WO2004100850A2 - Procede pour therapie, chirurgie et delivrance de medicaments sous ultrasons par contact en gaz - Google Patents

Procede pour therapie, chirurgie et delivrance de medicaments sous ultrasons par contact en gaz Download PDF

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Publication number
WO2004100850A2
WO2004100850A2 PCT/US2004/014354 US2004014354W WO2004100850A2 WO 2004100850 A2 WO2004100850 A2 WO 2004100850A2 US 2004014354 W US2004014354 W US 2004014354W WO 2004100850 A2 WO2004100850 A2 WO 2004100850A2
Authority
WO
WIPO (PCT)
Prior art keywords
ultrasound
transducer
specimen surface
gas contact
treated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/014354
Other languages
English (en)
Other versions
WO2004100850A3 (fr
Inventor
Mahesh C. Bhardwaj
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ULTRAN LABS Inc
Original Assignee
ULTRAN LABS Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ULTRAN LABS Inc filed Critical ULTRAN LABS Inc
Publication of WO2004100850A2 publication Critical patent/WO2004100850A2/fr
Publication of WO2004100850A3 publication Critical patent/WO2004100850A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Definitions

  • the present invention relates to a method of applying gas contact ultrasound therapy.
  • High energy ultrasound is used for cell disruption, particle size reduction, welding, cleaning, and for therapeutic and surgical applications and procedures.
  • the ultrasonic transducer the source of ultrasound
  • the transducer is either in direct or in indirect contact with the specimen to be treated.
  • the transducer is placed in a liquid, generally water or a gelatinous material, that acts as the carrier medium of ultrasound.
  • the carrier medium acts as a conduit for ultrasound delivery to the specimen surface for treatment.
  • a method for applying high power ultrasound without direct or indirect contact with the specimen to be treated comprising the steps of: providing a transducer, placing the transducer spaced apart from the specimen surface to be treated, and applying pulses of ultrasound via the transducer to the specimen surface at a distance from the specimen surface to be treated.
  • a carrier medium is not necessary to transmit the pulses of ultrasound to the skin surface when using the method of the present invention.
  • the method of the present invention can be used to provide ultrasound therapy, surgery, and enhance drug delivery to humans, animals, and polymeric substances. When used to enhance drug delivery, the human or animal epidermal surface will be initially exposed to one or more of drugs, molecules, compounds, or medicinal products before applying pulses of the gas contact ultrasound.
  • the drawing is a schematic illustration of an intense ultrasound field emanating from the ultrasonic transducer and the needle-type oscillating wavefront.
  • the present invention includes a method for applying high power ultrasound without direct or indirect contact with the specimen surface to be treated.
  • the transducer emits high frequency sound waves which penetrate and infiltrate the specimen surface.
  • the specimen surface can be human tissue, such as the dermis of the skin, or can be a polymer material.
  • the application of high power ultrasound without direct or indirect contact with the specimen surface allows for a novel approach to ultrasound therapy, surgery, and drug delivery techniques and enhancements.
  • An apparatus for application of high power ultrasound without contact is disclosed in the '573 patent (identified above).
  • Ultrasound is transmitted through a gaseous medium by bonding a facing layer of fibrous material to the transmission surface of a transducer, for example, a piezoelectric transducer without substantial penetration of the bonding agent into the facing layer of fibrous material.
  • the transient high pressure and temperature produced by the high power ultrasound it also should be possible to efficiently transfer drugs, molecules, compounds, medicinal products, etc. from the epidermis of human or animal skin into the deeper parts of the human or animal body.
  • the transducer frequency By manipulating the transducer frequency, active area dimensions, the field of ultrasound (such as by focusing it), excitation conditions, including pulse repetition frequency (if operating in a pulsed mode), or by excitation amplitude (if operating by a continuous wave), the magnitude of ultrasonic effects and depth of their penetration into the human body can be effectively controlled.
  • excitation conditions including pulse repetition frequency (if operating in a pulsed mode), or by excitation amplitude (if operating by a continuous wave
  • the sensation described herein is not analogous to the continuous effect of either very hot air or the continuous effect of air under high pressure alone.
  • the sensation is the feeling of short-lived pressure and temperature.
  • this sensation while felt in the area corresponding to that of the transducer or that of the exposed body part, is not flat and constant over the exposed region.
  • the sensation appears as if a very large number of needles, capable of emitting high pressures and temperatures simultaneously, act upon the specimen surface being irradiated. It is thought, without the intention of being bound by this theory, that the diameter of each so-called needle corresponds to that of the wavelength of ultrasound in air. For example, for 150 kHz and 350 kHz, it is 2.3 mm and 1.0 mm, respectively.
  • the intense pressures and temperatures felt are transient in nature. They last for very short durations of time which can be controlled by increasing or decreasing the pulse repetition rates by which the transducer is activated. Additionally, the magnitude of the effects reported herein will also depend upon the displacements within the irradiated parts of the human body. For example, at lower frequencies where the displacements are relatively large, the effects of pressure and temperature may be more intense and may last longer. For example, at 350 kHz, the sharpness of the effect was more intense and uniform relative to the same at 150 kHz.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un procédé d'application d'ultrasons par contact en gaz, sur une surface de spécimen, au moyen d'un transducteur, sans milieu vecteur. On peut utiliser ce procédé pour l'application d'ultrasons en thérapie et en chirurgie, pour améliorer la délivrance de médicaments au humains et aux animaux, ainsi que la délivrance de substances polymères.
PCT/US2004/014354 2003-05-08 2004-05-07 Procede pour therapie, chirurgie et delivrance de medicaments sous ultrasons par contact en gaz Ceased WO2004100850A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46879803P 2003-05-08 2003-05-08
US60/468,798 2003-05-08

Publications (2)

Publication Number Publication Date
WO2004100850A2 true WO2004100850A2 (fr) 2004-11-25
WO2004100850A3 WO2004100850A3 (fr) 2005-07-28

Family

ID=33452231

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/014354 Ceased WO2004100850A2 (fr) 2003-05-08 2004-05-07 Procede pour therapie, chirurgie et delivrance de medicaments sous ultrasons par contact en gaz

Country Status (1)

Country Link
WO (1) WO2004100850A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7553284B2 (en) 2005-02-02 2009-06-30 Vaitekunas Jeffrey J Focused ultrasound for pain reduction

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5413550A (en) * 1993-07-21 1995-05-09 Pti, Inc. Ultrasound therapy system with automatic dose control
US5807285A (en) * 1994-08-18 1998-09-15 Ethicon-Endo Surgery, Inc. Medical applications of ultrasonic energy

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7553284B2 (en) 2005-02-02 2009-06-30 Vaitekunas Jeffrey J Focused ultrasound for pain reduction

Also Published As

Publication number Publication date
WO2004100850A3 (fr) 2005-07-28

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