WO1998024378A1 - Appareil permettant d'acceder a l'espace pericardique et technique correspondante - Google Patents
Appareil permettant d'acceder a l'espace pericardique et technique correspondante Download PDFInfo
- Publication number
- WO1998024378A1 WO1998024378A1 PCT/US1997/022129 US9722129W WO9824378A1 WO 1998024378 A1 WO1998024378 A1 WO 1998024378A1 US 9722129 W US9722129 W US 9722129W WO 9824378 A1 WO9824378 A1 WO 9824378A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- jaws
- needle
- pericardium
- handle
- bore
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/28—Surgical forceps
- A61B17/29—Forceps for use in minimally invasive surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3417—Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating
- A61B17/3421—Cannulas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3478—Endoscopic needles, e.g. for infusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
- A61B2017/00247—Making holes in the wall of the heart, e.g. laser Myocardial revascularization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/28—Surgical forceps
- A61B17/29—Forceps for use in minimally invasive surgery
- A61B2017/2926—Details of heads or jaws
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
- A61B2018/00392—Transmyocardial revascularisation
Definitions
- the present invention is directed to treating the heart muscle and associated coronary vessels by providing access to the pericardial space between the heart and the pericardium (pericardial sac), without injuring the heart and associated coronary vessels.
- the present invention is directed to a device and method for safely accessing the pericardial space and directly infusing fluids including drugs therein or removing fluid(s) directly therefrom.
- pericardium (pericardial sac) dates back to the time of Galen (129-200 A.D.) the Greek physician and anatomist who created the term "pericardium.”
- the pericardium (pericardial sac) is a conical membranous sac in which the heart and the commencement of the great vessels are contained. Gray's Anatomy (1977 ed.) pp. 457-460.
- the pericardium is fluid-filled and functions to prevent dilation of the chambers of the heart, lubricates the surfaces of the heart, and maintains the heart in a fixed geometric position. It also provides a barrier to the spread of infection from adjacent structures in the chest cavity and prevents surrounding tissue(s) from adhering to the heart.
- the space between the pericardium and the heart is normally small in volume and includes the fluid therein. It has been reported by others that when fluid is injected into the pericardial space it accumulates in the atrioventricular and interventricular grooves, but not over the ventricular surfaces. See, Shabetai R, "Pericardial and Cardiac Pressure", in Circulation, 77:1 (1988).
- Pericardiocentesis or puncture of the pericardium, heretofore has been performed for; 1) diagnosis of pericardial disease(s) by study of the pericardial fluid; 2) withdrawal of pericardial fluid for the treatment of acute cardiac tamponade; and 3) infusion of therapeutic agents for the treatment of malignant effusion or tumors.
- pericardiocentesis procedures were performed in the United States and that less than 200 of these patients underwent therapy with the intrapericardial injection of drugs.
- intrapericardial injection of drugs is clinically limited to the treatment of abnormal pericardial conditions and diseases, such as malignant or loculated pericardial effusions and tumors.
- Drugs that have been injected into the pericardial space include antibiotic (sclerosing) agents, such as tetracycline, bleomycin and streptokinase.
- antibiotic sclerosing
- Intrapericardial drug delivery has not been clinically utilized for heart-specific treatments where pericardial pathology is normal, because the pericardial space is normally small and very difficult to access without invasive surgery or risk of cardiac injury by standard needle pericardiocentesis techniques.
- pericardiocentesis procedures are carried out by highly specialized, experienced personnel in the cardiac catheterization laboratory of medical facilities, assisted by fluoroscopy and electrocardiogram monitoring equipment.
- Electrocardiographic monitoring of pericardiocentesis, using the pericardial needle as an electrode is commonly employed, as disclosed in Bishop L.H., et al., "The Electrocardiogram as a Safeguard in Pericardiocentesis", in JAMA, 162:264 (1956), and Neill J. R., et al., "A Pericardiocentesis Electrode", in The New England Journal of Medicine, 264:711 (1961); Gotsman M.S., et al. "A Pericardiocentesis Electrode Needle", in Br.
- needle pericardiocentesis there are complications associated with needle pericardiocentesis. These complications include laceration of a coronary artery or the right ventricle, perforation of the right atrium or ventricle, puncture of the stomach or colon, pneumothorax, arrhythmia, tamponade, hypertension, ventricular fibrillation, and death. Complication rates for needle pericardiocentesis are increased in situations where the pericardial space and fluid effusion volume is small (i.e. the pericardial size is more like normal and not abnormally distended by the accumulation of fluid, e.g., blood).
- U.S. Patent No. 5,071,428 discloses a method and apparatus for accessing the pericardial space for the insertion of implantable defibrillation leads. This method requires griping the pericardium with a forceps device and cutting the pericardium with a scalpel (pericardiotomy) under direct vision through a subxiphoid surgical incision.
- Another method for intrapericardial injection of agents is performed by a device, available under the name PerDUCERTM pericardial access device, available from Comedicus Incorporated, 3839 Central Avenue, NE, Columbia Heights, Minnesota 55421.
- This device creates a lifted section of the pericardium, known as a "bleb" through suction.
- the bleb is secured in an instrument end by suction, and the tissue forming the bleb in this end takes the shape of the instrument end.
- the bleb is then punctured by a needle of limited travel, and a guidewire is inserted into the bleb.
- a fluid infusion catheter is then moved over the guidewire, for example, to aspirate fluids from or deliver therapeutic drugs to the pericardium, pericardial space or heart muscle, via the bleb.
- the present invention provides an alternate method of manually creating a controlled bleb.
- the present invention allows for safe access to the pericardial space without injury to the heart, in order to aspirate fluids directly from or to directly deliver fluids, i.e., therapeutic drugs, to the heart muscle. With such safe access to the heart, complications from contacting the heart muscle are greatly reduced and nearly eliminated. Additionally, by directly delivering drugs to the heart muscle via the pericardium (pericardial sac), side affects associated with drug delivery by conventional administration methods, i.e., oral or injection, can be reduced, such that lesser dosages are needed to achieve the desired effect of a specific drug. Moreover, this direct method of drug delivery allows for a wider range of drugs to be used.
- the apparatus of the present invention includes a shaft with a first distal end and a second proximal end.
- a bore extends through the shaft from the distal end to the proximal end.
- the first end includes jaws, that open and close, as at least one of the jaws is movable.
- the second end includes a handle, at least a portion of the handle in communication with a mechanism in communication with the movable jaw, such that upon movement of at least a portion of the handle, the jaws can be opened and closed at will and to any desired degree.
- a needle, for puncturing tissue e.g., a bleb of pericardium tissue
- grasped within the jaws is movably mounted within the bore and is in communication with a mechanism for limiting its travel with respect to the bore.
- the present invention additionally includes a method for mechanically creating a bleb of pericardium tissue, with the apparatus of the present invention, and subsequently accessing the pericardial space.
- This access includes the use of guidewires, catheters, and other instrumentation.
- FIG. 1 is a side view and with a partial cross-sectional view of the apparatus of the present invention
- FIG. 2 is a cross-sectional view of the apparatus of the present invention taken along line 2-2 of FIG. 1;
- FIG. 3 is a is a perspective view of the first or distal and of the apparatus with the jaws closed;
- FIG. 4 is a cross-sectional view of the apparatus of the present invention taken along line 4-4 of FIG. 1;
- FIG. 5 is a perspective view of the first or distal and of the apparatus with the jaws open.
- FIGs. 6A-6E are perspective views detailing the apparatus of the present invention performing the method of the present invention.
- FIGs. 1-5 detail the apparatus 20 of the present invention.
- the apparatus includes a body 22 having a shaft 24 with jaws 26, 27 at a first or distal end 28 and a handle 30, at a second or proximal end 31 , the handle 30 formed of a movable arm 32 and a fixed arm 33.
- the shaft 24 has a bore 34 extending therethrough, with distal 36 and proximal 37 portions, to accommodate a needle 38 and additional structures for fluid aspiration or infusion (detailed below) from or to the pericardial space 101 (FIGs. 6A-6E).
- a first jaw 26 and a second jaw 27 are at the first end 28 of the shaft
- the hinge 40 is preferably an arc-like piece, of a curvature conforming to that of the bore 34, and attaches by a pin 44 or the like at a second pivot point 44a to a rod 46.
- the second pivot point 44a moves within a well 48, cut into the body 22 of the shaft 24.
- the rod 46 terminates in a flange 50, piviotally mounted to the movable arm 32 at by a pin 51 at a pivot point 51a.
- Movement from the movable arm 32 moves the rod 46 (forward, toward the first end 28 of the shaft 24, or backward, toward the second end 34 of the shaft 24) within the bore 34, to ultimately move the jaws 26, 27 between the closed and open positions (in the direction of the arrow 42), to the degree desired by the operator.
- the jaws 26, 27 include cooperatingly arranged, preferably correspondingly configured, teeth 52, 53, in order to assist the jaws 26, 27, when brought together, to sufficiently grasp and retain tissue (i.e., the tissue of the pericardium, also known as the pericardial sac, forming the bleb).
- the teeth 52, 53 are preferably of a uniform pitch (as shown in the drawing figures) for the entire length of their respective jaws 26, 27, but could be of different pitches provided they remain cooperatingly arranged on each jaw 26, 27 and that the jaws 26, 27 remain able to close completely (FIG. 3).
- the jaws 26, 27 also include grooves 54, 55, for assisting in the gripping and traction on the tissue of the bleb without damaging it, as well as accommodating the needle and other related instrumentation, as discussed below. Additionally, it is preferred that the jaws 26, 27 be shaped such that upon incomplete closure (e.g., during the grasping and retaining of tissue) or complete closure (e.g., when the apparatus 20 is being moved into the body), there is a cavity 58 between them, for receiving tissue of the pericardium.
- the second end 32 of the shaft 24 is formed of the movable 32 and fixed 33 arms.
- the fixed arm 33 extends from the body 22 at an angle (approximately 60 degrees). Both arms 32, 33 terminate in loops 60, 61, to accommodate the fingers of an operator. While loops 60, 61 are preferred, other equivalent structures, such as crescent-shaped members or the like are also permissible.
- the movable arm 32 is piviotally mounted to the body 22 of the shaft
- this movable arm be rounded, so as to allow for movement (toward the distal 28 and proximal ends 32 of the shaft 24) of the movable arm 32 in the direction of the arrow 67, as the movable arm 32 is free to travel within a space 68 in the body 22 of the shaft. Travel of the movable arm 32 is confined to this space 68, by the abutment of the surface 69 of the body 22 and the surface of the movable arm 70, and the fixed arm 33.
- the flange 50 be on one side of the bore 36, while the portion of the movable arm 32 within the body 22 be on the other side, so as to straddle the needle 38 or other instrumentation in the bore 34, as shown in detail in FIG. 4. It is also preferred that portions of the flange 50 and movable arm 32 within the body 22, be of a diameter as close as possible to that of the bore 34, to allow for unobstructed passage of the needle 38 or other instrumentation through the bore 34.
- the movable arm 32 is preferably not biased, such that the ultimate position of the jaws 26, 27 (open or closed, as desired by the operator) depends on the position of the movable arm 32.
- the movable arm 32, hinge 40, rod 46 or flange 50 may be biased by springs or other equivalent mechanisms, such that the jaws 26, 27 are either open or closed when the apparatus 20 is not in use.
- the shaft 24, jaws, 26, 27 handle 30 and components controlling the movement of the jaws 26, 27 are preferably made of titanium, stainless steel or the like. Plastics, such as polycarbonate, polyamide, acrylonitrile/butadiene/styrene (ABS) copolymers, or the like, can also be used.
- the body 22 is preferably tubular in shape and the bore 34, is preferably circular in cross section.
- the proximal portion 37 of the bore 34 is of a diameter greater than that of the distal portion 36 of the bore 34.
- distal 36 and proximal 37 portions are designed to accommodate the needle 38, needle trigger 78 (in the proximal portion 37 of the bore 34), guidewire(s) 82, catheter(s) 108 (FIGs. 6D and 6E) and other instrumentation that can be inserted into and moved through the bore 34.
- the needle 38 is designed to extend past the jaws 26, 27 of the body 22 during use (if desired) (FIG. 5). However, movement of the needle is restricted by a needle trigger 78, preferably biased by a spring (not shown) that journals at least a portion of the needle 38 in the proximal portion 37 of the bore 34.
- the distal wall 73 of the proximal portion 37 of the bore 34 limits the travel of the needle trigger 78 (when it is activated by the operator), that ultimately limits the length of travel of the needle 38 in puncturing the bleb 104 (FIGs. 6B-6E).
- the needle 38 is typically made of stainless steel or titanium and includes a beveled end 80, in order to produce a sharp precise puncture of the bleb 104.
- the needle is of a diameter less than that of the distal 36 and proximal portions of the bore 34, to slide within the bore 34, and is typically of a diameter of approximately 21 gauge (approximately .813 mm in diameter).
- the needle trigger 78 that surrounds a portion of the needle 38 is preferably made of TEFLON®, and is designed to slide within the proximal portion 37 of the bore 34.
- the needle 38 is preferably hollow, to accommodate guidewires 82, catheters 108 (FIGs.
- catheter sheaths catheter sheath introducers and other cannulation devices, to be moved (slid) through the needle 38 or the bore 34 (if the needle 38 has been removed), in order to, for example, aspirate fluid from the pericardial sac 101 (FIGs. 6A-6E) or deliver fluid, such as therapeutic drugs, to the pericardial sac 101.
- FIGs. 6A-6E there is shown the apparatus 20 of the present invention in use for accessing the pericardium 100, and entering the pericardial space 101 surrounding the heart 102.
- a subxiphoid incision is made in the chest cavity of a patient.
- a standard mediastinscopy endoscope is inserted into this incision for direct vision and the apparatus 20 of the present invention is inserted through the endoscope.
- the apparatus 20 of the present invention is inserted through the endoscope.
- the operator advances the movable arm 32 (FIG. 1) of the apparatus 20 toward the first or distal end 28 (FIG. 1) of the shaft 24 (FIG. 1), moving the jaw 27, and thus, opening the jaws 26, 27.
- Pericardium 100 tissue as a result of back pressure exerted thereon, by the fluid in the pericardial space 101, now fills the cavity 58 (FIG. 1) between the jaws 26, 27 and the teeth 52, 53 (FIGs.
- the operator can move the apparatus 20 holding the bleb 104, in a direction away from the heart 102, to increase the size of the bleb 104.
- the operator activates the needle trigger 78, advancing the needle 38 toward the distal end 28 of the shaft 24 into the bleb
- the guidewire 82 is advanced through the needle 38 into the pericardial space 101 (FIG. 6C). With the guidewire 82 now advanced into the pericardial space 101, a fluid retrieving or delivering catheter 108 can now be advanced over the guidewire 82 (in the direction of the arrow 110), as shown in FIG. 6D.
- Advancement of the catheter 108 continues simultaneous with withdrawal of the guidewire 82 (in the direction of arrow 111) until the catheter 108 is properly positioned within the pericardial space 101, as shown in FIG. 6E.
- This catheter 108 allows for fluid aspiration directly from or fluid (e.g., drugs, therapeutic agents or the like) delivery directly into the pericardial space 101.
- fluid delivery there is provided a direct route for treating the heart 102 and associated coronary vessels 112.
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- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
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Abstract
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97950804A EP0952788A1 (fr) | 1996-12-05 | 1997-12-05 | Appareil permettant d'acceder a l'espace pericardique et technique correspondante |
| AU53704/98A AU744703B2 (en) | 1996-12-05 | 1997-12-05 | Apparatus and method for accessing the pericardial space |
| CA002273948A CA2273948A1 (fr) | 1996-12-05 | 1997-12-05 | Appareil permettant d'acceder a l'espace pericardique et technique correspondante |
| JP52576798A JP2001505464A (ja) | 1996-12-05 | 1997-12-05 | 心膜空隙にアクセスする装置及び方法 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/761,189 US5931810A (en) | 1996-12-05 | 1996-12-05 | Method for accessing the pericardial space |
| US08/761,189 | 1996-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO1998024378A1 true WO1998024378A1 (fr) | 1998-06-11 |
Family
ID=25061445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/022129 Ceased WO1998024378A1 (fr) | 1996-12-05 | 1997-12-05 | Appareil permettant d'acceder a l'espace pericardique et technique correspondante |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US5931810A (fr) |
| EP (1) | EP0952788A1 (fr) |
| JP (1) | JP2001505464A (fr) |
| AU (1) | AU744703B2 (fr) |
| CA (1) | CA2273948A1 (fr) |
| WO (1) | WO1998024378A1 (fr) |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6569082B1 (en) | 1999-08-10 | 2003-05-27 | Origin Medsystems, Inc. | Apparatus and methods for cardiac restraint |
| US6685672B1 (en) | 2000-07-13 | 2004-02-03 | Edwards Lifesciences Corporation | Multi-balloon drug delivery catheter for angiogenesis |
| US6692458B2 (en) | 2000-12-19 | 2004-02-17 | Edwards Lifesciences Corporation | Intra-pericardial drug delivery device with multiple balloons and method for angiogenesis |
| US7214180B2 (en) | 1999-08-10 | 2007-05-08 | Origin Medsystems, Inc. | Method for cardiac restraint |
| US7288096B2 (en) | 2003-01-17 | 2007-10-30 | Origin Medsystems, Inc. | Apparatus for placement of cardiac defibrillator and pacer |
| US7526342B2 (en) | 1999-08-10 | 2009-04-28 | Maquet Cardiovascular Llc | Apparatus for endoscopic cardiac mapping and lead placement |
| US7597698B2 (en) | 1999-08-10 | 2009-10-06 | Maquet Cardiovascular Llc | Apparatus and method for endoscopic encirclement of pulmonary veins for epicardial ablation |
| EP1525852A4 (fr) * | 2002-06-21 | 2010-02-03 | Vayu Kk | Catheter |
| WO2011043126A1 (fr) | 2009-10-06 | 2011-04-14 | オリンパス株式会社 | Dispositif de guidage |
| US8348891B2 (en) | 2009-09-22 | 2013-01-08 | Olympus Corporation | Surgical method and medical device |
| US8808173B2 (en) | 2009-09-22 | 2014-08-19 | Olympus Corporation | Space ensuring device |
| US8900123B2 (en) | 2009-03-02 | 2014-12-02 | Olympus Corporation | Endoscopy method and endoscope |
| CN104602627A (zh) * | 2012-11-13 | 2015-05-06 | 奥林巴斯株式会社 | 医疗器件 |
| US9393023B2 (en) | 2009-01-13 | 2016-07-19 | Atricure, Inc. | Apparatus and methods for deploying a clip to occlude an anatomical structure |
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| US6161543A (en) | 1993-02-22 | 2000-12-19 | Epicor, Inc. | Methods of epicardial ablation for creating a lesion around the pulmonary veins |
| US5897553A (en) | 1995-11-02 | 1999-04-27 | Medtronic, Inc. | Ball point fluid-assisted electrocautery device |
| US6409722B1 (en) | 1998-07-07 | 2002-06-25 | Medtronic, Inc. | Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue |
| US6283951B1 (en) | 1996-10-11 | 2001-09-04 | Transvascular, Inc. | Systems and methods for delivering drugs to selected locations within the body |
| NL1003024C2 (nl) | 1996-05-03 | 1997-11-06 | Tjong Hauw Sie | Prikkelgeleidingsblokkeringsinstrument. |
| US6237605B1 (en) | 1996-10-22 | 2001-05-29 | Epicor, Inc. | Methods of epicardial ablation |
| US7052493B2 (en) | 1996-10-22 | 2006-05-30 | Epicor Medical, Inc. | Methods and devices for ablation |
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| JP3615960B2 (ja) * | 1999-04-14 | 2005-02-02 | ペンタックス株式会社 | 内視鏡用針付生検鉗子 |
| US7226446B1 (en) | 1999-05-04 | 2007-06-05 | Dinesh Mody | Surgical microwave ablation assembly |
| US6277113B1 (en) | 1999-05-28 | 2001-08-21 | Afx, Inc. | Monopole tip for ablation catheter and methods for using same |
| EP1207788A4 (fr) | 1999-07-19 | 2009-12-09 | St Jude Medical Atrial Fibrill | Techniques d'ablation de tissus et dispositif correspondant |
| US20030187460A1 (en) * | 1999-08-10 | 2003-10-02 | Chin Albert K. | Methods and apparatus for endoscopic cardiac surgery |
| US7264587B2 (en) * | 1999-08-10 | 2007-09-04 | Origin Medsystems, Inc. | Endoscopic subxiphoid surgical procedures |
| US20050154370A1 (en) | 1999-10-29 | 2005-07-14 | Medtronic, Inc. | Methods and systems for providing therapies into the pericardial space |
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| WO1996040368A1 (fr) * | 1995-06-07 | 1996-12-19 | Cormedics Corp. | Appareil et procede permettant d'acceder a l'espace pericardique |
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- 1997-12-05 CA CA002273948A patent/CA2273948A1/fr not_active Abandoned
- 1997-12-05 EP EP97950804A patent/EP0952788A1/fr not_active Withdrawn
- 1997-12-05 AU AU53704/98A patent/AU744703B2/en not_active Ceased
- 1997-12-05 WO PCT/US1997/022129 patent/WO1998024378A1/fr not_active Ceased
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| US7597698B2 (en) | 1999-08-10 | 2009-10-06 | Maquet Cardiovascular Llc | Apparatus and method for endoscopic encirclement of pulmonary veins for epicardial ablation |
| US6569082B1 (en) | 1999-08-10 | 2003-05-27 | Origin Medsystems, Inc. | Apparatus and methods for cardiac restraint |
| US7214180B2 (en) | 1999-08-10 | 2007-05-08 | Origin Medsystems, Inc. | Method for cardiac restraint |
| US7526342B2 (en) | 1999-08-10 | 2009-04-28 | Maquet Cardiovascular Llc | Apparatus for endoscopic cardiac mapping and lead placement |
| US7398781B1 (en) | 1999-08-10 | 2008-07-15 | Maquet Cardiovascular, Llc | Method for subxiphoid endoscopic access |
| US6997898B2 (en) | 2000-07-13 | 2006-02-14 | Edwards Lifesciences Corporation | Multi-balloon drug delivery catheter for angiogenesis |
| US6685672B1 (en) | 2000-07-13 | 2004-02-03 | Edwards Lifesciences Corporation | Multi-balloon drug delivery catheter for angiogenesis |
| US6692458B2 (en) | 2000-12-19 | 2004-02-17 | Edwards Lifesciences Corporation | Intra-pericardial drug delivery device with multiple balloons and method for angiogenesis |
| EP1525852A4 (fr) * | 2002-06-21 | 2010-02-03 | Vayu Kk | Catheter |
| US7288096B2 (en) | 2003-01-17 | 2007-10-30 | Origin Medsystems, Inc. | Apparatus for placement of cardiac defibrillator and pacer |
| US9393023B2 (en) | 2009-01-13 | 2016-07-19 | Atricure, Inc. | Apparatus and methods for deploying a clip to occlude an anatomical structure |
| US8900123B2 (en) | 2009-03-02 | 2014-12-02 | Olympus Corporation | Endoscopy method and endoscope |
| US8348891B2 (en) | 2009-09-22 | 2013-01-08 | Olympus Corporation | Surgical method and medical device |
| US8808173B2 (en) | 2009-09-22 | 2014-08-19 | Olympus Corporation | Space ensuring device |
| WO2011043126A1 (fr) | 2009-10-06 | 2011-04-14 | オリンパス株式会社 | Dispositif de guidage |
| CN104602627A (zh) * | 2012-11-13 | 2015-05-06 | 奥林巴斯株式会社 | 医疗器件 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU5370498A (en) | 1998-06-29 |
| CA2273948A1 (fr) | 1998-06-11 |
| AU744703B2 (en) | 2002-02-28 |
| EP0952788A1 (fr) | 1999-11-03 |
| US5931810A (en) | 1999-08-03 |
| JP2001505464A (ja) | 2001-04-24 |
| US6156009A (en) | 2000-12-05 |
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