WO2004002425A3 - Process for promoting graft acceptance by depletion of hematopoietic stem cells - Google Patents

Process for promoting graft acceptance by depletion of hematopoietic stem cells Download PDF

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Publication number
WO2004002425A3
WO2004002425A3 PCT/US2003/020520 US0320520W WO2004002425A3 WO 2004002425 A3 WO2004002425 A3 WO 2004002425A3 US 0320520 W US0320520 W US 0320520W WO 2004002425 A3 WO2004002425 A3 WO 2004002425A3
Authority
WO
WIPO (PCT)
Prior art keywords
stem cells
hematopoietic stem
depletion
depleting
inactivating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/020520
Other languages
French (fr)
Other versions
WO2004002425A2 (en
Inventor
Julian D Down
Mary E White-Scharf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotransplant Inc
Original Assignee
Biotransplant Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotransplant Inc filed Critical Biotransplant Inc
Priority to AU2003245752A priority Critical patent/AU2003245752A1/en
Publication of WO2004002425A2 publication Critical patent/WO2004002425A2/en
Publication of WO2004002425A3 publication Critical patent/WO2004002425A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Therapeutic compositions and methods for modulating the immune system for promoting acceptance of a graft and for treating a hematologic malignancy in the absence of myeloablative therapies are disclosed. The described methodology includes the step of depleting and/or inactivating the hematopoietic stem cells of the recipient using a therapeutic composition comprising at least one antibody specific for depleting and/or inactivating hematopoietic stem cells while maintaining mature blood cells, preferably the antibody selectively depletes and/or inactivates primitive hematopoietic stem cells. The therapeutic composition preferably is administered prior to the administration of bone marrow, mobilized peripheral hematopoietic stem cells, or donor leucocytes.
PCT/US2003/020520 2002-06-28 2003-06-27 Process for promoting graft acceptance by depletion of hematopoietic stem cells Ceased WO2004002425A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003245752A AU2003245752A1 (en) 2002-06-28 2003-06-27 Process for promoting graft acceptance by depletion of hematopoietic stem cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39259002P 2002-06-28 2002-06-28
US60/392,590 2002-06-28
US35770603A 2003-02-04 2003-02-04
US10/357,706 2003-02-04

Publications (2)

Publication Number Publication Date
WO2004002425A2 WO2004002425A2 (en) 2004-01-08
WO2004002425A3 true WO2004002425A3 (en) 2004-08-26

Family

ID=30002887

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/020520 Ceased WO2004002425A2 (en) 2002-06-28 2003-06-27 Process for promoting graft acceptance by depletion of hematopoietic stem cells

Country Status (2)

Country Link
AU (1) AU2003245752A1 (en)
WO (1) WO2004002425A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008067115A2 (en) * 2006-11-03 2008-06-05 The Board Of Trustees Of The Leland Stanford Junior University Selective immunodepletion of endogenous stem cell niche for engraftment
JP2012505193A (en) 2008-10-10 2012-03-01 プロベルテ ファーマ，エス．エー． Orally administered immunostimulant for aquaculture
CN102271711B (en) * 2008-12-12 2014-06-18 国立大学法人东京大学 Each immune reconstitution promoting agent or infection preventing agent that maintains the graft-versus-tumor effect
US9540443B2 (en) 2011-01-26 2017-01-10 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies
NZ630363A (en) 2012-07-25 2018-09-28 Celldex Therapeutics Inc Anti-kit antibodies and uses thereof
WO2015050959A1 (en) * 2013-10-01 2015-04-09 Yale University Anti-kit antibodies and methods of use thereof
CN113975386A (en) 2014-05-23 2022-01-28 塞尔德克斯医疗公司 Treatment of eosinophil or mast cell related disorders
US20170209447A1 (en) * 2014-08-07 2017-07-27 Nitor Therapeutics Use of PNP Inhibitor to Treat Relapse of Malignancy after Hematopoietic Stem Cell Transplant
EP4257145B1 (en) 2014-08-26 2025-06-25 The Board of Trustees of the Leland Stanford Junior University Engraftment of stem cells with a combination of an agent that targets stem cells and modulation of immunoregulatory signaling
HK1256681A1 (en) 2015-04-06 2019-10-04 President And Fellows Of Harvard College Compositions and methods for non-myeloablative conditioning
AU2016310348B2 (en) 2015-08-26 2023-01-05 The Board Of Trustees Of The Leland Stanford Junior University Enhanced depletion of targeted cells with CD47 blockade and an immune costimulatory agonist
IL263744B2 (en) * 2016-06-17 2023-11-01 Magenta Therapeutics Inc Compositions and methods for depleting CD117 plus cells
KR20240093751A (en) * 2016-12-21 2024-06-24 노파르티스 아게 Antibody drug conjugates for ablating hematopoietic stem cells
KR20190109440A (en) 2017-01-30 2019-09-25 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 Non-Genotoxic Conditioning Regimen for Stem Cell Transplantation
WO2018183613A1 (en) * 2017-03-31 2018-10-04 The Children's Medical Center Corporation Antibody-mediated conditioning with immunosuppression to enable allogeneic transplantation
AU2019265019B2 (en) 2018-05-11 2025-11-06 Beam Therapeutics Inc. Methods of substituting pathogenic amino acids using programmable base editor systems
UY38265A (en) * 2018-06-20 2020-01-31 Novartis Ag DRUG ANTIBODY CONJUGATES FOR ABLATION OF HEMATOPOIETIC STEM CELLS
EP3886869A4 (en) 2018-11-28 2022-07-06 Forty Seven, Inc. GENETICALLY MODIFIED CSPH RESISTANT TO ABLATIVE TREATMENT
CA3137568A1 (en) * 2019-04-25 2020-10-29 Actinium Pharmaceuticals, Inc. Compositions and methods of immunodepletion for the treatment of malignant and non-malignant hematological diseases
EP4611807A1 (en) * 2022-11-04 2025-09-10 The Board of Trustees of the Leland Stanford Junior University Rebalancing the immune system through depletion of myeloid-biased hematopoietic stem cells

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007444A1 (en) * 1996-08-16 1998-02-26 Biotransplant, Inc. LO-CD2a ANTIBODY AND USES THEREOF FOR INHIBITING T CELL ACTIVATION AND PROLIFERATION
WO2001025398A2 (en) * 1999-10-01 2001-04-12 Biotransplant Incorporated Process for inducing functional tolerance to gene transfer products
WO2001030369A1 (en) * 1999-10-22 2001-05-03 Biotransplant, Inc. Process for inducing immunological tolerance for xenogeneic transplants
WO2001087310A1 (en) * 2000-05-18 2001-11-22 Biotransplant, Inc. Process for reducing antibody response against xenografts
WO2002033043A2 (en) * 2000-10-18 2002-04-25 Coriell Institute For Medical Research Method and marker for the isolation of human multipotent hematopoietic stem cells

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007444A1 (en) * 1996-08-16 1998-02-26 Biotransplant, Inc. LO-CD2a ANTIBODY AND USES THEREOF FOR INHIBITING T CELL ACTIVATION AND PROLIFERATION
WO2001025398A2 (en) * 1999-10-01 2001-04-12 Biotransplant Incorporated Process for inducing functional tolerance to gene transfer products
WO2001030369A1 (en) * 1999-10-22 2001-05-03 Biotransplant, Inc. Process for inducing immunological tolerance for xenogeneic transplants
WO2001087310A1 (en) * 2000-05-18 2001-11-22 Biotransplant, Inc. Process for reducing antibody response against xenografts
WO2002033043A2 (en) * 2000-10-18 2002-04-25 Coriell Institute For Medical Research Method and marker for the isolation of human multipotent hematopoietic stem cells

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BUHLER L. ET AL: "High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response", TRANSPLANTATION, vol. 69, no. 11, 15 June 2000 (2000-06-15), pages 2296 - 2304, XP002978334 *
BUHLER L. ET AL: "Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade", TRANSPLANTATION, vol. 73, no. 1, 15 January 2002 (2002-01-15), pages 12 - 22, XP002978708 *
GIOVINO MA ET AL: "Porcine hematopoiesis on primate stroma in long-term cultures: enhanced growth with neutralizing tumor necrosis factor-alpha and tumor growth factor-beta antibodies", TRANSPLANTATION, vol. 73, no. 5, 15 March 2002 (2002-03-15), pages 723 - 731, XP002978373 *

Also Published As

Publication number Publication date
AU2003245752A1 (en) 2004-01-19
AU2003245752A8 (en) 2004-01-19
WO2004002425A2 (en) 2004-01-08

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