WO2004002425A3 - Methodes permettant d'ameliorer l'acceptation d'une greffe par depletion des cellules souches hematopoietiques - Google Patents

Methodes permettant d'ameliorer l'acceptation d'une greffe par depletion des cellules souches hematopoietiques Download PDF

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Publication number
WO2004002425A3
WO2004002425A3 PCT/US2003/020520 US0320520W WO2004002425A3 WO 2004002425 A3 WO2004002425 A3 WO 2004002425A3 US 0320520 W US0320520 W US 0320520W WO 2004002425 A3 WO2004002425 A3 WO 2004002425A3
Authority
WO
WIPO (PCT)
Prior art keywords
stem cells
hematopoietic stem
depletion
depleting
inactivating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/020520
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English (en)
Other versions
WO2004002425A2 (fr
Inventor
Julian D Down
Mary E White-Scharf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotransplant Inc
Original Assignee
Biotransplant Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotransplant Inc filed Critical Biotransplant Inc
Priority to AU2003245752A priority Critical patent/AU2003245752A1/en
Publication of WO2004002425A2 publication Critical patent/WO2004002425A2/fr
Publication of WO2004002425A3 publication Critical patent/WO2004002425A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des compositions thérapeutiques et des méthodes qui permettent de moduler le système immunitaire pour améliorer l'acceptation d'une greffe et pour traiter une malignité hématologique en l'absence de thérapies myéloablatives. La méthodologie décrite comprend une étape qui consiste à appauvrir et/ou à inactiver les cellules souches hématopoïétiques du destinataire au moyen d'une composition thérapeutique comprenant au moins un anticorps spécifique pour appauvrir et/ou inactiver les cellules souches hématopoïétiques tout en préservant les cellules sanguines matures, de préférence l'anticorps appauvrit sélectivement et/ou inactive les cellules souches hématopoïétiques primitives. La composition thérapeutique est de préférence administrée avant l'administration de moelle osseuse, de cellules souches hématopoïétiques périphériques mobilisées ou de leucocytes du donneur.
PCT/US2003/020520 2002-06-28 2003-06-27 Methodes permettant d'ameliorer l'acceptation d'une greffe par depletion des cellules souches hematopoietiques Ceased WO2004002425A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003245752A AU2003245752A1 (en) 2002-06-28 2003-06-27 Process for promoting graft acceptance by depletion of hematopoietic stem cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39259002P 2002-06-28 2002-06-28
US60/392,590 2002-06-28
US35770603A 2003-02-04 2003-02-04
US10/357,706 2003-02-04

Publications (2)

Publication Number Publication Date
WO2004002425A2 WO2004002425A2 (fr) 2004-01-08
WO2004002425A3 true WO2004002425A3 (fr) 2004-08-26

Family

ID=30002887

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/020520 Ceased WO2004002425A2 (fr) 2002-06-28 2003-06-27 Methodes permettant d'ameliorer l'acceptation d'une greffe par depletion des cellules souches hematopoietiques

Country Status (2)

Country Link
AU (1) AU2003245752A1 (fr)
WO (1) WO2004002425A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008067115A2 (fr) * 2006-11-03 2008-06-05 The Board Of Trustees Of The Leland Stanford Junior University Immunodéplétion sélective de niche de cellules souches endogènes pour greffe
JP2012505193A (ja) 2008-10-10 2012-03-01 プロベルテ ファーマ，エス．エー． 水産養殖用経口投与免疫賦活剤
WO2010067671A1 (fr) * 2008-12-12 2010-06-17 小野薬品工業株式会社 Promoteur de reconstitution immunologique ou agent prophylactique pour infections, chacun d'entre eux conservant un effet greffe contre tumeur
AR085091A1 (es) 2011-01-26 2013-09-11 Kolltan Pharmaceuticals Inc Anticuerpos anti-kit y sus usos
RU2681730C2 (ru) 2012-07-25 2019-03-12 Селлдекс Терапьютикс Инк. Антитела против kit и их применения
WO2015050959A1 (fr) * 2013-10-01 2015-04-09 Yale University Anticorps anti-kits et leurs méthodes d'utilisation
CN113908269A (zh) 2014-05-23 2022-01-11 塞尔德克斯医疗公司 嗜酸性粒细胞或肥大细胞相关病症的治疗
WO2016022166A1 (fr) * 2014-08-07 2016-02-11 Nitor Therapeutics Utilisation d'inhibiteur de pnp pour traiter une récidive de tumeur maligne après transplantation de cellules souches hématopoïétiques
ES2845898T5 (en) 2014-08-26 2025-06-17 Univ Leland Stanford Junior Engraftment of stem cells with a combination of an agent that targets stem cells and modulation of immunoregulatory signaling
EP3280720A4 (fr) 2015-04-06 2018-12-05 President and Fellows of Harvard College Compositions et procédés s'appliquant au conditionnement non myéloablatif
PL3341015T5 (pl) 2015-08-26 2024-04-08 The Board Of Trustees Of The Leland Stanford Junior University Zwiększona deplecja komórek docelowych z blokadą cd47 i immunologicznym agonistą kostymulatorowym
KR20230066647A (ko) * 2016-06-17 2023-05-16 마젠타 테라퓨틱스 인코포레이티드 Cd117+ 세포의 고갈을 위한 조성물 및 방법
JOP20190155A1 (ar) * 2016-12-21 2019-06-23 Novartis Ag مترافقات عقار جسم مضاد لإزالة خلايا جذعية مكونة للدم
IL267912B2 (en) 2017-01-30 2023-09-01 Univ Leland Stanford Junior A genotoxic matching regimen for stem cell transplantation
US12485186B2 (en) 2017-03-31 2025-12-02 The Children's Medical Center Corporation Antibody-mediated conditioning with immunosuppression to enable allogeneic transplantation
KR20250134703A (ko) 2018-05-11 2025-09-11 빔 테라퓨틱스, 인크. 프로그래밍가능한 염기 편집기 시스템을 이용하여 병원성 아미노산을 치환하는 방법
TW202014209A (zh) * 2018-06-20 2020-04-16 瑞士商諾華公司 用於消融造血幹細胞之抗體藥物軛合物
AU2019390394C1 (en) 2018-11-28 2024-11-28 Forty Seven, LLC Genetically modified HSPCs resistant to ablation regime
JP2022530100A (ja) * 2019-04-25 2022-06-27 アクティニウム ファーマシューティカルズ インコーポレイテッド 悪性および非悪性血液疾患の治療のための免疫枯渇の組成物および方法
EP4611807A1 (fr) * 2022-11-04 2025-09-10 The Board of Trustees of the Leland Stanford Junior University Rééquilibrage du système immunitaire par déplétion de cellules souches hématopoïétiques orientées production de myéloïdes

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007444A1 (fr) * 1996-08-16 1998-02-26 Biotransplant, Inc. ANTICORPS LO-CD2a ET SON UTILISATION POUR INHIBER L'ACTIVATION ET LA PROLIFERATION DE CELLULES T
WO2001025398A2 (fr) * 1999-10-01 2001-04-12 Biotransplant Incorporated Technique permettant d'induire une tolerance fonctionnelle a des produits de transfert genique
WO2001030369A1 (fr) * 1999-10-22 2001-05-03 Biotransplant, Inc. Procede d'induction d'une tolerance immunologique pour des greffons heterologues
WO2001087310A1 (fr) * 2000-05-18 2001-11-22 Biotransplant, Inc. Procede de reduction de la reponse anticorps contre des xenogreffes
WO2002033043A2 (fr) * 2000-10-18 2002-04-25 Coriell Institute For Medical Research Methode et marqueur d'isolement de cellules souches humaines hematopoietiques multipotentes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007444A1 (fr) * 1996-08-16 1998-02-26 Biotransplant, Inc. ANTICORPS LO-CD2a ET SON UTILISATION POUR INHIBER L'ACTIVATION ET LA PROLIFERATION DE CELLULES T
WO2001025398A2 (fr) * 1999-10-01 2001-04-12 Biotransplant Incorporated Technique permettant d'induire une tolerance fonctionnelle a des produits de transfert genique
WO2001030369A1 (fr) * 1999-10-22 2001-05-03 Biotransplant, Inc. Procede d'induction d'une tolerance immunologique pour des greffons heterologues
WO2001087310A1 (fr) * 2000-05-18 2001-11-22 Biotransplant, Inc. Procede de reduction de la reponse anticorps contre des xenogreffes
WO2002033043A2 (fr) * 2000-10-18 2002-04-25 Coriell Institute For Medical Research Methode et marqueur d'isolement de cellules souches humaines hematopoietiques multipotentes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BUHLER L. ET AL: "High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response", TRANSPLANTATION, vol. 69, no. 11, 15 June 2000 (2000-06-15), pages 2296 - 2304, XP002978334 *
BUHLER L. ET AL: "Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade", TRANSPLANTATION, vol. 73, no. 1, 15 January 2002 (2002-01-15), pages 12 - 22, XP002978708 *
GIOVINO MA ET AL: "Porcine hematopoiesis on primate stroma in long-term cultures: enhanced growth with neutralizing tumor necrosis factor-alpha and tumor growth factor-beta antibodies", TRANSPLANTATION, vol. 73, no. 5, 15 March 2002 (2002-03-15), pages 723 - 731, XP002978373 *

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WO2004002425A2 (fr) 2004-01-08
AU2003245752A8 (en) 2004-01-19
AU2003245752A1 (en) 2004-01-19

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