WO2004002425A3 - Methodes permettant d'ameliorer l'acceptation d'une greffe par depletion des cellules souches hematopoietiques - Google Patents

Methodes permettant d'ameliorer l'acceptation d'une greffe par depletion des cellules souches hematopoietiques Download PDF

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Publication number
WO2004002425A3
WO2004002425A3 PCT/US2003/020520 US0320520W WO2004002425A3 WO 2004002425 A3 WO2004002425 A3 WO 2004002425A3 US 0320520 W US0320520 W US 0320520W WO 2004002425 A3 WO2004002425 A3 WO 2004002425A3
Authority
WO
WIPO (PCT)
Prior art keywords
stem cells
hematopoietic stem
depletion
depleting
inactivating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/020520
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English (en)
Other versions
WO2004002425A2 (fr
Inventor
Julian D Down
Mary E White-Scharf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotransplant Inc
Original Assignee
Biotransplant Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotransplant Inc filed Critical Biotransplant Inc
Priority to AU2003245752A priority Critical patent/AU2003245752A1/en
Publication of WO2004002425A2 publication Critical patent/WO2004002425A2/fr
Publication of WO2004002425A3 publication Critical patent/WO2004002425A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des compositions thérapeutiques et des méthodes qui permettent de moduler le système immunitaire pour améliorer l'acceptation d'une greffe et pour traiter une malignité hématologique en l'absence de thérapies myéloablatives. La méthodologie décrite comprend une étape qui consiste à appauvrir et/ou à inactiver les cellules souches hématopoïétiques du destinataire au moyen d'une composition thérapeutique comprenant au moins un anticorps spécifique pour appauvrir et/ou inactiver les cellules souches hématopoïétiques tout en préservant les cellules sanguines matures, de préférence l'anticorps appauvrit sélectivement et/ou inactive les cellules souches hématopoïétiques primitives. La composition thérapeutique est de préférence administrée avant l'administration de moelle osseuse, de cellules souches hématopoïétiques périphériques mobilisées ou de leucocytes du donneur.
PCT/US2003/020520 2002-06-28 2003-06-27 Methodes permettant d'ameliorer l'acceptation d'une greffe par depletion des cellules souches hematopoietiques Ceased WO2004002425A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003245752A AU2003245752A1 (en) 2002-06-28 2003-06-27 Process for promoting graft acceptance by depletion of hematopoietic stem cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39259002P 2002-06-28 2002-06-28
US60/392,590 2002-06-28
US35770603A 2003-02-04 2003-02-04
US10/357,706 2003-02-04

Publications (2)

Publication Number Publication Date
WO2004002425A2 WO2004002425A2 (fr) 2004-01-08
WO2004002425A3 true WO2004002425A3 (fr) 2004-08-26

Family

ID=30002887

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/020520 Ceased WO2004002425A2 (fr) 2002-06-28 2003-06-27 Methodes permettant d'ameliorer l'acceptation d'une greffe par depletion des cellules souches hematopoietiques

Country Status (2)

Country Link
AU (1) AU2003245752A1 (fr)
WO (1) WO2004002425A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3255061T (pt) * 2006-11-03 2021-07-26 Univ Leland Stanford Junior Imunodepleção seletiva de nicho de células estaminais endógenas para enxerto
JP2012505193A (ja) 2008-10-10 2012-03-01 プロベルテ ファーマ，エス．エー． 水産養殖用経口投与免疫賦活剤
US9156912B2 (en) * 2008-12-12 2015-10-13 The University Of Tokyo Immunological reconstitution promoter or prophylactic agent for infections each of which maintains graft-versus-tumor effect
EP3763740A1 (fr) 2011-01-26 2021-01-13 Celldex Therapeutics, Inc. Anticorps anti-kit et leurs utilisations
CN104812775B (zh) 2012-07-25 2019-05-03 塞尔德克斯医疗公司 抗kit抗体及其用途
WO2015050959A1 (fr) * 2013-10-01 2015-04-09 Yale University Anticorps anti-kits et leurs méthodes d'utilisation
EP3145543A4 (fr) 2014-05-23 2017-12-13 Celldex Therapeutics, Inc. Traitement des affections associées aux éosinophiles ou aux mastocytes
US20170209447A1 (en) * 2014-08-07 2017-07-27 Nitor Therapeutics Use of PNP Inhibitor to Treat Relapse of Malignancy after Hematopoietic Stem Cell Transplant
DK3656869T4 (da) 2014-08-26 2025-05-19 Univ Leland Stanford Junior Transplantation af stamceller med en kombination af et stof, som er rettet mod stamceller, og modulation af immunregulatorisk signalering
WO2016164502A1 (fr) 2015-04-06 2016-10-13 President And Fellows Of Harvard College Compositions et procédés s'appliquant au conditionnement non myéloablatif
ES2894335T5 (es) 2015-08-26 2024-06-27 Univ Leland Stanford Junior Reducción mejorada de células objetivo con bloqueo de CD47 y un agonista coestimulador inmune
MX2018015684A (es) 2016-06-17 2019-08-29 Magenta Therapeutics Inc Composiciones y metodos para el agotamiento de celulas cd117.
CN110099697B (zh) * 2016-12-21 2023-11-28 诺华股份有限公司 用于消融造血干细胞的抗体药物缀合物
BR112019015342A2 (pt) 2017-01-30 2020-03-10 The Board Of Trustees Of The Leland Stanford Junior University Regime de condicionamento não genotóxico para o transplante de células-tronco
US12485186B2 (en) 2017-03-31 2025-12-02 The Children's Medical Center Corporation Antibody-mediated conditioning with immunosuppression to enable allogeneic transplantation
AU2019265019B2 (en) 2018-05-11 2025-11-06 Beam Therapeutics Inc. Methods of substituting pathogenic amino acids using programmable base editor systems
UY38265A (es) * 2018-06-20 2020-01-31 Novartis Ag Conjugados anticuerpo droga para ablación de células madre hematopoyéticas
CA3120570A1 (fr) 2018-11-28 2020-06-04 Forty Seven, Inc. Csph genetiquement modifiees resistantes au traitement ablatif
US20220211885A1 (en) * 2019-04-25 2022-07-07 Actinium Pharmaceuticals, Inc. Compositions and methods of immunodepletion for the treatment of malignant and non-malignant hematological diseases
WO2024097131A1 (fr) * 2022-11-04 2024-05-10 The Board Of Trustees Of The Leland Stanford Junior University Rééquilibrage du système immunitaire par déplétion de cellules souches hématopoïétiques orientées production de myéloïdes

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007444A1 (fr) * 1996-08-16 1998-02-26 Biotransplant, Inc. ANTICORPS LO-CD2a ET SON UTILISATION POUR INHIBER L'ACTIVATION ET LA PROLIFERATION DE CELLULES T
WO2001025398A2 (fr) * 1999-10-01 2001-04-12 Biotransplant Incorporated Technique permettant d'induire une tolerance fonctionnelle a des produits de transfert genique
WO2001030369A1 (fr) * 1999-10-22 2001-05-03 Biotransplant, Inc. Procede d'induction d'une tolerance immunologique pour des greffons heterologues
WO2001087310A1 (fr) * 2000-05-18 2001-11-22 Biotransplant, Inc. Procede de reduction de la reponse anticorps contre des xenogreffes
WO2002033043A2 (fr) * 2000-10-18 2002-04-25 Coriell Institute For Medical Research Methode et marqueur d'isolement de cellules souches humaines hematopoietiques multipotentes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007444A1 (fr) * 1996-08-16 1998-02-26 Biotransplant, Inc. ANTICORPS LO-CD2a ET SON UTILISATION POUR INHIBER L'ACTIVATION ET LA PROLIFERATION DE CELLULES T
WO2001025398A2 (fr) * 1999-10-01 2001-04-12 Biotransplant Incorporated Technique permettant d'induire une tolerance fonctionnelle a des produits de transfert genique
WO2001030369A1 (fr) * 1999-10-22 2001-05-03 Biotransplant, Inc. Procede d'induction d'une tolerance immunologique pour des greffons heterologues
WO2001087310A1 (fr) * 2000-05-18 2001-11-22 Biotransplant, Inc. Procede de reduction de la reponse anticorps contre des xenogreffes
WO2002033043A2 (fr) * 2000-10-18 2002-04-25 Coriell Institute For Medical Research Methode et marqueur d'isolement de cellules souches humaines hematopoietiques multipotentes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BUHLER L. ET AL: "High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response", TRANSPLANTATION, vol. 69, no. 11, 15 June 2000 (2000-06-15), pages 2296 - 2304, XP002978334 *
BUHLER L. ET AL: "Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade", TRANSPLANTATION, vol. 73, no. 1, 15 January 2002 (2002-01-15), pages 12 - 22, XP002978708 *
GIOVINO MA ET AL: "Porcine hematopoiesis on primate stroma in long-term cultures: enhanced growth with neutralizing tumor necrosis factor-alpha and tumor growth factor-beta antibodies", TRANSPLANTATION, vol. 73, no. 5, 15 March 2002 (2002-03-15), pages 723 - 731, XP002978373 *

Also Published As

Publication number Publication date
AU2003245752A1 (en) 2004-01-19
WO2004002425A2 (fr) 2004-01-08
AU2003245752A8 (en) 2004-01-19

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