WO2001077384A3 - DETEKTION VON SNPs UND CYTOSIN-METHYLIERUNGEN - Google Patents
DETEKTION VON SNPs UND CYTOSIN-METHYLIERUNGEN Download PDFInfo
- Publication number
- WO2001077384A3 WO2001077384A3 PCT/IB2001/000713 IB0100713W WO0177384A3 WO 2001077384 A3 WO2001077384 A3 WO 2001077384A3 IB 0100713 W IB0100713 W IB 0100713W WO 0177384 A3 WO0177384 A3 WO 0177384A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- snp
- single nucleotide
- nucleotide polymorphisms
- methylations
- cytosine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2001250572A AU2001250572A1 (en) | 2000-04-07 | 2001-04-06 | Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations |
| US10/257,017 US20040241651A1 (en) | 2000-04-07 | 2001-04-06 | Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations |
| EP01923891A EP1268856A2 (de) | 2000-04-07 | 2001-04-06 | Detektion von snp's und cytosin-methylierungen |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10019173.8 | 2000-04-07 | ||
| DE10019173 | 2000-04-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2001077384A2 WO2001077384A2 (de) | 2001-10-18 |
| WO2001077384A3 true WO2001077384A3 (de) | 2002-07-25 |
Family
ID=7639166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IB2001/000713 Ceased WO2001077384A2 (de) | 2000-04-07 | 2001-04-06 | DETEKTION VON SNPs UND CYTOSIN-METHYLIERUNGEN |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20040241651A1 (de) |
| EP (1) | EP1268856A2 (de) |
| AU (1) | AU2001250572A1 (de) |
| WO (1) | WO2001077384A2 (de) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7888324B2 (en) | 2001-08-01 | 2011-02-15 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
| US9175291B2 (en) | 2012-10-11 | 2015-11-03 | Isis Pharmaceuticals Inc. | Modulation of androgen receptor expression |
| US9206478B2 (en) | 2002-12-31 | 2015-12-08 | Branhaven LLC | Methods and systems for inferring bovine traits |
Families Citing this family (186)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6262249B1 (en) * | 1998-06-23 | 2001-07-17 | Chiron Corporation | Pancreatic cancer genes |
| DE10048091A1 (de) * | 2000-09-28 | 2002-04-25 | Ernst Bayer | Anwendung chemisch modifizierter Oligodesoxyribonukleotide zur Unterdrückung der Proliferation von humanem Pankreastumor |
| US7612194B2 (en) * | 2001-07-24 | 2009-11-03 | Monsanto Technology Llc | Nucleic acid sequences from Diabrotica virgifera virgifera LeConte and uses thereof |
| US7425545B2 (en) * | 2001-07-25 | 2008-09-16 | Isis Pharmaceuticals, Inc. | Modulation of C-reactive protein expression |
| US6964950B2 (en) | 2001-07-25 | 2005-11-15 | Isis Pharmaceuticals, Inc. | Antisense modulation of C-reactive protein expression |
| US7407943B2 (en) | 2001-08-01 | 2008-08-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein B expression |
| US7176303B2 (en) * | 2003-11-06 | 2007-02-13 | Isis Pharmaceuticals, Inc. | Modulation of STAT5 expression |
| WO2003060160A2 (en) * | 2002-01-18 | 2003-07-24 | Genomar Asa | Verification of fish origin based on nucleic acid pattern recognition |
| EP1470254A2 (de) * | 2002-01-30 | 2004-10-27 | Epigenomics AG | Methode zur analyse von cytosin-methylierungsmustern |
| JP2003289869A (ja) * | 2002-04-02 | 2003-10-14 | Tosoh Corp | 非定型抗酸菌Mycobacteriumavium検出のためのオリゴヌクレオチドおよび検出法 |
| NZ582316A (en) * | 2002-05-06 | 2011-07-29 | Genesis Res & Dev Corp Ltd | Sucrose phosphate synthases (SPS) from Lolium perenne and Festuca arundinacea |
| ES2316501T3 (es) * | 2002-05-21 | 2009-04-16 | Mtm Laboratories Ag | Moleculas marcadoras asociadas con tumores pulmonares. |
| US7199107B2 (en) | 2002-05-23 | 2007-04-03 | Isis Pharmaceuticals, Inc. | Antisense modulation of kinesin-like 1 expression |
| JPWO2003100057A1 (ja) * | 2002-05-28 | 2005-09-22 | 独立行政法人産業技術総合研究所 | 化学物質センサシステム |
| JP2004016054A (ja) * | 2002-06-13 | 2004-01-22 | Takara Bio Inc | ポリペプチドの細胞表面局在化方法 |
| AU2003247303A1 (en) * | 2002-07-17 | 2004-02-02 | Index Pharmaceuticals Ab | Antisense compounds, methods and compositions for treating ngal-related inflammatory disorders |
| EP1403384A1 (de) * | 2002-09-26 | 2004-03-31 | Stichting Researchfonds Pathologie | Verfahren zum Nachweis und zur Karakterisierung von kutanem HPV und Primer und Sonden dafür |
| WO2004029577A2 (en) * | 2002-09-26 | 2004-04-08 | Fmc Corporation | Hemipteran myosin light chain kinase |
| US7511131B2 (en) * | 2002-11-13 | 2009-03-31 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
| US20060009410A1 (en) * | 2002-11-13 | 2006-01-12 | Crooke Rosanne M | Effects of apolipoprotein B inhibition on gene expression profiles in animals |
| US7144999B2 (en) * | 2002-11-23 | 2006-12-05 | Isis Pharmaceuticals, Inc. | Modulation of hypoxia-inducible factor 1 alpha expression |
| CA2743564C (en) | 2003-01-13 | 2013-11-12 | Monsanto Technology Llc | Glyphosate tolerant alfalfa events and methods for detection thereof |
| US7803781B2 (en) * | 2003-02-28 | 2010-09-28 | Isis Pharmaceuticals, Inc. | Modulation of growth hormone receptor expression and insulin-like growth factor expression |
| US7846906B2 (en) | 2003-02-28 | 2010-12-07 | Isis Pharmaceuticals, Inc. | Modulation of growth hormone receptor expression and insulin-like growth factor expression |
| WO2005012343A1 (en) * | 2003-07-10 | 2005-02-10 | Akzo Nobel N.V. | Babesia vaccines |
| DE602004008085T2 (de) * | 2003-08-12 | 2008-04-24 | Antisense Pharma Gmbh | Antisense-oligonukleotid zur hemmung der melanom-inhibierenden aktivität (mia) |
| US8227193B2 (en) * | 2003-10-01 | 2012-07-24 | The Regents Of The University Of California | Compositions and methods for gene expression |
| KR100520994B1 (en) * | 2003-10-27 | 2005-10-13 | Molecular marker associated with CMV resistance and use thereof | |
| ES2801379T3 (es) * | 2003-12-01 | 2021-01-11 | Epigenomics Ag | Métodos y ácidos nucleicos para el análisis de la expresión génica asociada con el desarrollo de trastornos proliferativos de células de próstata |
| US20050164271A1 (en) * | 2004-01-20 | 2005-07-28 | Sanjay Bhanot | Modulation of glucocorticoid receptor expression |
| WO2005094219A2 (en) * | 2004-03-24 | 2005-10-13 | United States Army Medical Research And Materiel Command | Unique chromosomal sequence of bacillus anthracis and methods of making and using thereof including real-time pcr assays |
| AU2005229157B2 (en) * | 2004-03-31 | 2011-07-21 | Commonwealth Scientific And Industrial Research Organisation | Genes involved in plant fibre development |
| US20060021087A1 (en) | 2004-04-09 | 2006-01-26 | Baum James A | Compositions and methods for control of insect infestations in plants |
| US7365058B2 (en) | 2004-04-13 | 2008-04-29 | The Rockefeller University | MicroRNA and methods for inhibiting same |
| PL1745062T3 (pl) * | 2004-04-22 | 2014-10-31 | Regado Biosciences Inc | Ulepszone modulatory czynników krzepnięcia |
| US20050287558A1 (en) * | 2004-05-05 | 2005-12-29 | Crooke Rosanne M | SNPs of apolipoprotein B and modulation of their expression |
| ES2360804T3 (es) * | 2004-05-24 | 2011-06-09 | Anamar Ab | Método para determinar un proceso de degradación tisular mediante la detección de neoepítopos de comp. |
| GB2414400B (en) | 2004-05-28 | 2009-01-14 | Cilag Ag Int | Injection device |
| GB2414399B (en) | 2004-05-28 | 2008-12-31 | Cilag Ag Int | Injection device |
| GB2414402B (en) | 2004-05-28 | 2009-04-22 | Cilag Ag Int | Injection device |
| GB2414401B (en) | 2004-05-28 | 2009-06-17 | Cilag Ag Int | Injection device |
| GB2414403B (en) | 2004-05-28 | 2009-01-07 | Cilag Ag Int | Injection device |
| GB2414406B (en) | 2004-05-28 | 2009-03-18 | Cilag Ag Int | Injection device |
| GB2414775B (en) | 2004-05-28 | 2008-05-21 | Cilag Ag Int | Releasable coupling and injection device |
| US7498315B2 (en) * | 2004-06-01 | 2009-03-03 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| US7807647B2 (en) * | 2004-06-01 | 2010-10-05 | Pronai Therapeutics, Inc. | Methods and compositions for cancer therapy |
| US8815599B2 (en) | 2004-06-01 | 2014-08-26 | Pronai Therapeutics, Inc. | Methods and compositions for the inhibition of gene expression |
| US7547514B2 (en) * | 2004-07-28 | 2009-06-16 | Canon U.S. Life Sciences, Inc. | Methods for monitoring genomic DNA of organisms |
| PL1786472T3 (pl) * | 2004-08-10 | 2013-06-28 | Kastle Therapeutics Llc | Antysensowna modulacja ekspresji apolipoproteiny B |
| US7759479B1 (en) * | 2004-09-13 | 2010-07-20 | Isis Pharmaceuticals, Inc. | Compositions and their uses directed to Gemin Genes |
| KR101138862B1 (ko) * | 2005-02-14 | 2012-05-14 | 삼성전자주식회사 | 단일염기 다형을 포함하는 유방암과 관련된 폴리뉴클레오티드, 그를 포함하는 마이크로어레이 및 진단 키트 및 그를이용한 유방암 진단 방법 |
| CN101163800B (zh) * | 2005-02-18 | 2013-04-17 | 佳能美国生命科学公司 | 鉴定生物的基因组dna的装置和方法 |
| US20070185044A1 (en) * | 2005-03-08 | 2007-08-09 | Dobie Kenneth W | Modulation of ace2 expression |
| GB2425062B (en) | 2005-04-06 | 2010-07-21 | Cilag Ag Int | Injection device |
| GB2424836B (en) | 2005-04-06 | 2010-09-22 | Cilag Ag Int | Injection device (bayonet cap removal) |
| GB2427826B (en) | 2005-04-06 | 2010-08-25 | Cilag Ag Int | Injection device comprising a locking mechanism associated with integrally formed biasing means |
| GB2424835B (en) | 2005-04-06 | 2010-06-09 | Cilag Ag Int | Injection device (modified trigger) |
| GB2424838B (en) | 2005-04-06 | 2011-02-23 | Cilag Ag Int | Injection device (adaptable drive) |
| EP1904639B1 (de) | 2005-07-06 | 2010-05-05 | Nestec S.A. | Dehydringene und promotoren aus kaffee |
| DE602005018480D1 (de) | 2005-08-30 | 2010-02-04 | Cilag Gmbh Int | Nadelvorrichtung für eine vorgefüllte Spritze |
| AU2014277739B2 (en) * | 2005-09-16 | 2017-02-02 | Monsanto Technology Llc | Methods for genetic control of insect infestations in plants and compositions thereof |
| AU2006292362B2 (en) | 2005-09-16 | 2013-02-14 | Monsanto Technology Llc | Methods for genetic control of insect infestations in plants and compositions thereof |
| US20110098656A1 (en) | 2005-09-27 | 2011-04-28 | Burnell Rosie L | Auto-injection device with needle protecting cap having outer and inner sleeves |
| US8658608B2 (en) * | 2005-11-23 | 2014-02-25 | Yale University | Modified triple-helix forming oligonucleotides for targeted mutagenesis |
| CA2631677C (en) | 2005-12-01 | 2014-08-12 | Pronai Therapeutics, Inc. | Amphoteric liposome formulation |
| WO2007109174A2 (en) * | 2006-03-16 | 2007-09-27 | Isis Pharmaceuticals, Inc. | Compositions and methods for modulation of mcl-1 expression |
| EP2023940B1 (de) | 2006-05-05 | 2011-06-22 | Isis Pharmaceuticals, Inc. | Verbindungen und verfahren zur modulation der expression von sglt2 |
| US8084734B2 (en) * | 2006-05-26 | 2011-12-27 | The George Washington University | Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays |
| GB2438590B (en) | 2006-06-01 | 2011-02-09 | Cilag Gmbh Int | Injection device |
| GB2438591B (en) | 2006-06-01 | 2011-07-13 | Cilag Gmbh Int | Injection device |
| GB2438593B (en) | 2006-06-01 | 2011-03-30 | Cilag Gmbh Int | Injection device (cap removal feature) |
| US7745595B2 (en) * | 2006-08-10 | 2010-06-29 | Medical Diagnostic Laboratories, Llc | Compositions and methods for detecting Atopobium vaginae |
| AU2014200037B2 (en) * | 2006-10-10 | 2016-06-02 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Prostate cancer-specific alterations in ERG gene expression and detection and treatment methods based on those alterations |
| US8188255B2 (en) | 2006-10-20 | 2012-05-29 | Exiqon A/S | Human microRNAs associated with cancer |
| WO2008046911A2 (en) * | 2006-10-20 | 2008-04-24 | Exiqon A/S | Novel human micrornas associated with cancer |
| CN101679979A (zh) | 2007-03-24 | 2010-03-24 | 基酶有限公司 | 施用与人载脂蛋白b互补的反义寡核苷酸 |
| US20110059895A1 (en) * | 2007-11-09 | 2011-03-10 | Isis Pharmaceuticals, Inc. | Modulation of factor 9 expression |
| WO2009065511A2 (en) * | 2007-11-23 | 2009-05-28 | Epigenomics Ag | Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders |
| CN102912019B (zh) * | 2007-11-30 | 2016-03-23 | 基因特力株式会社 | 使用膀胱癌特异性甲基化标记基因的膀胱癌诊断试剂盒和芯片 |
| JPWO2009093384A1 (ja) * | 2008-01-24 | 2011-05-26 | 独立行政法人産業技術総合研究所 | ポリヌクレオチド及びポリヌクレオチド類似体並びにこれらを用いた遺伝子発現制御方法 |
| US10150990B2 (en) * | 2008-04-21 | 2018-12-11 | Roche Molecular Systems, Inc. | Ribonucleotide tag nucleic acid detection |
| GB2461086B (en) | 2008-06-19 | 2012-12-05 | Cilag Gmbh Int | Injection device |
| GB2461089B (en) | 2008-06-19 | 2012-09-19 | Cilag Gmbh Int | Injection device |
| GB2461087B (en) | 2008-06-19 | 2012-09-26 | Cilag Gmbh Int | Injection device |
| GB2461084B (en) | 2008-06-19 | 2012-09-26 | Cilag Gmbh Int | Fluid transfer assembly |
| GB2461085B (en) | 2008-06-19 | 2012-08-29 | Cilag Gmbh Int | Injection device |
| US8110796B2 (en) | 2009-01-17 | 2012-02-07 | The George Washington University | Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays |
| GB0901593D0 (en) | 2009-01-30 | 2009-03-11 | Touchlight Genetics Ltd | Production of closed linear DNA |
| KR101805199B1 (ko) * | 2009-02-12 | 2017-12-05 | 큐알엔에이, 인크. | 신경교세포 유래된 신경영양성 인자 (gdnf)에 대한 자연 안티센스 전사체의 저해에 의한 신경교세포 유래된 신경영양성 인자 (gdnf) 관련된 질환의 치료 |
| WO2010093904A2 (en) * | 2009-02-12 | 2010-08-19 | Curna, Inc. | Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf |
| EP2408796B1 (de) | 2009-03-16 | 2020-04-22 | Ionis Pharmaceuticals, Inc. | Targeting Apolipoprotein B für die Reduktion von Apolipoprotein C-III |
| US9490113B2 (en) * | 2009-04-07 | 2016-11-08 | The George Washington University | Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry |
| ES2585360T3 (es) * | 2009-08-05 | 2016-10-05 | Curna, Inc. | Tratamiento de enfermedades relacionadas con un gen de la insulina (INS) por inhibición de la transcripción antisentido natural en un gen de la insulina (INS) |
| EP2322656A1 (de) * | 2009-11-17 | 2011-05-18 | Centre National de la Recherche Scientifique (C.N.R.S) | Verfahren zur Diagnose von Hautkrankheiten |
| GB201008719D0 (en) * | 2010-05-25 | 2010-07-07 | Nat Univ Ireland | Diagnostic method |
| CN107898791A (zh) | 2010-06-03 | 2018-04-13 | 药品循环有限责任公司 | 布鲁顿酪氨酸激酶(btk)抑制剂的应用 |
| WO2011163499A2 (en) * | 2010-06-23 | 2011-12-29 | Opko Curna, Llc | Treatment of sodium channel, voltage-gated, alpha subunit (scna) related diseases by inhibition of natural antisense transcript to scna |
| WO2012012467A2 (en) | 2010-07-19 | 2012-01-26 | Isis Pharmaceuticals, Inc. | Modulation of nuclear-retained rna |
| GB201013153D0 (en) * | 2010-08-04 | 2010-09-22 | Touchlight Genetics Ltd | Primer for production of closed linear DNA |
| AU2010360293B2 (en) * | 2010-09-06 | 2016-06-16 | Temasek Life Sciences Laboratory Limited | Molecular interaction between Xa10 and AvrXa10 |
| WO2012038827A2 (en) * | 2010-09-20 | 2012-03-29 | Prognomix Inc. | Genes linking several complications of type-2 diabetes (t2d) |
| US8648053B2 (en) * | 2010-10-20 | 2014-02-11 | Rosalind Franklin University Of Medicine And Science | Antisense oligonucleotides that target a cryptic splice site in Ush1c as a therapeutic for Usher syndrome |
| US8916344B2 (en) | 2010-11-15 | 2014-12-23 | Exact Sciences Corporation | Methylation assay |
| CA3077910A1 (en) * | 2010-11-17 | 2012-05-24 | Ionis Pharmaceuticals, Inc. | Modulation of alpha synuclein expression |
| AU2013206424B2 (en) * | 2010-11-24 | 2015-09-17 | E. I. Du Pont De Nemours And Company | Brassica gat event dp-073496-4 and compositions and methods for the identification and/or detection thereof |
| EP2663658B1 (de) * | 2011-01-12 | 2017-10-25 | Abbott Molecular Inc. | Materialen und verfahren zum nachweis von cytomegalovirus (cmv) |
| US9157125B2 (en) | 2011-02-02 | 2015-10-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | GRIN2A mutations and use thereof for the diagnosis of melanoma |
| MY185926A (en) * | 2011-07-15 | 2021-06-14 | Acgt Sdn Bhd | Ssr markers for plants and uses thereof |
| NZ621638A (en) * | 2011-08-25 | 2016-03-31 | Clinical Genomics Pty Ltd | Dna methylation in colorectal and breast cancer diagnostic methods |
| ES2796556T3 (es) | 2011-09-20 | 2020-11-27 | Ionis Pharmaceuticals Inc | Modulación antisentido de la expresión de GCGR |
| HUE039835T2 (hu) | 2011-10-17 | 2019-02-28 | Novozymes As | Alfa-amiláz variánsok és az azokat kódoló polinukleotidok |
| EP2776450B1 (de) | 2011-11-10 | 2018-04-04 | Shire Human Genetic Therapies, Inc. | Antisense-oligonukleotidmodulatoren des serotoninrezeptors 2c und verwendungen davon |
| EP2791365A1 (de) * | 2011-12-14 | 2014-10-22 | De Staat der Nederlanden, Vert. Door de Minister van VWS | Identifikation von poliovirus-strängen |
| AU2013203395A1 (en) | 2012-03-30 | 2013-10-17 | Isis Pharmaceuticals, Inc. | Compositions and methods for modulating TAU expression for reducing seizure and modifying a neurodegenerative syndrome |
| AU2013262709A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating MECP2 expression |
| CA2873769A1 (en) | 2012-05-16 | 2013-11-21 | Rana Therapeutics Inc. | Compositions and methods for modulating hemoglobin gene family expression |
| BR112014028634A2 (pt) | 2012-05-16 | 2017-06-27 | Rana Therapeutics Inc | composições e métodos para modulação da expressão de utrn |
| JP2015523854A (ja) | 2012-05-16 | 2015-08-20 | ラナ セラピューティクス インコーポレイテッド | Smn遺伝子ファミリー発現を調節するための組成物及び方法 |
| CA2873766A1 (en) | 2012-05-16 | 2013-11-21 | Rana Therapeutics Inc. | Compositions and methods for modulating atp2a2 expression |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| WO2014018375A1 (en) * | 2012-07-23 | 2014-01-30 | Xenon Pharmaceuticals Inc. | Cyp8b1 and uses thereof in therapeutic and diagnostic methods |
| CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
| JP6470044B2 (ja) * | 2012-09-03 | 2019-02-13 | 国立大学法人九州大学 | がんに対する免疫療法の有効性の予測方法 |
| SG10201706960TA (en) * | 2013-02-28 | 2017-10-30 | Arrowhead Res Corp | Organic compositions to treat epas1-related diseases |
| US9359643B2 (en) | 2013-03-08 | 2016-06-07 | Progenika Biopharma S.A. | Discrimination of blood type variants |
| US20160108478A1 (en) * | 2013-03-14 | 2016-04-21 | Cepheid | Methods of detecting lung cancer |
| ES2807379T3 (es) * | 2013-03-14 | 2021-02-22 | Ionis Pharmaceuticals Inc | Composiciones y métodos para regular la expresión de Tau |
| US9657098B2 (en) | 2013-03-15 | 2017-05-23 | Intrinsic Lifesciences, Llc | Anti-hepcidin antibodies and uses thereof |
| GB2517896B (en) | 2013-06-11 | 2015-07-08 | Cilag Gmbh Int | Injection device |
| GB2515039B (en) | 2013-06-11 | 2015-05-27 | Cilag Gmbh Int | Injection Device |
| GB2515032A (en) | 2013-06-11 | 2014-12-17 | Cilag Gmbh Int | Guide for an injection device |
| GB2515038A (en) | 2013-06-11 | 2014-12-17 | Cilag Gmbh Int | Injection device |
| WO2015188899A1 (en) * | 2014-06-12 | 2015-12-17 | Deutsches Krebsforschungszentrum | Novel ttv mirna sequences as an early marker for the future development of cancer and as a target for cancer treatment and prevention |
| EP3017044B1 (de) * | 2013-07-02 | 2020-02-26 | Ionis Pharmaceuticals, Inc. | Modulatoren des wachstumshormonrezeptors |
| TWI772856B (zh) | 2013-07-19 | 2022-08-01 | 美商百健Ma公司 | 用於調節τ蛋白表現之組合物 |
| TW201536329A (zh) | 2013-08-09 | 2015-10-01 | Isis Pharmaceuticals Inc | 用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法 |
| GB201315527D0 (en) * | 2013-08-30 | 2013-10-16 | Sec Dep For Health The | Assay for the detection of infection-causing e.coli strains |
| US11162096B2 (en) | 2013-10-14 | 2021-11-02 | Ionis Pharmaceuticals, Inc | Methods for modulating expression of C9ORF72 antisense transcript |
| CA2924277A1 (en) * | 2013-10-18 | 2015-04-23 | Institut De Cardiologie De Montreal | Genotyping tests and methods for evaluating plasma creatine kinase levels |
| US20160186261A1 (en) * | 2013-11-04 | 2016-06-30 | Jose U. Scher | Prevotella copri and enhanced susceptibility to arthritis |
| WO2015143400A1 (en) * | 2014-03-20 | 2015-09-24 | Pharmacyclics, Inc. | Phospholipase c gamma 2 and resistance associated mutations |
| RS60707B1 (sr) | 2014-04-01 | 2020-09-30 | Biogen Ma Inc | Kompozicije za modulaciju ekspresije sod-1 |
| CN110903337A (zh) | 2014-05-01 | 2020-03-24 | Ionis制药公司 | 用于调节生长激素受体表达的组合物和方法 |
| US10329570B2 (en) * | 2014-07-31 | 2019-06-25 | Academia Sinica | Antagonistic PD-1 aptamer and its applications in cancer therapy related applications |
| WO2016034611A1 (en) * | 2014-09-02 | 2016-03-10 | Max-Delbrück-Centrum für Molekulare Medizin | Antisense oligonucleotides targeting 3'utr region of a20 |
| AU2015321462B2 (en) | 2014-09-22 | 2020-04-30 | Intrinsic Lifesciences Llc | Humanized anti-hepcidin antibodies and uses thereof |
| EP3221700B1 (de) * | 2014-11-18 | 2022-06-22 | Blueprint Medicines Corporation | Fusionen von prkacb |
| PY1671153A (es) * | 2015-11-02 | 2018-04-02 | Monsanto Technology Llc | Evento transgénico de algodón mon 88702 y métodos de detección y usos del mismo |
| US11136597B2 (en) | 2016-02-16 | 2021-10-05 | Yale University | Compositions for enhancing targeted gene editing and methods of use thereof |
| JP7672192B2 (ja) | 2016-06-08 | 2025-05-07 | ユニバーシティー オブ アイオワ リサーチ ファンデーション | 心血管疾患の素因を検出するための組成物および方法 |
| ES2963428T3 (es) | 2016-09-29 | 2024-03-27 | Biogen Ma Inc | Compuestos y métodos para reducir la expresión de Tau |
| CN110191952A (zh) | 2016-10-07 | 2019-08-30 | 瑟卡尔纳制药有限公司 | 治疗癌症的新方法 |
| WO2018187493A1 (en) | 2017-04-04 | 2018-10-11 | Yale University | Compositions and methods for in utero delivery |
| NO344051B1 (en) * | 2017-05-04 | 2019-08-26 | Patogen As | Novel virus in Fish and Method for detection |
| CA3073705A1 (en) | 2017-05-11 | 2018-11-15 | The Research Foundation For The State University Of New York | Compositions and methods for loading extracellular vesicles with chemical and biological agents/molecules |
| GB201708617D0 (en) * | 2017-05-31 | 2017-07-12 | Blue Genomics Chile Spa | Salmonid genetics |
| GB201711782D0 (en) * | 2017-07-21 | 2017-09-06 | Ucl Business Plc | Diagnostic and Prognostic methods |
| TWI809004B (zh) | 2017-11-09 | 2023-07-21 | 美商Ionis製藥公司 | 用於降低snca表現之化合物及方法 |
| EA202091693A1 (ru) | 2018-01-12 | 2021-04-14 | Бристол-Маерс Сквибб Компани | Антисмысловые олигонуклеотиды, целенаправленно воздействующие на альфа-синуклеин, и их применения |
| BR112020013994A2 (pt) | 2018-01-12 | 2020-12-08 | Bristol-Myers Squibb Company | Oligonucleotídeos antissenso que direcionam alfa-sinucleína e seus usos |
| TWI840345B (zh) | 2018-03-02 | 2024-05-01 | 美商Ionis製藥公司 | Irf4表現之調節劑 |
| CA3094020A1 (en) | 2018-04-11 | 2019-10-17 | Ionis Pharmaceuticals, Inc. | Modulators of ezh2 expression |
| WO2019204256A1 (en) | 2018-04-18 | 2019-10-24 | Pioneer Hi-Bred International, Inc. | Improving agronomic characteristics in maize by modification of endogenous mads box transcription factors |
| WO2019204253A1 (en) | 2018-04-18 | 2019-10-24 | Pioneer Hi-Bred International, Inc. | Genes, constructs and maize event dp-202216-6 |
| TWI832851B (zh) * | 2018-05-18 | 2024-02-21 | 韓商奧利通公司 | 基質金屬蛋白酶-1之反義寡核苷酸 |
| WO2019233922A1 (en) * | 2018-06-05 | 2019-12-12 | F. Hoffmann-La Roche Ag | Oligonucleotides for modulating atxn2 expression |
| TW202028222A (zh) | 2018-11-14 | 2020-08-01 | 美商Ionis製藥公司 | Foxp3表現之調節劑 |
| EP3899024A4 (de) * | 2018-12-21 | 2023-05-31 | Ionis Pharmaceuticals, Inc. | Modulatoren der hsd17b13-expression |
| EP3693465A1 (de) * | 2019-02-05 | 2020-08-12 | Pharmaq AS | Neuartiger fisch-coronavirus |
| US20220195431A1 (en) * | 2019-02-22 | 2022-06-23 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing atxn3 expression |
| CN111718929B (zh) * | 2019-03-20 | 2022-10-18 | 中国科学院上海营养与健康研究所 | 利用环形rna进行蛋白翻译及其应用 |
| US11286485B2 (en) | 2019-04-04 | 2022-03-29 | Hoffmann-La Roche Inc. | Oligonucleotides for modulating ATXN2 expression |
| CN110343764B (zh) * | 2019-07-22 | 2020-05-26 | 武汉艾米森生命科技有限公司 | 检测结直肠癌相关基因甲基化的检测试剂的应用和试剂盒 |
| US20210024985A1 (en) * | 2019-07-26 | 2021-01-28 | Emory University | Devices and Methods Useful for Imaging Transient and Rare Mechanical Events in Cells |
| JP7386507B2 (ja) * | 2019-08-02 | 2023-11-27 | 国立大学法人信州大学 | 筋分化促進剤および筋分化促進方法および筋分化促進オリゴdna |
| WO2021154674A1 (en) * | 2020-01-27 | 2021-08-05 | Pioneer Hi-Bred International, Inc. | Maize event dp-056113-9 and methods of use thereof |
| US12559804B2 (en) * | 2020-02-17 | 2026-02-24 | Neogen Food Safety Us Holdco Corporation | Loop-mediated isothermal amplification primers for vibrio parahaemolyticus detection and uses thereof |
| DE102020108560B4 (de) * | 2020-03-27 | 2022-03-03 | Precision For Medicine Gmbh | CBX6 als epigenetischer Marker für die Identifizierung von Immunzellen, insbesondere Gedächtnis-B-Zellen |
| CN116368227A (zh) * | 2020-07-22 | 2023-06-30 | 弗洛里神经科学与心理健康研究所 | 用于治疗与scn2a中功能失去突变相关的障碍的组合物和方法 |
| CN116490622A (zh) * | 2020-09-04 | 2023-07-25 | 爱荷华大学研究基金会 | 用于预测和/或监测糖尿病及其治疗的方法和组合物 |
| CA3227115A1 (en) | 2021-07-21 | 2023-01-26 | Wen-Hsuan Chang | Unc13a antisense oligonucleotides |
| EP4396352A4 (de) | 2021-09-01 | 2025-10-01 | Ionis Pharmaceuticals Inc | Verbindungen und verfahren zur reduzierung der dmpk-expression |
| WO2024098031A1 (en) * | 2022-11-03 | 2024-05-10 | Camp4 Therapeutics Corporation | Modulation of abcb11 gene transcription using antisense oligonucleotides targeting regulatory rnas |
| AU2023385466A1 (en) * | 2022-11-22 | 2025-05-01 | Pioneer Hi-Bred International, Inc. | Maize event dp-051291-2 and methods for detection thereof |
| EP4431601A1 (de) * | 2023-03-17 | 2024-09-18 | Limagrain Europe | Verfahren zum ausschalten eines gens durch gezielte insertion von stopcodons |
| WO2025097032A2 (en) * | 2023-11-03 | 2025-05-08 | Forge Biologics, Inc. | Modified kozak sequences for production of recombinant aav |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995011995A1 (en) * | 1993-10-26 | 1995-05-04 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
| WO1999028498A2 (de) * | 1997-11-27 | 1999-06-10 | Epigenomics Gmbh | Verfahren zur herstellung komplexer dna-methylierungs-fingerabdrücke |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582908B2 (en) * | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
-
2001
- 2001-04-06 AU AU2001250572A patent/AU2001250572A1/en not_active Abandoned
- 2001-04-06 WO PCT/IB2001/000713 patent/WO2001077384A2/de not_active Ceased
- 2001-04-06 EP EP01923891A patent/EP1268856A2/de not_active Withdrawn
- 2001-04-06 US US10/257,017 patent/US20040241651A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995011995A1 (en) * | 1993-10-26 | 1995-05-04 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
| WO1999028498A2 (de) * | 1997-11-27 | 1999-06-10 | Epigenomics Gmbh | Verfahren zur herstellung komplexer dna-methylierungs-fingerabdrücke |
Non-Patent Citations (4)
| Title |
|---|
| HERMAN J G ET AL: "METHYLATION-SPECIFIC PCR: A NOVEL PCR ASSAY FOR METHYLATION STATUS OF CPG ISLANDS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, 1 September 1996 (1996-09-01), pages 9821 - 9826, XP002910406, ISSN: 0027-8424 * |
| NIEMEYER C M ET AL: "DNA MICROARRAYS**", ANGEWANDTE CHEMIE, VCH VERLAGSGESELLSCHAFT, WEINHEIM, DE, vol. 38, no. 19, 1999, pages 3039 - 3043, XP000961724, ISSN: 0044-8249 * |
| REIN ET AL: "Identifying 5-methylcytosine and related modifications in DNA genomes", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 26, no. 10, 1998, pages 2255 - 2264, XP002143106, ISSN: 0305-1048 * |
| WANG D G ET AL: "Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 280, 1998, pages 1077 - 1082, XP002089398, ISSN: 0036-8075 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7888324B2 (en) | 2001-08-01 | 2011-02-15 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
| US9206478B2 (en) | 2002-12-31 | 2015-12-08 | Branhaven LLC | Methods and systems for inferring bovine traits |
| US9175291B2 (en) | 2012-10-11 | 2015-11-03 | Isis Pharmaceuticals Inc. | Modulation of androgen receptor expression |
Also Published As
| Publication number | Publication date |
|---|---|
| US20040241651A1 (en) | 2004-12-02 |
| WO2001077384A2 (de) | 2001-10-18 |
| AU2001250572A1 (en) | 2001-10-23 |
| EP1268856A2 (de) | 2003-01-02 |
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