WO2003077832A3 - Dexanabinol et analogues de dexanabinol regulant des genes associes a l'inflammation - Google Patents

Dexanabinol et analogues de dexanabinol regulant des genes associes a l'inflammation Download PDF

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Publication number
WO2003077832A3
WO2003077832A3 PCT/IL2003/000223 IL0300223W WO03077832A3 WO 2003077832 A3 WO2003077832 A3 WO 2003077832A3 IL 0300223 W IL0300223 W IL 0300223W WO 03077832 A3 WO03077832 A3 WO 03077832A3
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WO
WIPO (PCT)
Prior art keywords
dexanabinol
diseases
disorders
related genes
inflammation related
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2003/000223
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English (en)
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WO2003077832A2 (fr
Inventor
Aaron Garzon
Ayelet Avraham
George Fink
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Pharmos Corp
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Pharmos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmos Corp filed Critical Pharmos Corp
Priority to AU2003214608A priority Critical patent/AU2003214608A1/en
Priority to IL16387703A priority patent/IL163877A0/xx
Priority to JP2003575886A priority patent/JP2005526768A/ja
Priority to EP03710188A priority patent/EP1485083A4/fr
Priority to CA002479676A priority patent/CA2479676A1/fr
Publication of WO2003077832A2 publication Critical patent/WO2003077832A2/fr
Publication of WO2003077832A3 publication Critical patent/WO2003077832A3/fr
Priority to US10/942,504 priority patent/US20050137251A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
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  • Pain & Pain Management (AREA)
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Abstract

L'invention concerne des compositions pharmaceutiques comprenant, en tant que principe actif, des dérivés cannabinoïdes, non psychotropes, qui modulent l'expression de gènes impliqués dans les processus immun et d'inflammation. La régulation de la transcription de médiateurs pro- et anti-inflammatoires est utile dans les applications thérapeutiques destinées à prévenir et à traiter l'inflammation aiguë et chronique, des maladies auto-immunes et des troubles associés, la douleur, des infections, des maladies hépatiques, des troubles cardio-vasculaires, gastro-intestinaux, des troubles des systèmes nerveux central et périphérique incluant des troubles neurodégénératifs, des maladies respiratoires, des maladies rénales, des complications post-opératoires, le rejet tissulaire et certains types de cancer.
PCT/IL2003/000223 2002-03-18 2003-03-16 Dexanabinol et analogues de dexanabinol regulant des genes associes a l'inflammation Ceased WO2003077832A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2003214608A AU2003214608A1 (en) 2002-03-18 2003-03-16 Dexanabinol and dexanabinol analogs regulate inflammation related genes
IL16387703A IL163877A0 (en) 2002-03-18 2003-03-16 Dexanabinol and dexanabinol analogsregulate inflammation related genes
JP2003575886A JP2005526768A (ja) 2002-03-18 2003-03-16 炎症関連遺伝子を調節するデキサナビノール及びデキサナビノール類似体
EP03710188A EP1485083A4 (fr) 2002-03-18 2003-03-16 Dexanabinol et analogues de dexanabinol regulant des genes associes a l'inflammation
CA002479676A CA2479676A1 (fr) 2002-03-18 2003-03-16 Dexanabinol et analogues de dexanabinol regulant des genes associes a l'inflammation
US10/942,504 US20050137251A1 (en) 2002-03-18 2004-09-16 Dexanabinol and dexanabinol analogs regulate inflammation related genes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL148736 2002-03-18
IL14873602A IL148736A0 (en) 2002-03-18 2002-03-18 Dexanabinol and dexanabinol analogs which regulate inflammation related genes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/942,504 Continuation US20050137251A1 (en) 2002-03-18 2004-09-16 Dexanabinol and dexanabinol analogs regulate inflammation related genes

Publications (2)

Publication Number Publication Date
WO2003077832A2 WO2003077832A2 (fr) 2003-09-25
WO2003077832A3 true WO2003077832A3 (fr) 2003-12-31

Family

ID=27840273

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2003/000223 Ceased WO2003077832A2 (fr) 2002-03-18 2003-03-16 Dexanabinol et analogues de dexanabinol regulant des genes associes a l'inflammation

Country Status (7)

Country Link
EP (1) EP1485083A4 (fr)
JP (1) JP2005526768A (fr)
AU (1) AU2003214608A1 (fr)
CA (1) CA2479676A1 (fr)
IL (1) IL148736A0 (fr)
WO (1) WO2003077832A2 (fr)
ZA (1) ZA200407182B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0326393D0 (en) * 2003-11-12 2003-12-17 Ares Trading Sa Cytokine antagonist molecules
JP2008507686A (ja) * 2004-07-23 2008-03-13 ノバルティス アクチエンゲゼルシャフト リウマチ様関節炎（ｒａ）のためのバイオマーカー
US20080262079A1 (en) * 2004-08-09 2008-10-23 Bernard Mach Cannabinoid Compositions and Methods of Use Thereof
SI1891961T1 (sl) * 2005-03-17 2010-01-29 Proyecto Biomedicina Cima Sl Uporaba 5'-metiltioadenozina (MTA) za preprečevanje in/ali zdravljenje avtoimunske bolezni in/ali transplantacijske zavrnitve
EP1752149A1 (fr) * 2005-07-29 2007-02-14 Laboratorios Del Dr. Esteve, S.A. CB1 Antagonists ou agonistes inverses comme agents thérapeutiques pour le traitement de l'inflammation impliquant l'expression de gène
CA2618705C (fr) * 2005-11-07 2014-04-22 Murty Pharmaceuticals, Inc. Administration amelioree de tetrahydrocannabinol
CN101240271B (zh) * 2006-08-28 2012-08-29 长春华普生物技术有限公司 Toll样受体调节性寡核苷酸及其用途
GB0713116D0 (en) * 2007-07-06 2007-08-15 Therapeutics Ltd E Treatment of melanoma
GB0719771D0 (en) * 2007-10-10 2007-11-21 Therapeutics Ltd E Dexanabinol in combination with inhibitors of BRAF or MEK for the treatment of melanoma
GB0915877D0 (en) * 2009-09-10 2009-10-14 E Therapeutics Plc Cancer cell apoptosis
GB201207305D0 (en) * 2012-04-26 2012-06-13 E Therapeutics Plc Therapy
EP2881111A4 (fr) * 2012-08-03 2015-12-16 Univ Ehime Inhibiteur de l'activation d'une cellule immunitaire et son utilisation
JP2017031120A (ja) * 2015-08-05 2017-02-09 オリザ油化株式会社 ＴＮＦ−α及びＩＬ−６産生抑制剤及びそれを用いた筋肉炎症抑制剤
WO2017068349A1 (fr) 2015-10-23 2017-04-27 E-Therapeutics Plc Cannabinoïde pour utilisation en immunothérapie
WO2018163716A1 (fr) * 2017-03-08 2018-09-13 日清オイリオグループ株式会社 Agent anti-inflammatoire, composition médicinale contre l'inflammation, et composition alimentaire contre l'inflammation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331560B1 (en) * 1995-09-11 2001-12-18 Yissum Research Development Co. Of The Hebrew University Of Jerusalem Tumor necrosis factor alpha (TNF-α) inhibiting pharmaceuticals

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004501145A (ja) * 2000-06-22 2004-01-15 ファーモス　コーポレイション 向精神作用をもたない新規なカンナビノイド

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331560B1 (en) * 1995-09-11 2001-12-18 Yissum Research Development Co. Of The Hebrew University Of Jerusalem Tumor necrosis factor alpha (TNF-α) inhibiting pharmaceuticals

Also Published As

Publication number Publication date
EP1485083A2 (fr) 2004-12-15
ZA200407182B (en) 2006-02-22
AU2003214608A1 (en) 2003-09-29
IL148736A0 (en) 2002-09-12
EP1485083A4 (fr) 2008-11-19
JP2005526768A (ja) 2005-09-08
WO2003077832A2 (fr) 2003-09-25
CA2479676A1 (fr) 2003-09-25

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