WO1994012648A3 - Production de sous-unites de recepteurs t solubles par co-transfection, utilisations des produits ainsi obtenus - Google Patents

Production de sous-unites de recepteurs t solubles par co-transfection, utilisations des produits ainsi obtenus Download PDF

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Publication number
WO1994012648A3
WO1994012648A3 PCT/FR1993/001165 FR9301165W WO9412648A3 WO 1994012648 A3 WO1994012648 A3 WO 1994012648A3 FR 9301165 W FR9301165 W FR 9301165W WO 9412648 A3 WO9412648 A3 WO 9412648A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptors
resulting products
transfection
producing soluble
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR1993/001165
Other languages
English (en)
Other versions
WO1994012648A2 (fr
Inventor
Marc Bonneville
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Immunotech SAS
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Immunotech SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM, Immunotech SAS filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Priority to JP6512850A priority Critical patent/JPH07506495A/ja
Priority to EP94900880A priority patent/EP0624201A1/fr
Priority to AU55668/94A priority patent/AU5566894A/en
Priority to US08/256,964 priority patent/US5723309A/en
Publication of WO1994012648A2 publication Critical patent/WO1994012648A2/fr
Publication of WO1994012648A3 publication Critical patent/WO1994012648A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention a pour objet un procédé de production de récepteurs T solubles, caractérisé en ce que l'on réalise une co-transfection dans une cellule-hôte des séquences d'ADN codant pour chacune des sous-unités constitutives du récepteur T délétées de la portiontransmembranaire du récepteur T, les produits ainsi obtenus, ainsi que leurs applications diagnostiques et thérapeutiques.
PCT/FR1993/001165 1992-11-25 1993-11-25 Production de sous-unites de recepteurs t solubles par co-transfection, utilisations des produits ainsi obtenus Ceased WO1994012648A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP6512850A JPH07506495A (ja) 1992-11-25 1993-11-25 可溶性ｔ受容体のサブユニットの共トランスフェクションによる産生，得られた生成物の用途
EP94900880A EP0624201A1 (fr) 1992-11-25 1993-11-25 Production de sous-unites de recepteurs t solubles par co-transfection, utilisations des produits ainsi obtenus
AU55668/94A AU5566894A (en) 1992-11-25 1993-11-25 Method for producing soluble t-receptors by co-transfection, and use of resulting products
US08/256,964 US5723309A (en) 1992-11-25 1993-11-25 Production of subunits of soluble T cell receptors by co-transfection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR92/14203 1992-11-25
FR9214203A FR2698880B1 (fr) 1992-11-25 1992-11-25 Procédé de production de récepteurs T solubles, produits ainsi obtenus et leur utilisation dans des compositions diagnostiques ou thérapeutiques.

Publications (2)

Publication Number Publication Date
WO1994012648A2 WO1994012648A2 (fr) 1994-06-09
WO1994012648A3 true WO1994012648A3 (fr) 1994-07-21

Family

ID=9435915

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1993/001165 Ceased WO1994012648A2 (fr) 1992-11-25 1993-11-25 Production de sous-unites de recepteurs t solubles par co-transfection, utilisations des produits ainsi obtenus

Country Status (7)

Country Link
US (1) US5723309A (fr)
EP (1) EP0624201A1 (fr)
JP (1) JPH07506495A (fr)
AU (1) AU5566894A (fr)
CA (1) CA2128705A1 (fr)
FR (1) FR2698880B1 (fr)
WO (1) WO1994012648A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996021028A2 (fr) * 1995-01-03 1996-07-11 Procept, Inc. Recepteurs de lymphocytes t heterodimeres solubles et leurs anticorps
US6759243B2 (en) 1998-01-20 2004-07-06 Board Of Trustees Of The University Of Illinois High affinity TCR proteins and methods
US6413776B1 (en) 1998-06-12 2002-07-02 Galapagos Geonomics N.V. High throughput screening of gene function using adenoviral libraries for functional genomics applications
DE69936927T2 (de) * 1998-10-21 2008-05-15 Altor Bioscience Corp., Miramar Polyspezifische bindemoleküle und deren verwendung
AU7524601A (en) * 2000-06-05 2001-12-17 Sunol Molecular Corp T cell receptor fusions and conjugates and methods of use thereof
US20020165149A1 (en) * 2000-12-08 2002-11-07 Kranz David M. Mutated class II major histocompatibility proteins
CA2513013A1 (fr) * 2002-01-10 2003-07-24 National Jewish Medical And Research Center Utilisation de recepteurs solubles de lymphocytes t .gamma..delta. pour reguler la fonction des lymphocytes t
DE60334474D1 (de) * 2002-07-12 2010-11-18 Univ Johns Hopkins Reagenzien und verfahren zum eingriff in einzigartige klonotype lymphozyten-rezeptoren
KR101131297B1 (ko) * 2003-11-10 2012-03-30 알토 바이오사이언스 코포레이션 가용성 티씨알 분자 및 이용 방법
CN104334741B (zh) * 2012-03-28 2018-08-17 歌德塔有限公司 组合的γ9δ2T细胞受体链交换
DK3129404T3 (da) * 2014-04-10 2026-04-20 Lava Therapeutics N V Immunglobuliner, der binder humane vgamma9vdelta2-t-cellereceptorer
US10501541B2 (en) 2015-01-27 2019-12-10 Lava Therapeutics B.V. Single domain antibodies targeting CD1d
EP4099015A1 (fr) 2016-06-10 2022-12-07 Gadeta B.V. Nouveau procédé d'identification de chaînes de récepteurs de lymphocytes t delta (ou de lymphocytes t gamma) ou de parties de celles-ci qui conditionnent une réponse anti-tumorale ou une réponse anti-infectieuse
EP3624823A1 (fr) 2017-05-18 2020-03-25 UMC Utrecht Holding B.V. Compositions et procédés pour thérapies de ciblage de cellules
AU2019344300A1 (en) 2018-09-19 2021-04-22 LAVA Therapeutics N.V. Dual acting CD1D immunoglobulin
MA55903A (fr) * 2019-05-08 2022-03-16 Janssen Biotech Inc Matières et méthodes pour moduler l'immunité médiée par les lymphocytes t
KR20230042035A (ko) 2020-07-08 2023-03-27 라바 테라퓨틱스 엔.브이. Psma와 감마-델타 t 세포 수용체에 결합할 수 있는 항체

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000209A1 (fr) * 1986-07-03 1988-01-14 T Cell Sciences, Inc. RECEPTEURS gamma, delta DE CELLULES T ET PROCEDES DE DETECTION
WO1989003996A1 (fr) * 1987-10-29 1989-05-05 T Cell Sciences, Inc. Polypeptides recepteurs d'antigenes de cellules t gamma, delta humaines et acides nucleiques
WO1991010438A1 (fr) * 1990-01-12 1991-07-25 Protein Design Labs, Inc. Antigenes chimeriques recepteurs d'antigenes de lymphocytes t solubles
WO1991018019A1 (fr) * 1990-05-15 1991-11-28 E.R. Squibb & Sons, Inc. Recepteurs solubles de lymphocytes t monocatenaires

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5314995A (en) * 1990-01-22 1994-05-24 Oncogen Therapeutic interleukin-2-antibody based fusion proteins

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000209A1 (fr) * 1986-07-03 1988-01-14 T Cell Sciences, Inc. RECEPTEURS gamma, delta DE CELLULES T ET PROCEDES DE DETECTION
WO1989003996A1 (fr) * 1987-10-29 1989-05-05 T Cell Sciences, Inc. Polypeptides recepteurs d'antigenes de cellules t gamma, delta humaines et acides nucleiques
WO1991010438A1 (fr) * 1990-01-12 1991-07-25 Protein Design Labs, Inc. Antigenes chimeriques recepteurs d'antigenes de lymphocytes t solubles
WO1991018019A1 (fr) * 1990-05-15 1991-11-28 E.R. Squibb & Sons, Inc. Recepteurs solubles de lymphocytes t monocatenaires

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GREGOIRE C;REBAI N;SCHWEISGUTH F;NECKER A;MAZZA G;AUPHAN N;MILLWARD A;SCHMITT-VERHULST A M;MALISSEN B;: "Engineered secreted T-cell receptor alpha beta heterodimers", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 88, no. 18, 1991, WASHINGTON US, pages 8077 - 8081 *
NOVOTNY J;GANJU RK;SMILEY ST;HUSSEY RE;LUTHER MA;RECNY MA;SILICIANO RF;REINHERZ EL;: "A soluble, single-chain T-cell receptor fragment endowed with antigen-combining properties.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 88, no. 19, 1991, WASHINGTON US, pages 8646 - 8650 *
SLANETZ A E;BOTHWELL A L M;: "Heterodimeric, disulfide-linked alpha / beta T cell receptors in solution.", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 21, no. 1, 1991, VCH VERLAGSGESELLSCHAFT, DEUTSCHLAND, pages 179 - 183 *

Also Published As

Publication number Publication date
EP0624201A1 (fr) 1994-11-17
WO1994012648A2 (fr) 1994-06-09
FR2698880A1 (fr) 1994-06-10
AU5566894A (en) 1994-06-22
JPH07506495A (ja) 1995-07-20
FR2698880B1 (fr) 1995-02-24
US5723309A (en) 1998-03-03
CA2128705A1 (fr) 1994-06-09

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