WO1992008792A3 - PROCEDE D'AUGMENTATION ET D'ACTIVATION DES MONOCYTES ET DES NEUTROPHILES ET D'INDUCTION DE LA MATURATION DE CELLULES MYELOïDES A L'AIDES DE L'INTERLEUKINE-5 - Google Patents

PROCEDE D'AUGMENTATION ET D'ACTIVATION DES MONOCYTES ET DES NEUTROPHILES ET D'INDUCTION DE LA MATURATION DE CELLULES MYELOïDES A L'AIDES DE L'INTERLEUKINE-5 Download PDF

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Publication number
WO1992008792A3
WO1992008792A3 PCT/US1991/008264 US9108264W WO9208792A3 WO 1992008792 A3 WO1992008792 A3 WO 1992008792A3 US 9108264 W US9108264 W US 9108264W WO 9208792 A3 WO9208792 A3 WO 9208792A3
Authority
WO
WIPO (PCT)
Prior art keywords
neutrophils
increasing
interleukin
myeloid cells
activating monocytes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1991/008264
Other languages
English (en)
Other versions
WO1992008792A2 (fr
Inventor
Loretta A Bober
Michael J Grace
Chuan-Chu Chou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to JP4501059A priority Critical patent/JPH06502644A/ja
Publication of WO1992008792A2 publication Critical patent/WO1992008792A2/fr
Publication of WO1992008792A3 publication Critical patent/WO1992008792A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5409—IL-5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Synchronisation In Digital Transmission Systems (AREA)

Abstract

Procédé d'augmentation et d'activation des monocytes et des neutrophiles, et induisant la maturation de cellules myéloïdes chez des mammifères par administration de IL-5. L'invention concerne également un procédé de production de IL-5.
PCT/US1991/008264 1990-11-16 1991-11-14 PROCEDE D'AUGMENTATION ET D'ACTIVATION DES MONOCYTES ET DES NEUTROPHILES ET D'INDUCTION DE LA MATURATION DE CELLULES MYELOïDES A L'AIDES DE L'INTERLEUKINE-5 Ceased WO1992008792A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4501059A JPH06502644A (ja) 1990-11-16 1991-11-14 インターロイキン５による単球および好中球の増加および活性化法および骨髄細胞の成熟誘導法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61506190A 1990-11-16 1990-11-16
US615,061 1990-11-16

Publications (2)

Publication Number Publication Date
WO1992008792A2 WO1992008792A2 (fr) 1992-05-29
WO1992008792A3 true WO1992008792A3 (fr) 1992-07-23

Family

ID=24463836

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/008264 Ceased WO1992008792A2 (fr) 1990-11-16 1991-11-14 PROCEDE D'AUGMENTATION ET D'ACTIVATION DES MONOCYTES ET DES NEUTROPHILES ET D'INDUCTION DE LA MATURATION DE CELLULES MYELOïDES A L'AIDES DE L'INTERLEUKINE-5

Country Status (6)

Country Link
EP (1) EP0557420A1 (fr)
JP (1) JPH06502644A (fr)
AU (1) AU9052591A (fr)
CA (1) CA2096329A1 (fr)
IE (1) IE913984A1 (fr)
WO (1) WO1992008792A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866134A (en) * 1995-03-24 1999-02-02 Schering Corporation Method for enhancing the antibody response to specific antigens with Interleukin-10
US6509313B1 (en) 1996-02-28 2003-01-21 Cornell Research Foundation, Inc. Stimulation of immune response with low doses of cytokines

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987004466A1 (fr) * 1986-01-15 1987-07-30 Amersham International Plc Interleukine
EP0261625A2 (fr) * 1986-09-20 1988-03-30 Tasuku Honjo Facteur de différenciation de cellule-B humaine et son procédé de préparation
EP0267779A2 (fr) * 1986-11-10 1988-05-18 Schering Biotech Corporation Facteur immune et pléiotropique humain et des mutéines de celui-ci
WO1988006891A1 (fr) * 1987-03-11 1988-09-22 Aktiebolaget Astra Procede de traitement de leucemies et de certaines autres maladies malignes
EP0299782A2 (fr) * 1987-07-17 1989-01-18 Schering Biotech Corporation Vecteurs d'expression du GM-CSF humain dans des cellules de mammifères
EP0378827A1 (fr) * 1988-12-21 1990-07-25 Schering Corporation Utilisation d'interleukine-4 pour abaisser le taux de glucose sanguin et ou effectuer une réduction de poids
WO1991013160A1 (fr) * 1990-02-28 1991-09-05 Schering Corporation Vecteurs d'expressions de cellules de mammiferes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992581A (en) * 1975-09-02 1976-11-16 Sperry Rand Corporation Phase locked loop NRZ data repeater
JPS5850054B2 (ja) * 1978-01-13 1983-11-08 沖電気工業株式会社 Ｐｌｌ回路
JPS56125134A (en) * 1980-03-08 1981-10-01 Nippon Telegr & Teleph Corp <Ntt> Timing pickup circuit
JPH063900B2 (ja) * 1987-08-10 1994-01-12 日本電気株式会社 タイミング抽出回路

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987004466A1 (fr) * 1986-01-15 1987-07-30 Amersham International Plc Interleukine
EP0261625A2 (fr) * 1986-09-20 1988-03-30 Tasuku Honjo Facteur de différenciation de cellule-B humaine et son procédé de préparation
EP0267779A2 (fr) * 1986-11-10 1988-05-18 Schering Biotech Corporation Facteur immune et pléiotropique humain et des mutéines de celui-ci
WO1988006891A1 (fr) * 1987-03-11 1988-09-22 Aktiebolaget Astra Procede de traitement de leucemies et de certaines autres maladies malignes
EP0299782A2 (fr) * 1987-07-17 1989-01-18 Schering Biotech Corporation Vecteurs d'expression du GM-CSF humain dans des cellules de mammifères
EP0378827A1 (fr) * 1988-12-21 1990-07-25 Schering Corporation Utilisation d'interleukine-4 pour abaisser le taux de glucose sanguin et ou effectuer une réduction de poids
WO1991013160A1 (fr) * 1990-02-28 1991-09-05 Schering Corporation Vecteurs d'expressions de cellules de mammiferes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Acta Haematologica Japonica, vol. 53, no. 4, July 1990, Y. YAMAGUCHI et al.: "Analysis of eosinophil-predominant colonies formed by human hemopoietic precursor cells in the presence of purified interleukin-5", pages 688-698, see the whole article, especially pages 695-698, paragraph: "Discussion" *
Biological Abstracts, vol. 89, no. 7, 1 May 1990, (Philadelphia, PA, US), H. EMA et al.: "In vitro differentiation of leukemic cells to eosinophils in the presence of interleukin-5 in two cases of acute myeloid leukemia with the translocation (8;21Xq22;q22)", see page AB-691, abstract no. 72613, & BLOOD 75(2): 350-356. 1990, see the abstract *
The Journal of Biochemistry, vol. 107, no. 2, February 1990, (Tokyo, JP), Y. MINAMITAKE et al.: "Structure of recombinant human interleukin 5 produced by Chinese hamster ovary cells", pages 292-297, see the whole article *

Also Published As

Publication number Publication date
JPH06502644A (ja) 1994-03-24
AU9052591A (en) 1992-06-11
IE913984A1 (en) 1992-05-20
WO1992008792A2 (fr) 1992-05-29
CA2096329A1 (fr) 1992-05-17
EP0557420A1 (fr) 1993-09-01

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