WO2002044192A1 - Glucopyranosyloxybenzyl benzene derivatives, medicinal compositions containing the same and intermediates in the production thereof - Google Patents
Glucopyranosyloxybenzyl benzene derivatives, medicinal compositions containing the same and intermediates in the production thereof Download PDFInfo
- Publication number
- WO2002044192A1 WO2002044192A1 PCT/JP2001/010115 JP0110115W WO0244192A1 WO 2002044192 A1 WO2002044192 A1 WO 2002044192A1 JP 0110115 W JP0110115 W JP 0110115W WO 0244192 A1 WO0244192 A1 WO 0244192A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optionally substituted
- substituted lower
- intermediates
- production
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/432,905 US7053060B2 (en) | 2000-11-30 | 2001-11-20 | Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof |
| CA002429833A CA2429833A1 (en) | 2000-11-30 | 2001-11-20 | Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof |
| JP2002546562A JP4212891B2 (ja) | 2000-11-30 | 2001-11-20 | グルコピラノシルオキシベンジルベンゼン誘導体、それを含有する医薬組成物およびその製造中間体 |
| AU2002223127A AU2002223127A1 (en) | 2000-11-30 | 2001-11-20 | Glucopyranosyloxybenzyl benzene derivatives, medicinal compositions containing the same and intermediates in the production thereof |
| EP01998555A EP1344780A4 (en) | 2000-11-30 | 2001-11-20 | GLUCOPYRANOSYLOXYBENZYLBENZOLE DERIVATIVES, MEDICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND INTERMEDIATE PRODUCTS FOR THEIR PREPARATION |
| US10/978,413 US7129381B2 (en) | 2000-11-30 | 2004-11-02 | Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000366192 | 2000-11-30 | ||
| JP2000-366192 | 2000-11-30 | ||
| JP2000380482 | 2000-12-14 | ||
| JP2000-380482 | 2000-12-14 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US10432905 A-371-Of-International | 2001-11-20 | ||
| US10/978,413 Division US7129381B2 (en) | 2000-11-30 | 2004-11-02 | Glucopyranosyloxybenzylbenzene derivatives, medicinal compositions containing the same and intermediates in the production thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2002044192A1 true WO2002044192A1 (en) | 2002-06-06 |
Family
ID=26605024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2001/010115 Ceased WO2002044192A1 (en) | 2000-11-30 | 2001-11-20 | Glucopyranosyloxybenzyl benzene derivatives, medicinal compositions containing the same and intermediates in the production thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7053060B2 (ja) |
| EP (1) | EP1344780A4 (ja) |
| JP (1) | JP4212891B2 (ja) |
| AR (1) | AR034280A1 (ja) |
| AU (1) | AU2002223127A1 (ja) |
| CA (1) | CA2429833A1 (ja) |
| PE (1) | PE20020573A1 (ja) |
| TW (1) | TWI290556B (ja) |
| WO (1) | WO2002044192A1 (ja) |
Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1367060A4 (en) * | 2001-02-14 | 2004-04-14 | Kissei Pharmaceutical | GLUCOPYRANOSYLOXYBENZYLBENZENE DERIVATIVES AND THEIR MEDICAL USE |
| WO2004050122A1 (ja) * | 2002-12-04 | 2004-06-17 | Kissei Pharmaceutical Co., Ltd. | 高血糖症に起因する疾患の予防又は治療剤 |
| JP2004196788A (ja) * | 2002-12-04 | 2004-07-15 | Kissei Pharmaceut Co Ltd | ベンジルフェノール誘導体、それを含有する医薬組成物およびその医薬用途 |
| WO2004099230A1 (en) * | 2003-05-12 | 2004-11-18 | Fujisawa Pharmaceutical Co., Ltd. | Monosaccharide compounds |
| JP2006510643A (ja) * | 2002-12-12 | 2006-03-30 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 新しい芳香族フルオログリコシド誘導体、該化合物を含有する医薬品、およびその使用 |
| JP2006510644A (ja) * | 2002-12-12 | 2006-03-30 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 新しい複素環フルオログリコシド誘導体、該化合物を含有する医薬品、およびその使用 |
| JP2006232825A (ja) * | 2005-01-31 | 2006-09-07 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| JP2007518682A (ja) * | 2003-08-01 | 2007-07-12 | 田辺製薬株式会社 | 新規化合物 |
| WO2007128761A2 (de) | 2006-05-04 | 2007-11-15 | Boehringer Ingelheim International Gmbh | Verwendungen von dpp iv inhibitoren |
| WO2007147478A1 (de) | 2006-06-23 | 2007-12-27 | Merck Patent Gmbh | 3 -amino- imidazo [1, 2-a] pyridinderivate als sglt inhibitoren |
| WO2008016132A1 (fr) | 2006-08-04 | 2008-02-07 | Daiichi Sankyo Company, Limited | Dérivé du benzyl phényl glucopyranoside |
| JPWO2005095429A1 (ja) * | 2004-03-31 | 2008-02-21 | キッセイ薬品工業株式会社 | フェノール誘導体、それを含有する医薬組成物及びその医薬用途 |
| WO2008070692A2 (en) | 2006-12-06 | 2008-06-12 | Smithkline Beecham Corporation | Bicyclic compounds and use as antidiabetics |
| DE102007008420A1 (de) | 2007-02-21 | 2008-08-28 | Merck Patent Gmbh | Benzimidazolderivate |
| WO2009049731A1 (de) | 2007-10-11 | 2009-04-23 | Merck Patent Gmbh | Imidazo [ 1, 2 -a] pyrimidinderivate zur behandlung von erkrankungen wie diabetes |
| WO2009096503A1 (ja) * | 2008-01-31 | 2009-08-06 | Daiichi Sankyo Company, Limited | ベンジルフェニルグルコピラノシド誘導体 |
| DE102008017590A1 (de) | 2008-04-07 | 2009-10-08 | Merck Patent Gmbh | Glucopyranosidderivate |
| US7767651B2 (en) | 2005-01-28 | 2010-08-03 | Chugai Seiyaku Kabushiki Kaisha | Spiroketal derivatives and use thereof as diabetic medicine |
| WO2011039338A2 (en) | 2009-10-02 | 2011-04-07 | Sanofi-Aventis | Use of compounds with sglt-1/sglt-2 inhibitor activity for producing medicaments for treatment of bone diseases |
| WO2011051864A1 (en) | 2009-11-02 | 2011-05-05 | Pfizer Inc. | Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2774619A1 (de) | 2013-03-04 | 2014-09-10 | BioActive Food GmbH | Zusammensetzung zur Behandlung von hyperglykämischen Erkrankungen |
| US9061060B2 (en) | 2008-07-15 | 2015-06-23 | Theracos Inc. | Deuterated benzylbenzene derivatives and methods of use |
| EP2944311A1 (de) | 2014-05-16 | 2015-11-18 | BioActive Food GmbH | Kombination von biologisch aktiven Substanzen zur Behandlung von hyperglykämischen Erkrankungen |
| US9573959B2 (en) | 2013-03-14 | 2017-02-21 | Msd International Gmbh | Methods for preparing SGLT2 inhibitors |
| WO2023222144A1 (zh) * | 2022-05-18 | 2023-11-23 | 上海科利生物医药有限公司 | 一类硫代糖苷列净类似物及其制备方法和应用 |
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|---|---|---|---|---|
| CN1020944C (zh) | 1990-01-30 | 1993-05-26 | 阿图尔-费希尔股份公司费希尔厂 | 紧固件 |
| WO2002044192A1 (en) * | 2000-11-30 | 2002-06-06 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxybenzyl benzene derivatives, medicinal compositions containing the same and intermediates in the production thereof |
| US7371732B2 (en) * | 2003-12-22 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Glucopyranosyloxy-substituted aromatic compounds, medicaments containing such compounds, their use and process for their manufacture |
| EA011158B1 (ru) | 2004-03-16 | 2009-02-27 | Бёрингер Ингельхайм Интернациональ Гмбх | Замещённые глюкопиранозилом бензольные производные, содержащие эти соединения лекарственные средства, их применение и способ их получения |
| TW200606129A (en) | 2004-07-26 | 2006-02-16 | Chugai Pharmaceutical Co Ltd | Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same |
| JP2008524162A (ja) | 2004-12-16 | 2008-07-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルコピラノシル置換ベンゼン誘導体、該化合物を含む薬物、その使用及びその製造方法 |
| JP5264183B2 (ja) | 2005-02-23 | 2013-08-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グルコピラノシル置換（（ヘテロ）アリールエチニル−ベンジル）−ベンゼン誘導体及びナトリウム依存性グルコース共輸送体２（ｓｇｌｔ２）インヒビターとしてのそれらの使用 |
| WO2006108842A1 (en) | 2005-04-15 | 2006-10-19 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted (heteroaryloxy-benzyl)-benzene derivatives as sglt inhibitors |
| UA91546C2 (uk) | 2005-05-03 | 2010-08-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ |
| US7723309B2 (en) | 2005-05-03 | 2010-05-25 | Boehringer Ingelheim International Gmbh | Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments |
| US7772191B2 (en) | 2005-05-10 | 2010-08-10 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein |
| EP1910390B1 (en) | 2005-07-27 | 2010-05-19 | Boehringer Ingelheim International GmbH | Glucopyranosyl-substituted ((hetero)cycloalyklethynyl-benzyl)-benzene derivatives and use thereof as sodium-dependent glucose cotransporter (sglt) inhibitors |
| JP5175191B2 (ja) | 2005-08-30 | 2013-04-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グリコピラノシル置換ベンジルベンゼン誘導体、該化合物を含有する医薬品及びその使用と製造方法 |
| BRPI0615882A2 (pt) | 2005-09-08 | 2011-05-31 | Boehringer Ingelheim Int | formas cristalinas de 1-cloro-4-(beta-d-glicopiranos-1-il)-2-(4-etinil-benzil)- benzeno, métodos para sua preparação e o uso para preparar medicamentos do mesmo |
| AR056195A1 (es) | 2005-09-15 | 2007-09-26 | Boehringer Ingelheim Int | Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos |
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| CN121175053A (zh) | 2023-05-24 | 2025-12-19 | 勃林格殷格翰动物保健有限公司 | 包含一或多种sglt-2抑制剂及替米沙坦的非人类哺乳动物中肾脏疾病和/或高血压的组合治疗和/或预防 |
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- 2001-11-20 EP EP01998555A patent/EP1344780A4/en not_active Withdrawn
- 2001-11-20 US US10/432,905 patent/US7053060B2/en not_active Expired - Fee Related
- 2001-11-20 AU AU2002223127A patent/AU2002223127A1/en not_active Abandoned
- 2001-11-20 CA CA002429833A patent/CA2429833A1/en not_active Abandoned
- 2001-11-20 JP JP2002546562A patent/JP4212891B2/ja not_active Expired - Fee Related
- 2001-11-29 TW TW090129522A patent/TWI290556B/zh not_active IP Right Cessation
- 2001-11-29 PE PE2001001204A patent/PE20020573A1/es not_active Application Discontinuation
- 2001-11-29 AR ARP010105567A patent/AR034280A1/es not_active Application Discontinuation
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2004
- 2004-11-02 US US10/978,331 patent/US20050113315A1/en not_active Abandoned
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Cited By (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7541341B2 (en) | 2001-02-14 | 2009-06-02 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof |
| EP1367060A4 (en) * | 2001-02-14 | 2004-04-14 | Kissei Pharmaceutical | GLUCOPYRANOSYLOXYBENZYLBENZENE DERIVATIVES AND THEIR MEDICAL USE |
| WO2004050122A1 (ja) * | 2002-12-04 | 2004-06-17 | Kissei Pharmaceutical Co., Ltd. | 高血糖症に起因する疾患の予防又は治療剤 |
| JP2004196788A (ja) * | 2002-12-04 | 2004-07-15 | Kissei Pharmaceut Co Ltd | ベンジルフェノール誘導体、それを含有する医薬組成物およびその医薬用途 |
| US7288528B2 (en) | 2002-12-12 | 2007-10-30 | Sanofi-Aventis Deutschland Gmbh | Aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof |
| JP2006510644A (ja) * | 2002-12-12 | 2006-03-30 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 新しい複素環フルオログリコシド誘導体、該化合物を含有する医薬品、およびその使用 |
| JP2006510643A (ja) * | 2002-12-12 | 2006-03-30 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 新しい芳香族フルオログリコシド誘導体、該化合物を含有する医薬品、およびその使用 |
| WO2004099230A1 (en) * | 2003-05-12 | 2004-11-18 | Fujisawa Pharmaceutical Co., Ltd. | Monosaccharide compounds |
| JP2007518682A (ja) * | 2003-08-01 | 2007-07-12 | 田辺製薬株式会社 | 新規化合物 |
| JPWO2005095429A1 (ja) * | 2004-03-31 | 2008-02-21 | キッセイ薬品工業株式会社 | フェノール誘導体、それを含有する医薬組成物及びその医薬用途 |
| US7767651B2 (en) | 2005-01-28 | 2010-08-03 | Chugai Seiyaku Kabushiki Kaisha | Spiroketal derivatives and use thereof as diabetic medicine |
| JP2006232825A (ja) * | 2005-01-31 | 2006-09-07 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| WO2007128761A2 (de) | 2006-05-04 | 2007-11-15 | Boehringer Ingelheim International Gmbh | Verwendungen von dpp iv inhibitoren |
| EP2397142A2 (de) | 2006-05-04 | 2011-12-21 | Boehringer Ingelheim International GmbH | Verwendungen von DPP IV Inhibitoren |
| EP2351568A2 (de) | 2006-05-04 | 2011-08-03 | Boehringer Ingelheim International GmbH | Verwendungen von dpp iv Inhibitoren |
| WO2007147478A1 (de) | 2006-06-23 | 2007-12-27 | Merck Patent Gmbh | 3 -amino- imidazo [1, 2-a] pyridinderivate als sglt inhibitoren |
| WO2008016132A1 (fr) | 2006-08-04 | 2008-02-07 | Daiichi Sankyo Company, Limited | Dérivé du benzyl phényl glucopyranoside |
| EP2325182A1 (en) | 2006-12-06 | 2011-05-25 | Glaxosmithkline LLC | Bicyclic compounds and use as antidiabetics |
| WO2008070692A2 (en) | 2006-12-06 | 2008-06-12 | Smithkline Beecham Corporation | Bicyclic compounds and use as antidiabetics |
| DE102007008420A1 (de) | 2007-02-21 | 2008-08-28 | Merck Patent Gmbh | Benzimidazolderivate |
| DE102007048716A1 (de) | 2007-10-11 | 2009-04-23 | Merck Patent Gmbh | Imidazo[1,2-a]pyrimidinderivate |
| WO2009049731A1 (de) | 2007-10-11 | 2009-04-23 | Merck Patent Gmbh | Imidazo [ 1, 2 -a] pyrimidinderivate zur behandlung von erkrankungen wie diabetes |
| WO2009096503A1 (ja) * | 2008-01-31 | 2009-08-06 | Daiichi Sankyo Company, Limited | ベンジルフェニルグルコピラノシド誘導体 |
| DE102008017590A1 (de) | 2008-04-07 | 2009-10-08 | Merck Patent Gmbh | Glucopyranosidderivate |
| WO2009124638A1 (de) | 2008-04-07 | 2009-10-15 | Merck Patent Gmbh | Glucopyranosidderivate |
| US9061060B2 (en) | 2008-07-15 | 2015-06-23 | Theracos Inc. | Deuterated benzylbenzene derivatives and methods of use |
| WO2011039338A2 (en) | 2009-10-02 | 2011-04-07 | Sanofi-Aventis | Use of compounds with sglt-1/sglt-2 inhibitor activity for producing medicaments for treatment of bone diseases |
| WO2011051864A1 (en) | 2009-11-02 | 2011-05-05 | Pfizer Inc. | Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2774619A1 (de) | 2013-03-04 | 2014-09-10 | BioActive Food GmbH | Zusammensetzung zur Behandlung von hyperglykämischen Erkrankungen |
| US9573959B2 (en) | 2013-03-14 | 2017-02-21 | Msd International Gmbh | Methods for preparing SGLT2 inhibitors |
| EP3466431A1 (en) | 2013-03-14 | 2019-04-10 | MSD International GmbH | Crystalline forms and methods for preparing sglt2 inhibitors |
| EP2944311A1 (de) | 2014-05-16 | 2015-11-18 | BioActive Food GmbH | Kombination von biologisch aktiven Substanzen zur Behandlung von hyperglykämischen Erkrankungen |
| WO2015173383A1 (de) | 2014-05-16 | 2015-11-19 | Bioactive Food Gmbh | Kombination von biologisch aktiven substanzen zur behandlung von hyperglykämischen erkrankungen |
| WO2023222144A1 (zh) * | 2022-05-18 | 2023-11-23 | 上海科利生物医药有限公司 | 一类硫代糖苷列净类似物及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20050059614A1 (en) | 2005-03-17 |
| JPWO2002044192A1 (ja) | 2004-04-02 |
| EP1344780A1 (en) | 2003-09-17 |
| JP4212891B2 (ja) | 2009-01-21 |
| CA2429833A1 (en) | 2002-06-06 |
| EP1344780A4 (en) | 2004-01-28 |
| US7129381B2 (en) | 2006-10-31 |
| US20050113315A1 (en) | 2005-05-26 |
| PE20020573A1 (es) | 2002-07-31 |
| US20040063170A1 (en) | 2004-04-01 |
| AU2002223127A1 (en) | 2002-06-11 |
| US7053060B2 (en) | 2006-05-30 |
| TWI290556B (en) | 2007-12-01 |
| AR034280A1 (es) | 2004-02-18 |
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