WO1993015061A3 - Verfahren zur herstellung von 2-arylbenzimidazol-5-sulfonsäuren - Google Patents

Verfahren zur herstellung von 2-arylbenzimidazol-5-sulfonsäuren Download PDF

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Publication number
WO1993015061A3
WO1993015061A3 PCT/EP1993/000179 EP9300179W WO9315061A3 WO 1993015061 A3 WO1993015061 A3 WO 1993015061A3 EP 9300179 W EP9300179 W EP 9300179W WO 9315061 A3 WO9315061 A3 WO 9315061A3
Authority
WO
WIPO (PCT)
Prior art keywords
arylbenzimidazole
alkyl
preparing
formula
sulphonic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP1993/000179
Other languages
English (en)
French (fr)
Other versions
WO1993015061A2 (de
Inventor
Ulrich Heywang
Ingeborg Stein
Ulrich Fechtel
Michael Casutt
Gerald Faller
Hartmut Haertner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Priority to JP51293293A priority Critical patent/JP4004061B2/ja
Priority to BR9303969A priority patent/BR9303969A/pt
Priority to US08/122,566 priority patent/US5473079A/en
Priority to DE59310162T priority patent/DE59310162D1/de
Priority to EP93914529A priority patent/EP0579827B1/de
Publication of WO1993015061A2 publication Critical patent/WO1993015061A2/de
Publication of WO1993015061A3 publication Critical patent/WO1993015061A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Die Erfindung betrifft ein verbessertes Verfahren zur Herstellung von 2-Arylbenzimidazol-5-sulfonsäuren der Formel (I), worin Ar unsubstituiertes oder durch eine oder mehrere C1-C6 Alkyl- oder Alkoxygruppen substituiertes Phenyl, und m 1, 2, oder 3 bedeuten, wobei man o-Phenylendiamin in Gegenwart von Schwefelsäure mit einem Benzoesäurederivat der Formel (II) Ar(-X)m, wobei Ar und m die angegebene Bedeutung besitzen und X COO Alkyl, worin Alkyl n-Alkyl mit 1 bis 6 C-Atomen bedeutet, COOH, COC1, COBr oder CN bedeutet, zwischen Raumtemperatur und 250 °C umsetzt, sowie neue Arylbenzimidazolsäuren der Formel (Ia), worin R und n die im Anspruch gegebene Bedeutung besitzen.
PCT/EP1993/000179 1992-02-04 1993-01-27 Verfahren zur herstellung von 2-arylbenzimidazol-5-sulfonsäuren Ceased WO1993015061A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP51293293A JP4004061B2 (ja) 1992-02-04 1993-01-27 ２−アリールベンズイミダゾール−５−スルフォニックアシッドの改良された製造方法
BR9303969A BR9303969A (pt) 1992-02-04 1993-01-27 Processo para produção de ácidos 2-arilbenzimidazol-5-sulfônicos
US08/122,566 US5473079A (en) 1992-02-04 1993-01-27 Process for preparing 2-arylbenzimidazole-5-sulfonic acids
DE59310162T DE59310162D1 (de) 1992-02-04 1993-01-27 Verfahren zur herstellung von 2-arylbenzimidazol-5-sulfonsäuren
EP93914529A EP0579827B1 (de) 1992-02-04 1993-01-27 Verfahren zur herstellung von 2-arylbenzimidazol-5-sulfonsäuren

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4203072.2 1992-02-04
DE4203072A DE4203072C1 (de) 1992-02-04 1992-02-04

Publications (2)

Publication Number Publication Date
WO1993015061A2 WO1993015061A2 (de) 1993-08-05
WO1993015061A3 true WO1993015061A3 (de) 1993-10-14

Family

ID=6450890

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1993/000179 Ceased WO1993015061A2 (de) 1992-02-04 1993-01-27 Verfahren zur herstellung von 2-arylbenzimidazol-5-sulfonsäuren

Country Status (7)

Country Link
US (1) US5473079A (de)
EP (1) EP0579827B1 (de)
JP (2) JP4004061B2 (de)
BR (1) BR9303969A (de)
DE (2) DE4203072C1 (de)
ES (1) ES2157925T3 (de)
WO (1) WO1993015061A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2157268T5 (es) † 1994-02-24 2004-12-01 SYMRISE GMBH & CO KG Preparados cosmeticos y dermatologicos que contienen acidos fenilen-1,4-bisbencimidazolsulfonicos.
DE19539623A1 (de) * 1995-10-16 1997-04-17 Haarmann & Reimer Gmbh Sulfonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als UV-Absorber
DE10030663A1 (de) * 2000-06-23 2002-01-10 Merck Patent Gmbh UV-B-Filter
DE10030664A1 (de) * 2000-06-23 2002-01-10 Merck Patent Gmbh Verfahren zur Herstellung von UV-Filter-Substanzen
DE10059254C2 (de) * 2000-11-29 2003-10-02 Haarmann & Reimer Gmbh Verfahren zur Herstellung von Phenylen-bis-benzimidazol-tetrasulfonsäure-di-natriumsalz
DE10243028A1 (de) * 2002-09-17 2004-03-25 Bayer Ag Verfahren zur Herstellung isolierter 3,4-Diaminobenzolsulfonsäure
DE10243027A1 (de) * 2002-09-17 2004-03-25 Bayer Ag 2-Phenyl-benzimidazol-5-sulfonsäure aus isolierter 3,4-Diaminobenzol-sulfonsäure sowie deren Verwendung in kosmetischen Zubereitungen
CN110540523B (zh) * 2018-07-05 2021-02-19 安徽圣诺贝化学科技有限公司 一种制备磺基取代苯并咪唑及其衍生物的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1450505A (fr) * 1965-04-24 1966-06-24 Chimetron Sarl Nouvelles cétones dérivées des benzimidazoles sulfonés et sulfamidés

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA470661A (en) * 1951-01-09 Philip Ham Garnet Guanidine thiosulfate reaction products
US2463264A (en) * 1942-12-23 1949-03-01 Ciba Ltd Derivatives of cyclic amidines and process of making same
US3324050A (en) * 1963-02-13 1967-06-06 Union Oil Co Method of curing a polyepoxide with bisheterocyclic aromatic compounds and resultingproducts
DE1282855B (de) * 1966-08-27 1968-11-14 Merck Ag E Kosmetisches Lichtschutzmittel
US3586673A (en) * 1968-02-05 1971-06-22 Eastman Kodak Co Preparation of symmetrically and unsymmetrically substituted stilbenebisbenzoxazoles
US3655632A (en) * 1970-09-15 1972-04-11 Kuraray Co Process for the production of aromatic polybenzimidazoles
DE2750947A1 (de) * 1977-11-15 1979-05-17 Hoechst Ag Neue fluorhaltige benz-azol-derivate, verfahren zu ihrer herstellung und ihre verwendung als optische aufheller
DE2939916A1 (de) * 1979-10-02 1981-04-23 Hoechst Ag, 6000 Frankfurt Quaternierte, verbrueckte benzimidazolyl-benzimidazole, verfahren zu deren herstellung und deren verwendung
DE3305578A1 (de) * 1983-02-18 1984-08-23 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von 4,4'-bis-benz-ox(-thi,-imid) -azol-2-yl-stilbenen

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1450505A (fr) * 1965-04-24 1966-06-24 Chimetron Sarl Nouvelles cétones dérivées des benzimidazoles sulfonés et sulfamidés

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, Band 48, (Columbus, Ohio, US), L.S. EFROS: "Imidazole derivatives. VII. Preparation of sulfonic acids of benzimidazole by baking method", siehe Spalte 4524, & ZHUR. OBSHCHEI KHIM. 23, 835-41 (1953), siehe Zusammenfassung *
Chemical Abstracts, Band 84, Nr. 7, 14. August 1967, (Columbus, Ohio, US), K.K. PREOBRAZHENSKII et al.: "2-Alkylbenzimidazoles and their sulfo derivates", siehe Seite 454, Zusammenfassung Nr. 30963t, & ZH. PRIKL. KHIM. (LENINGRAD) 1975, 48(10), 2241-4, siehe Zusammenfassung *

Also Published As

Publication number Publication date
DE4203072C1 (de) 1992-11-12
JP2007204492A (ja) 2007-08-16
EP0579827B1 (de) 2001-04-18
US5473079A (en) 1995-12-05
ES2157925T3 (es) 2001-09-01
JP4004061B2 (ja) 2007-11-07
JPH06506703A (ja) 1994-07-28
EP0579827A1 (de) 1994-01-26
BR9303969A (pt) 1994-08-02
WO1993015061A2 (de) 1993-08-05
DE59310162D1 (de) 2001-05-23

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