WO2000008157A3 - Genes humains transporteurs d'anions atnov - Google Patents

Genes humains transporteurs d'anions atnov Download PDF

Info

Publication number
WO2000008157A3
WO2000008157A3 PCT/US1999/017823 US9917823W WO0008157A3 WO 2000008157 A3 WO2000008157 A3 WO 2000008157A3 US 9917823 W US9917823 W US 9917823W WO 0008157 A3 WO0008157 A3 WO 0008157A3
Authority
WO
WIPO (PCT)
Prior art keywords
atnov
anion transporter
transporter genes
expression
genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/017823
Other languages
English (en)
Other versions
WO2000008157A2 (fr
Inventor
Boris Laubert
Gizela Cardoso
Ping Hu
Andrew P Miller
Alan J Buckler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Axys Pharmaceuticals Inc
Original Assignee
Axys Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axys Pharmaceuticals Inc filed Critical Axys Pharmaceuticals Inc
Priority to AU53406/99A priority Critical patent/AU5340699A/en
Priority to EP99939045A priority patent/EP1141282A2/fr
Publication of WO2000008157A2 publication Critical patent/WO2000008157A2/fr
Publication of WO2000008157A3 publication Critical patent/WO2000008157A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne des méthodes permettant d'isoler des gènes Atnov. Les compositions d'acide nucléique Atnov permettent d'identifier des protéines homologues ou associées ainsi que les séquences d'ADN codant pour ces protéines, de produire des compositions qui modulent l'expression ou la fonction de la protéine, et d'étudier les mécanismes physiologiques associés. En outre, la modulation de l'activité génique in vivo est utilisée à des fins prophylactiques et thérapeutiques, telles que l'identification du type cellulaire sur la base de l'expression et analogues.
PCT/US1999/017823 1998-08-07 1999-08-06 Genes humains transporteurs d'anions atnov Ceased WO2000008157A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU53406/99A AU5340699A (en) 1998-08-07 1999-08-06 Human anion transporter genes atnov
EP99939045A EP1141282A2 (fr) 1998-08-07 1999-08-06 Genes humains transporteurs d'anions atnov

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9583598P 1998-08-07 1998-08-07
US60/095,835 1998-08-07

Publications (2)

Publication Number Publication Date
WO2000008157A2 WO2000008157A2 (fr) 2000-02-17
WO2000008157A3 true WO2000008157A3 (fr) 2000-11-23

Family

ID=22253806

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/017823 Ceased WO2000008157A2 (fr) 1998-08-07 1999-08-06 Genes humains transporteurs d'anions atnov

Country Status (3)

Country Link
EP (1) EP1141282A2 (fr)
AU (1) AU5340699A (fr)
WO (1) WO2000008157A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4953300A (en) * 1999-06-03 2000-12-28 Sankyo Company Limited Novel transporter gene expressed in liver
EP2316848A1 (fr) 1999-09-21 2011-05-04 Chugai Seiyaku Kabushiki Kaisha Gènes transporteurs OATP-B, C, D et E
AU2001263814A1 (en) * 2000-03-27 2001-10-08 Bayer Aktiengesellschaft Regulation of human oatp2-related protein
CN1324855A (zh) * 2000-05-24 2001-12-05 上海博德基因开发有限公司 一种新的多肽——人组织阴离子转运多肽10和编码这种多肽的多核苷酸
GB0013105D0 (en) * 2000-05-30 2000-07-19 Univ Bristol Therapeutic compounds
US20020090622A1 (en) * 2000-08-23 2002-07-11 Monisola Adeokun Chemical compounds
US7807447B1 (en) 2000-08-25 2010-10-05 Merck Sharp & Dohme Corp. Compositions and methods for exon profiling
JP2004531213A (ja) * 2000-10-27 2004-10-14 インサイト・ゲノミックス・インコーポレイテッド 輸送体及びイオンチャネル
GB0213579D0 (en) * 2002-06-13 2002-07-24 Astrazeneca Ab Methods
GB0317592D0 (en) 2003-07-26 2003-08-27 Astrazeneca Ab Method
DE102008011008B4 (de) 2008-02-25 2013-05-29 Otto R. Hofmann Vorrichtung und Verfahren zur Beeinflussung von elektrisch leitfähigen Fluiden mit Hilfe der Lorentzkraft

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997031111A2 (fr) * 1996-02-22 1997-08-28 Introgene B.V. Famille de transporteurs d'anions organiques, acides nucleiques codant ceux-ci, cellules les comprenant et procedes d'utilisation associes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997031111A2 (fr) * 1996-02-22 1997-08-28 Introgene B.V. Famille de transporteurs d'anions organiques, acides nucleiques codant ceux-ci, cellules les comprenant et procedes d'utilisation associes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ABE T., ET AL.: "Identification of a Novel Gene Family Encoding Human Liver-specific Organic Anion Transporter LST-1", J. BIOL. CHEM., vol. 274, no. 24, 11 June 1999 (1999-06-11), pages 17159 - 17163, XP000877288 *
Embase accession number AB026257.1 Created 08-JUN-1999 , Sequence characterization: Homo sapiens mRNA for organic anion transporter OATP-C, complete *
HSIANG B.H., ZHU Y., WANG Z., WU Y., SASSEVILLE V., YANG W.-P.,: "A novel human hepatic organic anion transporting polypeptide (OATP2) Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-coa reductase inhibitor transporter.", JOURNAL OF BIOLOGICAL CHEMISTRY (MICROFILMS), vol. 274, no. 52, 24 December 1999 (1999-12-24), MD US, pages 37161 - 37168, XP002131865 *
KULLAK-UBLICK ET AL: "Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver", GASTROENTEROLOGY, vol. 109, 1 October 1995 (1995-10-01), pages 1274 - 1282, XP002092892, ISSN: 0016-5085 *

Also Published As

Publication number Publication date
EP1141282A2 (fr) 2001-10-10
WO2000008157A2 (fr) 2000-02-17
AU5340699A (en) 2000-02-28

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