WO2001025213A3 - Pyrroloimidazol-derivate und ihre verwendung als arzneimittel - Google Patents

Pyrroloimidazol-derivate und ihre verwendung als arzneimittel Download PDF

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Publication number
WO2001025213A3
WO2001025213A3 PCT/EP2000/009904 EP0009904W WO0125213A3 WO 2001025213 A3 WO2001025213 A3 WO 2001025213A3 EP 0009904 W EP0009904 W EP 0009904W WO 0125213 A3 WO0125213 A3 WO 0125213A3
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WO
WIPO (PCT)
Prior art keywords
radical
optionally substituted
medicaments
imidazole
anellated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/009904
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English (en)
French (fr)
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WO2001025213B1 (de
WO2001025213A2 (de
Inventor
Alexander Doemling
Barbara Beck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Morphochem GmbH
Original Assignee
Morphochem AG fuer Kombinatorische Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US10/089,917 priority Critical patent/US6699883B1/en
Application filed by Morphochem AG fuer Kombinatorische Chemie filed Critical Morphochem AG fuer Kombinatorische Chemie
Priority to JP2001528159A priority patent/JP2003511373A/ja
Priority to AU18531/01A priority patent/AU1853101A/en
Priority to EP00981195A priority patent/EP1228044A2/de
Priority to CA002386795A priority patent/CA2386795A1/en
Publication of WO2001025213A2 publication Critical patent/WO2001025213A2/de
Publication of WO2001025213A3 publication Critical patent/WO2001025213A3/de
Publication of WO2001025213B1 publication Critical patent/WO2001025213B1/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Die vorliegende Erfindung betrifft 3-Pyrroloimidazol-Derivate der allgemeinen Formel (I), worin der Imidazolrest ein gegebenenfalls substituierter Imidazolcyclus ist, X, Y, A und B unabhängig voneinander Kohlenstoff- oder Stickstoffatome sind, die Reste Z unabhängig voneinander ein Wasserstoffatom, ein Halogenatom, ein Pseudohalogen, einen gegebenenfalls substituierten Alkyl-, Alkenyl-, Alkinyl-, Aralkyl-, Aralkenyl-, Aralkinyl-, Cycloalkyl-, Cycloalkenyl-, Cycloalkinyl-, Cycloaralkyl-, Cycloaralkenyl-, Cycloaralkinyl-, Aryl-, Alkoxyrest oder ein gegebenenfalls substituierten Ring darstellen, an den ein oder zwei weitere gegebenenfalls substituierte Ring anelliert sein können, und/oder mindestens zwei der Reste Z Teil eines gegebenenfalls substituierten Rings sein können, an den ein oder zwei weitere, gegebenenfalls substituierte Ring anelliert sein können, und pharmazeutische Zusammensetzungen, die mindestens eine der vorstehenden Verbindungen, gegebenenfalls in Kombination mit an sich üblichen Trägern und/oder Adjuvantien und/oder Hilfsstoffen enthalten, und ihre Verwendung, insbesondere als tumor- und krebsauflösende und ganz besonders als antibiotische, insbesondere antibakterielle, Arzneimittel.
PCT/EP2000/009904 1999-10-07 2000-10-09 Pyrroloimidazol-derivate und ihre verwendung als arzneimittel Ceased WO2001025213A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/089,917 US6699883B1 (en) 1999-10-07 1999-10-09 Pyrroloimidazole derivatives and their use as medicaments
JP2001528159A JP2003511373A (ja) 1999-10-07 2000-10-09 ピロロイミダゾール誘導体とその薬剤としての使用
AU18531/01A AU1853101A (en) 1999-10-07 2000-10-09 Pyrrolo imidazole derivatives and their use as medicaments
EP00981195A EP1228044A2 (de) 1999-10-07 2000-10-09 Pyrroloimidazol-derivate und ihre verwendung als arzneimittel
CA002386795A CA2386795A1 (en) 1999-10-07 2000-10-09 Pyrrolo imidazole derivatives and their use as medicaments

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19948417.1 1999-10-07
DE19948417A DE19948417A1 (de) 1999-10-07 1999-10-07 Imidazol-Derivate und ihre Verwendung als Arzneimittel

Publications (3)

Publication Number Publication Date
WO2001025213A2 WO2001025213A2 (de) 2001-04-12
WO2001025213A3 true WO2001025213A3 (de) 2001-06-07
WO2001025213B1 WO2001025213B1 (de) 2001-10-18

Family

ID=7924877

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/009904 Ceased WO2001025213A2 (de) 1999-10-07 2000-10-09 Pyrroloimidazol-derivate und ihre verwendung als arzneimittel

Country Status (7)

Country Link
US (1) US6699883B1 (de)
EP (1) EP1228044A2 (de)
JP (1) JP2003511373A (de)
AU (1) AU1853101A (de)
CA (1) CA2386795A1 (de)
DE (1) DE19948417A1 (de)
WO (1) WO2001025213A2 (de)

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US7641701B2 (en) * 2003-09-30 2010-01-05 X-Spine Systems, Inc. Spinal fusion system and method for fusing spinal bones
WO2006015123A1 (en) 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7626021B2 (en) * 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
CA2573573A1 (en) * 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US7361764B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7405302B2 (en) * 2005-10-11 2008-07-29 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) * 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) * 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
EA200901212A1 (ru) * 2007-03-29 2010-04-30 Новартис Аг 3-имидазолилиндолы, предназначенные для лечения пролиферативных заболеваний
TW200920369A (en) * 2007-10-26 2009-05-16 Amira Pharmaceuticals Inc 5-lipoxygenase activating protein (flap) inhibitor
MX2010012814A (es) * 2008-05-23 2010-12-20 Amira Pharmaceuticals Inc Inhibidor de proteina activadora de 5-lipoxigenasa.
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
LT3141252T (lt) 2009-06-17 2018-11-12 Vertex Pharmaceuticals Inc. Gripo virusų replikacijos inhibitoriai
RU2013132681A (ru) 2010-12-16 2015-01-27 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
TWI627173B (zh) * 2013-09-26 2018-06-21 比利時商健生藥品公司 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物
LT3068776T (lt) 2013-11-13 2019-08-12 Vertex Pharmaceuticals Incorporated Gripo virusų replikacijos inhibitoriai
JP6618901B2 (ja) 2013-11-13 2019-12-11 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
EP3294735B8 (de) 2015-05-13 2022-01-05 Vertex Pharmaceuticals Incorporated Hemmer der influenzavirenreplikation
EP3294717B1 (de) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Verfahren zur herstellung von inhibitoren der influenzavirenreplikation
DK3272745T3 (da) 2016-07-21 2019-09-02 Inst Farmakologii Polskiej Akademii Nauk Imidazolylsubstituerede indolderivater, der binder 5-ht7-serotoninreceptor, og farmaceutiske sammensætninger deraf
KR20240058859A (ko) 2021-08-12 2024-05-03 쿨레온 엘엘씨 환각성 및 비환각성 세로토닌 수용체 작용제 및 이의 제조 및 사용 방법

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4466976A (en) * 1981-10-13 1984-08-21 Schering Aktiengesellschaft Antiinflammatory and antiallergic imidazole derivatives
US4866084A (en) * 1987-07-17 1989-09-12 Harbor Branch Oceanographic Institution, Inc. Topsentin compounds effective against viruses and certain tumors
JPH02188579A (ja) * 1989-01-13 1990-07-24 Taisho Pharmaceut Co Ltd インドリルイミダゾール誘導体
US4970226A (en) * 1989-10-03 1990-11-13 Harbor Branch Oceanographic Institution, Inc. Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents
US5852011A (en) * 1994-05-31 1998-12-22 Mitsui Chemicals, Inc. Benzimidazole derivatives
WO1999032483A1 (en) * 1997-12-23 1999-07-01 Astrazeneca Ab New pharmaceutically active compounds
WO1999065909A1 (en) * 1998-06-19 1999-12-23 Pfizer Products Inc. PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS
EP1026170A1 (de) * 1999-02-04 2000-08-09 Hoechst Marion Roussel Erythromycin-Derivate, ihr Verfahren zur Herstellung und ihre Verwendung als Arzneimittel

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Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4466976A (en) * 1981-10-13 1984-08-21 Schering Aktiengesellschaft Antiinflammatory and antiallergic imidazole derivatives
US4866084A (en) * 1987-07-17 1989-09-12 Harbor Branch Oceanographic Institution, Inc. Topsentin compounds effective against viruses and certain tumors
JPH02188579A (ja) * 1989-01-13 1990-07-24 Taisho Pharmaceut Co Ltd インドリルイミダゾール誘導体
US4970226A (en) * 1989-10-03 1990-11-13 Harbor Branch Oceanographic Institution, Inc. Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents
US5852011A (en) * 1994-05-31 1998-12-22 Mitsui Chemicals, Inc. Benzimidazole derivatives
WO1999032483A1 (en) * 1997-12-23 1999-07-01 Astrazeneca Ab New pharmaceutically active compounds
WO1999065909A1 (en) * 1998-06-19 1999-12-23 Pfizer Products Inc. PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS
EP1026170A1 (de) * 1999-02-04 2000-08-09 Hoechst Marion Roussel Erythromycin-Derivate, ihr Verfahren zur Herstellung und ihre Verwendung als Arzneimittel

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Title
MATTHEWS D P ET AL.: "Synthesis and Cardiotonic Activity of Novel Biimidazoles", JOURNAL OF MEDICINAL CHEMISTRY., vol. 33, no. 1, 1990, AMERICAN CHEMICAL SOCIETY. WASHINGTON., US, pages 317 - 327, XP000942263, ISSN: 0022-2623 *
PATENT ABSTRACTS OF JAPAN vol. 014, no. 459 (C - 0767) 4 October 1990 (1990-10-04) *
RODRIGUES PEREIRA E ET AL: "Synthesis and Biological Evaluation of Monoindolyl and Indolocarbazolyl Oxazolones and Imidazolones", CHEMICAL AND PHARMACEUTICAL BULLETIN,JP,PHARMACEUTICAL SOCIETY OF JAPAN. TOKYO, vol. 45, no. 4, April 1997 (1997-04-01), pages 733 - 736, XP002921915, ISSN: 0009-2363 *
See also references of EP1228044A2 *

Also Published As

Publication number Publication date
WO2001025213B1 (de) 2001-10-18
CA2386795A1 (en) 2001-04-12
WO2001025213A2 (de) 2001-04-12
US6699883B1 (en) 2004-03-02
AU1853101A (en) 2001-05-10
JP2003511373A (ja) 2003-03-25
EP1228044A2 (de) 2002-08-07
DE19948417A1 (de) 2001-04-19

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