WO1987005300A3 - Conservation de proteines - Google Patents

Conservation de proteines Download PDF

Info

Publication number
WO1987005300A3
WO1987005300A3 PCT/GB1987/000143 GB8700143W WO8705300A3 WO 1987005300 A3 WO1987005300 A3 WO 1987005300A3 GB 8700143 W GB8700143 W GB 8700143W WO 8705300 A3 WO8705300 A3 WO 8705300A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein preservation
preservation
protein
water
dependant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1987/000143
Other languages
English (en)
Other versions
WO1987005300A2 (fr
Inventor
James Arthur Hayward
David Samuel Johnston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Vascular Devices Ltd
Original Assignee
Biocompatibles Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatibles Ltd filed Critical Biocompatibles Ltd
Publication of WO1987005300A2 publication Critical patent/WO1987005300A2/fr
Publication of WO1987005300A3 publication Critical patent/WO1987005300A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)

Abstract

Un procédé de conservation d'un matériau ayant une structure hydrosensible consiste à mettre le matériau en contact avec une solution aqueuse d'un composé de polyhydroxy, puis à retirer l'eau du matériau.
PCT/GB1987/000143 1986-02-28 1987-02-27 Conservation de proteines Ceased WO1987005300A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8604983 1986-02-28
GB868604983A GB8604983D0 (en) 1986-02-28 1986-02-28 Protein preservation

Publications (2)

Publication Number Publication Date
WO1987005300A2 WO1987005300A2 (fr) 1987-09-11
WO1987005300A3 true WO1987005300A3 (fr) 1987-10-22

Family

ID=10593832

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1987/000143 Ceased WO1987005300A2 (fr) 1986-02-28 1987-02-27 Conservation de proteines

Country Status (4)

Country Link
EP (1) EP0259425A1 (fr)
JP (1) JPS63502592A (fr)
GB (1) GB8604983D0 (fr)
WO (1) WO1987005300A2 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6921527B2 (en) 1992-07-08 2005-07-26 Nektar Therapeutics Composition for pulmonary administration comprising a drug and a hydrophobic amino acid
US7300919B2 (en) 1992-09-29 2007-11-27 Nektar Therapeutics Pulmonary delivery of active fragments of parathyroid hormone
US7306787B2 (en) 1997-09-29 2007-12-11 Nektar Therapeutics Engineered particles and methods of use
US7521069B2 (en) 1994-03-07 2009-04-21 Novartis Ag Methods and compositions for pulmonary delivery of insulin
US7628978B2 (en) 1997-09-29 2009-12-08 Novartis Pharma Ag Stabilized preparations for use in metered dose inhalers
US8877162B2 (en) 2000-05-10 2014-11-04 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery
US9421166B2 (en) 2001-12-19 2016-08-23 Novartis Ag Pulmonary delivery of aminoglycoside
US9554993B2 (en) 1997-09-29 2017-01-31 Novartis Ag Pulmonary delivery particles comprising an active agent

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8715238D0 (en) * 1987-06-29 1987-08-05 Quadrant Bioresources Ltd Food process
GB8801338D0 (en) * 1988-01-21 1988-02-17 Quadrant Bioresources Ltd Preservation of viruses
US5958670A (en) * 1988-05-18 1999-09-28 Cobe Laboratories, Inc. Method of freezing cells and cell-like materials
US5045446A (en) * 1988-08-26 1991-09-03 Cryopharm Corporation Lyophilization of cells
WO1990003795A1 (fr) * 1988-10-05 1990-04-19 Vestar, Inc. Procede de fabrication de liposomes a stabilite amelioree pendant le sechage
US5059518A (en) * 1988-10-20 1991-10-22 Coulter Corporation Stabilized lyophilized mammalian cells and method of making same
US5030560A (en) * 1988-11-04 1991-07-09 Immucor, Inc. Method for drying mammalian cells for use in solid phase immunoassays and articles incorporating same
US5192663A (en) * 1988-11-04 1993-03-09 Immucor, Inc. Article having an organic dye and a monolayer of dried mammalian cells and a method for utilizing the article
USRE38385E1 (en) 1989-02-16 2004-01-13 Nektar Therapeutics Storage of materials
GB8903593D0 (en) 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
FR2645741B1 (fr) * 1989-03-20 1995-06-23 Dior Christian Parfums Procede pour fixer un produit sur la membrane d'un keratinocyte au moyen d'une liaison ligand-recepteur, procede de preparation d'un tel produit, produit obtenu, composition cosmetique ou pharmaceutique le contenant et son procede de preparation
ZA902663B (en) * 1989-04-07 1991-12-24 Syntex Inc Interleukin-1 formulation
US5270057A (en) * 1990-03-20 1993-12-14 Akzo N.V. Stabilized gonadotropin containing preparations
IE64738B1 (en) * 1990-03-20 1995-09-06 Akzo Nv Stabilized gonadotropin containing preparations
US5384132A (en) * 1990-03-20 1995-01-24 Akzo N.V. Stabilized gonadotropin containing preparations
GB9010742D0 (en) * 1990-05-14 1990-07-04 Quadrant Bioresources Ltd Stabilization of biological macromolecular substances
IL100626A0 (en) * 1991-01-11 1992-09-06 Cryopharm Corp A method of forming dry cells,diagnostic panels containing the same and diagnostic methods utilizing the same
AU659645B2 (en) 1991-06-26 1995-05-25 Inhale Therapeutic Systems Storage of materials
AU672775B2 (en) * 1992-01-21 1996-10-17 Cobe Laboratories Inc. Method of freezing cells and cell-like materials
DE69426292T2 (de) * 1993-02-23 2001-05-17 Genentech, Inc. Stabilisierung von mit organischen lösungsmittel behandelten polypeptiden mit einem hilfsstoff
EP0615747B1 (fr) * 1993-03-18 1999-09-29 Terumo Kabushiki Kaisha Liposome encapsulant de l'hémoglobine et procédé pour sa préparation
US5674528A (en) * 1994-06-15 1997-10-07 Terumo Kabushiki Kaisha Hemoglobin-encapsulated liposome
US6586006B2 (en) 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US6309671B1 (en) 1995-04-14 2001-10-30 Inhale Therapeutic Systems Stable glassy state powder formulations
GB9508691D0 (en) * 1995-04-28 1995-06-14 Pafra Ltd Stable compositions
DE69628007T2 (de) * 1995-06-07 2003-11-27 Elan Drug Delivery Ltd., Ruddington Verfahren zur stabilen einarbeitung von substanzen in trockene geschäumte glasmatrizen und auf diese weise hergestellte zusammensetzungen
US6632648B1 (en) 1996-05-14 2003-10-14 Elan Drug Delivery Limited Methods of terminal sterilization of fibrinogen
US6468782B1 (en) 1996-12-05 2002-10-22 Quadrant Healthcare (Uk) Limited Methods of preserving prokaryotic cells and compositions obtained thereby
ATE230923T1 (de) 1997-02-07 2003-02-15 Elan Drug Delivery Ltd Verfahren und zusammensetzungen zur herstellung getrockneter, lagerungsstabiler blutplättchen
US6770478B2 (en) 2000-02-10 2004-08-03 The Regents Of The University Of California Erythrocytic cells and method for preserving cells
WO2001058266A1 (fr) 2000-02-10 2001-08-16 The Regents Of The University Of California Plaquettes et procedes therapeutiques
EP2395073B1 (fr) * 2002-11-01 2017-09-06 GlaxoSmithKline Biologicals S.A. Séchage
ES2502691B1 (es) * 2013-09-25 2015-07-07 Sani-Red, S.L. Método de conservación y estabilización de proteínas, aplicable para desarrollos industriales de formulaciones de productos sanitarios, farmacéuticos y cosméticos
WO2016209907A1 (fr) 2015-06-25 2016-12-29 The Regents Of The University Of California Films de support stables pour microscopie électronique

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1855591A (en) * 1926-02-03 1932-04-26 Wallerstein Co Inc Invertase preparation and method of making the same
FR2532178A1 (fr) * 1982-08-31 1984-03-02 Asahi Chemical Ind Procede pour stabiliser le facteur de necrose tumorale et solution aqueuse ou poudre stables contenant ce facteur
EP0111216A2 (fr) * 1980-03-31 1984-06-20 Takeda Chemical Industries, Ltd. Méthode pour essai immunoenzymatique, conjugué peptide-enzyme, son lyophilisat, anticorps et trousse de réactifs
WO1986001103A1 (fr) * 1984-08-08 1986-02-27 The Liposome Company, Inc. Liposomes deshydrates
WO1986003938A1 (fr) * 1985-01-11 1986-07-17 The Regents Of The University Of California Procede de conservation de liposomes
WO1987000196A1 (fr) * 1985-07-09 1987-01-15 Quadrant Bioresources Limited Protection des proteines et similaires

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1855591A (en) * 1926-02-03 1932-04-26 Wallerstein Co Inc Invertase preparation and method of making the same
EP0111216A2 (fr) * 1980-03-31 1984-06-20 Takeda Chemical Industries, Ltd. Méthode pour essai immunoenzymatique, conjugué peptide-enzyme, son lyophilisat, anticorps et trousse de réactifs
FR2532178A1 (fr) * 1982-08-31 1984-03-02 Asahi Chemical Ind Procede pour stabiliser le facteur de necrose tumorale et solution aqueuse ou poudre stables contenant ce facteur
WO1986001103A1 (fr) * 1984-08-08 1986-02-27 The Liposome Company, Inc. Liposomes deshydrates
WO1986003938A1 (fr) * 1985-01-11 1986-07-17 The Regents Of The University Of California Procede de conservation de liposomes
WO1987000196A1 (fr) * 1985-07-09 1987-01-15 Quadrant Bioresources Limited Protection des proteines et similaires

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Archives of Biochemistry and Biophysics", Volume 242, No. 1, October 1985, Academic Press, Inc. L.M. CROWE et al.: "Preservation of Freeze-Dried Liposomes by Trehalose", pages 240-247, see the whole document *
Biochemistry, Volume 24, 1985, American Chemical Society, (Washington, US), J. SZEBENI et al.: "Encapsulation of Hemoglobin in Phospholipid Liposomes: Characterization and Stability", pages 2827-2832, see pages 2827-2828 cited in the application *
CHEMICAL ABSTRACTS, Volume 103, No. 12, 23 September 1985, (Columbus, Ohio, US) T.D. MADDEN et al.: "Protection of Large Unilamellar Vesicles by Trehalose During Dehydration: Retention of Vesicle Contents", see page 316, Abstract 92759a, & Biochim. Biophys, Acta 198k, 817(1), 67-74 cited in the application *
CHEMICAL ABSTRACTS, Volume 85, No. 3, 19 July 1976, (Columbus, Ohio, US), P. LABRUDE et al.: "Lyophilization of Hemoglobin Solutions. Study of Protector Compounds Capable of Preventing the Formation of Methemoglobin", see page 415, Abstract 18011u, & J. Pharm. Belg. 1976, 31(2), 191-8 *
Science, Volume 223, No. 4637, 17 February 1984, American Association for the Advancement of Science, (Washington, US), J.H. CROWE et al.: "Preservation of Membranes in Anhydrobiotic Organisms: the role of Trehalose", pages 701-703, see the whole document cited in the application *
The Proceedings of Biotech '84 Europe, Volume 1, American Chemical Society "World Biotech Report 1984", pages 379-390, see pages 382-385 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6921527B2 (en) 1992-07-08 2005-07-26 Nektar Therapeutics Composition for pulmonary administration comprising a drug and a hydrophobic amino acid
US7300919B2 (en) 1992-09-29 2007-11-27 Nektar Therapeutics Pulmonary delivery of active fragments of parathyroid hormone
US7521069B2 (en) 1994-03-07 2009-04-21 Novartis Ag Methods and compositions for pulmonary delivery of insulin
US7097827B2 (en) 1995-04-14 2006-08-29 Inhale Therapeutic Systems, Inc. Devices, compositions and methods for the pulmonary delivery of aerosolized medicaments
US7306787B2 (en) 1997-09-29 2007-12-11 Nektar Therapeutics Engineered particles and methods of use
US7628978B2 (en) 1997-09-29 2009-12-08 Novartis Pharma Ag Stabilized preparations for use in metered dose inhalers
US9554993B2 (en) 1997-09-29 2017-01-31 Novartis Ag Pulmonary delivery particles comprising an active agent
US8877162B2 (en) 2000-05-10 2014-11-04 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery
US9439862B2 (en) 2000-05-10 2016-09-13 Novartis Ag Phospholipid-based powders for drug delivery
US9421166B2 (en) 2001-12-19 2016-08-23 Novartis Ag Pulmonary delivery of aminoglycoside

Also Published As

Publication number Publication date
EP0259425A1 (fr) 1988-03-16
GB8604983D0 (en) 1986-04-09
JPS63502592A (ja) 1988-09-29
WO1987005300A2 (fr) 1987-09-11

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