WO1987007182A1 - Dispositif d'alimentation et de melange constants de matieres granulaires ou pulverulentes - Google Patents

Dispositif d'alimentation et de melange constants de matieres granulaires ou pulverulentes Download PDF

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Publication number
WO1987007182A1
WO1987007182A1 PCT/JP1986/000264 JP8600264W WO8707182A1 WO 1987007182 A1 WO1987007182 A1 WO 1987007182A1 JP 8600264 W JP8600264 W JP 8600264W WO 8707182 A1 WO8707182 A1 WO 8707182A1
Authority
WO
WIPO (PCT)
Prior art keywords
mixing
raw material
powder
storage tank
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1986/000264
Other languages
English (en)
Japanese (ja)
Inventor
Kiyoshi Morimoto
Masuo Moriyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to PCT/JP1986/000264 priority Critical patent/WO1987007182A1/fr
Priority to EP19860903566 priority patent/EP0299065A4/fr
Priority to KR1019880700069A priority patent/KR880701131A/ko
Publication of WO1987007182A1 publication Critical patent/WO1987007182A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80—Forming a predetermined ratio of the substances to be mixed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80—Forming a predetermined ratio of the substances to be mixed
    • B01F35/88—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise
    • B01F35/881—Forming a predetermined ratio of the substances to be mixed by feeding the materials batchwise by weighing, e.g. with automatic discharge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/0082—Dust eliminating means; Mould or press ram cleaning means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
    • B30B15/30—Feeding material to presses
    • B30B15/302—Feeding material in particulate or plastic state to moulding presses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/60—Mixing solids with solids

Definitions

  • the present invention relates to an apparatus for quantitatively supplying and mixing powders and granules. More particularly, the present invention relates to an apparatus capable of automatically mixing at least two types of raw material particles in a predetermined amount. By combining such a device with a tablet manufacturing machine or the like, it is possible to automatically and efficiently produce raw materials to tablets.
  • a compression molding machine when powders are compressed by a compression molding machine, different raw material powders are used as pre-processes, for example, in tablet molding, the main raw material powders and a lubricant (usually, an inorganic salt of stearate, talc, etc. Process to be used.
  • a lubricant usually, an inorganic salt of stearate, talc, etc. Process to be used.
  • Raw material meter Mixing Mixing, granulation, drying and sizing Lubricant mixing
  • the purpose of mixing in these processes is mainly divided into the main component uniformity and the fact that the lubricant added to avoid problems in tablet manufacturing is mixed with other components uniformly. Is done. In the former, comparison is made by mixing before the tableting before mixing, that is, by mixing the active ingredient and excipients after the raw materials are weighed, or because it is homogenized in the next granulation step. There are few problems.
  • the latter is based on the main raw material side granules formulated by a granulator, such as the drug (drug, excipient, binder, etc.), or the particles between ungranulated granules.
  • a granulator such as the drug (drug, excipient, binder, etc.)
  • the particles between ungranulated granules By adding and mixing an appropriate amount of 1, the pressure transmission during compression molding is alleviated.
  • the mortar filling is improved by increasing the fluidity of the powder, and the tablet characteristic values such as suppressing weight fluctuations are always uniform. 3 Improve the release of tablets from punches and reduce the friction coefficient of mortar wall during release
  • the mixing operation before tableting has a very important role.
  • the present invention relates to a storage tank for at least two different types of raw material powders, a device for measuring a desired amount of raw material powder from each storage tank, a device for discharging and moving the measured powder and granular material to a mixing tank,
  • the present invention relates to a device for mixing powder and granules, and a device for automatically dispensing and dispensing powder and granules in which a container for holding a certain amount of the mixture is integrally provided (hereinafter referred to as the device of the present invention).
  • FIG. 1 shows an example in which two types of raw materials are used for an apparatus in which the apparatus of the present invention is combined with a tableting machine.
  • the raw material storage tank (1) 3 contains one raw material powder and is supplied to the measuring vessel (1) 7 with the measuring device 8 via the electromagnetic feeder trough 5 by the electromagnetic feeder 16 Is done. Similarly, the powder material of the other raw material in the raw material storage tank (2) 16 is weighed by the electromagnetic feeder 18 through the electromagnetic feeder trough 17 and the measuring device 20 (2) Supplied to 19.
  • the electromagnetic feeder stops via the measuring device.
  • each raw material supplied to the weighing container has a predetermined weight within the set error range.
  • each raw material is sent to the mixer 11 by the raw material discharge on-off valve 10 or 2.
  • the presence or absence of particulate matter in each weighing container is confirmed by the weight setting comparator 26 via each weighing device or by the raw material discharge confirmation sensor 9 or 21 provided in each weighing container. You.
  • the mixer stirring motor 13 of the mixer 11 operates to mix the raw materials by the stirring blade 14. After mixing for a certain period of time, until a predetermined amount is detected by the powder / particle detection sensor 24 provided in the container 23 for holding the powder / particle mixture via the powder / particle discharge on-off valve 15 The mixture is supplied to the powder-particle holding container with stirring, and the on-off valve 15 is stopped.
  • the mixture in the container for holding the granular material is supplied to a tableting machine via a suitable feeding device and tableted.
  • valve a valve, a shutter, or the like using electricity or compressed air can be used.
  • electromagnetic feeder a screw feeder, a table feeder, etc.
  • An electromagnetic feeder, a screw feeder, a table feeder, or the like may be used in place of the raw material discharge on-off valve.
  • a valve When supplying raw materials from one container to the next, a valve is convenient as a raw material transfer device if the containers are arranged in a vertical relationship, but if a small amount supply control is required, an electromagnetic feeder etc. Is preferred. .
  • steps may be operated sequentially from st art, but steps that do not affect each other may be operated independently.
  • the timer can be set to control the time schedule so that the next process starts after confirming the end of the previous process, but it is possible to start each process using a computer. What is necessary is just to set up software so that the termination can be confirmed, and such a design is extremely easy for those skilled in the art. Automatically recording the weighed value in each process makes subsequent management easier. A circuit should be set up so that an alarm is issued when an abnormality occurs in each process and a part or the whole of the device is stopped.
  • Raw material (1) is sent from a raw material storage tank 3 to a measuring vessel 7 by an electromagnetic feeder 6.
  • the electromagnetic feeder 16 is activated when the amount of the mixture in the mixer becomes equal to or less than a predetermined amount and the powder volume detector 12 detects this.
  • the weight setting comparator confirms that the amount detected by the weighing device 8 is the preset amount, the electromagnetic loudspeaker 6 is stopped.
  • the on / off valve 15 for discharging the particulates operates to supply the mixture to the container 23 for retaining the particulates, and the amount predetermined by the particulate detection sensor 24 is used.
  • the on-off valve stops. Also, this valve is controlled so as to stop while any of the steps (1) to (c) is operating.
  • the necessary number of sets of equipment necessary for the automatic supply of raw materials from the raw material container to the mixer are set in the equipment corresponding to the number of raw materials. You only need to incorporate it.
  • the device of the present invention can take various measures to simplify the attachment / detachment to / from the processing device in the subsequent process and to enable the entire device to be washed with water or the like.
  • the contact area between the powder and granules is treated with a special composite resin, and all corners are rounded to eliminate blind spots.
  • a one-touch coupling is used for easy attachment / detachment of main parts.
  • C All valves are sanitary type and easy to clean. Each detector, weighing unit, and bearing use part are made waterproof.
  • Table 1 shows the names and amounts of raw materials for conducting the test
  • Table 2 shows the characteristics of the granules obtained by granulating them with a fluid bed granulator and formulating them.
  • Table 3 shows the conditions.
  • the main raw material granules were produced by spray granulation of an aqueous solution of HPC-L into a mixture of lactose and potato starch while heating using a fluid bed granulator.
  • Table 4 shows the tablet characteristics in the case of processing by the V-type mixer and in the case of using the apparatus of the present invention.
  • magnesium stearate contained in the tablets obtained in Test Example 1 magnesium was quantified by atomic absorption spectrometry, and the percentage of ownership by the V-type mixer treatment and the treatment with the present apparatus was determined. Compared. As shown in Table 5, the device of the present invention has a small mixing variation with time, and is advantageous in terms of content uniformity. number 5
  • the tablet compression molding pressure and the release pressure from the die based on the degree of mixing of the lubricant were measured. Table 6 shows the results. Compared to the case of using a V-type mixer, the device of the present invention showed good pressure transmission, reduced the pressure during compression molding, and tended to decrease the tablet discharge pressure from the die wall. 6
  • the time required for disassembly, washing, and drying of the apparatus of the present invention was about 40 minutes, and it was confirmed that the apparatus could sufficiently withstand use.
  • FIG. 1 shows an example of a diagram in which the powdered and granular material quantitative supply mixing device according to the present invention is combined with a tableting machine.
  • the names of each part are as follows.
  • Electromagnetic feeder trough (2) 18: Electromagnetic feeder (2), 19: Measuring container (2).

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Dispositif de pesage, alimentation et mélange automatiques de matières brutes granulaires ou pulvérulentes, comportant des cuves de stockage pour au moins deux types de matières différentes. Un organe de pesage de quantités désirées de matières brutes provenant des cuves de stockage, un organe de décharge et de transfert dans une cuve de mélange des matières granulaires ou pulvérulentes pesées, un organe de mélange des matières granulaires ou pulvérulentes pesées, et un organe permettant de maintenir constante la quantité du mélange résultant, tous ces organes étant réunis de manière solidaire.
PCT/JP1986/000264 1986-05-23 1986-05-23 Dispositif d'alimentation et de melange constants de matieres granulaires ou pulverulentes Ceased WO1987007182A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PCT/JP1986/000264 WO1987007182A1 (fr) 1986-05-23 1986-05-23 Dispositif d'alimentation et de melange constants de matieres granulaires ou pulverulentes
EP19860903566 EP0299065A4 (fr) 1986-05-23 1986-05-23 Dispositif d'alimentation et de melange constants de matieres granulaires ou pulverulentes.
KR1019880700069A KR880701131A (ko) 1986-05-23 1986-05-23 분립체 정량 공급 혼합장치

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1986/000264 WO1987007182A1 (fr) 1986-05-23 1986-05-23 Dispositif d'alimentation et de melange constants de matieres granulaires ou pulverulentes

Publications (1)

Publication Number Publication Date
WO1987007182A1 true WO1987007182A1 (fr) 1987-12-03

Family

ID=13874443

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1986/000264 Ceased WO1987007182A1 (fr) 1986-05-23 1986-05-23 Dispositif d'alimentation et de melange constants de matieres granulaires ou pulverulentes

Country Status (3)

Country Link
EP (1) EP0299065A4 (fr)
KR (1) KR880701131A (fr)
WO (1) WO1987007182A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6402363B1 (en) 1995-12-11 2002-06-11 Stephen B. Maguire Weigh scale blender
US6467943B1 (en) * 1997-05-02 2002-10-22 Stephen B. Maguire Reduced size gravimetric blender
US9010988B2 (en) 2006-06-17 2015-04-21 Stephen B. Maguire Gravimetric blender with power hopper cover
CN108144540A (zh) * 2018-03-01 2018-06-12 苏州维洛克电子科技有限公司 一种新型混料装置
JP2018183817A (ja) * 2018-06-20 2018-11-22 ヘーエーアー プロセス エンジニアリング ナームロゼ フェンノートシャップ 錠剤の連続生産のための方法と、この方法を実行するための錠剤成形システムと、粒径が大きく異なる粒子を含む少なくとも２つの成分の錠剤を生産するためのこの錠剤成形システムの使用
US10138075B2 (en) 2016-10-06 2018-11-27 Stephen B. Maguire Tower configuration gravimetric blender
US10201915B2 (en) 2006-06-17 2019-02-12 Stephen B. Maguire Gravimetric blender with power hopper cover
CN114210218A (zh) * 2021-11-02 2022-03-22 深圳逗点生物技术有限公司 一种微量粉末分装方法、粉末混合方法、固化方法及滤芯
CN117358135A (zh) * 2023-12-08 2024-01-09 格莱德(福建)生物科技有限公司 一种可称重定量投加的犬饲料颗粒加工设备

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527107A (en) * 1990-02-02 1996-06-18 Buehler Ag Plant for continuous mixing and homgenization
GB0130131D0 (en) * 2001-12-17 2002-02-06 Glaxo Group Ltd Novel process and apparatus
WO2005005029A1 (fr) * 2003-07-11 2005-01-20 Charl Marais Appareil pour le melange de materiaux particulaires
CN103127872B (zh) * 2013-02-05 2015-03-25 江苏协诚科技发展有限公司 一种自动配料系统及生产工艺
CN105612048A (zh) 2013-06-27 2016-05-25 Gea工艺工程有限公司 用于药片的连续生产的方法，用于执行此方法的压片系统，以及用于生产包含具有明显不同的颗粒尺寸的颗粒的至少两种成分的药片的压片系统的用途
DE102020115919A1 (de) 2020-06-17 2021-12-23 Fette Compacting Gmbh Verfahren zum Betreiben einer Mischeinrichtung einer Anlage

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60183028A (ja) * 1984-03-01 1985-09-18 Kubota Ltd 計量配合装置

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE459860A (fr) *
GB456852A (en) * 1935-07-20 1936-11-17 Simon Ltd Henry Improvements relating to the blending or mixing of grain or other materials
JPS6142324A (ja) * 1984-07-31 1986-02-28 ナシヨナル　フオルジユ　ユ−ロプ 粉末状成分の混合装置

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60183028A (ja) * 1984-03-01 1985-09-18 Kubota Ltd 計量配合装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0299065A4 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6402363B1 (en) 1995-12-11 2002-06-11 Stephen B. Maguire Weigh scale blender
US6467943B1 (en) * 1997-05-02 2002-10-22 Stephen B. Maguire Reduced size gravimetric blender
US9010988B2 (en) 2006-06-17 2015-04-21 Stephen B. Maguire Gravimetric blender with power hopper cover
US10166699B2 (en) 2006-06-17 2019-01-01 Stephen B. Maguire Gravimetric blender with power hopper cover
US10201915B2 (en) 2006-06-17 2019-02-12 Stephen B. Maguire Gravimetric blender with power hopper cover
US10138075B2 (en) 2016-10-06 2018-11-27 Stephen B. Maguire Tower configuration gravimetric blender
CN108144540A (zh) * 2018-03-01 2018-06-12 苏州维洛克电子科技有限公司 一种新型混料装置
CN108144540B (zh) * 2018-03-01 2023-12-19 安徽千乾新材料科技有限公司 一种混料装置
JP2018183817A (ja) * 2018-06-20 2018-11-22 ヘーエーアー プロセス エンジニアリング ナームロゼ フェンノートシャップ 錠剤の連続生産のための方法と、この方法を実行するための錠剤成形システムと、粒径が大きく異なる粒子を含む少なくとも２つの成分の錠剤を生産するためのこの錠剤成形システムの使用
CN114210218A (zh) * 2021-11-02 2022-03-22 深圳逗点生物技术有限公司 一种微量粉末分装方法、粉末混合方法、固化方法及滤芯
CN117358135A (zh) * 2023-12-08 2024-01-09 格莱德(福建)生物科技有限公司 一种可称重定量投加的犬饲料颗粒加工设备
CN117358135B (zh) * 2023-12-08 2024-03-12 格莱德(福建)生物科技有限公司 一种可称重定量投加的犬饲料颗粒加工设备

Also Published As

Publication number Publication date
KR880701131A (ko) 1988-07-26
EP0299065A1 (fr) 1989-01-18
EP0299065A4 (fr) 1989-05-16

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