WO2001077384A3 - DETEKTION VON SNPs UND CYTOSIN-METHYLIERUNGEN - Google Patents

DETEKTION VON SNPs UND CYTOSIN-METHYLIERUNGEN Download PDF

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Publication number
WO2001077384A3
WO2001077384A3 PCT/IB2001/000713 IB0100713W WO0177384A3 WO 2001077384 A3 WO2001077384 A3 WO 2001077384A3 IB 0100713 W IB0100713 W IB 0100713W WO 0177384 A3 WO0177384 A3 WO 0177384A3
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snp
single nucleotide
nucleotide polymorphisms
methylations
cytosine
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French (fr)
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WO2001077384A2 (de
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Alexander Olek
Christian Piepenbrock
Kurt Berlin
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Epigenomics AG
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Epigenomics AG
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Priority to AU2001250572A priority Critical patent/AU2001250572A1/en
Priority to US10/257,017 priority patent/US20040241651A1/en
Priority to EP01923891A priority patent/EP1268856A2/de
Publication of WO2001077384A2 publication Critical patent/WO2001077384A2/de
Publication of WO2001077384A3 publication Critical patent/WO2001077384A3/de
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Abstract

Beschrieben wird ein Satz von Oligonukleotiden oder PNA-Oligomeren und ein Verfahren, das sich zur Detektion von Cytosin-Methylierungen und SNPs in genomischen DNA-Proben eignet. Dieses Verfahren dient der Diagnose und/oder Prognose nachteiliger Ereignisse für Patienten oder Individuen, wie Erkrankungen.
PCT/IB2001/000713 2000-04-07 2001-04-06 DETEKTION VON SNPs UND CYTOSIN-METHYLIERUNGEN Ceased WO2001077384A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2001250572A AU2001250572A1 (en) 2000-04-07 2001-04-06 Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations
US10/257,017 US20040241651A1 (en) 2000-04-07 2001-04-06 Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations
EP01923891A EP1268856A2 (de) 2000-04-07 2001-04-06 Detektion von snp's und cytosin-methylierungen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10019173.8 2000-04-07
DE10019173 2000-04-07

Publications (2)

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WO2001077384A2 WO2001077384A2 (de) 2001-10-18
WO2001077384A3 true WO2001077384A3 (de) 2002-07-25

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PCT/IB2001/000713 Ceased WO2001077384A2 (de) 2000-04-07 2001-04-06 DETEKTION VON SNPs UND CYTOSIN-METHYLIERUNGEN

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US (1) US20040241651A1 (de)
EP (1) EP1268856A2 (de)
AU (1) AU2001250572A1 (de)
WO (1) WO2001077384A2 (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7888324B2 (en) 2001-08-01 2011-02-15 Genzyme Corporation Antisense modulation of apolipoprotein B expression
US9175291B2 (en) 2012-10-11 2015-11-03 Isis Pharmaceuticals Inc. Modulation of androgen receptor expression
US9206478B2 (en) 2002-12-31 2015-12-08 Branhaven LLC Methods and systems for inferring bovine traits

Families Citing this family (186)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262249B1 (en) * 1998-06-23 2001-07-17 Chiron Corporation Pancreatic cancer genes
DE10048091A1 (de) * 2000-09-28 2002-04-25 Ernst Bayer Anwendung chemisch modifizierter Oligodesoxyribonukleotide zur Unterdrückung der Proliferation von humanem Pankreastumor
US7612194B2 (en) * 2001-07-24 2009-11-03 Monsanto Technology Llc Nucleic acid sequences from Diabrotica virgifera virgifera LeConte and uses thereof
US7425545B2 (en) * 2001-07-25 2008-09-16 Isis Pharmaceuticals, Inc. Modulation of C-reactive protein expression
US6964950B2 (en) 2001-07-25 2005-11-15 Isis Pharmaceuticals, Inc. Antisense modulation of C-reactive protein expression
US7407943B2 (en) 2001-08-01 2008-08-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein B expression
US7176303B2 (en) * 2003-11-06 2007-02-13 Isis Pharmaceuticals, Inc. Modulation of STAT5 expression
WO2003060160A2 (en) * 2002-01-18 2003-07-24 Genomar Asa Verification of fish origin based on nucleic acid pattern recognition
EP1470254A2 (de) * 2002-01-30 2004-10-27 Epigenomics AG Methode zur analyse von cytosin-methylierungsmustern
JP2003289869A (ja) * 2002-04-02 2003-10-14 Tosoh Corp 非定型抗酸菌Mycobacteriumavium検出のためのオリゴヌクレオチドおよび検出法
NZ582316A (en) * 2002-05-06 2011-07-29 Genesis Res & Dev Corp Ltd Sucrose phosphate synthases (SPS) from Lolium perenne and Festuca arundinacea
ES2316501T3 (es) * 2002-05-21 2009-04-16 Mtm Laboratories Ag Moleculas marcadoras asociadas con tumores pulmonares.
US7199107B2 (en) 2002-05-23 2007-04-03 Isis Pharmaceuticals, Inc. Antisense modulation of kinesin-like 1 expression
JPWO2003100057A1 (ja) * 2002-05-28 2005-09-22 独立行政法人産業技術総合研究所 化学物質センサシステム
JP2004016054A (ja) * 2002-06-13 2004-01-22 Takara Bio Inc ポリペプチドの細胞表面局在化方法
AU2003247303A1 (en) * 2002-07-17 2004-02-02 Index Pharmaceuticals Ab Antisense compounds, methods and compositions for treating ngal-related inflammatory disorders
EP1403384A1 (de) * 2002-09-26 2004-03-31 Stichting Researchfonds Pathologie Verfahren zum Nachweis und zur Karakterisierung von kutanem HPV und Primer und Sonden dafür
WO2004029577A2 (en) * 2002-09-26 2004-04-08 Fmc Corporation Hemipteran myosin light chain kinase
US7511131B2 (en) * 2002-11-13 2009-03-31 Genzyme Corporation Antisense modulation of apolipoprotein B expression
US20060009410A1 (en) * 2002-11-13 2006-01-12 Crooke Rosanne M Effects of apolipoprotein B inhibition on gene expression profiles in animals
US7144999B2 (en) * 2002-11-23 2006-12-05 Isis Pharmaceuticals, Inc. Modulation of hypoxia-inducible factor 1 alpha expression
CA2743564C (en) 2003-01-13 2013-11-12 Monsanto Technology Llc Glyphosate tolerant alfalfa events and methods for detection thereof
US7803781B2 (en) * 2003-02-28 2010-09-28 Isis Pharmaceuticals, Inc. Modulation of growth hormone receptor expression and insulin-like growth factor expression
US7846906B2 (en) 2003-02-28 2010-12-07 Isis Pharmaceuticals, Inc. Modulation of growth hormone receptor expression and insulin-like growth factor expression
WO2005012343A1 (en) * 2003-07-10 2005-02-10 Akzo Nobel N.V. Babesia vaccines
DE602004008085T2 (de) * 2003-08-12 2008-04-24 Antisense Pharma Gmbh Antisense-oligonukleotid zur hemmung der melanom-inhibierenden aktivität (mia)
US8227193B2 (en) * 2003-10-01 2012-07-24 The Regents Of The University Of California Compositions and methods for gene expression
KR100520994B1 (en) * 2003-10-27 2005-10-13 Molecular marker associated with CMV resistance and use thereof
ES2801379T3 (es) * 2003-12-01 2021-01-11 Epigenomics Ag Métodos y ácidos nucleicos para el análisis de la expresión génica asociada con el desarrollo de trastornos proliferativos de células de próstata
US20050164271A1 (en) * 2004-01-20 2005-07-28 Sanjay Bhanot Modulation of glucocorticoid receptor expression
WO2005094219A2 (en) * 2004-03-24 2005-10-13 United States Army Medical Research And Materiel Command Unique chromosomal sequence of bacillus anthracis and methods of making and using thereof including real-time pcr assays
AU2005229157B2 (en) * 2004-03-31 2011-07-21 Commonwealth Scientific And Industrial Research Organisation Genes involved in plant fibre development
US20060021087A1 (en) 2004-04-09 2006-01-26 Baum James A Compositions and methods for control of insect infestations in plants
US7365058B2 (en) 2004-04-13 2008-04-29 The Rockefeller University MicroRNA and methods for inhibiting same
PL1745062T3 (pl) * 2004-04-22 2014-10-31 Regado Biosciences Inc Ulepszone modulatory czynników krzepnięcia
US20050287558A1 (en) * 2004-05-05 2005-12-29 Crooke Rosanne M SNPs of apolipoprotein B and modulation of their expression
ES2360804T3 (es) * 2004-05-24 2011-06-09 Anamar Ab Método para determinar un proceso de degradación tisular mediante la detección de neoepítopos de comp.
GB2414400B (en) 2004-05-28 2009-01-14 Cilag Ag Int Injection device
GB2414399B (en) 2004-05-28 2008-12-31 Cilag Ag Int Injection device
GB2414402B (en) 2004-05-28 2009-04-22 Cilag Ag Int Injection device
GB2414401B (en) 2004-05-28 2009-06-17 Cilag Ag Int Injection device
GB2414403B (en) 2004-05-28 2009-01-07 Cilag Ag Int Injection device
GB2414406B (en) 2004-05-28 2009-03-18 Cilag Ag Int Injection device
GB2414775B (en) 2004-05-28 2008-05-21 Cilag Ag Int Releasable coupling and injection device
US7498315B2 (en) * 2004-06-01 2009-03-03 Pronai Therapeutics, Inc. Methods and compositions for the inhibition of gene expression
US7807647B2 (en) * 2004-06-01 2010-10-05 Pronai Therapeutics, Inc. Methods and compositions for cancer therapy
US8815599B2 (en) 2004-06-01 2014-08-26 Pronai Therapeutics, Inc. Methods and compositions for the inhibition of gene expression
US7547514B2 (en) * 2004-07-28 2009-06-16 Canon U.S. Life Sciences, Inc. Methods for monitoring genomic DNA of organisms
PL1786472T3 (pl) * 2004-08-10 2013-06-28 Kastle Therapeutics Llc Antysensowna modulacja ekspresji apolipoproteiny B
US7759479B1 (en) * 2004-09-13 2010-07-20 Isis Pharmaceuticals, Inc. Compositions and their uses directed to Gemin Genes
KR101138862B1 (ko) * 2005-02-14 2012-05-14 삼성전자주식회사 단일염기 다형을 포함하는 유방암과 관련된 폴리뉴클레오티드, 그를 포함하는 마이크로어레이 및 진단 키트 및 그를이용한 유방암 진단 방법
CN101163800B (zh) * 2005-02-18 2013-04-17 佳能美国生命科学公司 鉴定生物的基因组dna的装置和方法
US20070185044A1 (en) * 2005-03-08 2007-08-09 Dobie Kenneth W Modulation of ace2 expression
GB2425062B (en) 2005-04-06 2010-07-21 Cilag Ag Int Injection device
GB2424836B (en) 2005-04-06 2010-09-22 Cilag Ag Int Injection device (bayonet cap removal)
GB2427826B (en) 2005-04-06 2010-08-25 Cilag Ag Int Injection device comprising a locking mechanism associated with integrally formed biasing means
GB2424835B (en) 2005-04-06 2010-06-09 Cilag Ag Int Injection device (modified trigger)
GB2424838B (en) 2005-04-06 2011-02-23 Cilag Ag Int Injection device (adaptable drive)
EP1904639B1 (de) 2005-07-06 2010-05-05 Nestec S.A. Dehydringene und promotoren aus kaffee
DE602005018480D1 (de) 2005-08-30 2010-02-04 Cilag Gmbh Int Nadelvorrichtung für eine vorgefüllte Spritze
AU2014277739B2 (en) * 2005-09-16 2017-02-02 Monsanto Technology Llc Methods for genetic control of insect infestations in plants and compositions thereof
AU2006292362B2 (en) 2005-09-16 2013-02-14 Monsanto Technology Llc Methods for genetic control of insect infestations in plants and compositions thereof
US20110098656A1 (en) 2005-09-27 2011-04-28 Burnell Rosie L Auto-injection device with needle protecting cap having outer and inner sleeves
US8658608B2 (en) * 2005-11-23 2014-02-25 Yale University Modified triple-helix forming oligonucleotides for targeted mutagenesis
CA2631677C (en) 2005-12-01 2014-08-12 Pronai Therapeutics, Inc. Amphoteric liposome formulation
WO2007109174A2 (en) * 2006-03-16 2007-09-27 Isis Pharmaceuticals, Inc. Compositions and methods for modulation of mcl-1 expression
EP2023940B1 (de) 2006-05-05 2011-06-22 Isis Pharmaceuticals, Inc. Verbindungen und verfahren zur modulation der expression von sglt2
US8084734B2 (en) * 2006-05-26 2011-12-27 The George Washington University Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
GB2438590B (en) 2006-06-01 2011-02-09 Cilag Gmbh Int Injection device
GB2438591B (en) 2006-06-01 2011-07-13 Cilag Gmbh Int Injection device
GB2438593B (en) 2006-06-01 2011-03-30 Cilag Gmbh Int Injection device (cap removal feature)
US7745595B2 (en) * 2006-08-10 2010-06-29 Medical Diagnostic Laboratories, Llc Compositions and methods for detecting Atopobium vaginae
AU2014200037B2 (en) * 2006-10-10 2016-06-02 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Prostate cancer-specific alterations in ERG gene expression and detection and treatment methods based on those alterations
US8188255B2 (en) 2006-10-20 2012-05-29 Exiqon A/S Human microRNAs associated with cancer
WO2008046911A2 (en) * 2006-10-20 2008-04-24 Exiqon A/S Novel human micrornas associated with cancer
CN101679979A (zh) 2007-03-24 2010-03-24 基酶有限公司 施用与人载脂蛋白b互补的反义寡核苷酸
US20110059895A1 (en) * 2007-11-09 2011-03-10 Isis Pharmaceuticals, Inc. Modulation of factor 9 expression
WO2009065511A2 (en) * 2007-11-23 2009-05-28 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
CN102912019B (zh) * 2007-11-30 2016-03-23 基因特力株式会社 使用膀胱癌特异性甲基化标记基因的膀胱癌诊断试剂盒和芯片
JPWO2009093384A1 (ja) * 2008-01-24 2011-05-26 独立行政法人産業技術総合研究所 ポリヌクレオチド及びポリヌクレオチド類似体並びにこれらを用いた遺伝子発現制御方法
US10150990B2 (en) * 2008-04-21 2018-12-11 Roche Molecular Systems, Inc. Ribonucleotide tag nucleic acid detection
GB2461086B (en) 2008-06-19 2012-12-05 Cilag Gmbh Int Injection device
GB2461089B (en) 2008-06-19 2012-09-19 Cilag Gmbh Int Injection device
GB2461087B (en) 2008-06-19 2012-09-26 Cilag Gmbh Int Injection device
GB2461084B (en) 2008-06-19 2012-09-26 Cilag Gmbh Int Fluid transfer assembly
GB2461085B (en) 2008-06-19 2012-08-29 Cilag Gmbh Int Injection device
US8110796B2 (en) 2009-01-17 2012-02-07 The George Washington University Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
GB0901593D0 (en) 2009-01-30 2009-03-11 Touchlight Genetics Ltd Production of closed linear DNA
KR101805199B1 (ko) * 2009-02-12 2017-12-05 큐알엔에이, 인크. 신경교세포 유래된 신경영양성 인자 (gdnf)에 대한 자연 안티센스 전사체의 저해에 의한 신경교세포 유래된 신경영양성 인자 (gdnf) 관련된 질환의 치료
WO2010093904A2 (en) * 2009-02-12 2010-08-19 Curna, Inc. Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
EP2408796B1 (de) 2009-03-16 2020-04-22 Ionis Pharmaceuticals, Inc. Targeting Apolipoprotein B für die Reduktion von Apolipoprotein C-III
US9490113B2 (en) * 2009-04-07 2016-11-08 The George Washington University Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry
ES2585360T3 (es) * 2009-08-05 2016-10-05 Curna, Inc. Tratamiento de enfermedades relacionadas con un gen de la insulina (INS) por inhibición de la transcripción antisentido natural en un gen de la insulina (INS)
EP2322656A1 (de) * 2009-11-17 2011-05-18 Centre National de la Recherche Scientifique (C.N.R.S) Verfahren zur Diagnose von Hautkrankheiten
GB201008719D0 (en) * 2010-05-25 2010-07-07 Nat Univ Ireland Diagnostic method
CN107898791A (zh) 2010-06-03 2018-04-13 药品循环有限责任公司 布鲁顿酪氨酸激酶(btk)抑制剂的应用
WO2011163499A2 (en) * 2010-06-23 2011-12-29 Opko Curna, Llc Treatment of sodium channel, voltage-gated, alpha subunit (scna) related diseases by inhibition of natural antisense transcript to scna
WO2012012467A2 (en) 2010-07-19 2012-01-26 Isis Pharmaceuticals, Inc. Modulation of nuclear-retained rna
GB201013153D0 (en) * 2010-08-04 2010-09-22 Touchlight Genetics Ltd Primer for production of closed linear DNA
AU2010360293B2 (en) * 2010-09-06 2016-06-16 Temasek Life Sciences Laboratory Limited Molecular interaction between Xa10 and AvrXa10
WO2012038827A2 (en) * 2010-09-20 2012-03-29 Prognomix Inc. Genes linking several complications of type-2 diabetes (t2d)
US8648053B2 (en) * 2010-10-20 2014-02-11 Rosalind Franklin University Of Medicine And Science Antisense oligonucleotides that target a cryptic splice site in Ush1c as a therapeutic for Usher syndrome
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
CA3077910A1 (en) * 2010-11-17 2012-05-24 Ionis Pharmaceuticals, Inc. Modulation of alpha synuclein expression
AU2013206424B2 (en) * 2010-11-24 2015-09-17 E. I. Du Pont De Nemours And Company Brassica gat event dp-073496-4 and compositions and methods for the identification and/or detection thereof
EP2663658B1 (de) * 2011-01-12 2017-10-25 Abbott Molecular Inc. Materialen und verfahren zum nachweis von cytomegalovirus (cmv)
US9157125B2 (en) 2011-02-02 2015-10-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services GRIN2A mutations and use thereof for the diagnosis of melanoma
MY185926A (en) * 2011-07-15 2021-06-14 Acgt Sdn Bhd Ssr markers for plants and uses thereof
NZ621638A (en) * 2011-08-25 2016-03-31 Clinical Genomics Pty Ltd Dna methylation in colorectal and breast cancer diagnostic methods
ES2796556T3 (es) 2011-09-20 2020-11-27 Ionis Pharmaceuticals Inc Modulación antisentido de la expresión de GCGR
HUE039835T2 (hu) 2011-10-17 2019-02-28 Novozymes As Alfa-amiláz variánsok és az azokat kódoló polinukleotidok
EP2776450B1 (de) 2011-11-10 2018-04-04 Shire Human Genetic Therapies, Inc. Antisense-oligonukleotidmodulatoren des serotoninrezeptors 2c und verwendungen davon
EP2791365A1 (de) * 2011-12-14 2014-10-22 De Staat der Nederlanden, Vert. Door de Minister van VWS Identifikation von poliovirus-strängen
AU2013203395A1 (en) 2012-03-30 2013-10-17 Isis Pharmaceuticals, Inc. Compositions and methods for modulating TAU expression for reducing seizure and modifying a neurodegenerative syndrome
AU2013262709A1 (en) 2012-05-16 2015-01-22 Rana Therapeutics, Inc. Compositions and methods for modulating MECP2 expression
CA2873769A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics Inc. Compositions and methods for modulating hemoglobin gene family expression
BR112014028634A2 (pt) 2012-05-16 2017-06-27 Rana Therapeutics Inc composições e métodos para modulação da expressão de utrn
JP2015523854A (ja) 2012-05-16 2015-08-20 ラナ セラピューティクス インコーポレイテッド Smn遺伝子ファミリー発現を調節するための組成物及び方法
CA2873766A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics Inc. Compositions and methods for modulating atp2a2 expression
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
WO2014018375A1 (en) * 2012-07-23 2014-01-30 Xenon Pharmaceuticals Inc. Cyp8b1 and uses thereof in therapeutic and diagnostic methods
CN104704129A (zh) 2012-07-24 2015-06-10 药品循环公司 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变
JP6470044B2 (ja) * 2012-09-03 2019-02-13 国立大学法人九州大学 がんに対する免疫療法の有効性の予測方法
SG10201706960TA (en) * 2013-02-28 2017-10-30 Arrowhead Res Corp Organic compositions to treat epas1-related diseases
US9359643B2 (en) 2013-03-08 2016-06-07 Progenika Biopharma S.A. Discrimination of blood type variants
US20160108478A1 (en) * 2013-03-14 2016-04-21 Cepheid Methods of detecting lung cancer
ES2807379T3 (es) * 2013-03-14 2021-02-22 Ionis Pharmaceuticals Inc Composiciones y métodos para regular la expresión de Tau
US9657098B2 (en) 2013-03-15 2017-05-23 Intrinsic Lifesciences, Llc Anti-hepcidin antibodies and uses thereof
GB2517896B (en) 2013-06-11 2015-07-08 Cilag Gmbh Int Injection device
GB2515039B (en) 2013-06-11 2015-05-27 Cilag Gmbh Int Injection Device
GB2515032A (en) 2013-06-11 2014-12-17 Cilag Gmbh Int Guide for an injection device
GB2515038A (en) 2013-06-11 2014-12-17 Cilag Gmbh Int Injection device
WO2015188899A1 (en) * 2014-06-12 2015-12-17 Deutsches Krebsforschungszentrum Novel ttv mirna sequences as an early marker for the future development of cancer and as a target for cancer treatment and prevention
EP3017044B1 (de) * 2013-07-02 2020-02-26 Ionis Pharmaceuticals, Inc. Modulatoren des wachstumshormonrezeptors
TWI772856B (zh) 2013-07-19 2022-08-01 美商百健Ma公司 用於調節τ蛋白表現之組合物
TW201536329A (zh) 2013-08-09 2015-10-01 Isis Pharmaceuticals Inc 用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
GB201315527D0 (en) * 2013-08-30 2013-10-16 Sec Dep For Health The Assay for the detection of infection-causing e.coli strains
US11162096B2 (en) 2013-10-14 2021-11-02 Ionis Pharmaceuticals, Inc Methods for modulating expression of C9ORF72 antisense transcript
CA2924277A1 (en) * 2013-10-18 2015-04-23 Institut De Cardiologie De Montreal Genotyping tests and methods for evaluating plasma creatine kinase levels
US20160186261A1 (en) * 2013-11-04 2016-06-30 Jose U. Scher Prevotella copri and enhanced susceptibility to arthritis
WO2015143400A1 (en) * 2014-03-20 2015-09-24 Pharmacyclics, Inc. Phospholipase c gamma 2 and resistance associated mutations
RS60707B1 (sr) 2014-04-01 2020-09-30 Biogen Ma Inc Kompozicije za modulaciju ekspresije sod-1
CN110903337A (zh) 2014-05-01 2020-03-24 Ionis制药公司 用于调节生长激素受体表达的组合物和方法
US10329570B2 (en) * 2014-07-31 2019-06-25 Academia Sinica Antagonistic PD-1 aptamer and its applications in cancer therapy related applications
WO2016034611A1 (en) * 2014-09-02 2016-03-10 Max-Delbrück-Centrum für Molekulare Medizin Antisense oligonucleotides targeting 3'utr region of a20
AU2015321462B2 (en) 2014-09-22 2020-04-30 Intrinsic Lifesciences Llc Humanized anti-hepcidin antibodies and uses thereof
EP3221700B1 (de) * 2014-11-18 2022-06-22 Blueprint Medicines Corporation Fusionen von prkacb
PY1671153A (es) * 2015-11-02 2018-04-02 Monsanto Technology Llc Evento transgénico de algodón mon 88702 y métodos de detección y usos del mismo
US11136597B2 (en) 2016-02-16 2021-10-05 Yale University Compositions for enhancing targeted gene editing and methods of use thereof
JP7672192B2 (ja) 2016-06-08 2025-05-07 ユニバーシティー オブ アイオワ リサーチ ファンデーション 心血管疾患の素因を検出するための組成物および方法
ES2963428T3 (es) 2016-09-29 2024-03-27 Biogen Ma Inc Compuestos y métodos para reducir la expresión de Tau
CN110191952A (zh) 2016-10-07 2019-08-30 瑟卡尔纳制药有限公司 治疗癌症的新方法
WO2018187493A1 (en) 2017-04-04 2018-10-11 Yale University Compositions and methods for in utero delivery
NO344051B1 (en) * 2017-05-04 2019-08-26 Patogen As Novel virus in Fish and Method for detection
CA3073705A1 (en) 2017-05-11 2018-11-15 The Research Foundation For The State University Of New York Compositions and methods for loading extracellular vesicles with chemical and biological agents/molecules
GB201708617D0 (en) * 2017-05-31 2017-07-12 Blue Genomics Chile Spa Salmonid genetics
GB201711782D0 (en) * 2017-07-21 2017-09-06 Ucl Business Plc Diagnostic and Prognostic methods
TWI809004B (zh) 2017-11-09 2023-07-21 美商Ionis製藥公司 用於降低snca表現之化合物及方法
EA202091693A1 (ru) 2018-01-12 2021-04-14 Бристол-Маерс Сквибб Компани Антисмысловые олигонуклеотиды, целенаправленно воздействующие на альфа-синуклеин, и их применения
BR112020013994A2 (pt) 2018-01-12 2020-12-08 Bristol-Myers Squibb Company Oligonucleotídeos antissenso que direcionam alfa-sinucleína e seus usos
TWI840345B (zh) 2018-03-02 2024-05-01 美商Ionis製藥公司 Irf4表現之調節劑
CA3094020A1 (en) 2018-04-11 2019-10-17 Ionis Pharmaceuticals, Inc. Modulators of ezh2 expression
WO2019204256A1 (en) 2018-04-18 2019-10-24 Pioneer Hi-Bred International, Inc. Improving agronomic characteristics in maize by modification of endogenous mads box transcription factors
WO2019204253A1 (en) 2018-04-18 2019-10-24 Pioneer Hi-Bred International, Inc. Genes, constructs and maize event dp-202216-6
TWI832851B (zh) * 2018-05-18 2024-02-21 韓商奧利通公司 基質金屬蛋白酶-1之反義寡核苷酸
WO2019233922A1 (en) * 2018-06-05 2019-12-12 F. Hoffmann-La Roche Ag Oligonucleotides for modulating atxn2 expression
TW202028222A (zh) 2018-11-14 2020-08-01 美商Ionis製藥公司 Foxp3表現之調節劑
EP3899024A4 (de) * 2018-12-21 2023-05-31 Ionis Pharmaceuticals, Inc. Modulatoren der hsd17b13-expression
EP3693465A1 (de) * 2019-02-05 2020-08-12 Pharmaq AS Neuartiger fisch-coronavirus
US20220195431A1 (en) * 2019-02-22 2022-06-23 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing atxn3 expression
CN111718929B (zh) * 2019-03-20 2022-10-18 中国科学院上海营养与健康研究所 利用环形rna进行蛋白翻译及其应用
US11286485B2 (en) 2019-04-04 2022-03-29 Hoffmann-La Roche Inc. Oligonucleotides for modulating ATXN2 expression
CN110343764B (zh) * 2019-07-22 2020-05-26 武汉艾米森生命科技有限公司 检测结直肠癌相关基因甲基化的检测试剂的应用和试剂盒
US20210024985A1 (en) * 2019-07-26 2021-01-28 Emory University Devices and Methods Useful for Imaging Transient and Rare Mechanical Events in Cells
JP7386507B2 (ja) * 2019-08-02 2023-11-27 国立大学法人信州大学 筋分化促進剤および筋分化促進方法および筋分化促進オリゴdna
WO2021154674A1 (en) * 2020-01-27 2021-08-05 Pioneer Hi-Bred International, Inc. Maize event dp-056113-9 and methods of use thereof
US12559804B2 (en) * 2020-02-17 2026-02-24 Neogen Food Safety Us Holdco Corporation Loop-mediated isothermal amplification primers for vibrio parahaemolyticus detection and uses thereof
DE102020108560B4 (de) * 2020-03-27 2022-03-03 Precision For Medicine Gmbh CBX6 als epigenetischer Marker für die Identifizierung von Immunzellen, insbesondere Gedächtnis-B-Zellen
CN116368227A (zh) * 2020-07-22 2023-06-30 弗洛里神经科学与心理健康研究所 用于治疗与scn2a中功能失去突变相关的障碍的组合物和方法
CN116490622A (zh) * 2020-09-04 2023-07-25 爱荷华大学研究基金会 用于预测和/或监测糖尿病及其治疗的方法和组合物
CA3227115A1 (en) 2021-07-21 2023-01-26 Wen-Hsuan Chang Unc13a antisense oligonucleotides
EP4396352A4 (de) 2021-09-01 2025-10-01 Ionis Pharmaceuticals Inc Verbindungen und verfahren zur reduzierung der dmpk-expression
WO2024098031A1 (en) * 2022-11-03 2024-05-10 Camp4 Therapeutics Corporation Modulation of abcb11 gene transcription using antisense oligonucleotides targeting regulatory rnas
AU2023385466A1 (en) * 2022-11-22 2025-05-01 Pioneer Hi-Bred International, Inc. Maize event dp-051291-2 and methods for detection thereof
EP4431601A1 (de) * 2023-03-17 2024-09-18 Limagrain Europe Verfahren zum ausschalten eines gens durch gezielte insertion von stopcodons
WO2025097032A2 (en) * 2023-11-03 2025-05-08 Forge Biologics, Inc. Modified kozak sequences for production of recombinant aav

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011995A1 (en) * 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
WO1999028498A2 (de) * 1997-11-27 1999-06-10 Epigenomics Gmbh Verfahren zur herstellung komplexer dna-methylierungs-fingerabdrücke

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6582908B2 (en) * 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011995A1 (en) * 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
WO1999028498A2 (de) * 1997-11-27 1999-06-10 Epigenomics Gmbh Verfahren zur herstellung komplexer dna-methylierungs-fingerabdrücke

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HERMAN J G ET AL: "METHYLATION-SPECIFIC PCR: A NOVEL PCR ASSAY FOR METHYLATION STATUS OF CPG ISLANDS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, 1 September 1996 (1996-09-01), pages 9821 - 9826, XP002910406, ISSN: 0027-8424 *
NIEMEYER C M ET AL: "DNA MICROARRAYS**", ANGEWANDTE CHEMIE, VCH VERLAGSGESELLSCHAFT, WEINHEIM, DE, vol. 38, no. 19, 1999, pages 3039 - 3043, XP000961724, ISSN: 0044-8249 *
REIN ET AL: "Identifying 5-methylcytosine and related modifications in DNA genomes", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 26, no. 10, 1998, pages 2255 - 2264, XP002143106, ISSN: 0305-1048 *
WANG D G ET AL: "Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 280, 1998, pages 1077 - 1082, XP002089398, ISSN: 0036-8075 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7888324B2 (en) 2001-08-01 2011-02-15 Genzyme Corporation Antisense modulation of apolipoprotein B expression
US9206478B2 (en) 2002-12-31 2015-12-08 Branhaven LLC Methods and systems for inferring bovine traits
US9175291B2 (en) 2012-10-11 2015-11-03 Isis Pharmaceuticals Inc. Modulation of androgen receptor expression

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