WO2001044445A3 - Lyases humaines et proteines associees - Google Patents

Lyases humaines et proteines associees Download PDF

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Publication number
WO2001044445A3
WO2001044445A3 PCT/US2000/033815 US0033815W WO0144445A3 WO 2001044445 A3 WO2001044445 A3 WO 2001044445A3 US 0033815 W US0033815 W US 0033815W WO 0144445 A3 WO0144445 A3 WO 0144445A3
Authority
WO
WIPO (PCT)
Prior art keywords
associated proteins
hlyap
lyases
provides
human lyases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/033815
Other languages
English (en)
Other versions
WO2001044445A2 (fr
WO2001044445A8 (fr
Inventor
Henry Yue
Olga Bandman
Y Tom Tang
Jennifer L Hillman
Dyung Aina M Lu
Mariah R Baughn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc filed Critical Incyte Genomics Inc
Priority to EP00988059A priority Critical patent/EP1242590A2/fr
Priority to CA002390689A priority patent/CA2390689A1/fr
Priority to AU24309/01A priority patent/AU2430901A/en
Priority to JP2001545523A priority patent/JP2003530084A/ja
Publication of WO2001044445A2 publication Critical patent/WO2001044445A2/fr
Publication of WO2001044445A3 publication Critical patent/WO2001044445A3/fr
Anticipated expiration legal-status Critical
Publication of WO2001044445A8 publication Critical patent/WO2001044445A8/fr
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)

Abstract

La présente invention concerne d'une part des lyases humaines et protéines associées (HLYAP), et d'autre part des polynucléotides identifiant et codant ces HLYAP. L'invention concerne également de vecteurs d'expression, des cellules hôtes, des anticorps, des agonistes et des antagonistes. L'invention concerne enfin des procédés se rapportant au diagnostic, au traitement ou à la prévention de troubles liés à l'expression des HLYAP.
PCT/US2000/033815 1999-12-16 2000-12-13 Lyases humaines et proteines associees Ceased WO2001044445A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP00988059A EP1242590A2 (fr) 1999-12-16 2000-12-13 Lyases humaines et proteines associees
CA002390689A CA2390689A1 (fr) 1999-12-16 2000-12-13 Lyases humaines et proteines associees
AU24309/01A AU2430901A (en) 1999-12-16 2000-12-13 Human lyases and associated proteins
JP2001545523A JP2003530084A (ja) 1999-12-16 2000-12-13 ヒトリアーゼおよび関連タンパク質

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17230799P 1999-12-16 1999-12-16
US60/172,307 1999-12-16

Publications (3)

Publication Number Publication Date
WO2001044445A2 WO2001044445A2 (fr) 2001-06-21
WO2001044445A3 true WO2001044445A3 (fr) 2001-12-13
WO2001044445A8 WO2001044445A8 (fr) 2002-06-20

Family

ID=22627151

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/033815 Ceased WO2001044445A2 (fr) 1999-12-16 2000-12-13 Lyases humaines et proteines associees

Country Status (5)

Country Link
EP (1) EP1242590A2 (fr)
JP (1) JP2003530084A (fr)
AU (1) AU2430901A (fr)
CA (1) CA2390689A1 (fr)
WO (1) WO2001044445A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004013320A1 (fr) * 2002-07-30 2004-02-12 Bayer Healthcare Ag Regulation de la methyltransferase humaine
US7078419B2 (en) 2003-03-10 2006-07-18 Boehringer Ingelheim Pharmaceuticals, Inc. Cytokine inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962302A (en) * 1998-02-20 1999-10-05 Incyte Pharmaceuticals, Inc. Human N-acetylneuraminate lyase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962302A (en) * 1998-02-20 1999-10-05 Incyte Pharmaceuticals, Inc. Human N-acetylneuraminate lyase

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BAIROCH A: "Prosite: A Dictionary of Protein Sites and Patterns - User Manual; Release 16.0", July 1999, EXPASY, GENEVA, XP002174193 *
DATABASE EMBL [online] 26 May 1999 (1999-05-26), XP002174196, retrieved from EBI Database accession no. AL049787 *
DATABASE EMBL [online] 26 May 1999 (1999-05-26), XP002174197, retrieved from EBI Database accession no. AL049788 *
DATABASE EMBL [online] 27 May 1999 (1999-05-27), XP002174195, retrieved from EBI Database accession no. AI682225 *
DATABASE SWALL [online] 1 November 1999 (1999-11-01), XP002174194, retrieved from EBI Database accession no. Q9Y273 *
LINSS JUTTA ET AL: "Cloning and characterization of the gene encoding ATP-dependent phosphoenolpyruvate carboxykinase in Trypanosoma cruzi: Comparison of primary and predicted secondary structure with host GTP-dependent enzyme.", GENE (AMSTERDAM), vol. 136, no. 1-2, 1993, pages 69 - 77, XP001018900, ISSN: 0378-1119 *
MATTE ALLAN ET AL: "Crystal structure of Escherichia coli phosphoenolpyruvate carboxykinase: A new structural family with the P-loop nucleoside triphosphate hydrolase fold.", JOURNAL OF MOLECULAR BIOLOGY, vol. 256, no. 1, 1996, pages 126 - 143, XP002174191, ISSN: 0022-2836 *
MATTE ALLAN ET AL: "Structure and mechanism of phosphoenolpyruvate carboxykinase.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 13, 1997, pages 8105 - 8108, XP002174238, ISSN: 0021-9258 *
WHITBY FRANK G ET AL: "Crystal structure of human uroporphyrinogen decarboxylase.", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 17, no. 9, 1 May 1998 (1998-05-01), pages 2463 - 2471, XP002174192, ISSN: 0261-4189 *

Also Published As

Publication number Publication date
AU2430901A (en) 2001-06-25
EP1242590A2 (fr) 2002-09-25
WO2001044445A2 (fr) 2001-06-21
WO2001044445A8 (fr) 2002-06-20
JP2003530084A (ja) 2003-10-14
CA2390689A1 (fr) 2001-06-21

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