UY28126A1 - Uso de glucocorticoides selectivos para la superficie ocular en el tratamiento de la sequedad ocular - Google Patents

Uso de glucocorticoides selectivos para la superficie ocular en el tratamiento de la sequedad ocular

Info

Publication number
UY28126A1
UY28126A1 UY28126A UY28126A UY28126A1 UY 28126 A1 UY28126 A1 UY 28126A1 UY 28126 A UY28126 A UY 28126A UY 28126 A UY28126 A UY 28126A UY 28126 A1 UY28126 A1 UY 28126A1
Authority
UY
Uruguay
Prior art keywords
eye
treatment
dry eyes
drought
rimexolone
Prior art date
Application number
UY28126A
Other languages
English (en)
Inventor
Ernesto J Castillo
John M Yanni
Daniel A Gamache
Steven T Miller
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of UY28126A1 publication Critical patent/UY28126A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Se describen composiciones oftálmicas tópicas y métodos para el tratamiento de la sequedad ocular. Las composiciones y métodos del invento se basan en el descubrimiento de que las propiedades selectivas para la superficie ocular de la rimexolona glucocorticoide hacen que este agente antiinflamatorio sea especialmente apropiado para el tratamiento de la sequedad ocular. Como resultado de la limitada capacidad de la rimexolona de penetrar la córnea, una alta porción de la droga se mantiene en la superficie del ojo, que es el lugar primario de las afecciones inflamatorias asociadas con la sequedad ocular. Esto permite que se utilice una concentración muy baja de la droga, lo que a su vez reduce la posibilidad de un aumento de la presión intraocular y la formación de cataratas.
UY28126A 2002-12-24 2003-12-15 Uso de glucocorticoides selectivos para la superficie ocular en el tratamiento de la sequedad ocular UY28126A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43625502P 2002-12-24 2002-12-24

Publications (1)

Publication Number Publication Date
UY28126A1 true UY28126A1 (es) 2004-06-30

Family

ID=32682365

Family Applications (1)

Application Number Title Priority Date Filing Date
UY28126A UY28126A1 (es) 2002-12-24 2003-12-15 Uso de glucocorticoides selectivos para la superficie ocular en el tratamiento de la sequedad ocular

Country Status (23)

Country Link
US (3) US20040132704A1 (es)
EP (1) EP1575597B1 (es)
JP (1) JP2006513213A (es)
KR (2) KR100889170B1 (es)
CN (1) CN100388919C (es)
AR (1) AR042790A1 (es)
AT (1) ATE419856T1 (es)
AU (1) AU2003299696B2 (es)
BR (1) BR0317774A (es)
CA (1) CA2507375C (es)
CY (1) CY1108862T1 (es)
DE (1) DE60325770D1 (es)
DK (1) DK1575597T3 (es)
ES (1) ES2316867T3 (es)
MX (1) MXPA05006985A (es)
PL (1) PL378877A1 (es)
PT (1) PT1575597E (es)
RU (1) RU2330668C2 (es)
SI (1) SI1575597T1 (es)
TW (1) TWI335819B (es)
UY (1) UY28126A1 (es)
WO (1) WO2004058273A1 (es)
ZA (1) ZA200503975B (es)

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UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
US8664180B2 (en) 2012-02-06 2014-03-04 Bausch & Lomb Incorporated Ophthalmic compositions containing diglycine
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TW201406761A (zh) 2012-05-18 2014-02-16 Incyte Corp 做爲ｊａｋ抑制劑之哌啶基環丁基取代之吡咯并吡啶及吡咯并嘧啶衍生物
KR102242077B1 (ko) 2012-11-15 2021-04-20 인사이트 홀딩스 코포레이션 룩솔리티니브의 서방성 제형
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WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
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TW201924683A (zh) 2017-12-08 2019-07-01 美商英塞特公司 用於治療骨髓增生性贅瘤的低劑量組合療法
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Also Published As

Publication number Publication date
ZA200503975B (en) 2006-12-27
US20060058277A1 (en) 2006-03-16
SI1575597T1 (sl) 2009-04-30
US20080096852A1 (en) 2008-04-24
CN1732008A (zh) 2006-02-08
RU2330668C2 (ru) 2008-08-10
TW200418492A (en) 2004-10-01
HK1076248A1 (en) 2006-01-13
KR20050086937A (ko) 2005-08-30
AR042790A1 (es) 2005-07-06
EP1575597B1 (en) 2009-01-07
CY1108862T1 (el) 2014-07-02
PT1575597E (pt) 2009-02-02
PL378877A1 (pl) 2006-05-29
MXPA05006985A (es) 2005-08-16
TWI335819B (en) 2011-01-11
CN100388919C (zh) 2008-05-21
DE60325770D1 (de) 2009-02-26
BR0317774A (pt) 2005-11-22
EP1575597A1 (en) 2005-09-21
JP2006513213A (ja) 2006-04-20
WO2004058273A1 (en) 2004-07-15
RU2005123388A (ru) 2006-01-20
US20040132704A1 (en) 2004-07-08
CA2507375A1 (en) 2004-07-15
ES2316867T3 (es) 2009-04-16
KR100889170B1 (ko) 2009-03-16
KR20090018222A (ko) 2009-02-19
AU2003299696B2 (en) 2009-08-13
DK1575597T3 (da) 2009-03-16
AU2003299696A1 (en) 2004-07-22
ATE419856T1 (de) 2009-01-15
CA2507375C (en) 2009-11-24

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