DK1295944T3 - GDP-dissociationsstimulerende protein, hjernespecifikt nukleosomsamlingsprotein, skeletmuskelspecifikt ubiquitinkonjugerende enzym, celleproliferationsprotein, phosphatidylinositolkinase, nelbeslægtede proteiner - Google Patents
GDP-dissociationsstimulerende protein, hjernespecifikt nukleosomsamlingsprotein, skeletmuskelspecifikt ubiquitinkonjugerende enzym, celleproliferationsprotein, phosphatidylinositolkinase, nelbeslægtede proteinerInfo
- Publication number
- DK1295944T3 DK1295944T3 DK02026841T DK02026841T DK1295944T3 DK 1295944 T3 DK1295944 T3 DK 1295944T3 DK 02026841 T DK02026841 T DK 02026841T DK 02026841 T DK02026841 T DK 02026841T DK 1295944 T3 DK1295944 T3 DK 1295944T3
- Authority
- DK
- Denmark
- Prior art keywords
- protein
- specific
- nel
- brain
- cell proliferation
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 8
- 102000004169 proteins and genes Human genes 0.000 title 3
- 101710107897 Nucleosome assembly protein Proteins 0.000 title 1
- 102000017343 Phosphatidylinositol kinases Human genes 0.000 title 1
- 108050005377 Phosphatidylinositol kinases Proteins 0.000 title 1
- 101100133168 Rattus norvegicus Nell2 gene Proteins 0.000 title 1
- 102000003431 Ubiquitin-Conjugating Enzyme Human genes 0.000 title 1
- 108060008747 Ubiquitin-Conjugating Enzyme Proteins 0.000 title 1
- 210000004556 brain Anatomy 0.000 title 1
- 230000004663 cell proliferation Effects 0.000 title 1
- 210000002027 skeletal muscle Anatomy 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 102000003839 Human Proteins Human genes 0.000 abstract 1
- 108090000144 Human Proteins Proteins 0.000 abstract 1
- 208000026350 Inborn Genetic disease Diseases 0.000 abstract 1
- 208000024556 Mendelian disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6341096 | 1996-03-19 | ||
| JP06916397A JP3646191B2 (ja) | 1996-03-19 | 1997-03-05 | ヒト遺伝子 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1295944T3 true DK1295944T3 (da) | 2007-09-17 |
Family
ID=26404531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02026841T DK1295944T3 (da) | 1996-03-19 | 1997-03-19 | GDP-dissociationsstimulerende protein, hjernespecifikt nukleosomsamlingsprotein, skeletmuskelspecifikt ubiquitinkonjugerende enzym, celleproliferationsprotein, phosphatidylinositolkinase, nelbeslægtede proteiner |
Country Status (8)
| Country | Link |
|---|---|
| US (7) | US5831058A (da) |
| EP (6) | EP1295944B1 (da) |
| JP (1) | JP3646191B2 (da) |
| AT (1) | ATE362536T1 (da) |
| CA (2) | CA2200371C (da) |
| DE (1) | DE69737740T2 (da) |
| DK (1) | DK1295944T3 (da) |
| ES (1) | ES2284770T3 (da) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6410506B1 (en) * | 1995-05-19 | 2002-06-25 | Human Genome Sciences, Inc. | Transforming growth factor α HII |
| US20030170864A1 (en) * | 2000-05-30 | 2003-09-11 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CA2274732A1 (en) * | 1996-12-18 | 1998-06-25 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| US5976837A (en) * | 1997-03-14 | 1999-11-02 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
| US5863779A (en) * | 1997-08-21 | 1999-01-26 | Incyte Pharmaceuticals, Inc. | UBC7-like ubiquitin-conjugating enzyme |
| WO1999050421A1 (en) * | 1998-03-27 | 1999-10-07 | University Of Leeds | Ubiquitin conjugating enzyme |
| US6171790B1 (en) | 1998-05-01 | 2001-01-09 | Incyte Pharmaceuticals, Inc. | Human protease associated proteins |
| JP2000109433A (ja) * | 1998-08-05 | 2000-04-18 | Otsuka Pharmaceut Co Ltd | 神経変性疾患治療剤 |
| AU4649600A (en) * | 1999-04-22 | 2000-11-10 | Joel F. Habener | Bridge-1, a transcription factor |
| US7884066B2 (en) * | 1999-10-05 | 2011-02-08 | The Regents Of The University Of California | NELL-1 enhanced bone mineralization |
| AU2001240820A1 (en) * | 2000-03-15 | 2001-09-24 | Oxford Glycosciences (Uk) Ltd. | Proteins, genes and their use for diagnosis and treatment of vascular dementia |
| US6689877B2 (en) * | 2000-11-06 | 2004-02-10 | The Board Of Regents Of The University Of Nebraska | Methods and compositions for the treatment of human immunodeficiency virus infection |
| US20030039968A1 (en) * | 2001-07-10 | 2003-02-27 | Applera Corporation | Isolated human secreted proteins, nucleic acid molecules encoding human secreted proteins, and uses thereof |
| US20040049024A1 (en) * | 2001-12-07 | 2004-03-11 | Geoff Clark | Compositions and methods related to the minn1 tumor suppressor gene and protein |
| AU2003299314A1 (en) | 2002-12-16 | 2004-07-09 | Develogen Aktiengesellschaft Fur Entwicklungsbiologische Forschung | Fwd, pp2c1, adk3, cg3860, cdk4, cg7134, eip75b involved in the regulation of energy homeostasis |
| DE602004032107D1 (de) | 2003-02-07 | 2011-05-19 | Univ California | Nell-peptidexpressionssysteme und knochenbildende aktivität des nell-peptids |
| US7691607B2 (en) | 2004-02-09 | 2010-04-06 | The Regents Of The University Of California | Expression system of NELL peptide |
| KR20120064120A (ko) | 2004-06-01 | 2012-06-18 | 제넨테크, 인크. | 항체 약물 접합체 및 방법 |
| US20100111856A1 (en) | 2004-09-23 | 2010-05-06 | Herman Gill | Zirconium-radiolabeled, cysteine engineered antibody conjugates |
| KR101270829B1 (ko) | 2004-09-23 | 2013-06-07 | 제넨테크, 인크. | 시스테인 유전자조작 항체 및 접합체 |
| EP1817059A2 (en) | 2004-12-01 | 2007-08-15 | Genentech, Inc. | Conjugates of 1,8-bis-naphthalimides with an antibody |
| MX2010003718A (es) * | 2007-10-19 | 2010-04-21 | Genentech Inc | Anticuerpos anti-tenb2 producidos por ingenieria de cisteina y conjugados de farmaco y anticuerpo. |
| CA2739608A1 (en) * | 2008-10-07 | 2010-04-15 | The Regents Of The University Of California | Recombinant nell protein production |
| CA2809819A1 (en) | 2009-09-09 | 2011-03-17 | Centrose, Llc | Extracellular targeted drug conjugates |
| DK2528625T3 (da) | 2010-04-15 | 2013-10-14 | Spirogen Sarl | Pyrrolobenzodiazepiner og konjugater deraf |
| BR112012030311A2 (pt) | 2010-06-08 | 2017-01-24 | Genentech Inc | anticorpo |
| JP5889912B2 (ja) | 2010-11-17 | 2016-03-22 | ジェネンテック， インコーポレイテッド | アラニニルメイタンシノール抗体コンジュゲート |
| KR101992502B1 (ko) | 2011-05-12 | 2019-06-24 | 제넨테크, 인크. | 프레임워크 시그너처 펩티드를 사용하여 동물 샘플에서 치료 항체를 검출하기 위한 다중 반응 모니터링 lc-ms/ms 방법 |
| JP6104257B2 (ja) | 2011-10-14 | 2017-03-29 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | ピロロベンゾジアゼピンおよびそのコンジュゲート |
| WO2013130093A1 (en) | 2012-03-02 | 2013-09-06 | Genentech, Inc. | Biomarkers for treatment with anti-tubulin chemotherapeutic compounds |
| EP2906250B1 (en) | 2012-10-12 | 2018-05-30 | ADC Therapeutics SA | Pyrrolobenzodiazepine-anti-psma antibody conjugates |
| AU2013328625B2 (en) | 2012-10-12 | 2016-12-15 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| CN104837502B (zh) | 2012-10-12 | 2018-08-10 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓及其结合物 |
| US10695433B2 (en) | 2012-10-12 | 2020-06-30 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| US10751346B2 (en) | 2012-10-12 | 2020-08-25 | Medimmune Limited | Pyrrolobenzodiazepine—anti-PSMA antibody conjugates |
| DK2906298T3 (da) | 2012-10-12 | 2018-12-17 | Adc Therapeutics Sa | Pyrrolobenzodiazepin-antistofkonjugater |
| ES2649990T3 (es) | 2012-10-12 | 2018-01-16 | Medimmune Limited | Conjugados de anticuerpos anti-CD22-pirrolobenzodiazepinas |
| CN105246894A (zh) | 2012-12-21 | 2016-01-13 | 斯皮罗根有限公司 | 用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物 |
| CN105189507A (zh) | 2012-12-21 | 2015-12-23 | 斯皮罗根有限公司 | 吡咯并苯并二氮杂卓及其结合物 |
| SG11201507214SA (en) | 2013-03-13 | 2015-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| NZ710746A (en) | 2013-03-13 | 2018-11-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| CA2905181C (en) | 2013-03-13 | 2020-06-02 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof for providing targeted therapy |
| EP3033111B1 (en) | 2013-08-12 | 2019-03-13 | Genentech, Inc. | 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment |
| US10010624B2 (en) | 2013-10-11 | 2018-07-03 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| EP3054986B1 (en) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| EP3054985B1 (en) | 2013-10-11 | 2018-12-26 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| JP6671292B2 (ja) | 2013-12-16 | 2020-03-25 | ジェネンテック， インコーポレイテッド | ペプチド模倣化合物及びその抗体−薬物コンジュゲート |
| KR20170042495A (ko) | 2013-12-16 | 2017-04-19 | 제넨테크, 인크. | 펩티드모방체 화합물 및 그의 항체-약물 접합체 |
| BR112016013258A2 (pt) | 2013-12-16 | 2018-01-16 | Genentech Inc | composto conjugado anticorpo-droga, composição farmacêutica, método para tratar câncer e kit |
| CN104189884A (zh) * | 2014-08-19 | 2014-12-10 | 承德医学院 | Urantide的应用 |
| JP6531166B2 (ja) | 2014-09-10 | 2019-06-12 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | ピロロベンゾジアゼピン及びそのコンジュゲート |
| WO2016040825A1 (en) | 2014-09-12 | 2016-03-17 | Genentech, Inc. | Anthracycline disulfide intermediates, antibody-drug conjugates and methods |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| MX2017003123A (es) | 2014-09-12 | 2017-05-12 | Genentech Inc | Anticuerpos y conjugados modificados geneticamente con cisteina. |
| US20160074527A1 (en) | 2014-09-17 | 2016-03-17 | Genentech, Inc. | Pyrrolobenzodiazepines and antibody disulfide conjugates thereof |
| AU2015352545B2 (en) | 2014-11-25 | 2020-10-15 | Adc Therapeutics Sa | Pyrrolobenzodiazepine-antibody conjugates |
| MX2017007169A (es) | 2014-12-03 | 2018-05-02 | Genentech Inc | Compuestos de amina cuaternaria y conjugados de anticuerpofármaco de los mismos. |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| CA2996902C (en) | 2015-10-02 | 2020-06-02 | Genentech, Inc. | Pyrrolobenzodiazepine antibody drug conjugates and methods of use |
| EP3362100B1 (en) | 2015-10-16 | 2022-06-22 | Genentech, Inc. | Hindered disulfide drug conjugates |
| EP3365025B1 (en) | 2015-10-20 | 2020-07-15 | Genentech, Inc. | Calicheamicin-antibody-drug conjugates and methods of use |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| US20170315132A1 (en) | 2016-03-25 | 2017-11-02 | Genentech, Inc. | Multiplexed total antibody and antibody-conjugated drug quantification assay |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| EP3458101B1 (en) | 2016-05-20 | 2020-12-30 | H. Hoffnabb-La Roche Ag | Protac antibody conjugates and methods of use |
| EP3465221B1 (en) | 2016-05-27 | 2020-07-22 | H. Hoffnabb-La Roche Ag | Bioanalytical method for the characterization of site-specific antibody-drug conjugates |
| US10639378B2 (en) | 2016-06-06 | 2020-05-05 | Genentech, Inc. | Silvestrol antibody-drug conjugates and methods of use |
| WO2018031662A1 (en) | 2016-08-11 | 2018-02-15 | Genentech, Inc. | Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof |
| EP3522933B1 (en) | 2016-10-05 | 2021-12-15 | F. Hoffmann-La Roche AG | Methods for preparing antibody drug conjugates |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| MX375569B (es) | 2017-02-08 | 2025-03-04 | Adc Therapeutics Sa | Conjugados de pirrolobenzodiazepinas y anticuerpos |
| PT3612537T (pt) | 2017-04-18 | 2022-08-29 | Medimmune Ltd | Conjugados de pirrolobenzodiazepina |
| ES2977788T3 (es) | 2017-04-20 | 2024-08-30 | Adc Therapeutics Sa | Terapia combinada con un conjugado de anticuerpo anti-AXL y fármaco |
| MX2019015042A (es) | 2017-06-14 | 2020-08-06 | Adc Therapeutics Sa | Regimen de dosificacion. |
| DK3668874T3 (da) | 2017-08-18 | 2022-02-14 | Medimmune Ltd | Pyrrolobenzodiazepin-konjugater |
| IL273387B2 (en) | 2017-09-20 | 2023-10-01 | Ph Pharma Co Ltd | Thylanstatin analogs |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
| JP7708662B2 (ja) | 2018-10-24 | 2025-07-15 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | コンジュゲート化された化学的分解誘導物質および使用方法 |
| EP3894427A1 (en) | 2018-12-10 | 2021-10-20 | Genentech, Inc. | Photocrosslinking peptides for site specific conjugation to fc-containing proteins |
| GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
| KR102890251B1 (ko) | 2019-03-15 | 2025-11-25 | 메드임뮨 리미티드 | 암의 치료에 사용하기 위한 아제티도벤조디아제핀 이량체 및 이를 포함하는 컨쥬게이트 |
| GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
| CN117980327A (zh) | 2021-11-03 | 2024-05-03 | 杭州多禧生物科技有限公司 | 抗体的特异性偶联 |
| EP4637833A2 (en) | 2022-12-23 | 2025-10-29 | Genentech, Inc. | Cereblon degrader conjugates, and uses thereof |
| EP4698230A2 (en) | 2023-04-17 | 2026-02-25 | Peak Bio, Inc. | Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates |
| WO2026006688A2 (en) | 2024-06-28 | 2026-01-02 | Firefly Bio, Inc. | Degrader antibody conjugates and uses thereof |
| WO2026006689A2 (en) | 2024-06-28 | 2026-01-02 | Firefly Bio, Inc. | Bcl-xl degrader antibody conjugates and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05268957A (ja) | 1992-03-27 | 1993-10-19 | Bio Material Kenkyusho:Kk | ラット多機能プロテアーゼ構成因子およびそのｄｎａ |
| JP3125235B2 (ja) | 1992-04-22 | 2001-01-15 | 株式会社バイオマテリアル研究所 | ヒト２６ｓプロテアソーム |
| JPH05317059A (ja) | 1992-05-22 | 1993-12-03 | Bio Material Kenkyusho:Kk | ラットプロテアソームのコンポーネントおよび そのｄｎａ |
| US5470577A (en) * | 1993-07-07 | 1995-11-28 | Trustees Of Boston University | Stimulation of tanning by DNA fragments or single-stranded DNA |
| AU713364B2 (en) * | 1995-05-19 | 1999-12-02 | Human Genome Sciences, Inc. | Transforming growth factor alpha HII |
| US5863779A (en) * | 1997-08-21 | 1999-01-26 | Incyte Pharmaceuticals, Inc. | UBC7-like ubiquitin-conjugating enzyme |
| DE602004032107D1 (de) * | 2003-02-07 | 2011-05-19 | Univ California | Nell-peptidexpressionssysteme und knochenbildende aktivität des nell-peptids |
-
1997
- 1997-03-05 JP JP06916397A patent/JP3646191B2/ja not_active Expired - Fee Related
- 1997-03-19 EP EP02026841A patent/EP1295944B1/en not_active Expired - Lifetime
- 1997-03-19 DK DK02026841T patent/DK1295944T3/da active
- 1997-03-19 ES ES02026841T patent/ES2284770T3/es not_active Expired - Lifetime
- 1997-03-19 CA CA002200371A patent/CA2200371C/en not_active Expired - Fee Related
- 1997-03-19 AT AT02026841T patent/ATE362536T1/de active
- 1997-03-19 EP EP10185775A patent/EP2361982A1/en not_active Withdrawn
- 1997-03-19 EP EP97104842A patent/EP0796913A3/en not_active Ceased
- 1997-03-19 DE DE69737740T patent/DE69737740T2/de not_active Expired - Lifetime
- 1997-03-19 CA CA2641565A patent/CA2641565C/en not_active Expired - Fee Related
- 1997-03-19 EP EP10182760A patent/EP2272960A1/en not_active Withdrawn
- 1997-03-19 EP EP07014998A patent/EP1860189A1/en not_active Withdrawn
- 1997-03-19 EP EP04004141A patent/EP1439230A3/en not_active Withdrawn
- 1997-03-19 US US08/820,170 patent/US5831058A/en not_active Expired - Lifetime
-
2004
- 2004-02-20 US US10/781,841 patent/US20060134634A1/en not_active Abandoned
-
2006
- 2006-11-07 US US11/593,525 patent/US7674889B2/en not_active Expired - Fee Related
-
2007
- 2007-07-06 US US11/774,330 patent/US7592438B2/en not_active Expired - Fee Related
-
2009
- 2009-07-27 US US12/510,074 patent/US7858754B2/en not_active Expired - Fee Related
-
2010
- 2010-01-19 US US12/689,917 patent/US8048995B2/en not_active Expired - Fee Related
- 2010-12-23 US US12/977,497 patent/US8106171B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7858754B2 (en) | 2010-12-28 |
| US20100160611A1 (en) | 2010-06-24 |
| US8048995B2 (en) | 2011-11-01 |
| JP3646191B2 (ja) | 2005-05-11 |
| CA2200371A1 (en) | 1997-09-19 |
| ES2284770T3 (es) | 2007-11-16 |
| US7592438B2 (en) | 2009-09-22 |
| CA2641565A1 (en) | 1997-09-19 |
| EP1439230A3 (en) | 2004-09-22 |
| DE69737740D1 (de) | 2007-06-28 |
| JPH09308492A (ja) | 1997-12-02 |
| EP1295944B1 (en) | 2007-05-16 |
| CA2200371C (en) | 2007-07-10 |
| EP2361982A1 (en) | 2011-08-31 |
| US20060134634A1 (en) | 2006-06-22 |
| US20080032337A1 (en) | 2008-02-07 |
| DE69737740T2 (de) | 2008-01-31 |
| US20110105718A1 (en) | 2011-05-05 |
| ATE362536T1 (de) | 2007-06-15 |
| US5831058A (en) | 1998-11-03 |
| EP1860189A1 (en) | 2007-11-28 |
| CA2641565C (en) | 2012-11-13 |
| US20070111285A1 (en) | 2007-05-17 |
| EP1295944A2 (en) | 2003-03-26 |
| EP0796913A3 (en) | 2001-01-31 |
| US8106171B2 (en) | 2012-01-31 |
| EP1295944A3 (en) | 2004-04-21 |
| US7674889B2 (en) | 2010-03-09 |
| US20100048878A1 (en) | 2010-02-25 |
| EP1439230A2 (en) | 2004-07-21 |
| EP0796913A2 (en) | 1997-09-24 |
| EP2272960A1 (en) | 2011-01-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1295944T3 (da) | GDP-dissociationsstimulerende protein, hjernespecifikt nukleosomsamlingsprotein, skeletmuskelspecifikt ubiquitinkonjugerende enzym, celleproliferationsprotein, phosphatidylinositolkinase, nelbeslægtede proteiner | |
| Watanabe et al. | The neutrophil chemoattractant produced by the rat kidney epithelioid cell line NRK-52E is a protein related to the KC/gro protein | |
| DE69833784D1 (de) | Polypeptide mit aminopeptidaseaktivität und für diese kodierende nukleinsäuren | |
| DK1005540T3 (da) | IKK-beta-proteiner, nukleinsyrer og fremgangsmåder | |
| WO2000027994A3 (en) | Chlamydia pneumoniae genome sequence | |
| DE68929043D1 (de) | Für androgen-rezeptor-protein kodierende dna | |
| TR199802252T2 (xx) | N�ral ve renal geli�menin uyar�lmas� i�in ret ligand� (RetL) | |
| DE60132075D1 (de) | Wnt-1 verwandte polypeptide und dafür kodierende nukleinsäuren | |
| DE69840230D1 (de) | Polypeptide mit prolyldipeptidylaminopeptidase-aktivität und dafür kodierende nukleinsäuren | |
| ATE450603T1 (de) | Polypeptide mit verzweigungsenzym-aktivität und für diese kodierende nukleinsäuren | |
| DE69930955D1 (de) | Polypeptide mit lysophospholipaseaktivität und nukleinesäuren die sie kodieren | |
| WO1998014596A3 (en) | Disease associated protein tyrosine phosphatases | |
| EP0947583A3 (de) | Expressionsaktivierende Nukleinsäurefragmente des Melanom-inhibierenden Proteins (MIA) | |
| ATE421531T1 (de) | Apoptose-bezogene verbindungen und deren verwendung | |
| ATE209684T1 (de) | Dna-sequenzen für matrix-metallproteasen, ihre herstellung und verwendung | |
| DK0804558T3 (da) | Tripeptidylaminopeptidase | |
| DE69837475D1 (de) | Polypeptide mit aminopeptidaseaktivität und dafür kodierende nukleinsäuren | |
| EP0192175A3 (de) | Polypeptide des Rhinovirusstammes HRV2 sowie die hierfür codierenden DNA-Moleküle | |
| WO1998011234A3 (en) | Human protein kinases | |
| WO2000008157A3 (en) | Human anion transporter genes atnov | |
| EP0261403A3 (de) | Polypeptide des Rhinovirusstammes HRV89 sowie die hierfür codierenden DNA-Moleküle | |
| DE69632457D1 (de) | Neue menschliche proteine, die cyclin abhängigen kinasen ähneln, sowie methoden zu deren verwendung | |
| ATE288491T1 (de) | Polypeptide mit 5-aminolevulinsäure synthaseaktivität und deren nukleinsäuren | |
| Jaisson et al. | Involvement of lysine 1047 in type I collagen‐mediated activation of polymorphonuclear neutrophils | |
| ATE479753T1 (de) | Menschliches tsc403 gen |