WO1987002869A1 - Adsorbant pour une substance mutagene contenue dans la fumee du tabac et son utilisation - Google Patents

Adsorbant pour une substance mutagene contenue dans la fumee du tabac et son utilisation Download PDF

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Publication number
WO1987002869A1
WO1987002869A1 PCT/JP1986/000571 JP8600571W WO8702869A1 WO 1987002869 A1 WO1987002869 A1 WO 1987002869A1 JP 8600571 W JP8600571 W JP 8600571W WO 8702869 A1 WO8702869 A1 WO 8702869A1
Authority
WO
WIPO (PCT)
Prior art keywords
adsorbent
filter
powder
cellulose
tobacco
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1986/000571
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English (en)
Japanese (ja)
Inventor
Shinichiro Kusunoki
Takuto Nishikawa
Michiko Yagi
Midori Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Advance KK
Original Assignee
Advance KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP25205585A external-priority patent/JPS62111679A/ja
Priority claimed from JP21815886A external-priority patent/JPS6374477A/ja
Application filed by Advance KK filed Critical Advance KK
Publication of WO1987002869A1 publication Critical patent/WO1987002869A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES OF CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
    • A24D3/00—Tobacco smoke filters, e.g. filter tips or filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces of cigars or cigarettes
    • A24D3/06—Use of materials for tobacco smoke filters
    • A24D3/12—Use of materials for tobacco smoke filters of ion exchange materials
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES OF CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
    • A24D3/00—Tobacco smoke filters, e.g. filter tips or filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces of cigars or cigarettes
    • A24D3/06—Use of materials for tobacco smoke filters
    • A24D3/08—Use of materials for tobacco smoke filters of organic materials as carrier or major constituent
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES OF CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
    • A24D3/00—Tobacco smoke filters, e.g. filter tips or filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces of cigars or cigarettes
    • A24D3/06—Use of materials for tobacco smoke filters
    • A24D3/16—Use of materials for tobacco smoke filters of inorganic materials

Definitions

  • the present invention relates to an adsorbent for a mutagen present in tobacco smoke during smoking, a method of using the adsorbent, and a tobacco filter containing the adsorbent.
  • tobacco smoke contains a wide variety of carcinogens, such as polycyclic aromatic hydrocarbons such as benzo (a) pyrene and benzo (a) antracene. It has been confirmed that it is contained.
  • carcinogens such as polycyclic aromatic hydrocarbons such as benzo (a) pyrene and benzo (a) antracene. It has been confirmed that it is contained.
  • an object of the present invention is to provide an adsorbent for a mutagenic substance which can significantly reduce the total mutagenic activity in tobacco smoke without lowering the original flavor of tobacco.
  • Another object of the present invention is to provide a method for removing mutagenic substances present in tobacco smoke using the adsorbent, and a filter for tobacco having the adsorbent. Disclosure of the invention
  • the present invention relates to an adsorbent for a mutagenic substance present in tobacco smoke, comprising a polysaccharide or a modified product thereof.
  • the present invention also relates to a method for removing the mutagenic substance from tobacco smoke by adsorbing the mutagenic substance present in the tobacco smoke to a polysaccharide or a modified product thereof.
  • the present invention relates to a filter for tobacco, particularly a filter for cigarettes, comprising a polysaccharide or a modified product thereof.
  • FIG. 1 is a graph showing the relationship between tar content and specific mutagenic activity in various cigarettes.
  • FIG. 2 is an explanatory view showing the structure of the filter of the present invention and a state in which the filter is mounted on a cigarette body.
  • FIG. 3 is a graph showing the relationship between the amounts of various adsorbents of the present invention and the total mutagenic activity.
  • FIG. 4 is a graph showing the relationship between the amount of the adsorbent having various particle diameters of the present invention and the mutagen removal rate.
  • polysaccharide refers to a high molecular compound in which about 7 or more monosaccharide molecules are condensed, and includes not only monopolysaccharides composed of the same disaccharide molecule but also various monosaccharides. Saccharides include complex polysaccharides composed of derivatives thereof. Representative polysaccharides according to the present invention include cellulose, agarose, amirose, chitin, chitosan and derivatives thereof. Preferably, the polysaccharide is cellulose.
  • the above polysaccharide can be used as an adsorbent in any shape such as powder, granular material, porous rosemary fiber-like material, etc., but is used in the form of powder. I prefer to do it.
  • the size of the powder is not particularly critical, but generally the average particle size is between 0.1 and 200'm, preferably between 0.1 and 40'm. Preferably, a powder of 1 to 10'm is used.
  • polysaccharide powders for example, mechanically process animal and plant raw materials (eg, crushing, cutting). Use what has been prepared.
  • Typical examples of such powders include cellulose powder, such as cotton powder, pulp powder, hemp powder, or cellulose-based regenerated textile powder.
  • crystalline cellulose powder obtained by subjecting pulp to hydrolysis or cellulose treatment is used. It is preferable to use fine particles having an average particle size of 0.1 to 200 m, particularly 1 to 10 m, as the crystalline cellulose powder.
  • the use of fine particles with an average particle size of 1 to 10 m can maximize the mutagenic substance adsorption effect without changing the tobacco smoke suction resistance. It is preferable to separate the particles into an average particle size ⁇ m by centrifugation.
  • agarose powder eg, manufactured by Wako Pure Chemical Industries KK
  • amyloose powder eg, manufactured by Hanoi Chemicals
  • chitin powder eg, manufactured by Hanoi Chemicals KK
  • chitosan powder A body (eg, the chitin powder obtained by subjecting the chitin powder to an alkaline treatment) and the like can also be used.
  • modified polysaccharide means a material obtained by chemically modifying the above polysaccharide, particularly polysaccharide powder, and for example, ion exchange polysaccharide or hemipolysaccharide. And dyed polysaccharides.
  • the ion-exchanged polysaccharide is obtained by introducing various dissociable substituents into the polysaccharide, especially the powder thereof, to give an ion-exchange resin-like property.
  • a typical example thereof is amino.
  • Ethyl (AE) Cellulose
  • Jethylaminocetyl (DEAE) Senorelose
  • Triethylaminotechnyl (TE.4 £) Cellulose, etc.
  • Cell-based anion exchanger Carboxysimethyl (CM) — senorose, phosphate (P) — cellulose, snorejotyl (SE) — cell ⁇ — cell, etc. Paruru can cite the agarose-ion exchanger.
  • Hemin-stained polysaccharides are obtained by subjecting polysaccharides, especially powders, to ripening in an aqueous solution of 2-chloro-piethylamine and NaOH, followed by dyeing with hemin.
  • polysaccharides especially powders
  • ripening in an aqueous solution of 2-chloro-piethylamine and NaOH, followed by dyeing with hemin.
  • hemi-dyed cellulose powder is installed.
  • the adsorbent of the present invention can be used in various modes. .
  • the adsorbent of the present invention is combined with a cigarette filter.
  • the adsorbent of the present invention is blended into a foaming polymer such as, for example, polyvinyl alcohol (PVA) or polyvinyl formal (PVF), and then foamed.
  • PVA polyvinyl alcohol
  • PVF polyvinyl formal
  • the adsorbent can be dispersed throughout the filter.
  • the average particle size of the adsorbent compounded during the filter molding is preferably from 0.1 to 200 m, particularly preferably from 1 to 10 ⁇ um. Further, it can be used in such a form that it is dispersed between cellulose acetate fibers for a filter or that an adsorbent aggregate unit is inserted into the space between cellulose acetates.
  • the average particle size of the adsorbent powder is preferably 50 to 200 ⁇ um. Further, it can be used by dispersing it in tobacco leaves. Furthermore, it can be effectively used as a component of a mutagen-removing layer in a pipe to be attached to a cigarette when smoking. '
  • the amount of the adsorbent of the present invention can be appropriately selected according to the conditions of use.However, when the adsorbent is used in one type, 1 to 500 pieces of tobacco is used. Use 100 g to 100 rag and 1 to 1 g per cigarette. Example
  • mutagenic activity was measured by the following method. T / JP86 / 00571
  • the cigarette smoke particle phase is collected by an automatic suction device onto a ottoman glass filter GFZC ( ⁇ 37 «), and the filter is eluted with dimethyl sulfoxide (DMS0).
  • CSC dimethyl sulfoxide
  • Suction was performed once every 20 seconds at a speed of 650 m / min for 2 seconds, and the suction was repeated 12 times with one cigarette.
  • the mutagenicity of the obtained CSC (300 ⁇ g / plate) was determined by the method of Ames et al. [BNAmes et al., Utant Res.
  • an SD-based rat weighing about IC'Og was treated with polychlorinated biphenyl (PCB) to prepare an enzyme-induced liver.
  • PCB polychlorinated biphenyl
  • the amount of CSC was determined by measuring the absorbance at 260 nm with a spectrophotometer, calculating the weight per cigarette (), and measuring it with a precision electronic balance (! Let ler AE 163). .
  • T is the total mutagenic activity of one cigarette
  • C S is the number of restored colonies per plate (excluding the number of spontaneously restored colonies), and C S C is the number of cigarettes per cigarette.
  • the mutagenic activity of CSC increases linearly from 400 to 500 ⁇ g / plate, regardless of the type of cigarette and the presence or absence of the filter. Therefore, the number of recovered colonies of 300 g / P1ate The total mutagenic activity was determined based on the above, and the specific mutagenic activity (Specific mutagenicity) was also shown under the same conditions.
  • Fig. 1 compares the amount of tar in cigarettes and the specific mutagenic activity, and the specific mutagenic activity was calculated according to the method described above, using several hundreds of recovered colonies of CSC 300 ⁇ g / plate. Then, the number of return colonies per rag of CSC was shown (the average value of 20 cigarettes each).
  • the amount of tarl per cigarette () is Japan I cited a cigarette industry brochure.
  • the cigarettes whose results are shown in Figure 1 are Mild Seven (1), Seven Star (2), Cabin '85 Mild (3), Highlight (4), Mild Dossier light (5), Hope (6), Eco (7), Piece (8) ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ (1)
  • the cigarettes (1) to (9) are made by Japan Tobacco Industry Co., Ltd.), furthermore, LQM (Rigid Manger) (10), Lark (Rigid) Majors (U), Norament 100's [Filip Morris: (12), Lark Mold 100's [Rejected Mars] ( 13), Lark 100's (Rejected Magic) (14), Serum Lite (L'J 'Reynolds) (15), Larks -No, 'One Lite [ Rigid Marsers (16), Rack Streamer (Brown-and-Dark Realm Sons) (17), Nuclear Gentlemen Console: Philip Morris) (18), Mor: Earl 'Jay Reynolds' (19), Jumpy MFD. DLRH' I.C.
  • Example 1 Comparison of mutagen removal rates due to differences in adsorbents
  • the filter body (1) in Fig. 2 consists of a cellulose acetate filter part (2) and a centrally located mutagen adsorbent filling space (3) located in the center of the filter part (2). (4) is connected to the cigarette body (5).
  • Example 2 A panel test was performed using the five types of filters used in Example 1. Evaluation is 7 levels compared to Filter No. 5 (very;; 3, 3; 2, 3; +1, equivalent; 0, ⁇ bad; -1, bad; — 2, very bad;-3), the results of 17 people (12 males, 5 females) are summarized in Table 2. This shows that the filter of the present invention It shows that the characteristics are almost the same. In addition, the adsorbents shown in the filter shown in Table 2 are listed below.
  • Filter I. 1 Activated carbon 80 rag (normal Lark filter)
  • Filter o. 2 Ahi 'cell 25 mg
  • Filter-5 Activated carbon 0 mg (cell ⁇ -acetate filter only)
  • the powder ⁇ is mixed with foaming foam / vinyl alcohol ( ⁇ VA) foam 11 and the resulting material is molded into a cylindrical shape with a diameter of 7 mm and a length of 10 mm.
  • a (mark), B (mark), C (mark), and D (mark) each have a crystal of 0.4'm4m40'm100m.
  • the relationship between the weight (g) of the crystalline cellulose powder contained in the foaming polymer (PVA) 1 ⁇ made of cellulose powder and the removal rate of the mutagen was shown.
  • An expandable polymer PVA containing 35 g / of crystalline cellulose powder having an average particle diameter of 4 m was prepared, and the diameter of the polymer was adjusted in the same manner as in Example 4. It is molded into a cylindrical filter with a length of 10, and the crystalline cellulose powder is placed together with the PVA filter.
  • a smoking experiment was performed according to the method described above.
  • Triethylaminocetinoreser ore obtained by reacting crystalline cellulose powder (Asahi Kasei Co., Ltd .; Ahicell SF) having an average particle size of 6 m with 2-chloroacetylamine. Cellulose was stained with hemin, and then unadsorbed hemin was sufficiently removed to obtain a hemi-stained cell mouth powder. An adsorbent was obtained by mixing 2% by weight of hemine-stained powder with ⁇ -crystalline powder that had been dyed. The total mutagen removal rate and specific mutagenic activity were measured in the same manner as in Examples 4 and 5.
  • the total mutagen removal rate is 45% when unfiltered cellulosic adsorbent alone is 0% when no filter is used, whereas hemi-stained cellulosic The value was 55 for the adsorbent containing 2% by weight of powder.
  • cellulo-acetate-tofu When the filter was used at 0%, the non-stained cellulose adsorbent reduced by 15%, while the adsorbent containing 2% by weight of hemi-stained cellulose powder reduced by 30%.
  • the filter was used at 0%, the non-stained cellulose adsorbent reduced by 15%, while the adsorbent containing 2% by weight of hemi-stained cellulose powder reduced by 30%.
  • a panel test was performed using the four filters of the present invention used in Example 4. Evaluation was performed on a five-point scale (very good; ⁇ 2, good ⁇ ; +1; normal; 0, bad; -1; very bad; _2); 34 (34 males, Table 4 summarizes the results for 10 women). This indicates that the filter of the present invention has almost the same flavor characteristics.
  • a panel test was performed by mounting the filter on the holder part of the Mimphthalo finoleta made by Fance. For cigarettes, Mild Seven (Japan Tobacco Inc.) was used.
  • the adsorbent contained in the filter ⁇ 1 No. 6 is as follows.
  • the adsorbent of the present invention can effectively and selectively adsorb and remove mutagens in tobacco without lowering the original flavor of tobacco, and can be used for diseases such as lung cancer caused by smoking. It greatly contributes to lowering the appearance rate of

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Cigarettes, Filters, And Manufacturing Of Filters (AREA)

Abstract

L'adsorbant pour une substance mutagène contenue dans la fumée de tabac comprend un polysaccharide (par exemple de la cellulose) ou son produit modifié (par exemple un polysaccharide à échange d'ions).
PCT/JP1986/000571 1985-11-12 1986-11-11 Adsorbant pour une substance mutagene contenue dans la fumee du tabac et son utilisation Ceased WO1987002869A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP60/252055 1985-11-12
JP25205585A JPS62111679A (ja) 1985-11-12 1985-11-12 たばこ用フイルタ材
JP21815886A JPS6374477A (ja) 1986-09-18 1986-09-18 たばこ用フイルタ材
JP61/218158 1986-09-18

Publications (1)

Publication Number Publication Date
WO1987002869A1 true WO1987002869A1 (fr) 1987-05-21

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Application Number Title Priority Date Filing Date
PCT/JP1986/000571 Ceased WO1987002869A1 (fr) 1985-11-12 1986-11-11 Adsorbant pour une substance mutagene contenue dans la fumee du tabac et son utilisation

Country Status (2)

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EP (1) EP0246330A4 (fr)
WO (1) WO1987002869A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2285908A (en) * 1994-01-25 1995-08-02 Gallaher Ltd Filter material
DE19541873A1 (de) * 1995-11-09 1997-05-15 Rhodia Ag Rhone Poulenc Filterzigarette
EP2789249B8 (fr) * 2011-12-06 2018-12-26 Japan Tobacco Inc. Filtre à cigarette et cigarette

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2607208A1 (de) * 1976-02-23 1977-08-25 Hoechst Ag Zigarettenfilter
JPS54110399A (en) * 1978-02-15 1979-08-29 Daicel Chem Ind Ltd Powder-containing cigarette filter
JPS60110276A (ja) * 1983-11-21 1985-06-15 東レ株式会社 タバコフイルタ−
JPH05132799A (ja) * 1991-06-25 1993-05-28 Internatl Business Mach Corp <Ibm> 電気メツキ方法及びその装置

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2739913A (en) * 1953-07-02 1956-03-27 Philip Morris And Co Ltd Inc Tobacco product and method of making said product
GB996141A (en) * 1964-06-04 1965-06-23 British American Tobacco Co Improvements in or relating to a filter assembly for a smoking tobacco product and method of making the same and smoking tobacco product including the filter assembly

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2607208A1 (de) * 1976-02-23 1977-08-25 Hoechst Ag Zigarettenfilter
JPS54110399A (en) * 1978-02-15 1979-08-29 Daicel Chem Ind Ltd Powder-containing cigarette filter
JPS60110276A (ja) * 1983-11-21 1985-06-15 東レ株式会社 タバコフイルタ−
JPH05132799A (ja) * 1991-06-25 1993-05-28 Internatl Business Mach Corp <Ibm> 電気メツキ方法及びその装置

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
R.E. KIRK, D.F. OTHMER HEN "Encyclopedia of Chemical Technology" Vol. 14 (1955) The Interscience Encyclopedia, Inc. (New York), p. 260 *
See also references of EP0246330A4 *
Toxicology, Vol. 15, No.3, (1980), I. FROLIN, et al (Screening of Tobacco Smoke constituents for Mutagenicity using the Ames' Test), p.219-232 *

Also Published As

Publication number Publication date
EP0246330A1 (fr) 1987-11-25
EP0246330A4 (fr) 1988-04-26

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