WO2001007028A3 - Utilisation d'antagonistes de recepteurs de retinoides dans le traitement du cancer de la prostate - Google Patents

Utilisation d'antagonistes de recepteurs de retinoides dans le traitement du cancer de la prostate Download PDF

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Publication number
WO2001007028A3
WO2001007028A3 PCT/US2000/019849 US0019849W WO0107028A3 WO 2001007028 A3 WO2001007028 A3 WO 2001007028A3 US 0019849 W US0019849 W US 0019849W WO 0107028 A3 WO0107028 A3 WO 0107028A3
Authority
WO
WIPO (PCT)
Prior art keywords
retinoid receptor
prostate carcinoma
treatment
receptor antagonists
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/019849
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English (en)
Other versions
WO2001007028A2 (fr
Inventor
Roshantha A Chandraratna
Geoffrey Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Sales LLC
Original Assignee
Allergan Sales LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Sales LLC filed Critical Allergan Sales LLC
Priority to AU62280/00A priority Critical patent/AU6228000A/en
Publication of WO2001007028A2 publication Critical patent/WO2001007028A2/fr
Publication of WO2001007028A3 publication Critical patent/WO2001007028A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des méthodes de traitement du cancer de la prostate consistant à administrer une dose thérapeutiquement efficace d'un antagoniste de récepteurs de rétinoïdes. Par ailleurs, la présente invention concerne des méthodes destinées à inhiber le développement d'une cellule cancéreuse ou tumeur de la prostate, cette méthode consistant à faire réagir ladite cellule ou tumeur au contact d'une dose efficace d'un antagoniste de récepteurs de rétinoïdes.
PCT/US2000/019849 1999-07-23 2000-07-21 Utilisation d'antagonistes de recepteurs de retinoides dans le traitement du cancer de la prostate Ceased WO2001007028A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU62280/00A AU6228000A (en) 1999-07-23 2000-07-21 The use of retinoid receptor antagonists in the treatment of prostate carcinoma

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14528799P 1999-07-23 1999-07-23
US60/145,287 1999-07-23

Publications (2)

Publication Number Publication Date
WO2001007028A2 WO2001007028A2 (fr) 2001-02-01
WO2001007028A3 true WO2001007028A3 (fr) 2001-08-30

Family

ID=22512422

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/019849 Ceased WO2001007028A2 (fr) 1999-07-23 2000-07-21 Utilisation d'antagonistes de recepteurs de retinoides dans le traitement du cancer de la prostate

Country Status (2)

Country Link
AU (1) AU6228000A (fr)
WO (1) WO2001007028A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
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EP1689700A1 (fr) 2003-11-25 2006-08-16 Novo Nordisk A/S Nouveaux anilides salicyliques
BRPI0616454A2 (pt) 2005-09-30 2011-06-21 Vitae Pharmaceuticals, Inc. métodos de tratamento de cáncer
US10653650B2 (en) 2011-12-13 2020-05-19 Io Therapeutics, Inc. Treatment of diseases by concurrently eliciting remyelination effects and immunomodulatory effects using selective RXR agonists
MX352727B (es) 2011-12-13 2017-12-06 Dartmouth College Tratamiento de trastorno autoinmune al usar agonistas de rxr.
WO2017075607A1 (fr) 2015-10-31 2017-05-04 Io Therapeutics, Inc. Traitement des troubles du système nerveux au moyen de combinaisons d'agonistes de pxr et d'hormones thyroïdiennes
DK3380086T3 (da) 2015-11-25 2021-11-22 Io Therapeutics Inc Cyp26-resistente rar-alpha-selektive agonister i behandling af cancer
KR20180121983A (ko) 2016-03-10 2018-11-09 아이오 테라퓨틱스, 인크. Rxr 작용제 및 갑상선 호르몬의 조합을 사용한 근육 질환의 치료
CA3016876C (fr) 2016-03-10 2021-12-28 Io Therapeutics, Inc. Traitement de maladies auto-immunes a l'aide de combinaisons d'agonistes de rxr et d'hormones thyroidiennes
SG11201810951RA (en) 2016-06-10 2019-01-30 Io Therapeutics Inc Receptor selective retinoid and rexinoid compounds and immune modulators for cancer immunotherapy
SG11202000230VA (en) 2017-07-11 2020-02-27 Vertex Pharma Carboxamides as modulators of sodium channels
KR20200029544A (ko) 2017-07-13 2020-03-18 아이오 테라퓨틱스, 인크. 암 면역요법을 위해 면역 조절제와 조합된 면역조절 레티노이드 및 렉시노이드 화합물
KR20200044889A (ko) 2017-08-31 2020-04-29 아이오 테라퓨틱스, 인크. 암 면역요법을 위해 면역 조절제와 조합된 rar 선택적 작용제
US11517549B2 (en) 2017-09-20 2022-12-06 Io Therapeutics, Inc. Treatment of disease with esters of selective RXR agonists
US12441703B2 (en) 2019-01-10 2025-10-14 Vertex Pharmaceuticals Incorporated Carboxamides as modulators of sodium channels
WO2020146612A1 (fr) 2019-01-10 2020-07-16 Vertex Pharmaceuticals Incorporated Esters et carbamates utilisés en tant que modulateurs de canaux sodiques
US10966950B2 (en) 2019-06-11 2021-04-06 Io Therapeutics, Inc. Use of an RXR agonist in treating HER2+ cancers
EP4173639A4 (fr) * 2020-06-26 2024-03-13 RaQualia Pharma Inc. Méthode de sélection d'un patient cancéreux pour lequel une polythérapie d'un rétinoïde et d'un agent de traitement du cancer sera efficace, et médicament combiné d'un rétinoïde et d'un agent de traitement du cancer
MX2024006978A (es) 2021-12-07 2024-07-19 Io Therapeutics Inc Uso de un agonista de rxr y taxanos en el tratamiento de cáncer her2+.

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997024348A1 (fr) * 1995-12-29 1997-07-10 Vision Pharmaceuticals L.P. Acides carboxyliques et esters de ((3''-thioxacyclohex-1''-enyl))-but-3'-en-1'-ynyl)aryle et heteroaryle presentant une activite biologique de type retinoide
US5728846A (en) * 1996-12-12 1998-03-17 Allergan Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives
US5739338A (en) * 1996-11-05 1998-04-14 Allergan N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity
US5763635A (en) * 1996-06-21 1998-06-09 Allergan Tetrahydronaphthalene derivatives substituted in the 8 position with alkyhidene groups having retinoid and/or retinoid antagonist-like biological activity
US5773594A (en) * 1996-06-21 1998-06-30 Allergan Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5808124A (en) * 1996-06-21 1998-09-15 Allergan O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5919970A (en) * 1997-04-24 1999-07-06 Allergan Sales, Inc. Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
WO1999033821A1 (fr) * 1997-12-24 1999-07-08 Allergan Sales, Inc. Derives de benzopyrane et benzothyopyrane presentant une activite retinoïde de type antagoniste

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997024348A1 (fr) * 1995-12-29 1997-07-10 Vision Pharmaceuticals L.P. Acides carboxyliques et esters de ((3''-thioxacyclohex-1''-enyl))-but-3'-en-1'-ynyl)aryle et heteroaryle presentant une activite biologique de type retinoide
US5763635A (en) * 1996-06-21 1998-06-09 Allergan Tetrahydronaphthalene derivatives substituted in the 8 position with alkyhidene groups having retinoid and/or retinoid antagonist-like biological activity
US5773594A (en) * 1996-06-21 1998-06-30 Allergan Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5808124A (en) * 1996-06-21 1998-09-15 Allergan O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
US5739338A (en) * 1996-11-05 1998-04-14 Allergan N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity
US5728846A (en) * 1996-12-12 1998-03-17 Allergan Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives
US5919970A (en) * 1997-04-24 1999-07-06 Allergan Sales, Inc. Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity
WO1999033821A1 (fr) * 1997-12-24 1999-07-08 Allergan Sales, Inc. Derives de benzopyrane et benzothyopyrane presentant une activite retinoïde de type antagoniste

Also Published As

Publication number Publication date
AU6228000A (en) 2001-02-13
WO2001007028A2 (fr) 2001-02-01

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