WO1994015902B1 - Composes a selectivite envers les recepteurs de retinoides x - Google Patents

Composes a selectivite envers les recepteurs de retinoides x

Info

Publication number
WO1994015902B1
WO1994015902B1 PCT/US1993/010204 US9310204W WO9415902B1 WO 1994015902 B1 WO1994015902 B1 WO 1994015902B1 US 9310204 W US9310204 W US 9310204W WO 9415902 B1 WO9415902 B1 WO 9415902B1
Authority
WO
WIPO (PCT)
Prior art keywords
carbons
acyl
lower alkyl
including halogen
represents hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1993/010204
Other languages
English (en)
Other versions
WO1994015902A1 (fr
Filing date
Publication date
Priority to CA002153235A priority Critical patent/CA2153235C/fr
Priority to JP6515962A priority patent/JPH08505852A/ja
Priority to MX9306629A priority patent/MX9306629A/es
Priority to PT94901195T priority patent/PT678086E/pt
Priority to DK94901195T priority patent/DK0678086T3/da
Priority to KR1019950702842A priority patent/KR100306855B1/ko
Priority to BR9307784A priority patent/BR9307784A/pt
Priority to AU55868/94A priority patent/AU691477B2/en
Priority to DE69327255T priority patent/DE69327255T2/de
Priority to AT94901195T priority patent/ATE187434T1/de
Priority to AU62258/94A priority patent/AU6225894A/en
Priority to PCT/US1993/010204 priority patent/WO1994015902A1/fr
Application filed filed Critical
Priority to ES94901195T priority patent/ES2139063T3/es
Priority to EP94901195A priority patent/EP0678086B1/fr
Priority claimed from PCT/US1993/010204 external-priority patent/WO1994015902A1/fr
Publication of WO1994015902A1 publication Critical patent/WO1994015902A1/fr
Publication of WO1994015902B1 publication Critical patent/WO1994015902B1/fr
Anticipated expiration legal-status Critical
Priority to GR20000400533T priority patent/GR3032841T3/el
Ceased legal-status Critical Current

Links

Abstract

Composés, compositions et procédés destinés à moduler les processus induits par les récepteurs de rétinoïdes X à l'aide de composés de type rétinoïde qui activent sélectivement des membres du sous-groupe des récepteurs de rétinoïdes X (RXR), de préférence aux membres du sous-groupe des récepteurs de l'acide rétinoïque (RAR). Lesdits composés sont par exemple des dérivés de benzyle bicyclique, de pyridinyle, de thiophène, de furanyle et de pyrrole. Dans les procédés décrits, on emploie des composés destinés à moduler les processus induits sélectivement par les récepteurs de rétinoïdes X.
PCT/US1993/010204 1992-04-22 1993-10-22 Composes a selectivite envers les recepteurs de retinoides x Ceased WO1994015902A1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
AU62258/94A AU6225894A (en) 1993-01-11 1993-10-22 Compounds having selectivity for retinoid x receptors
MX9306629A MX9306629A (es) 1993-01-11 1993-10-22 Compuestos que tienen actividad selectiva para receptores retinoide x, medios para modulacion de procesos mediados pr receptores de retinoide x.
PT94901195T PT678086E (pt) 1993-01-11 1993-10-22 Compostos com selectividade para receptores de retinoides x
DK94901195T DK0678086T3 (da) 1993-01-11 1993-10-22 Forbindelser med selektivitet over for retinoid-X-receptorer
KR1019950702842A KR100306855B1 (ko) 1993-01-11 1993-10-22 레티노이드x수용체에대한선택성을갖는화합물
BR9307784A BR9307784A (pt) 1993-01-11 1993-10-22 Compostos tendo seletivamente para receptores de retinóide X
AU55868/94A AU691477B2 (en) 1992-04-22 1993-10-22 Compounds having selectivity for retinoid X receptors
DE69327255T DE69327255T2 (de) 1993-01-11 1993-10-22 Selektivitaet fuer retinoid x rezeptoren enthaltende verbindungen
AT94901195T ATE187434T1 (de) 1993-01-11 1993-10-22 Selektivitaet fuer retinoid x rezeptoren enthaltende verbindungen
CA002153235A CA2153235C (fr) 1993-01-11 1993-10-22 Composes selectifs pour les recepteurs de la retinoide x; moyens permettant la modulation de procedes via ces recepteurs
JP6515962A JPH08505852A (ja) 1993-01-11 1993-10-22 レチノイドｘレセプターに対する選択性を有する化合物
PCT/US1993/010204 WO1994015902A1 (fr) 1993-01-11 1993-10-22 Composes a selectivite envers les recepteurs de retinoides x
ES94901195T ES2139063T3 (es) 1993-01-11 1993-10-22 Compuestos que tienen selectividad por receptores de retinoides x.
EP94901195A EP0678086B1 (fr) 1993-01-11 1993-10-22 Composes a selectivite envers les recepteurs de retinoides x
GR20000400533T GR3032841T3 (en) 1993-01-11 2000-03-03 Compounds having selectivity for retinoid x receptors.

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US322393A 1993-01-11 1993-01-11
US08/003,223 1993-01-11
US2774793A 1993-03-05 1993-03-05
US08/027,747 1993-03-05
US5205193A 1993-04-21 1993-04-21
US08/052,051 1993-04-21
PCT/US1993/010204 WO1994015902A1 (fr) 1993-01-11 1993-10-22 Composes a selectivite envers les recepteurs de retinoides x

Publications (2)

Publication Number Publication Date
WO1994015902A1 WO1994015902A1 (fr) 1994-07-21
WO1994015902B1 true WO1994015902B1 (fr) 1994-09-15

Family

ID=27485257

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/010204 Ceased WO1994015902A1 (fr) 1992-04-22 1993-10-22 Composes a selectivite envers les recepteurs de retinoides x

Country Status (14)

Country Link
EP (1) EP0678086B1 (fr)
JP (1) JPH08505852A (fr)
KR (1) KR100306855B1 (fr)
AT (1) ATE187434T1 (fr)
AU (2) AU6225894A (fr)
BR (1) BR9307784A (fr)
CA (1) CA2153235C (fr)
DE (1) DE69327255T2 (fr)
DK (1) DK0678086T3 (fr)
ES (1) ES2139063T3 (fr)
GR (1) GR3032841T3 (fr)
MX (1) MX9306629A (fr)
PT (1) PT678086E (fr)
WO (1) WO1994015902A1 (fr)

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Publication number Priority date Publication date Assignee Title
US5466861A (en) * 1992-11-25 1995-11-14 Sri International Bridged bicyclic aromatic compounds and their use in modulating gene expression of retinoid receptors
ES2141978T3 (es) * 1994-12-30 2000-04-01 Ligand Pharm Inc Retinoides triciclicos, metodos para su produccion y uso.
US7115728B1 (en) 1995-01-30 2006-10-03 Ligand Pharmaceutical Incorporated Human peroxisome proliferator activated receptor γ
WO1997010813A1 (fr) 1995-09-18 1997-03-27 Ligand Pharmaceuticals Incorporated Antagonistes de ppar gamma pour le traitement de l'obesite
BR9610875A (pt) * 1995-10-06 1999-07-13 Ligand Pharm Inc Modulares rxr seletivos - dimeros e processos para seu uso
US5726191A (en) 1995-11-16 1998-03-10 Hoffmann-La Roche Inc. Aromatic carboxylic acid esters
US5998393A (en) * 1996-04-05 1999-12-07 Kang; Sewon Methods for assessing 1,25(OH)2 D3 activity in skin and for enhancing the therapeutic use of 1,25(OH)2 D3
US7098025B1 (en) 1997-07-25 2006-08-29 Ligand Pharmaceuticals Incorporated Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor
EP1077920A1 (fr) * 1998-05-11 2001-02-28 Novo Nordisk A/S Nouveaux composes et leur preparation et utilisation
WO1999058486A1 (fr) * 1998-05-11 1999-11-18 Novo Nordisk A/S Nouveaux composes, leur preparation et utilisation
AU4676999A (en) 1998-06-12 1999-12-30 Ligand Pharmaceuticals, Inc. Treatment of anti-estrogen resistant breast cancer using rxr modulators
FR2779720B1 (fr) * 1998-06-12 2002-08-16 Galderma Rech Dermatologique Nouveaux composes diarylselenures et leur utilisation en medecine humaine ou veterinaire ainsi qu'en cosmetologie
EP1142870A1 (fr) 1998-12-14 2001-10-10 Nuclear Receptor Research Limited Nouveaux ligands d'un recepteur nucleaire
PL353792A1 (en) 1999-08-27 2003-12-01 Ligand Pharmaceuticals Incorporatedligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
US6667313B1 (en) 1999-08-27 2003-12-23 Ligand Pharmaceuticals Inc. 8-substituted-6-triflouromethyl-9-pyrido [3,2-G] quinoline compounds as androgen receptor modulators
WO2001019770A2 (fr) 1999-09-14 2001-03-22 Ligand Pharmaceuticals Incorporated Modulateurs rxr a profil pharmacologique ameliore
DK1248604T4 (da) 2000-01-21 2012-05-21 Novartis Ag Kombinationer indeholdende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler
JP4118675B2 (ja) * 2000-10-02 2008-07-16 エフ．ホフマン−ラ ロシュ アーゲー 気腫治療用新規レチノイド
EP1935869A1 (fr) * 2000-10-02 2008-06-25 F. Hoffmann-La Roche Ag Retinoides destines au traitement de l'emphyseme
CA2438586A1 (fr) 2001-03-14 2002-09-19 Eli Lilly And Company Modulateurs des recepteurs x de retinoides
AU2002333655A1 (en) * 2001-09-25 2003-04-07 Smithkline Beecham Corporation Bicyclic heterocycles as rxr ligands
JP5249484B2 (ja) * 2001-12-11 2013-07-31 第一三共株式会社 医薬組成物
US9050310B2 (en) 2004-06-25 2015-06-09 Minas Theodore Coroneo Treatment of ocular lesions
US8652534B2 (en) 2009-10-14 2014-02-18 Berry Pharmaceuticals, LLC Compositions and methods for treatment of mammalian skin
AU2011218019B2 (en) * 2010-02-19 2016-03-24 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Novel bexarotene analogs
CN109589324B (zh) 2012-11-08 2022-06-14 国立大学法人山口大学 角结膜病症的治疗剂
CN105377258B (zh) 2013-05-22 2020-08-28 国立大学法人山口大学 视网膜脉络膜病症的抑制剂
US20160263189A1 (en) 2013-10-23 2016-09-15 Acadia Pharmaceuticals Inc. Treatment of a neurodegenerative disease or disorder
WO2015187850A2 (fr) * 2014-06-03 2015-12-10 Duke University Composés et méthodes destinés au traitement de troubles oculaires
US10759762B2 (en) 2014-10-10 2020-09-01 High Force Research Limited Fluorescent synthetic retinoids
US11045441B2 (en) 2015-10-13 2021-06-29 Wisconsin Alumni Research Foundation Use of retinoic acid and analogs thereof to treat central neural apneas
US10238626B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
US10238655B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Dihydroindene and tetrahydronaphthalene compounds
US10231947B2 (en) 2017-01-23 2019-03-19 Arizona Board Of Regents On Behalf Of Arizona State University Isochroman compounds and methods of use thereof
KR102841468B1 (ko) * 2018-03-01 2025-08-04 디제이 테라퓨틱스 엘엘씨 벡사로텐 유도체 및 암 치료에서 이의 용도
EP3887401A2 (fr) 2018-11-26 2021-10-06 Denali Therapeutics Inc. Procédés de traitement du métabolisme lipidique dérégulé
CN117285437B (zh) * 2023-09-20 2024-09-17 沈阳药科大学 一种贝沙罗汀类衍生物及其制备方法和应用、一种抗肿瘤药物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601670B1 (fr) * 1986-07-17 1988-10-07 Cird Nouveaux derives bicycliques aromatiques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire et en cosmetique
FR2605626B1 (fr) * 1986-10-27 1989-06-02 Oreal Nouveaux derives aromatiques bicycliques, leur procede de preparation et leur utilisation en cosmetique et en medecine humaine et veterinaire

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