WO1987007139A1 - Poudre corporelle sous forme liquide, poudre corporelle contenant des principes actifs et methode pour sa preparation - Google Patents

Poudre corporelle sous forme liquide, poudre corporelle contenant des principes actifs et methode pour sa preparation Download PDF

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Publication number
WO1987007139A1
WO1987007139A1 PCT/US1987/001288 US8701288W WO8707139A1 WO 1987007139 A1 WO1987007139 A1 WO 1987007139A1 US 8701288 W US8701288 W US 8701288W WO 8707139 A1 WO8707139 A1 WO 8707139A1
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WO
WIPO (PCT)
Prior art keywords
lbs
composition
liquid powder
potato starch
powder composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1987/001288
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English (en)
Inventor
Garry D. Fields
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP87503555A priority Critical patent/JPH01501147A/ja
Publication of WO1987007139A1 publication Critical patent/WO1987007139A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/12—Face or body powders for grooming, adorning or absorbing

Definitions

  • the present invention relates to body powders. More * specifically, this invention relates to a body powder in ⁇ 5 liquid form which can be used by itself or as a carrier for active ingredients intended for topical and mucous tissue application to animals, including humans. This invention also relates to a method of preparing a liquid body powder having optimal characteristics for applying to the skin in 10 terms of its smoothness, adherence, consistency and rate of evaporation after application.
  • the liquid powders of this invention are useful for many purposes including to improve the smoothness of the skin, prevent irritation, absorb perspiration and deliver active ingredients to the human and 15 animal body.
  • the above and other objects of the invention are attained by forming an aqueous solution or suspension of ingredients comprising a substantial quantity of potato starch in accordance with a specific procedure and temperature regime.
  • the product obtained is a stable liquid product having a desirable thickness for easy application and general stability which assures a long shelf life..
  • various other components can be added to the potato starch.
  • Preferred components are veegum, cetyl alcohol, stearic acid, glycerin, and optionally Peg-8-oleate.
  • the variation of the amounts of these components in the liquid powder composition results in a final product which may be in the form of a liquid lotion, of heavy lotion, a gel-like preparation, a light cream or a heavy cream, among others.
  • the amount of water contained in the composition also contributes to and helps determine the final consistency of the liquid powder product.
  • This liquid powder composition finds a remarkable use as an oil-free wet lubricant which leaves no excess residues encountered in talcum powders or oil-based lubricants used by the prior art.
  • This composition is also useful for its skin soothing characteristics and for use in prostheses and orthotics.
  • As a water-based composition it will not clog valves, makes no mess on clothing articles, is ideal for attaining complete contact with suction sockets and helping control sweating and can be washed off easily at the end of the day.
  • a liquid powder composition comprising per 400 lbs. of composition a ou - s., po a o s arc ; about 1-12 lbs.; veegum; about 3.6-12 lbs., cetyl alcohol; about 2-10 lbs., stearic acid; about 3-10 lbs., glycerin; about 0.5 lbs., Peg-8 oleate; and the remainder, water.
  • the above-described liquid powder composition further comprises an agent selected from about .0.005-100 parts of an active agent; and about 0.005-1 parts of a fragrance per 100 parts of the carrier composition.
  • An even more preferred embodiment of the above-described composition comprises about 1-10 parts of an active ingredient, or about 0.1-0.3 parts of a fragrance per 100 parts of the carrier composition.
  • a process for obtaining a liquid powder composition comprising (1) adding together about 1-12 lbs. veegum, about 3.6-12 lbs. cetyl alcohol, about 2-10 lbs. stearic acid, about 3-10
  • a more preferred way of conducting the above process involves adding a first portion of between about 12 and 48 lbs. of potato starch and a second portion of between, about 40 and 52 lbs. of potato starch.
  • an agent selected from an active ingredient and a fragrance can be added to the liquid powder composition.
  • These ingredients are added to the composition preferably subsequent to step (5) of the above process at a temperature at which they remain stable.
  • the liquid powder composition comprises per 400 lbs. of composition about 52-100 lbs. of potato starch, about 2-6 lbs. of veegum, about 4-6 lbs. of cetyl alcohol, about 2-6 lbs. of stearic acid, about 7-9 lbs. of glycerin, about 1.6-4 lbs. of Peg-8-oleate; and the remainder water.
  • the liquid powder composition may additionally contain a fragrance which can be selected from any fragrances known in the art, such as perfumes, essences, and the like.
  • fragrances While a variety of fragrances can be employed, a preferred fragrance which is utilized to prepare the The fragrance is preferably added to the liquid powder composition in an amount of about 0.005 to 1 parts per 100 parts of the composition. A still more preferred amount of fragrance is between about 0.1 and 0.3 parts per 100 parts of the composition.
  • E eressence ⁇ 1160 (Emery Chemicals, Cincinnati, OH) can be used in the composition of the invention.
  • the composition may additionally contain an active ingredient.
  • the basic liquid powder composition acts as a carrier for the active ingredient.
  • active ingredients are contemplated within the confines of this invention. For all practical matters, any ingredient which would be applied to the skin of humans or animals or to mucous tissues thereof can be utilized with the present composition.
  • Suitable active ingredients for the liquid powder composition of this invention are anti-itch, anti-inflammatory, antimicrobial, antiviral, antibacterial, antifungal, antiperspirant, analgesic, wound-healing, antihistiminic, antiemetic and skin improving agents, herbs, plant parts, extracts thereof and mixtures thereof, among others.
  • active ingredients can be added to the liquid powder composition in amounts known in the art and can be administered to animals, including humans in a preventative manner or as a means for treating a condition requiring the administration of the ingredient thereof.
  • various of the active ingredients and/or fragrances may be combined in a single composition.
  • the components are added in amounts known in the art and within the ranges disclosed herein.
  • Preferred amounts for the addition of the active ingredients are about 0.005 to 100 parts of the active ingredient per 100 parts of the composition. A more preferred range is between about 1 and 10 parts of the active ingredient per 100 parts of the composition.
  • the liquid powder composition containing an active ingredient is intended for cutaneous, intravaginal, intranasal, intrauterine and intralesional use, among others in animals including humans, and for intramammary use in animals.
  • any compounds, plant parts, herbs, extracts thereof and mixtures thereof known in the art for having a medicinal or pharmaceutical use, among others, are suitable for use in the present composition.
  • active agents can be cited: cortical steroids as an anti-inflammatory, amirozglycosides as an antibiotic, corticosteroids as an
  • TM anti-itch Emery Industries, Mauldin, SC
  • Wickenol 340 and Germeben R II Sutton Labs, Inc., Chatham, NJ
  • acetyl salicylic as an analgesic
  • teramicin as a wound-healing agent
  • certain herbs as a skin improving agent, among others.
  • herbs and plant part that can be utilized are as follows: aloe, comfrey, calendula and other herbal preparations with properties known to give specific beneficial results to the user of the product.
  • the extracts of the herbs and plant parts are prepared as is known in the art and the extracted preparations are then added to the liquid powder carrier of the invention.
  • Example 1 A most preferred composition for the liquid powder composition of the invention is described in Example 1 hereinbelow.
  • the process for obtaining the liquid powder composition the Cetyl alcohol and the stearic acid can be melted together by heating these ingredients to their melting points or approximately 140 ⁇ F.
  • the glycerin and the Peg-8 Oleate are then added at room temperature to the melted ingredients, then raising the temperature first up to about 145 ⁇ F and then up to about
  • the ingredients and the water are mixed for a period of time sufficient to allow cooling to a temperature between about 145 ⁇ F and 150 ⁇ F.
  • the first portion of the potato starch is added at this point and the admixture is homogenized until the preparation cools to below about 135 ⁇ F.
  • the remaining amount of potato starch is added at this point while the preparation cools to about room temperature and the composition is then homogenized to obtain a product in the form of a lotion, a gel or a cream. At this point the liquid powder composition is in condition for packaging.
  • the veegum can be added at the time of the second addition of potato starch instead of being incorporated with the Cetyl alcohol, stearic acid, glycerin Peg-8 oleate and water.
  • the agent selected from the active ingredient and the fragrance can be added to the composition as soon as the * temperature is lowered to below about 135 ⁇ F.
  • the active ingredient and/or the fragrance are added prior to the last addition of potato starch to the composi ⁇ tion in amounts between about 0.005 and 100 parts of the active ingredient and about 0.005 and 1 parts of the frag ⁇ rance per 100 parts of the composition.
  • the mixing of the veegum, Cetyl alcohol, stearic acid, glycerin and Peg-8 oleate with the water is conducted at about 145 ⁇ -150 ⁇ F for between about 15 minutes and 75 minutes, preferably between 30 minutes and 60 minutes.
  • the admixture is homogenized at a temperature of below about 135 ⁇ F, typically for a period of between about 1 hour to 3 hours, preferably between 1.5 and 2.5 hours.
  • the admixing of the last portion of the potato starch to the rest of the ingredients and cooling of the composition to ambient temperature is typically conducted for about 1 hour to 4 hours, preferably 1.5 hours to 3.5 hours.
  • Homogenization subsequent to the addition of the potato starch to the mixture is typically conducted at about room temperature for between about 0.5 hours and 1.5 hours.
  • the above-described steps can be conducted for different periods of time as suitable for various purposes, such as attaining a specific consistency of the product.
  • the composition when the liquid powder composition is prepared by adding an active ingredient and/or a fragrance, the composition can be homogenized immediately after such addition and prior to the subsequent addition of the last portion of the potato starch.
  • This homogenization __ is typically conducted for between about 0.5 hours and 3 hours, preferably between about 0.5 hours and 1.5 hours.
  • the cooling of the preparation occurring during steps (5) and (6) can be aided and accelerated by conducting the process in a cooling tank provided with a refrigerating system.
  • composition of this exemplary formulation is as follows.
  • the cetyl alcohol and stearic acid were melted together by heating them to approximately 170 ⁇ F which is approximately the melting point of these ingredients.
  • the glycerin and Peg-8 oleate, both initially at room temperature were then added to, and mixed with, the melted ingredients, and the resulting mixture was then reheated to 170 ⁇ F.
  • all the water, preheated to 150 ⁇ F, was added to the initial mixture and, with the temperature maintained at 150 ⁇ F, the Germeben II and the fragrance, both of which were initially at room temperature, were added to the aqueous mixture.
  • the mixture is then permitted to cool to 145*F, and 24 lbs. of the potato starch, initially at room temperature, were added. The mixture was then permitted to cool while mixing and homogenizing, and it thickened. After the temperature of the resulting mixture dropped below 120°F, the remaining starch and the veegum which were initially at room temperature, were added and the entire mixture was then stirred in order to attain complete homogenization. This latter step can take place at a temperature between 120 ⁇ F and room temperature, although a temperature close to 120°F facilitates the homogenization.
  • a liquid powder composition of this exemplary formulation is as follows.
  • Example 2 A composition as that described in Example 2 was prepared and 8 lbs. of Germeben II TM were added thereto. Various amounts of Magnabrite brand veegum were added as follows.
  • Example 2 Three samples were prepared according to the formulation of Example 2, also containing Germeben II TM 8 lbs. The amount of glycerin was varied to contain 7, 8 and 9 lbs. of glycerin. All three yielded satisfactory results with the preparation containing 8 lbs. of glycerin being the best.
  • Example 5 The amounts of stearic acid and Cetyl alcohol were varied in the composition of Example 2 also containing 8
  • the initial amount of starch was varied in the composi ⁇ tion described in Example 2 also containing 8 lbs. of Germeben II TM. Potato starch was added in amounts of 12, 24,

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

Une composition de poudre liquide comprend pour 400 livres de composition 40 à 150 livres d'amidon de pomme de terre, 1 à 12 livres de veegum, 3,6 à 12 livres d'alcool cétylique, 2 à 10 livres d'acide stéarique, 3 à 10 livres de glycérine, 0,5 livre d'oléate de Peg-8 et le reste en eau. Cette composition de poudre liquide peut être utilisée comme support, pour les prothèses et l'orthoptie et en général comme lubrifiant humide exempt d'huile qui ne laisse aucun résidu en excès comme le font les poudres de talc et les lubrifiants à base d'huile. Cette composition est préparée par un procédé consistant dans l'ordre suivant à ajouter ensemble le veegum, l'alcool cétylique, l'alcool stéarique, la glycérine et l'oléate de Peg-8 et à élever la température tout d'abord à 145°F et puis à 175°F; à ajouter les ingrédients chauffés à l'eau préchauffée entre 130 et 200°F, à mélanger les ingrédients et l'eau tout en laissant refroidir à une température de 145°F-150°F, à y ajouter 10 à 50 livres d'amidon de pomme de terre, à homogénéiser le mélange tout en laissant refroidir à une température inférieure à 135°F, à y ajouter 30 à 100 livres d'amidon de pomme de terre tout en laissant refroidir à la température ambiante, puis à homogénéiser le mélange pour obtenir la poudre liquide sous forme d'une lotion, d'un gel ou d'une crème. La composition de poudre liquide peut en outre comporter un principe actif et/ou un parfum.
PCT/US1987/001288 1986-05-20 1987-05-29 Poudre corporelle sous forme liquide, poudre corporelle contenant des principes actifs et methode pour sa preparation Ceased WO1987007139A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP87503555A JPH01501147A (ja) 1986-05-20 1987-05-29 流動体ボディパウダー、活性成分含有ボディパウダーおよびそれらの製造方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86854386A 1986-05-30 1986-05-30
US868,543 1986-05-30
US91673586A 1986-10-08 1986-10-08
US916,735 1986-10-08

Publications (1)

Publication Number Publication Date
WO1987007139A1 true WO1987007139A1 (fr) 1987-12-03

Family

ID=27128059

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1987/001288 Ceased WO1987007139A1 (fr) 1986-05-20 1987-05-29 Poudre corporelle sous forme liquide, poudre corporelle contenant des principes actifs et methode pour sa preparation

Country Status (5)

Country Link
EP (1) EP0270632A4 (fr)
JP (1) JPH01501147A (fr)
AU (1) AU7514987A (fr)
NZ (1) NZ220364A (fr)
WO (1) WO1987007139A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1022017A3 (fr) * 1999-01-20 2001-08-22 Stada Arzneimittel Ag Compositions cosmetiques ou pharmaceutiques pour l'application locale ayant une stabilité ameliorée

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3783104B2 (ja) * 2004-03-31 2006-06-07 小林製薬株式会社 抗真菌性外用組成物

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2838440A (en) * 1953-10-29 1958-06-10 Rohm & Haas Dusting powder of carboxylic cationexchange resin and powder base
US4137302A (en) * 1976-04-02 1979-01-30 Lever Brothers Company Cosmetic composition
US4302443A (en) * 1980-02-21 1981-11-24 Terry Corporation Non-irritating antiperspirant
US4568539A (en) * 1983-08-03 1986-02-04 Johnson & Johnson Baby Products Company Body powder compositions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3726M (fr) * 1964-01-15 1965-12-06 Andre David Garson Nouvelle composition a usages divers.
GB1357731A (en) * 1970-02-12 1974-06-26 Ethichem Ltd Free flowing powder compositions and ointments containing them'

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2838440A (en) * 1953-10-29 1958-06-10 Rohm & Haas Dusting powder of carboxylic cationexchange resin and powder base
US4137302A (en) * 1976-04-02 1979-01-30 Lever Brothers Company Cosmetic composition
US4302443A (en) * 1980-02-21 1981-11-24 Terry Corporation Non-irritating antiperspirant
US4568539A (en) * 1983-08-03 1986-02-04 Johnson & Johnson Baby Products Company Body powder compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0270632A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1022017A3 (fr) * 1999-01-20 2001-08-22 Stada Arzneimittel Ag Compositions cosmetiques ou pharmaceutiques pour l'application locale ayant une stabilité ameliorée

Also Published As

Publication number Publication date
JPH01501147A (ja) 1989-04-20
NZ220364A (en) 1990-04-26
AU7514987A (en) 1987-12-22
EP0270632A4 (en) 1991-04-17
EP0270632A1 (fr) 1988-06-15

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