WO2002100833A1 - Rho KINASE INHIBITORS - Google Patents

Rho KINASE INHIBITORS Download PDF

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Publication number
WO2002100833A1
WO2002100833A1 PCT/JP2002/005609 JP0205609W WO02100833A1 WO 2002100833 A1 WO2002100833 A1 WO 2002100833A1 JP 0205609 W JP0205609 W JP 0205609W WO 02100833 A1 WO02100833 A1 WO 02100833A1
Authority
WO
WIPO (PCT)
Prior art keywords
substituted
hydrogen
unsubstituted alkyl
rho kinase
kinase inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/005609
Other languages
English (en)
French (fr)
Inventor
Naonori Imazaki
Masafumi Kitano
Naohito Ohashi
Kazuki Matsui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Priority to EP02733352A priority Critical patent/EP1403255A4/en
Priority to JP2003503602A priority patent/JPWO2002100833A1/ja
Priority to US10/480,526 priority patent/US7199147B2/en
Publication of WO2002100833A1 publication Critical patent/WO2002100833A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
PCT/JP2002/005609 2001-06-12 2002-06-06 Rho KINASE INHIBITORS Ceased WO2002100833A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP02733352A EP1403255A4 (en) 2001-06-12 2002-06-06 RHO KINASE INHIBITORS
JP2003503602A JPWO2002100833A1 (ja) 2001-06-12 2002-06-06 Ｒｈｏキナーゼ阻害剤
US10/480,526 US7199147B2 (en) 2001-06-12 2002-06-06 Rho kinase inhibitors

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001176826 2001-06-12
JP2001-176826 2001-06-12
JP2001398992 2001-12-28
JP2001-398992 2001-12-28

Publications (1)

Publication Number Publication Date
WO2002100833A1 true WO2002100833A1 (en) 2002-12-19

Family

ID=26616749

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/005609 Ceased WO2002100833A1 (en) 2001-06-12 2002-06-06 Rho KINASE INHIBITORS

Country Status (4)

Country Link
US (1) US7199147B2 (ja)
EP (1) EP1403255A4 (ja)
JP (1) JPWO2002100833A1 (ja)
WO (1) WO2002100833A1 (ja)

Cited By (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003064397A1 (en) * 2002-01-25 2003-08-07 Vertex Pharmaceuticals Incorporated Indazole compounds useful as protein kinase inhibitors
WO2004039366A1 (en) * 2002-11-01 2004-05-13 Pharmacia & Upjohn Company Llc Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy
WO2004062666A3 (en) * 2003-01-16 2004-10-07 Univ London Use of rho-kinase inhibitorrs for treatment of benign prostatic hyperplasia
WO2004085406A1 (en) 2003-03-24 2004-10-07 F. Hoffmann-La Roche Ag Benzyl-pyridazinons as reverse transcriptase inhibitors
WO2004091662A1 (ja) * 2003-04-18 2004-10-28 Senju Pharmaceutical Co. Ltd. 角膜知覚回復剤
WO2004091605A1 (ja) * 2003-04-17 2004-10-28 Toyama Chemical Co., Ltd. アルキルエーテル誘導体またはその塩を含有する網膜神経疾患の予防・治療剤
WO2005035506A1 (ja) 2003-10-15 2005-04-21 Ube Industries, Ltd. 新規インダゾール誘導体
WO2005082890A1 (en) 2004-02-20 2005-09-09 Smithkline Beecham Corporation Novel compounds
JP2006517574A (ja) * 2003-02-14 2006-07-27 グラクソ　グループ　リミテッド カルボキサミド誘導体
WO2006112313A1 (ja) * 2005-04-13 2006-10-26 Ube Industries, Ltd. インダゾール誘導体を有効成分として含む網膜神経細胞保護剤
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
JP2006526660A (ja) * 2003-06-05 2006-11-24 バーテックス　ファーマシューティカルズ　インコーポレイテッド Ｖｒ１レセプターのモジュレーター
WO2007039563A1 (en) 2005-09-30 2007-04-12 N.V. Organon 9-azabicyclo [3 . 3 . 1] nonane derivatives as monoamine reuptake inhibitors
JP2007513901A (ja) * 2003-12-09 2007-05-31 バイエル・ヘルスケア・アクチェンゲゼルシャフト ヘテロアリール置換ベンゼン
JP2007516173A (ja) * 2003-06-19 2007-06-21 スミスクライン ビーチャム コーポレーション 化合物
US7271190B2 (en) 2001-10-25 2007-09-18 Asahi Kasei Pharma Corporation Indazole compounds as β3 adrenoceptor agonist
WO2007142323A1 (ja) 2006-06-08 2007-12-13 Ube Industries, Ltd. 側鎖にスピロ環構造を有する新規インダゾール誘導体
JP2008516929A (ja) * 2004-10-14 2008-05-22 ラボラトワール テラメックス インダゾール、ベンゾイソオキサゾールおよびベンゾイソチアゾール、その製造方法、医薬組成物およびエストロゲン様物質としての使用
US7396833B2 (en) 2003-12-22 2008-07-08 Memory Pharmaceuticals Corporation Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof
WO2008105442A1 (ja) 2007-02-28 2008-09-04 Asahi Kasei Pharma Corporation スルホンアミド誘導体
US7429664B2 (en) 2002-09-25 2008-09-30 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
JP2008543956A (ja) * 2005-06-28 2008-12-04 サノフィ−アベンティス Ｒｈｏ−キナーゼの阻害剤としてのイソキノリン誘導体
JP2008545008A (ja) * 2005-06-30 2008-12-11 プロシディオン・リミテッド Ｇｐｃｒアゴニスト
US7473701B2 (en) 2002-03-11 2009-01-06 Aventis Pharma S.A. Substituted indazoles, compositions containing them, method of production and use
JP2009502830A (ja) * 2005-07-26 2009-01-29 サノフィ−アベンティス Ｒｈｏ−キナーゼ阻害剤としてのシクロヘキシルアミンイソキノロン誘導体
JP2009502829A (ja) * 2005-07-26 2009-01-29 サノフィ−アベンティス Ｒｈｏ−キナーゼ阻害剤としてのピペリジニル置換されたイソキノロン誘導体
US7488737B2 (en) 2004-04-22 2009-02-10 Memory Pharmaceutical Corporation Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
WO2009028631A1 (ja) 2007-08-29 2009-03-05 Senju Pharmaceutical Co., Ltd. 角膜内皮細胞接着促進剤
US7521447B2 (en) 2003-03-03 2009-04-21 Array Biopharma Inc. P38 inhibitors and methods of use thereof
US7524958B2 (en) * 2004-06-18 2009-04-28 Neurosearch A/S Certain 9-aza-bicyclo[3.3.1] nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US7563800B2 (en) 2006-12-19 2009-07-21 Roche Palo Alto Llc Substituted pyrazolo[3,4-D]pyrimidines as p38 map kinase inhibitors
JP2009530345A (ja) * 2006-03-22 2009-08-27 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｍｄｍ２及びｐ５３間の相互作用のインヒビターとしての環式アルキルアミン誘導体
US7601726B2 (en) 2005-08-25 2009-10-13 Roche Palo Alto Llc Substituted pyrazolo[3,4-d]pyrimidines as p38 MAP kinase inhibitors
US7605170B2 (en) 2005-12-01 2009-10-20 N.V. Organon 8-azabicyclo[3.2.1]octane derivatives
US7618984B2 (en) 2005-08-30 2009-11-17 Asahi Kasei Pharma Corporation Sulfonamide compound
JP2009541377A (ja) * 2006-07-01 2009-11-26 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｈｓｐ９０誘発疾患を治療するためのインダゾール誘導体
US7625924B2 (en) 2004-12-22 2009-12-01 Memory Pharmaceuticals Corporation Nicotinic alpha-7 receptor ligands and preparation and uses thereof
US7632831B2 (en) 2004-05-07 2009-12-15 Memory Pharmaceuticals Corporation 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof
US7652135B2 (en) 2003-09-23 2010-01-26 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
US7655662B2 (en) 2005-12-22 2010-02-02 Alcon Research, Ltd. (Indazol-5-yl)-pyrazines and (1,3-dihydro-indol-2-one)-pyrazines for treating glaucoma and controlling intraocular pressure
JP2010513319A (ja) * 2006-12-18 2010-04-30 インスパイアー ファーマシューティカルズ，インコーポレイティド 細胞骨格活性ｒｈｏキナーゼインヒビター化合物、組成物及び使用
JP2010514716A (ja) * 2006-12-27 2010-05-06 サノフィ−アベンティス シクロアルキルアミン置換イソキノロン誘導体
JP2010514715A (ja) * 2006-12-27 2010-05-06 サノフィ−アベンティス Ｒｈｏキナーゼ阻害剤としての置換イソキノロン及びイソキノリノン誘導体
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