DK1248604T4 - Kombinationer indeholdende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler - Google Patents

Kombinationer indeholdende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler

Info

Publication number: DK1248604T4
Authority: DK; Denmark
Prior art keywords: inhibitors; insulin; glucose; fructose; nvp
Prior art date: 2000-01-21

Application number

DK01909661.9T

Other languages

English (en)

Other versions

DK1248604T3 (da

Inventor

Thomas Edward Hughes

David Grenville Holmes

Edwin Bernard Villhauer

Boerk Balkan

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-21

Filing date

2001-01-19

Publication date

2012-05-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27049636&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1248604(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-01-19 Application filed by Novartis Ag filed Critical Novartis Ag

2007-02-19 Publication of DK1248604T3 publication Critical patent/DK1248604T3/da

2012-05-21 Application granted granted Critical

2012-05-21 Publication of DK1248604T4 publication Critical patent/DK1248604T4/da

Links

239000003472 antidiabetic agent Substances 0.000 title abstract 2
229940124213 Dipeptidyl peptidase 4 (DPP IV) inhibitor Drugs 0.000 title 1
229940125708 antidiabetic agent Drugs 0.000 title 1
239000003603 dipeptidyl peptidase IV inhibitor Substances 0.000 title 1
239000003112 inhibitor Substances 0.000 abstract 10
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
208000002705 Glucose Intolerance Diseases 0.000 abstract 2
102000003638 Glucose-6-Phosphatase Human genes 0.000 abstract 2
108010086800 Glucose-6-Phosphatase Proteins 0.000 abstract 2
102000007390 Glycogen Phosphorylase Human genes 0.000 abstract 2
108010046163 Glycogen Phosphorylase Proteins 0.000 abstract 2
102000004877 Insulin Human genes 0.000 abstract 2
108090001061 Insulin Proteins 0.000 abstract 2
102000002727 Protein Tyrosine Phosphatase Human genes 0.000 abstract 2
102000053067 Pyruvate Dehydrogenase Acetyl-Transferring Kinase Human genes 0.000 abstract 2
101710159466 [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial Proteins 0.000 abstract 2
239000003623 enhancer Substances 0.000 abstract 2
229940125396 insulin Drugs 0.000 abstract 2
201000009104 prediabetes syndrome Diseases 0.000 abstract 2
108020000494 protein-tyrosine phosphatase Proteins 0.000 abstract 2
SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 abstract 2
VFFZWMWTUSXDCB-ZDUSSCGKSA-N 6-[2-[[2-[(2s)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]ethylamino]pyridine-3-carbonitrile Chemical compound N1([C@@H](CCC1)C#N)C(=O)CNCCNC1=CC=C(C#N)C=N1 VFFZWMWTUSXDCB-ZDUSSCGKSA-N 0.000 abstract 1
208000010444 Acidosis Diseases 0.000 abstract 1
108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 abstract 1
102100025012 Dipeptidyl peptidase 4 Human genes 0.000 abstract 1
102000027487 Fructose-Bisphosphatase Human genes 0.000 abstract 1
108010017464 Fructose-Bisphosphatase Proteins 0.000 abstract 1
229940122904 Glucagon receptor antagonist Drugs 0.000 abstract 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
206010022489 Insulin Resistance Diseases 0.000 abstract 1
208000007976 Ketosis Diseases 0.000 abstract 1
206010027417 Metabolic acidosis Diseases 0.000 abstract 1
208000008589 Obesity Diseases 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
239000000674 adrenergic antagonist Substances 0.000 abstract 1
230000003178 anti-diabetic effect Effects 0.000 abstract 1
206010003246 arthritis Diseases 0.000 abstract 1
230000030136 gastric emptying Effects 0.000 abstract 1
239000008103 glucose Substances 0.000 abstract 1
230000009229 glucose formation Effects 0.000 abstract 1
230000002440 hepatic effect Effects 0.000 abstract 1
230000001771 impaired effect Effects 0.000 abstract 1
230000003914 insulin secretion Effects 0.000 abstract 1
230000004140 ketosis Effects 0.000 abstract 1
235000020824 obesity Nutrition 0.000 abstract 1
229930029653 phosphoenolpyruvate Natural products 0.000 abstract 1
DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical compound OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
230000019491 signal transduction Effects 0.000 abstract 1
150000003384 small molecules Chemical class 0.000 abstract 1
208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
229960001254 vildagliptin Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK01909661.9T 2000-01-21 2001-01-19 Kombinationer indeholdende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler DK1248604T4 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US48923400A	2000-01-21	2000-01-21
US61926200A	2000-07-19	2000-07-19
PCT/EP2001/000590 WO2001052825A2 (en)	2000-01-21	2001-01-19	Combinations comprising dipeptidylpeptidase-iv inhibitors and antidiabetic agents

Publications (2)

Publication Number	Publication Date
DK1248604T3 DK1248604T3 (da)	2007-02-19
DK1248604T4 true DK1248604T4 (da)	2012-05-21

Family

ID=27049636

Family Applications (5)

Application Number	Title	Priority Date	Filing Date
DK01909661.9T DK1248604T4 (da)	2000-01-21	2001-01-19	Kombinationer indeholdende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler
DK06121895T DK1741446T3 (da)	2000-01-21	2001-01-19	Kombinationer indeholdende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler
DK06121898.8T DK1743655T3 (da)	2000-01-21	2001-01-19	Kombinationer omfattende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler
DK06121894.7T DK1741445T3 (da)	2000-01-21	2001-01-19	Kombinationer omfattende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler
DK06121896.2T DK1741447T3 (da)	2000-01-21	2001-01-19	Kombinationer omfattende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler

Family Applications After (4)

Application Number	Title	Priority Date	Filing Date
DK06121895T DK1741446T3 (da)	2000-01-21	2001-01-19	Kombinationer indeholdende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler
DK06121898.8T DK1743655T3 (da)	2000-01-21	2001-01-19	Kombinationer omfattende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler
DK06121894.7T DK1741445T3 (da)	2000-01-21	2001-01-19	Kombinationer omfattende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler
DK06121896.2T DK1741447T3 (da)	2000-01-21	2001-01-19	Kombinationer omfattende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler

Country Status (17)

Country	Link
US (1)	US20030139434A1 (da)
EP (5)	EP1741446B1 (da)
JP (7)	JP2003520226A (da)
CN (3)	CN1400908A (da)
AT (2)	ATE385421T1 (da)
AU (1)	AU2001237321A1 (da)
BR (1)	BRPI0107715B8 (da)
CA (2)	CA2397554C (da)
CY (6)	CY1106303T1 (da)
DE (3)	DE60124861T2 (da)
DK (5)	DK1248604T4 (da)
ES (5)	ES2487897T3 (da)
FR (1)	FR08C0017I2 (da)
LU (1)	LU91436I2 (da)
NL (1)	NL300346I1 (da)
PT (5)	PT1741447E (da)
WO (1)	WO2001052825A2 (da)

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KR20020079988A (ko)	2000-03-08	2002-10-21	메타베이시스 테라퓨틱스, 인크.	신규한 아릴 프럭토스-1,6-비스포스파타제 억제제
GB0014969D0 (en) *	2000-06-19	2000-08-09	Smithkline Beecham Plc	Novel method of treatment
US7078397B2 (en)	2000-06-19	2006-07-18	Smithkline Beecham Corporation	Combinations of dipeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diabetes mellitus
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ATE370943T1 (de)	2001-06-27	2007-09-15	Smithkline Beecham Corp	Fluoropyrrolidine als dipeptidyl-peptidase inhibitoren
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GB0205165D0 (en)	2002-03-06	2002-04-17	Astrazeneca Ab	Chemical compounds
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CN102964347B (zh) *	2002-08-21	2015-11-18	勃林格殷格翰制药两合公司	8-[3-氨基-哌啶-1-基]-黄嘌呤化合物，其制备方法及作为药物制剂的用途
US7407955B2 (en)	2002-08-21	2008-08-05	Boehringer Ingelheim Pharma Gmbh & Co., Kg	8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
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KR20060041309A (ko)	2003-08-13	2006-05-11	다케다 야쿠힌 고교 가부시키가이샤	４-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도
US7169926B1 (en)	2003-08-13	2007-01-30	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
US7678909B1 (en)	2003-08-13	2010-03-16	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
US20060287251A1 (en) *	2003-09-02	2006-12-21	Hans-Ulrich Demuth	Combination therapy for glycaemic control
JP2007505121A (ja)	2003-09-08	2007-03-08	武田薬品工業株式会社	ジペプチジルぺプチダーゼ阻害剤
KR20150132601A (ko)	2003-11-17	2015-11-25	노파르티스 아게	디펩티딜 펩티다제 ⅳ 억제제의 용도
US20070149451A1 (en) *	2003-11-17	2007-06-28	Holmes David G	Combination of a dpp IV inhibitor and an antiobesity or appetite regulating agent
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2001
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Also Published As

Publication number	Publication date
WO2001052825A3 (en)	2002-03-28
DE60124861D1 (de)	2007-01-11
CY2008010I2 (el)	2009-11-04
WO2001052825A2 (en)	2001-07-26
BRPI0107715B1 (pt)	2016-07-05
EP1248604B2 (en)	2012-02-29
JP2011162550A (ja)	2011-08-25
AU2001237321A1 (en)	2001-07-31
ES2436610T3 (es)	2014-01-03
ES2487897T3 (es)	2014-08-25
CA2397554C (en)	2009-09-22
DK1741447T3 (da)	2013-12-09
DK1741446T3 (da)	2008-06-02
CN1977842A (zh)	2007-06-13
EP1741445B1 (en)	2013-08-14
FR08C0017I2 (fr)	2010-12-31
HK1102424A1 (en)	2007-11-23
EP1741447A2 (en)	2007-01-10
EP1741446A2 (en)	2007-01-10
DK1741445T3 (da)	2013-11-04
HK1102405A1 (en)	2007-11-23
CY1114593T1 (el)	2016-10-05
ES2301142T3 (es)	2008-06-16
HK1102422A1 (en)	2007-11-23
EP1743655B1 (en)	2014-06-25
FR08C0017I1 (da)	2008-07-18
JP6374995B2 (ja)	2018-08-15
JP6095589B2 (ja)	2017-03-15
JP5824224B2 (ja)	2015-11-25
CY1114466T1 (el)	2016-10-05
US20030139434A1 (en)	2003-07-24
JP2014088435A (ja)	2014-05-15
CA2673615A1 (en)	2001-07-26
CY1107423T1 (el)	2010-07-28
EP1741447A3 (en)	2007-01-17
JP2017081994A (ja)	2017-05-18
DE60132723D1 (de)	2008-03-20
JP2015214572A (ja)	2015-12-03
CN1400908A (zh)	2003-03-05
CY1106303T1 (el)	2011-10-12
EP1741445A3 (en)	2007-01-24
CY2008010I1 (el)	2009-11-04
CA2397554A1 (en)	2001-07-26
EP1248604B1 (en)	2006-11-29
JP2011116772A (ja)	2011-06-16
PT1741447E (pt)	2013-12-11
JP5835910B2 (ja)	2015-12-24
DK1743655T3 (da)	2014-08-18
DE60124861T2 (de)	2007-05-10
JP2003520226A (ja)	2003-07-02
HK1108359A1 (en)	2008-05-09
ES2275654T3 (es)	2007-06-16
BR0107715A (pt)	2002-11-19
PT1741446E (pt)	2008-05-09
PT1743655E (pt)	2014-09-09
ES2433476T3 (es)	2013-12-11
EP1741446B1 (en)	2008-02-06
DK1248604T3 (da)	2007-02-19
EP1741445A2 (en)	2007-01-10
JP6104331B2 (ja)	2017-03-29
EP1248604A2 (en)	2002-10-16
ATE385421T1 (de)	2008-02-15
EP1741446A3 (en)	2007-01-17
JP2006273873A (ja)	2006-10-12
ES2275654T5 (es)	2012-06-07
LU91436I9 (da)	2019-01-02
LU91436I2 (fr)	2008-07-09
EP1741447B1 (en)	2013-09-18
ATE346613T1 (de)	2006-12-15
CY1115449T1 (el)	2017-01-04
BRPI0107715B8 (pt)	2021-05-25
EP1743655A1 (en)	2007-01-17
DE60132723T2 (de)	2009-01-29
CN102327614A (zh)	2012-01-25
PT1248604E (pt)	2007-01-31
PT1741445E (pt)	2013-11-11
DE122008000018I1 (de)	2008-08-14
NL300346I1 (da)	2008-07-01
CA2673615C (en)	2013-07-16

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WO2005035722A3 (en)	2007-08-02	Variant polypeptides containing plekstrin homology domains and uses therefor