WO2003048202A3 - Gène activant le facteur nucléaire kappa b - Google Patents

Gène activant le facteur nucléaire kappa b Download PDF

Info

Publication number
WO2003048202A3
WO2003048202A3 PCT/JP2002/012644 JP0212644W WO03048202A3 WO 2003048202 A3 WO2003048202 A3 WO 2003048202A3 JP 0212644 W JP0212644 W JP 0212644W WO 03048202 A3 WO03048202 A3 WO 03048202A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
dna
activating
recombinant vector
activation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/012644
Other languages
English (en)
Other versions
WO2003048202A2 (fr
Inventor
Akio Matsuda
Shuji Muramatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Pharma Corp
Original Assignee
Asahi Kasei Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2001368692A external-priority patent/JP2006166701A/ja
Priority claimed from JP2002291302A external-priority patent/JP2006166705A/ja
Application filed by Asahi Kasei Pharma Corp filed Critical Asahi Kasei Pharma Corp
Priority to AU2002349784A priority Critical patent/AU2002349784A1/en
Publication of WO2003048202A2 publication Critical patent/WO2003048202A2/fr
Anticipated expiration legal-status Critical
Publication of WO2003048202A3 publication Critical patent/WO2003048202A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Cette invention a trait à des protéines capables d'activer le NF-λ B, utilisées pour le diagnostic, le traitement ou la prévention d'états pathologiques associés à une activation excessive ou à l'inhibition du NF-λ B. Grâce à l'utilisation d'un NF-λ B-Luc plasmidique, un ADNc capable d'activer le NF-λ B a été cloné à partir d'une banque d'ADNc issue de fibroblastes pulmonaires et analogue, puis la séquence d'ADN et la séquence aminoacide dérivée déterminées. La protéine, l'ADN codant cette protéine, un vecteur de recombinaison contenant cet ADN ainsi qu'un transformant contenant ce vecteur, se révèlent des plus utiles pour le criblage d'une substance inhibant le NF-λ B ou stimulant son activation.
PCT/JP2002/012644 2001-12-03 2002-12-03 Gène activant le facteur nucléaire kappa b Ceased WO2003048202A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002349784A AU2002349784A1 (en) 2001-12-03 2002-12-03 Nf-kappab activating genes

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP2001368692A JP2006166701A (ja) 2001-12-03 2001-12-03 ＮＦ−κＢ活性化遺伝子
JP2001-368692 2001-12-03
US33582901P 2001-12-05 2001-12-05
US60/335,829 2001-12-05
JP2002-291302 2002-10-03
JP2002291302A JP2006166705A (ja) 2002-10-03 2002-10-03 ＮＦ−κＢ活性化遺伝子
US41576902P 2002-10-04 2002-10-04
US60/415,769 2002-10-04

Publications (2)

Publication Number Publication Date
WO2003048202A2 WO2003048202A2 (fr) 2003-06-12
WO2003048202A3 true WO2003048202A3 (fr) 2004-07-01

Family

ID=27482716

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/012644 Ceased WO2003048202A2 (fr) 2001-12-03 2002-12-03 Gène activant le facteur nucléaire kappa b

Country Status (2)

Country Link
AU (1) AU2002349784A1 (fr)
WO (1) WO2003048202A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9562049B2 (en) 2012-12-21 2017-02-07 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090176722A9 (en) 2000-01-28 2009-07-09 Shiv Srivastava Androgen-regulated PMEPA1 gene and polypeptides
AU2003245990A1 (en) * 2002-06-26 2004-01-19 Bayer Healthcare Ag Regulation of human map kinase kinase kinase
AU2003301621A1 (en) * 2002-10-22 2004-05-13 Oregon Health And Science University Apoptotic response regulation through interaction of tripartite motif protein 32 with pias
AU2003290432A1 (en) * 2002-12-26 2004-07-22 Asahi Kasei Pharma Corporation T cell activating gene
WO2004106937A2 (fr) * 2003-06-02 2004-12-09 Bayer Healthcare Ag Diagnostic et therapeutique pour des maladies associees au recepteur 6 de purine p2y (p2y6) couple a la proteine g
EP1636258A2 (fr) * 2003-06-10 2006-03-22 Xantos Biomedicine AG Nouveau facteur angiogenique et ses inhibiteurs
US7498298B2 (en) 2003-11-06 2009-03-03 Seattle Genetics, Inc. Monomethylvaline compounds capable of conjugation to ligands
KR20120064120A (ko) 2004-06-01 2012-06-18 제넨테크, 인크. 항체 약물 접합체 및 방법
KR101270829B1 (ko) 2004-09-23 2013-06-07 제넨테크, 인크. 시스테인 유전자조작 항체 및 접합체
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
JP2007054042A (ja) * 2005-07-26 2007-03-08 Japan Science & Technology Agency インターフェロン誘導分子ｉｐｓ−１
EP2324044A4 (fr) * 2008-08-04 2012-04-25 Univ Miami Sting (stimulateur de gènes d interféron), un régulateur de réponses immunitaires innées
WO2010053877A2 (fr) * 2008-11-04 2010-05-14 The Regents Of The University Of Colorado, A Body Corporate Protéine associée au cmh ii et ses utilisations
CA2809819A1 (fr) 2009-09-09 2011-03-17 Centrose, Llc Conjugues medicamenteux cibles a visee extracellulaire
DK2528625T3 (da) 2010-04-15 2013-10-14 Spirogen Sarl Pyrrolobenzodiazepiner og konjugater deraf
BR112012030311A2 (pt) 2010-06-08 2017-01-24 Genentech Inc anticorpo
JP5889912B2 (ja) 2010-11-17 2016-03-22 ジェネンテック， インコーポレイテッド アラニニルメイタンシノール抗体コンジュゲート
KR101992502B1 (ko) 2011-05-12 2019-06-24 제넨테크, 인크. 프레임워크 시그너처 펩티드를 사용하여 동물 샘플에서 치료 항체를 검출하기 위한 다중 반응 모니터링 lc-ms/ms 방법
CN103030688B (zh) * 2011-09-30 2014-09-17 北京大学 抑制癌细胞生长的短肽及其编码基因与应用
JP6104257B2 (ja) 2011-10-14 2017-03-29 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ ピロロベンゾジアゼピンおよびそのコンジュゲート
WO2013130093A1 (fr) 2012-03-02 2013-09-06 Genentech, Inc. Biomarqueurs pour un traitement à base de composés chimiothérapeutiques anti-tubuline
EP2906250B1 (fr) 2012-10-12 2018-05-30 ADC Therapeutics SA Conjugués pyrrolobenzodiazepine-anticorps anti-psma
ES2649990T3 (es) 2012-10-12 2018-01-16 Medimmune Limited Conjugados de anticuerpos anti-CD22-pirrolobenzodiazepinas
DK2906298T3 (en) 2012-10-12 2018-12-17 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
US10751346B2 (en) 2012-10-12 2020-08-25 Medimmune Limited Pyrrolobenzodiazepine—anti-PSMA antibody conjugates
CN104837502B (zh) 2012-10-12 2018-08-10 麦迪穆有限责任公司 吡咯并苯并二氮杂卓及其结合物
AU2013328625B2 (en) 2012-10-12 2016-12-15 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
US10695433B2 (en) 2012-10-12 2020-06-30 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
CA2905181C (fr) 2013-03-13 2020-06-02 Medimmune Limited Pyrrolobenzodiazepines et ses conjugues servant a fournir une therapie ciblee
SG11201507214SA (en) 2013-03-13 2015-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
NZ710746A (en) 2013-03-13 2018-11-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
EP3033111B1 (fr) 2013-08-12 2019-03-13 Genentech, Inc. Conjugués anticorps-médicament dimérique 1-(chlorométhyl)-2,3-dihydro-1 h-benzo [e]indole, et méthodes d'utilisation et de traitement
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
EP3054985B1 (fr) 2013-10-11 2018-12-26 Medimmune Limited Conjugués anticorps-pyrrolobenzodiazépine
US10010624B2 (en) 2013-10-11 2018-07-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
EP3054986B1 (fr) 2013-10-11 2019-03-20 Medimmune Limited Conjugués anticorps-pyrrolobenzodiazépine
BR112016013258A2 (pt) 2013-12-16 2018-01-16 Genentech Inc composto conjugado anticorpo-droga, composição farmacêutica, método para tratar câncer e kit
KR20170042495A (ko) 2013-12-16 2017-04-19 제넨테크, 인크. 펩티드모방체 화합물 및 그의 항체-약물 접합체
JP6671292B2 (ja) 2013-12-16 2020-03-25 ジェネンテック， インコーポレイテッド ペプチド模倣化合物及びその抗体−薬物コンジュゲート
JP6531166B2 (ja) 2014-09-10 2019-06-12 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ ピロロベンゾジアゼピン及びそのコンジュゲート
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
MX2017003123A (es) 2014-09-12 2017-05-12 Genentech Inc Anticuerpos y conjugados modificados geneticamente con cisteina.
WO2016040825A1 (fr) 2014-09-12 2016-03-17 Genentech, Inc. Intermédiaires disulfure d'anthracycline, conjugué anticorps-médicaments et procédés
US20160074527A1 (en) 2014-09-17 2016-03-17 Genentech, Inc. Pyrrolobenzodiazepines and antibody disulfide conjugates thereof
AU2015352545B2 (en) 2014-11-25 2020-10-15 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
MX2017007169A (es) 2014-12-03 2018-05-02 Genentech Inc Compuestos de amina cuaternaria y conjugados de anticuerpofármaco de los mismos.
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
CA2996902C (fr) 2015-10-02 2020-06-02 Genentech, Inc. Conjugues anticorps-medicaments de pyrrolobenzodiazepine et methodes d'utilisation
EP3362100B1 (fr) 2015-10-16 2022-06-22 Genentech, Inc. Conjugués médicamenteux à pont disulfure encombré
EP3365025B1 (fr) 2015-10-20 2020-07-15 Genentech, Inc. Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
US20170315132A1 (en) 2016-03-25 2017-11-02 Genentech, Inc. Multiplexed total antibody and antibody-conjugated drug quantification assay
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
EP3458101B1 (fr) 2016-05-20 2020-12-30 H. Hoffnabb-La Roche Ag Conjugués anticorps-protac et procédés d'utilisation
EP3465221B1 (fr) 2016-05-27 2020-07-22 H. Hoffnabb-La Roche Ag Procédé bioanalytique pour la caractérisation de conjugués anticorps-médicament spécifiques d'un site
US10639378B2 (en) 2016-06-06 2020-05-05 Genentech, Inc. Silvestrol antibody-drug conjugates and methods of use
WO2018031662A1 (fr) 2016-08-11 2018-02-15 Genentech, Inc. Promédicaments de pyrrolobenzodiazépine et conjugués d'anticorps de ceux-ci
EP3522933B1 (fr) 2016-10-05 2021-12-15 F. Hoffmann-La Roche AG Procédés de préparation de conjugués anticorps-médicament
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
JP2020514321A (ja) 2017-02-01 2020-05-21 モデルナティーエックス， インコーポレイテッド 活性化がん遺伝子変異ペプチドをコードする免疫調節治療ｍＲＮＡ組成物
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
MX375569B (es) 2017-02-08 2025-03-04 Adc Therapeutics Sa Conjugados de pirrolobenzodiazepinas y anticuerpos
PT3612537T (pt) 2017-04-18 2022-08-29 Medimmune Ltd Conjugados de pirrolobenzodiazepina
ES2977788T3 (es) 2017-04-20 2024-08-30 Adc Therapeutics Sa Terapia combinada con un conjugado de anticuerpo anti-AXL y fármaco
MX2019015042A (es) 2017-06-14 2020-08-06 Adc Therapeutics Sa Regimen de dosificacion.
DK3668874T3 (da) 2017-08-18 2022-02-14 Medimmune Ltd Pyrrolobenzodiazepin-konjugater
IL273387B2 (en) 2017-09-20 2023-10-01 Ph Pharma Co Ltd Thylanstatin analogs
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
GB201814281D0 (en) 2018-09-03 2018-10-17 Femtogenix Ltd Cytotoxic agents
JP7708662B2 (ja) 2018-10-24 2025-07-15 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト コンジュゲート化された化学的分解誘導物質および使用方法
EP3894427A1 (fr) 2018-12-10 2021-10-20 Genentech, Inc. Peptides de photoréticulation pour conjugaison spécifique de site à des protéines contenant fc
GB201901197D0 (en) 2019-01-29 2019-03-20 Femtogenix Ltd G-A Crosslinking cytotoxic agents
KR102890251B1 (ko) 2019-03-15 2025-11-25 메드임뮨 리미티드 암의 치료에 사용하기 위한 아제티도벤조디아제핀 이량체 및 이를 포함하는 컨쥬게이트
AU2020405068A1 (en) 2019-12-18 2022-07-07 Stinginn Llc Substituted 1,2, 4-triazoles and methods of use
US11897888B1 (en) 2020-04-30 2024-02-13 Stinginn Llc Small molecular inhibitors of sting signaling compositions and methods of use
GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
CN117980327A (zh) 2021-11-03 2024-05-03 杭州多禧生物科技有限公司 抗体的特异性偶联
EP4637833A2 (fr) 2022-12-23 2025-10-29 Genentech, Inc. Conjugués d'agent de dégradation de céréblon et leurs utilisations
EP4698230A2 (fr) 2023-04-17 2026-02-25 Peak Bio, Inc. Anticorps et conjugués anticorps-médicament et procédés d'utilisation, processus synthétiques et intermédiaires
WO2026006688A2 (fr) 2024-06-28 2026-01-02 Firefly Bio, Inc. Conjugués d'anticorps de dégradation et leurs utilisations
WO2026006689A2 (fr) 2024-06-28 2026-01-02 Firefly Bio, Inc. Conjugués anticorps-dégradeur de bcl-xl et leurs utilisations

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994023045A1 (fr) * 1993-04-07 1994-10-13 Boehringer Ingelheim International Gmbh Procede d'inhibition de la transcription de genes
WO1996017927A2 (fr) * 1994-12-05 1996-06-13 Karo Bio Ab Lignee cellulaire comportant des genes rapporteurs
US5932425A (en) * 1997-02-18 1999-08-03 Signal Pharmaceuticals, Inc. Compositions and methods for modulating cellular NF-κB activation
EP0955372A2 (fr) * 1998-03-20 1999-11-10 Suntory Limited Procédé de criblage de composés qui inhibent l'activation par NF-kappa B
WO2001072296A1 (fr) * 2000-03-27 2001-10-04 Astacarotene Ab Procede d'inhibition de l'expression de cytokines et de chimiokines inflammatoires

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994023045A1 (fr) * 1993-04-07 1994-10-13 Boehringer Ingelheim International Gmbh Procede d'inhibition de la transcription de genes
WO1996017927A2 (fr) * 1994-12-05 1996-06-13 Karo Bio Ab Lignee cellulaire comportant des genes rapporteurs
US5932425A (en) * 1997-02-18 1999-08-03 Signal Pharmaceuticals, Inc. Compositions and methods for modulating cellular NF-κB activation
EP0955372A2 (fr) * 1998-03-20 1999-11-10 Suntory Limited Procédé de criblage de composés qui inhibent l'activation par NF-kappa B
WO2001072296A1 (fr) * 2000-03-27 2001-10-04 Astacarotene Ab Procede d'inhibition de l'expression de cytokines et de chimiokines inflammatoires

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 1 April 1992 (1992-04-01), retrieved from EBI Database accession no. M86377 *
DATABASE EMBL [online] 27 February 1992 (1992-02-27), retrieved from EBI Database accession no. M86699 *
DATABASE EMBL [online] XP002233369, retrieved from EBI Database accession no. BC000633 *
DOUVILLE E M J ET AL: "MULTIPLE CDNAS ENCODING THE ESK KINASE PREDICT TRANSMEMBRANE AND INTRACELLULAR ENZYME ISOFORMS", MOLECULAR AND CELLULAR BIOLOGY, vol. 12, no. 6, 1992, pages 2681 - 2689, XP009006945, ISSN: 0270-7306 *
KWON BYUNGSUK ET AL: "Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand", JOURNAL OF BIOLOGICAL CHEMISTRY, THE AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, INC.,, US, vol. 274, no. 10, 5 March 1999 (1999-03-05), pages 6056 - 6061, XP002147323, ISSN: 0021-9258 *
MILLS G B ET AL: "EXPRESSION OF TTK A NOVEL HUMAN PROTEIN KINASE IS ASSOCIATED WITH CELL PROLIFERATION", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 267, no. 22, M86699, 1992, pages 16000 - 16006, XP002233366, ISSN: 0021-9258, Retrieved from the Internet <URL:EBI> *
WANG CUN-YU ET AL: "NK-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.", SCIENCE (WASHINGTON D C), vol. 281, no. 5383, pages 1680 - 1683, XP002233368, ISSN: 0036-8075 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9562049B2 (en) 2012-12-21 2017-02-07 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
US9567340B2 (en) 2012-12-21 2017-02-14 Medimmune Limited Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases

Also Published As

Publication number Publication date
AU2002349784A1 (en) 2003-06-17
AU2002349784A8 (en) 2003-06-17
WO2003048202A2 (fr) 2003-06-12

Similar Documents

Publication Publication Date Title
WO2003048202A3 (fr) Gène activant le facteur nucléaire kappa b
WO2004043382A3 (fr) Variants ameliores de l&#39;erythropoietine et methodes d&#39;utilisation
GB2292382B (en) Obesity (OB) peptides capable of modulating body weight of animals, allelic variants, analogs and fragments thereof, derivatives, nucleic acid sequences, vect
EP1308459A3 (fr) Séquences d&#39;ADN complementaires pleine longueur
EP2258383A3 (fr) Peptides antigènes dérivés de la télomérase
WO2002061076A1 (fr) Proteine associee a l&#39;adiponectine
WO1999053040A3 (fr) Sequences d&#39;acide nucleique humain provenant de tissu de tumeur ovarienne
WO2002044320A3 (fr) Genes humains de l&#39;elongase, leurs utilisations et composes destines a leur modulation
WO2003042362A8 (fr) Pgc-1$g(b), un nouvel homologue du pgc-1 et leurs utilisations
WO2003031598A3 (fr) Sequences d&#39;acides nucleiques et d&#39;acides amines codant des polypeptides de facteur viii a expresseur a haut rendement et leurs procedes d&#39;utilisation
WO2004069200A3 (fr) Inhibiteurs specifiques de l&#39;activation de nfat par la calcineurine et leur utilisation en traitement de maladies immunologiques
IL135687A0 (en) A novel human checkpoint kinase, hcds1, compositions and methods
WO2002077171A3 (fr) Proteines kinases humaines isolees, molecules d&#39;acides nucleiques codant ces proteines kinases, et utlisations correspondantes
WO1997022695A3 (fr) Sequences nucleotidiques, proteines, medicaments et agents diagnostiques utiles dans le traitement du cancer
WO2000061742A3 (fr) Traitement d&#39;une insuffisance cardiaque
EP1281763A3 (fr) FACTEUR DE TRANSCRIPTION &#34;Early growth response-1&#34; (EGR-1)
WO1998011234A3 (fr) Proteines kinases humaines
WO2000040723A3 (fr) Methodes et produits servant a l&#39;administration d&#39;acides nucleiques
WO2002094859A3 (fr) Peptides mage-a1 permettant le traitement ou la prevention du cancer
WO2001092496A3 (fr) Proteines kinases humaines isolees, molecules d&#39;acide nucleique codant pour ces proteines kinases humaines et utilisations de celles-ci
WO2004078112A3 (fr) Gene induisant l&#39;apoptose
WO2004072277A3 (fr) Gene associe a la phosphorylation d&#39;elk1
WO2002016567A3 (fr) Proteines de kinases humaines isolees, molecules d&#39;acide nucleique codant des proteines de kinases humaines, et utilisations associees
WO2002018536A3 (fr) Proteine bard1 tronquee, et ses applications diagnostiques et therapeutiques
WO2002031146A3 (fr) Recepteurs d&#39;hormone nucleaire humaine isoles, molecules d&#39;acides nucleiques codant des recepteurs d&#39;hormone nucleaire humaine, et utilisations

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SK SL TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase