyl pyridine which is substituted at the 2-position with a leaving group such as a halogen, a loweralkoxy or a loweralkylthio group, with methylchloroacetylcarbamate.
• the quaternary intermediate thus formed is treated with ammonia, preferably in the presence of a protic solvent in order to form the desired product.
• the compound 2-(methoxycarbonylamino)-6-(phenylsulfinyl) imidazo [1,2-a] pyridine is depicted structurally as: ##STR1## and the imidazo [1,2-a] pyridines nucleus is numbered as follows: ##STR2##
• the process of this invention is depicted schematically in the following reaction: ##STR3## wherein X is a leaving group selected from a halogen, such as chlorine, bromine or iodine; loweralkoxy or loweralkylthio.
• the preferred leaving groups are chlorine, bromine, methoxy and methylthio.
• the 5-phenylsulfinyl pyridine substituted at the 2-position with the X leaving group (II) is treated with methylchloroacetylcarbamate.
• the reactants are generally combined in a solvent which for optimum results should be a polar aprotic solvent. Suitable solvents are acetonitrile, dimethylformamide, hexamethylphosphoramide, dimethylacetamide, dimethoxyethane, triethylphosphate and the like.
• the reaction is carried out at from 50° to 150° C over a period of from 1 to 50 hours, however, it is preferred to heat the reaction at from 75° to 100° C for 1 to 24 hours.
• the reaction product is a quaternary ammonium salt and remains in solution at the conclusion of the reaction. By diluting the reaction mixture with large amounts of ether, it would be possible to isolate compound III. However, generally it is preferred not to isolate the product.
• Compound III is then treated with an excess amount of ammonia which displaces the leaving group X and forms the 2-amino compound.
• the reaction is run at rom temperature or less, preferably from 0° C to room temperature.
• the reaction mixture is stirred at the above designated temperatures for from 5 minutes to 2 hours.
• the 2-amino compound is not necessarily isolated. It is preferred to cyclize the 2-amino compound in situ by heating the reaction mixture at temperatures up to 100° C for from 1 to 4 hours. It has been found that the reaction is facilitated by the addition of a protolytic source to the reaction mixture prior to heating. Methanol is preferred especially in quantities in excess of a single molar equivalent. A variation of the above would entail the addition of a quantity of ammonia saturated methanol to the solution of compound III, and completing the reaction as described. Following the above described heating step, the product (I) is isolated using known techniques.
• the starting materials for the above process are prepared by different procedures, depending upon the nature of the X substituent.
• X is halogen compound II is prepared from 5-phenylthio-2-amino pyridine by diazotization in the presence of halogen ions.
• the reaction is carried out in aqueous mineral acid, preferably a hydrohalic acid wherein the halogen of the acid matches the halogen atom to be added onto the substrate.
• the starting 2-amino starting material is combined with the mineral acid and an equimolar quantity of sodium nitrite is slowly added. The addition must be of such a rate that the temperature does not exceed 10° C.
• the reaction mixture is allowed to rise to about 15° C and the solution neutralized with a strong base such as sodium or potassium hydroxide maintaining the temperature at 15° C or less.
• a strong base such as sodium or potassium hydroxide maintaining the temperature at 15° C or less.
• the 2-chloro compound may also be prepared from phosphorous pentachloride in phosphorous oxychloride.
• the reaction mixture is heated to 100° C for from 1-6 hours and the phosphorous oxychloride removed, and the residue added to ice.
• the chloro compound is then isolated using known techniques.
• the compound where X is loweralkoxy, preferably methoxy is prepared from the 2-chloro or bromo compound and sodium methoxide.
• the reaction is carried out in a solvent such as methanol or N-methylpyrrolidinone at from 50° to 150° C and is complete in from 1-12 hours. Where the reaction temperature exceeds the reflux temperature of the reaction mixture, the reaction is carried out in a pressurized bomb.
• the product 2-methoxy compound is isolated using known techniques.
• the 5-(phenylthio)-pyridine-2-thione (VI) is then oxidized to the sulfoxide (VII) using mild oxidizing agents.
• the preferred oxidizing agent is metachloroperbenzoic acid in a non-reactive solvent.
• the reaction is complete in from about 15 minutes to 2 hours and, in order to prevent oxidation of the thione group, the temperature is maintained at room temperature or less.
• the product is isolated using known techniques.
• the 5-(phenylsulfinyl)-pyridine-2-thione (VII) is converted to the methylthio compound (II, X ⁇ SCH 3 ) by reacting it with dimethylsulfate.
• the reaction is carried out in basic solution in aqueous media.
• the bases employed are generally alkali metal hydroxides such as sodium or potassium hydroxide.
• the dimethylsulfate is generally used in excess quantities and the reaction is complete in from 1 to 3 hours at from room temperature to 50° C.
• the phenylthio compound may be employed as the starting material, and the oxidation thereof deferred until the completion of the reaction sequence.
• the reaction conditions above described for the processes involving the phenylsulfinyl compound would be unchanged for the reaction involving the phenylthio compound.
• the compound thus produced would be the 2-methyoxycarbonylamino)-6-(phenylthio) imidazo [1,2-a] pyridine.
• This compound could be oxidized to the analogous phenylsulfinyl compound with mild oxidizing agents such as metachloroperbenzoic acid, peracetic acid or hydrogen peroxide.
• Non-reactive solvents are employed and the reaction is generally complete in from 2 to 10 hours at from room temperature to 50° C.
• the compounds prepared by the processes of this invention are useful for the treatment and control of helminthiasis, a parasitic disease which causes widespread and often serious infections in domesticated animals such as cattle and sheep, and in man.
• the compounds are normally used in unit dosage forms such as tablets, capsules, drenches, paste formulations and the like, wherein the active ingredient is intimately admixed with a suitable inert carrier.
• the compound may also be employed in feeds.
• a suspension of 5-(phenylthio)-2-pyridone (4.06 g., .02 mole) in 50 ml. of phosphorous oxychloride containing 10 g. of phosphorous pentachloride is heated at reflux for 6 hours. Excess phosphorous oxychloride is removed in vacuo and the residue is poured onto icewater mixture. The mixture is cooled and the pH adjusted to neutral with dilute aqueous sodium hydroxide. The resultant suspension is extracted with methylene chloride. The combined extracts are washed with water, dried and evaporated in vacuo to yield 2-chloro-5-(phenylthio)pyridine.
• 2-amino-5-(phenylthio) pyridine (30 g., 0.15 moles) is added portionwise to 30 ml. of concentrated hydrochloric acid at 0°.
• the resultant suspension is cooled to -15° C and 20.7 g. of sodium nitrite in 40 ml. of water is added dropwise while keeping the temperature at -15° to -10° C.
• an aqueous 30% sodium hydroxide solution is slowly added to pH7 while not allowing the temperature to exceed 0° C.
• the resultant mixture is extracted with methylene chloride and the combined extracts are washed with water, dried and evaporated in vacuo to yield 2-chloro-5-(phenylthio) pyridine.
• 2-Amino-5-(phenylthio)pyridine (16.9 g., 0.1 mole) is added to 40 ml. of 48% hydrobromic acid, cooled to 10° C in an ice bath. While maintaining a temperature of 0°, the resultant hydrobromide salt is treated with 37.5 g. of bromine dropwise. The temperature is reduced and maintained at -10° while 14.0 g. of sodium nitrite in 200 ml. of water is added dropwise. After 1 hour at 0° C, the pH of the reaction mixture is adjusted to pH7 with 30% aqueous sodium hydroxide. Following the same workup as for the 2-chloro ananlogue, there is obtained 2-bromo-5-(phenylthio) pyridine.
• Example 11 The procedure of Example 11 may be repeated using 2-bromo-5-(phenylsulfinyl)pyridine, 2methoxy-5-(phenylsulfinyl)pyridine, or 2-(methylthio)-5(phenylsulfinyl) pyridine as starting materials.
• the product produced is 2-(methoxycarbonylamino)-6-(phenylsulfinyl)-imidazo [1,2-a] pyridine.
• Example 11 The procedure of Example 11 may be repeated using 2-chloro-5-(phenylthio)pyridine as the starting material affording as product 2-(methoxycarbonylamino)-6-(phenylthio)imidazo [1,2-a] pyridine.

Landscapes

• Chemical & Material Sciences (AREA)
• Organic Chemistry (AREA)
• Nitrogen Condensed Heterocyclic Rings (AREA)

Priority Applications (4)

Applications Claiming Priority (1)

Publications (1)

Family

ID=25195267

Family Applications (1)

Country Status (4)

Cited By (6)

Citations (1)

• 1977
  • 1977-06-16 US US05/806,974 patent/US4092321A/en not_active Expired - Lifetime
• 1978
  • 1978-05-31 SE SE7806366A patent/SE7806366L/xx unknown
  • 1978-06-06 FI FI781797A patent/FI781797A7/fi not_active Application Discontinuation
  • 1978-06-15 DK DK269478A patent/DK269478A/da unknown

Patent Citations (1)

Non-Patent Citations (2)

Also Published As

Similar Documents