WO2004110128A2 - Systeme pbod (plusieurs corps sur demande) - Google Patents

Systeme pbod (plusieurs corps sur demande) Download PDF

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Publication number
WO2004110128A2
WO2004110128A2 PCT/US2004/026528 US2004026528W WO2004110128A2 WO 2004110128 A2 WO2004110128 A2 WO 2004110128A2 US 2004026528 W US2004026528 W US 2004026528W WO 2004110128 A2 WO2004110128 A2 WO 2004110128A2
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WO
WIPO (PCT)
Prior art keywords
pbod
tube
liquid
dose
gas
Prior art date
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Ceased
Application number
PCT/US2004/026528
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English (en)
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WO2004110128A3 (fr
WO2004110128A8 (fr
Inventor
Louis A. Coffelt, Jr.
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Individual
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Individual
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Priority to US11/578,745 priority Critical patent/US20070257066A1/en
Priority to PCT/US2004/026528 priority patent/WO2004110128A2/fr
Publication of WO2004110128A2 publication Critical patent/WO2004110128A2/fr
Publication of WO2004110128A8 publication Critical patent/WO2004110128A8/fr
Publication of WO2004110128A3 publication Critical patent/WO2004110128A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0026—Ophthalmic product dispenser attachments to facilitate positioning near the eye

Definitions

  • a pbod consists essentially of: a dose of liquid having the form of one ball; and a dose of gas having the form of a plurality of balls (bubbles); and the ball of liquid encloses the balls of gas; and the pbod is assembled on demand. Portions of the present description are previously disclosed in COFFELT 9 JR. U.S. patent application No. 10/827,901 filed 19 April 2004 (19.04.04).
  • Pbod systems are capable of providing a solution to numerous problems. Obviously, there are many pertinent problems in many various technologies, which are incorporated herein by reference. The pbod may be used in any of these pertinent arts. The following are examples of these pertinent arts and problems.
  • pendant drops The art of forming pendant drops is well known. And further, there are many arts, which utilize the pendant drop, or droplet. For example, fuel injection, surgery, chemical / biological arts, or eye drops, including many others. And within these arts, a typical range of quantities is in the microliter range. For example, an over-the-counter pendant eye drop is between 15 to 30 microliters. It is also well known, an optimal quantity of liquid for opthalmic medicament applications is in the 5 to 7 microliter range. For example, TIMOLOL (Bausch & Lomb , Rochester, NY,U.S.). And in light of the high cost of opthalmic medicament, a 3 microliter dose is most likely highly desireable.
  • Examples of complex dispensing apparatus include, Cohen et al U.S. patent No. RE 38,007 discloses a microdispensing opthalmic pump.
  • the systems of Cohen inescapably dispense a plurality of droplets.
  • the systems in Cohen are required to contain several complex moving parts.
  • this complex prior system includes springs, balls, moving pistons, and check valves. Therefore, the systems of Cohen are subject to failure, error, repair, or recalibration due to the inescapable inherent frictional forces present in the system.
  • Further example of complex prior systems include Ershow et al U.S. patent No. 5,756050 discloses a device for dispensing microdoses (microdrops / drops). For example, BIOMEK.
  • RTM.1000 (BECKMAN) Automated Laboratory Workstation for dispensing cell lines and bacteria. Further attempts to solve these pertinent problems are disclosed in Coffelt,Jr. U.S. patent No. 6,206,297 gasdrop and apparatus for manufacturing gasdrop. The accuracy of dosages in the gasdrop, in the microliter range, is unknown. Excessive fuel emissions is also a well known problem. The emissions of combustion engines clearly must be reduced to a minimum. And it is obvious, if the same quantity of power can be produced from less fuel, the emissions will most likely be less. Pbod systems is a pioneering technology. This technology is disclosed in Coffelt,Jr. International Publication No. WO 02/43845, published under the Patent Cooperation Treaty 06 June 2002, Dual microliter dosage system.
  • a "pbod” is a “dosdrop”; and a “pbod” is a “microdose” where each of these terms refer to the same structure.
  • the objective of these changes in name is to attain the most suitable name for this pioneering article of manufacture.
  • a pbod refers to "plural body on demand”.
  • a pbod consists essentially of: a dose of liquid having the form of one first ball; and a dose of gas having the form of a plurality of balls (bubbles); and the ball of liquid encloses the balls of gas; and the pbod is assembled on demand. And the pbod is ejected from the system on demand.
  • the prior pbod systems in WO 02/43845 utilize distinct discrete complex metering apparatus, first, to inject a dose of liquid into the flow channel; and second, insert a syringe needle into the dose of liquid; and ' third, inject a dose of gas into the liquid via the needle.
  • the dose of gas is formed by inserting the needle into the liquid; and displacing the plunger of the syringe.
  • a motive gas ejects this dose of liquid and dose of gas having the form of one pbod. Where this motive gas may form a portion of the dose of gas.
  • the prior art motive gas does NOT form the complete dose of gas.
  • the prior art does not contemplate any method or or apparatus to attain the results of the present invention.
  • the present pioneering discovery will be greatly appreciated for providing simple, reliable pbod systems, which transport a unitary body of liquid and gas to a target. Where optimal accurate doses of liquid and gas are attainable. Further, provide a pbod system which is capable of allowing the doses to vary over a range of quantities IF desired. Further, provide a pbod system capable of being adapted to be used, for example, in a doctor-patient or self ⁇ instill enviornment; and possibly chemical / biological enviornment , for example, pipette systems; fuel injection enviornment, including many other technologies, which rely on this type of fluid and/or gas transportation. The present pioneering discovery will be greatly appreciated for providing reliable pbod systems, which may provide a solution to problems in many various technologies.
  • a pbod consists essentially of: a dose of liquid having the form of one first ball; and a dose of gas having the form of a plurality of balls (bubbles); and the ball of liquid encloses the balls of gas; and these components of the pbod are assembled on demand. For example, first, the ball of liquid is disjointed from the gas; and second, the ball of liquid encloses the gas.
  • a novel pbod system resides in a pbod system where a complete dose of gas is formed essentially by a motive gas. Where this motive gas is the sole source of this complete dose of gas. And this dose of gas is subsequently the complete dose of gas in one pbod.
  • the present disclosure includes a second discovery. Where this second discovery is summarized as a pbod capable of being dispensed from any indiscriminate selected initial velocity. For example, a pbod having an initial velocity, which is either vertical, horizontal, or any other selected orientation.
  • the present disclosure includes a third discovery. This third discovery is summarized as a succession of identical bubbles formed essentially by a motive gas. Where the spacing of these bubbles appears to be nearly identical. Further, the diameter of these identical bubbles is inversely proportional to the flow speed. For example, a greater flow speed forms smaller bubbles. (i.e. 0.003cm or 0.03cm dia.)
  • the present disclosure includes a fourth discovery.
  • This fourth discovery is summarized as a pbod system, which utilizes inherent residual liquid in a discharge tube. This system ejects a pbod from the discharge tube; and a dose of liquid inherently remains in the discharge tube; and this residual liquid inherently forms a plurality of transverse walls; and this residual liquid is used in conjunction with an additional dose of liquid to form a subsequent pbod.
  • a 3 ul dose of liquid is added to 1 ul residual liquid to form a 3 ul pbod.
  • FIG. 1 is a right side perspective sectional view of a pbod dispenser, including: a flexible bottle (40); a dispensing tip (100A); a liquid (50); gas (60); and a pbod (70).
  • FIG. 2 is a right side sectional view of pbod dispensing tip (100A); and bottle (40).
  • FIG. 3 is a top view of pbod dispensing tip (100A).
  • FIG. 4 is a right side view of structure (22).
  • FIG. 5 is a right side sectional view of pbod dispensing tip (100A); and the axis of tube (27) is horizontal.
  • FIG. 6 is a right side sectional view of pbod dispensing tip (100A); and tip (100A) contains a dose (77) of liquid (50).
  • FIG. 7 is a right side sectional view of pbod dispensing tip (100A); and tip (100A) contains the dose (77); and dose (77) encloses a dose (10) of gas (60); and dose (10) having the form of a plurality of balls (bubbles).
  • FIG. 8 is a front sectional view of a prototype R22; and a succession of identical bubbles (204).
  • FIG. 9 is a front view of a prototype RlI; and a pbod (70).
  • FIG. 1 does not show resin (5) for clarity; and FIG. 1 does not show resin (1) for clarity.
  • FIG. 2 does not show portions of cap (45) for clarity; and does not show portions of cap (41) for clarity.
  • FIG. 5 does not show portions of tube (43) for clarity; and a single line is utilized to represent tube (43).
  • the present pioneering discovery resides in pbod systems, Including, a pbod system where a complete dose of gas is formed essentially by a motive gas. Where this dose of gas is the complete dose of gas in one pbod.
  • the pbod is referred to as a "microdose" in the International Application published under the Patent Cooperation Treaty under No. WO 02/43845, 06 June 2002 (06.06.02), Dual Microliter Dosage System.
  • the structure of the microdose in WO 02/43845 is the same structure disclosed in the present specification. Where this structure is presently identified by the term "pbod". The name is changed to attain the most suitable name for this pioneering article of manufacture.
  • a pbod consists essentially of: a dose of liquid having the form of one first ball; and a dose of gas having the form of a plurality of balls (bubbles); and the ball of liquid encloses the balls of gas; and these components of the pbod are assembled on demand. For example, first, the liquid is disjointed from the gas, and second, the ball of liquid encloses the balls of gas. The pbod is subsequently ejected from the system.
  • Each dose, liquid, gas, motive gas, and additional pertinent parameters must be capable to assemble a pbod on demand. If a pbod is formed, it can be concluded, all pertinent parameters are capable to form one pbod.
  • a pbod exists in two states. First, a non-discrete pbod attached to a surface. Second, a discrete pbod.
  • Objectives of the present invention include, provide a pbod system where a complete dose of gas is formed essentially by a motive gas. Further, provide a pbod system, which is simple, relatively inexpensive, and substantially more reliable over the prior art. Further, provide a pbod system capable of attaining optimal dosages. i.e. opthalmic, fuel-injection, including many others. Further, provide a pbod system, which is not subject to substantial frictional forces, recalibration, or mechanical failure due to frictional forces. i.e. moving pistons.
  • a second discovery includes a pbod capable of being dispensed from from any indiscriminate selected initial velocity. For example, a pbod having an initial velocity, which is either vertical, horizontal, or any other selected orientation.
  • a third discovery includes a succession of identical bubbles formed essentially by a motive gas. Where the spacing of these bubbles appears to be nearly identical. Further, the diameter of these identical bubbles is inversely proportional to the flow speed. For example, a greater flow speed forms smaller bubbles. For example, a flow speed of [x] forms bubbles of 0.03 cm diameter; and a flow speed of [y] forms bubbles of 0.003 cm diameter; where [y] is greater than [x] .
  • a fourth discovery includes a pbod system, which utilizes inherent residual liquid in a discharge tube.
  • this pbod system ejects a pbod from the discharge tube; and second, a dose of liquid inherently remains in the discharge tube; and third, this residual liquid inherently forms a plurality of transverse walls; and this residual liquid is used in conjunction with an additional dose of liquid to form a subsequent pbod. For example, a 3 ul dose of liquid is added to 1 ul residual liquid to form a 3 ul pbod.
  • the present • specification contains well known structures having axis of symmetry. Where these structures have a longitudinal axis of symmetry, and a transverse axis of symmetry.
  • the transverse axis of symmetry coincides with a diameter of the tube.
  • the longitudinal axis of symmetry is a line perpendicular to the diameter and intersecting the mid-point of the diameter.
  • the following embodiments are described with reference to the longitudinal axis of symmetry.
  • the longitudinal axis of symmetry of tube (27) is vertical.
  • the term "axis" as used hereinafter means: " the longitudinal axis of symmetry" .
  • transverse as used hereinafter means: " a direction perpendicular to the longitudinal axis of symmetry" .
  • a transverse direction is disposed in a horizontal plane relative to the axis of tube (27).
  • FIG. 1 is a right side perspective sectional view of a pbod dispensing tip (100A). Dispensing tip (100A) is symmetrical, therefore, the left side perspective sectional view is a mirror image of FIG. 1.
  • the lower end of tip (100A) is a cylindrical shaped tube (27). Tube (27) having a flat annular outlet (25).
  • a conical shaped tube (28) is rigidly attached to the upper end of tube (27).
  • the upper end of tube (28) is monolithic with a transverse disc shaped wall.
  • This disc shaped wall having a centrally located opening (35).
  • tube (28), the disc shaped wall, and opening (35) can be a standard VISINE dispensing tip. i.e. over-the- counter eye drops.
  • FIG. 2 shows tube (27) is attached to tube (28) by an annular epoxy resin (4).
  • Resin (4) forms a leak-tight seal at this point of attachment.
  • FIG. 1 shows the inner diameter surface of tube (27) and the inner diameter surface of tube (28) forms a continuous flow channel.
  • the axis of tube (27) is co-axial with the axis of tube (28).
  • tube (27) and tube (28) are clearly standard methods to form tube (27) and tube (28) as a unitary body. Therefore, the lower end of tip (100A) does not show the joints and resin (4) in FIG. 1.
  • a cylindrical shaped tube (29) is rigidly attahced to the upper end of tube (28). This attachment is formed by annular epoxy resin (4). An annular leak-tight seal is formed at this point of attahment.
  • Tube (29) is co-axial with tube (28) .
  • the lower end of tube (29) is co-planar with the upper end of tube (28).
  • K cylindrical shaped tube (11) is rigidly attached to the upper end of tube (29).
  • the upper flat annular surface 5 of tube (11) is co-planar with the upper flat annular surface of tube (29).
  • Tube (11) is attached to tube (29) by annular epoxy resin (2).
  • the boundaries of resin (2) are limited to the lower flat annular surface of tube (11).
  • the boundaries of resin (2) are also limited to the outer surface of tube .0 (29).
  • FIG. 2 shows a structure (22) is rigidly attached to the upper end of tube (29). This attachment is formed by epoxy resin (1).
  • Resin (1) is located at two places, one at the lower left side of structure (22), and one at the lower right .5 side of structure (22) (FIG. 2).
  • the boundaries of resin (1) are limited to the outer surface of structure (22).
  • the boundaries of resin (1) are also limited to the width of structure (22) indicated by the dimension "N”.
  • the boundaries of resin (1) are also limited to the upper flat surface of i0 tube (11), and the upper flat surface of tube (29).
  • Structure (22) is formed of two flat rectangular converging walls.
  • FIG. 2 and FIG. 4 show structure (22) having an inverted V shape.
  • FIG. 3 is a top view of dispensing tip (100A) .
  • FIG. 3 .5 does not show resin (1) for clarity.
  • FIG. 3 shows structure (22) is centrally located on tube (11). And the width of structure (22) is indicated by dimension "N”.
  • FIG. 4 is a right side view of structure (22).
  • the height of structure (22) is indicated by dimension "V”.
  • the distance between the lower end of the walls is indicated by dimension "Y”.
  • a tube (43) is rigidly attached to the lower portion of tube (27), as shown in FIG. 2. This attachment is formed by an annular epoxy resin (5). Resin (5) provides a leak- 5 tight seal. Outlet (25) is located near the mid-point of the axial length of tube (43). Tube (43) is co-axial with tube (27).
  • Tube (43) is rigidly attached to a bottle (40) as shown in FIG. 2. This attachment is formed by an annular epoxy resin (6). Resin (6) forms a leak-tight seal.
  • the lower end of tube (43) includes a removeable cap (45), and a removeable seal (44).
  • a removeable cap 45
  • a removeable seal 44
  • the 5 cap and tip on a standard VISINE bottle (eye drop bottle) - Bottle (40) also includes a removeable cap (41), and a removeable seal (42).
  • FIG. 2 shows bottle (40) contains an appropriate quantity of liquid (50).
  • the appropriate quantity of liquid (50) O can be determined according to the objectives set forth in the following ' experiments .
  • FIG. 1 depicts a general embodiment of a pbod dispenser.
  • a pbod dispenser used to self-instill a pbod on the eye.
  • FIG. 1 shows point S is on the left side vertical wall of bottle (40). And point T is on the right side vertical wall of bottle (40). Where these points S and point T are the typical points used to dispense a 30ul pendant drop from a standard VISINE eye drop bottle. :0
  • Prototype R29 is similar to FIG. 1. Prototype R29 utilizes a VISINE bottle (40). Where points S and point T are on the vertical side walls of the VISINE bottle (40); and the axis of tube (27) is vertical.
  • dispensing tip (100A) is located near the neck of the VISINE bottle. Where an objective of this location is to avoid damage to the dispensing tip (100A) 0 during collapsing of the bottle walls.
  • FIG. 1 shows an appropriate quantity of liquid (50) located in the lower portion of bottle (40).
  • the appropriate quantity of liquid (50) can be determined according to the objectives set forth in the following 5 experiments. For example, bottle (40) is rotated such that structure (22) is immersed in liquid (50); and bottle (40) is rotated such that structure (22) is surrounded by gas (60).
  • FIG. 1 shows a complete pbod dispensing apparatus.
  • FIG. 1 shows a dynamic state.
  • the pbod dispensing apparatus has ejected a pbod (70).
  • Pbod (70) consists essentially of: a dose (77) of liquid (50) having the form of one first ball; and a dose (10) of gas (60) having the form of a plurality of bubbles (75); and dose (77) encloses dose (10); and dose (77) and dose (10) are assembled on demand.
  • This pbod dispensing apparatus shown in FIG. 1 forms a motive gas (65). Where this motive gas (65) is the sole source of the dose (10). Dose (10) is formed essentially by motive gas (65). For example, a syringe needle does not exist in this novel pbod system.
  • Pbod (70) contains three bubbles (75). Where this quantity of three bubbles (75) is within the capabilities of the present specification. And these three bubbles (75) form the complete dose (10).
  • dose (10) is 1 ul of gas (60); therefore, the first bubble (75) contains 0.3 ul of gas (60); and the second bubble (75')! " 56ntains 0.3 ul of gas (60); and the third bubble (75) contains 0.3 ul of gas (60); and each of these three bubbles (75) is formed by motive gas (65).
  • the motive gas (65) forms the three bubbles (75). Arid these three bubbles (75) form the complete dose (10) of pbod (70).
  • FIG. 8 shows a front sectional view of a prototype R22.
  • Prototype R22 is formed of a VISINE bottle (200); and a VISINE dispensing tip (201); and a tube (202).
  • VISINE tip (201) is located at the typical location on the bottle, which dispenses a 30 ul pendant drop.
  • the VISINE tip (201) is not altered.
  • the VISINE bottle (200) is not altered.
  • Tube (202) is cut to fit into the inner diameter of tip (201>). Where these cuts form an inverted conical shape at the upper end of tube (202). Tube (202) is fitted to tip (201) such that a leak-tight seal is formed.
  • Prototype R22 is utilized to form a succession of identical bubbles (204).
  • FIG. 8 shows succession (204) is formed of eight bubbles; and each of these bubbles have identical diameters. For example, for a bubble diameter of 0.007 cm, the variance of the diameter is estimated to be within approximately" plus of minus 0.002 cm.
  • FIG. 8 shows a dynamic state. And also shows a selected quantity of liquid (207) disposed in prototype R22. The upper end of liquid (207) is indicated by the arcuate line at point (211).
  • the concise steps, which form the configura-' tion shown in FIG. 8 are set forth in the following experiment E.
  • FIG. 8 does not show the inherent phenomenon, which causes the succession of identical bubbles ' (204) to be formed.
  • FIG. 8 shows the succession of identical bubbles (204) is located near the axis of tube (202). And liquid (207) encloses bubbles (204).
  • Prototype R22 is described further in the followig table.
  • FIG. 9 shows a front view of a prototype RlI.
  • One of the objectives of prototype RIl is to show a very reliable pbod system.
  • prototype RlI dispenses more than three hundred consecutive pbods; and each pbod contains 7 ul of liquid; and there is no overspray for any trial.
  • prototype RIl utilizes inherent residual liquid located in the discharge tube.
  • FIG. 9 shows the upper end of prototype RlI is a flexible VISINE bottle (300). Where this VISINE bottle does not contain a dispensing tip.
  • the upper end of a tube (301) is rigidly attached to the lower end of the neck of the VISINE bottle (300). Tube (301) is co-axial with the neck of the VISINE bottle. This attachment is formed by an annular epoxy resin (311). Resin (311) forms an annular leak-tight seal .
  • the upper end of a tube (302) is inserted approximately 0.5 cm into the lower end of tube (301).
  • the lower end of tube (301) is indicated by reference numeral (310).
  • Prototype RIl is utilized to dispense a pbod (70)..-
  • the scale of FIG. 9 is not suitable to show the interior structure of pbod (70); and therefore, a dot is utilized to show pbod (70) .
  • Prototype RIl is described further in the following table.
  • a concise method of utilizing prototype RlI is provided in the following Experiment Q.
  • the following prototypes are particular embodiments of the appended figures of the drawing. Where the present description of these figures, and the following description in the prototype table define the structure of the prototype.
  • Each prototype table contains a list of the pertinent figures of the drawing.
  • PROTOTYPE R29, FIG. 2, FIG. 3, and FIG. 4 define the configuration of prototype R29
  • the present description of these figures define the configuration of prototype R29
  • the corresponding parts of prototype R29 are further defined in the prototype table PROTOTYPE R29, and prototype R29 is similar to FIG. 1.
  • All prototypes presented herein are made by the present Inventor. All prototypes are made by hand.
  • only one prototype R29 exists.
  • the cuts are made according to the following steps: First, placing one sheet of paper (20 Ib) on a rigid solid horizontal wooden table; second, placing the part on the sheet of paper; third, placing the cutting edge of the blade on the surface of the part; and the cutting edge of the blade resides approx- imately horizontal; and the cutting edge of the blade remains approximately horizontal throughout the entire cut; fourth, slowly increasing the force on the handle in one vertical direction until cutting begins; and maintaining an approximate constant speed throughout the entire cut; and maintaining only one vertical direction of cutting throughout the entire cut.
  • each entire surface is cut with only one continuous motion. For example, while cutting a 0.5 cm diameter tube, the blade traverses a vertical distance of 0.5 cm in one continuous motion.
  • prototype R29 The parts of prototype R29 are assembled according to the following steps, including:
  • the axis of tube (27) is perpendicular and co-planar with the axis of the neck of the VISINE bottle (40); and dispensing tip (100A) is located near the neck of the VISINE bottle (40).
  • prototype R29 The parts of prototype R29 are placed by hand at the desired location; and the epoxy resin is applied; and the location of the part is adjusted as necessary using a narrow steel rod and magnifying glass ( approximately 3 times power). The dimensions of the prototype are checked after drying.
  • structure (22) is formed from one flat sheet of PVC; and first, cut to the desired width; and second, bend to two flat parallel walls; and third, cut to the desired height; and fourth, seperate the two walls to the desired dimension Y.
  • Prototype R29 is previously described and shown in FIG. 2, FIG. 3, FIG. 4, and similar to FIG. 1; and further described as follows:
  • resin (1) is 0.1 cm wide; 0.13 length; 0.08 cm height; and is located at two places; and the 0.13 cm length of resin (1) coincides with the dimension N of structure (22).
  • annular seal from portion of VISINE dispensing tip; 1.0 cm OD; 0.9 cm ID ⁇ ; and 0.2 cm length (PFIZER, INC.)
  • Prototype R22 is previously described and shown in FIG. 8; and further described as follows:
  • tube (202) tube; and each end is flat; 0.317 cm OD; 0.078 cm ID; 6.5 cm length; polyethelene ; translucent; the upper end of tube (202) is cut to accomodate the lower end ID of tip (201) such that a leak-tight seal is formed
  • tube (302) 0.08 cm ID; 3.0 cm length; the upper end OD of tube (302) is cut such that tube (302) can be inserted into tube (301); and such that a leak- tight seal is formed; polyethelene
  • EXPERIMENT X prototype R29 ; measure diameter of liquid on test paper.
  • EXPERIMENT U prototype R29 ; other person executes Experiment X EXPERIMENT M: prototype R29 ; measure mass of pbod EXPERIMENT Q: prototype RIl ;, form pbod utilizing residual liquid; and observe diameter of discrete pbod i.e. FIG. 9
  • EXPERIMENT E prototype R22 ; form succession of identical bubbles
  • EXPERIMENT V prototype R29 ; eject a pbod having a vertical initial velocity i.e. a direction opposite to a gravity vector
  • EXPERIMENT H prototype R29 ; . eject a pbod having a horizontal initial velocity
  • EXPERIMENT L prototype R29 ; eject a pbod having a 45 degree initial velocity; and a 135 degree initial velocity
  • EXe.] waiting approximately 1 to 2 seconds; and do not wait more than approximately 5 seconds to execute step [Xf.];
  • outlet (25) is disposed approximately 9 cm above the test paper for all trials in Experiment X;
  • [Xg.] placing bottle (40) at a typical rest position for the VISINE bottle (i.e. the axis of tube (27) is horizontal); and measuring the outer diameter of the liquid on the test paper; and recording data.
  • EXPERIMENT V is executed according to the following steps [Va . ] to [Vc ] as follows :
  • EXPERIMENT H is executed according to the following steps [Ha.] to [Hc] as follows:
  • [La.] to [Lc] as follows: [La.] Holding bottle (40) at points S and point T such that the axis of tube (27) is vertical and liquid (50) is disposed at the lower portion of bottle (40) as shown in FIG. 1; and subsequently rotating bottle (40) such that structure (22) is immersed in liquid (50) (i.e. FIG. 1 rotated 90 degrees); [Lb.] rotating bottle (40) to 45 degrees from the position of FIG. 1 (i.e. the initial velocity of the pbod is 45 degrees from a gravity vector);
  • EXPERIMENT E is executed according to the following steps [Ea.] to [Ef.] as follows:
  • Tube (302) and tube (302) contain residual liquid at the end of step [Qe. ] .
  • Liquid i [50) REFRESH LIQUIGEL ( lot No. 30469 ) prototype R29
  • Liquid ( 50 ) REFRESH LIQUIGEL ( lot No . 30469 ) prototype R29 (ALLERGAN, INC . ) ( expire : Mar 06 )
  • Liquid (50) REFRESH LIQUIGEL ( lot No. 30469 prototype R29 (ALLERGMF, INC.) ( expire: Mar 06 )
  • prototype R29 is not used between 24 July 2004, 8:40am to 24 July 2004, 10:22pm ; and cap (45) and seal (44) is on neck (43) during this period of rest ; TOTAL hours at rest between trial 601 to trial 602: 14 hours. Further, prototype R29 is allowed to rest for periods of between 5 to 10 hours, without cap (45); and dispenses a pbod on the first subsequent trial.
  • Liquid (50) REFRESH LIQUIGEL ( lot No. 30469 ) prototype R29 (ALLERGMT, INC.) ( expire: Mar 06 )
  • Liquid (50) REFRESH LIQUIGEL ( lot No. 30469 ) prototype R29 (ALLERGAN, INC.) ( expire: Mar 06 )
  • IMPORTANT NOTE ten occurrence of overspray is observed to be a hollow body (i.e. one ball of liquid encloses one ball of air). All occurrence of overspray is measured to be approximately 0.008 inches diameter. In light of the results of Experiment Q, it is contemplated that a possible source of the overspray is residual liquid is ejected immediately after the pbod is ejected.
  • overspray does NOT occur for any trials in Experiment Q, therefore, this item is omitted in the following tables.
  • the table contains a series of dashes (-) and ⁇ x' There is a total of thirty characters for each line (i.e. trial No. 13 contains 28 dashes and 2 "x") .
  • Each character represents 1 mm length of tube (302) .
  • Tube (302) is 30 mm length, therefore 30 characters per line. Therefore, each character represents the respective location (i.e. in trial 13, the residual liquid in tube (302) is 2 mm length; and located at the upper end of tube (302); and air occupies the lower 28 mm length ) .
  • Trial Nos. 1 to 10 successfully dispense a pbod, each having an estimated diameter of 3.0 mm; and no overspray occurs .
  • Liquid (50) REFRESH LIQUIGEL (lot No. 30469) (ALLERGAN, INC.)
  • Liquid (50) REFRESH LIQUIdEL ( lot No. 30469 ) prototype R29
  • Trials Nos. 621 to 670 dispense pbods having a dia. Between 0.150 to 0.180; and four occurrence of overspray.
  • Trial No. 1 dispenses a pbod having a narrow parabolic path, where the height is about ' 5 cm, and the horizontal distance is about 1 cm.
  • Trials No. 2 to 5 are not successful.
  • Trials Nos. 6 and 7 dispense a pbod (similar path to trial No. 1).
  • Trial Nos. 8 to 10 are not successful.
  • Trial No. 11 dispenses a pbod (similar path to trial No. 1); and each pbod contains approximately
  • Trials Nos. 5 and 6 dispense a pbod a horizontal distance of about 4 cm. Trials Nos. 7 to 10 are not successful. And each pbod contains approximately 3 ul of liquid (50). Dose (77) is about 3 ul ; and dose (10) is about 0.7 ul ; and each pbod contains approximately three bubbles (75).
  • liquid (50) stops flowing upon reaching opening (35) as shown in FIG. 6 (i.e. the lower -end. of dose (77) is at opening (35) in FIG. 6), and the upper portion of tip (100A) contains a dose (77) of liquid (50), and a portion of this dose (77) is disposed between structure (22); seventh, a motive gas (65) imposes this dose (77) to flow from top to bottom in FIG. 7 as shown by the vertical arrow; eighth, motive gas (65) forms a dose (10) of gas (60), and dose (77) encloses this dose (10), and dose (10) has the form of a plurality of bubbles (75), and this dose (10) is the complete dose of gas in pbod (70).
  • FIG. 7 does not show the inherent phenomenon, which causes dose (10) to be formed.
  • Experiment H and Experiment L are similar to the above-described events of Experiment V.
  • EXPERIMENT E RESULTS prototype R22; liquid (207) is REFRESH LIQUIGEL (ALLERGAN,INC):
  • Experiment E forms a succession of identical bubbles (204). For a collapsing speed of about 0.1 cm per second, the diameter of the bubbles is approximately 0.03 cm, and spaced about 0.09 cm equally distant; and this trial contains about 30 bubbles.
  • Several additional consecutive trials are executed having identical results to the above-described results of Experiment E.
  • bottle (200) contains air (212); and second, about sixty microliters of liquid (207) is disposed in tip (201) such that the ⁇ upper surface (211) is about 0.2 cm above opening (35); and third, tip (201) is place on bottle (200); and fourth, a pressure drop over opening (35) imposes liquid
  • EXPERIMENT E RESULTS Variations of prototype R22 have disensed pbods. For example, where the length of tube (202) is 1 cm or 0.5 cm; and the pbod contains about 7 ul liquid (207).
  • the present discolsure includes several pioneering discoveries. Including, a complete dose of gas formed essentially by a motive gas; and a pbod formed utilizing inherent residual liquid in a discharge tube; and a pbod ejected from any indiscriminate selected initial velocity; and a succession of identical bubbles capable of forming the complete dose of gas in one pbod.
  • the best mode for carrying out these present discoveries is set forth in the present respective experiments and f.-- 1 prototypes.
  • the best mode to form a complete dose of gas is imposing an appropriate motive gas to flow through an appropriate flow channel. Where this motive gas imposes a dose of liquid to flow through .the flow channel; and the motive gas forms the. complete dose of gas.
  • dispensing tip (100A) which are capable of dispensing a pbod.
  • Several of these embodiments are set forth in Coffelt, Jr. U.S. patent application No. 10/827,901 filed 19 April 2004 (19.04.04).
  • structure (22) may ' have an arch shape.
  • the prototypes in 10/827,901 dispense pbods, and it is contemplated that these alternate embodiments will " have successfull results in conjuntction with Experiment X.
  • Experiment X and the prototypes of 10/827, 901 should have similar results to the above results.
  • the prototypes in 10/827,901 have dispensed 3 ul pbods having initial velocities of 135 degrees, 45 degrees, including other orientations.
  • the dispensing tip can be integrally formed with a lens. Therefore, allowing dose (77) to be observed in FIG. 6.
  • dose (77) can be enhanced by utilizing a dose verification system.
  • This dose verification system is summarized as a tube having the characteristic of two distinct different translucencies .
  • the tube containing no liquid will have a first translucency [a]; and the tube containing a liquid will have a second translucency [b] .
  • This change in translucency can be attained by the " tube having a smooth outer surface; and a rough inner surface. Observing the 'tube without liquid produces an approximate translucent ima£e; and observing the tube with liquid produces a transparent image.
  • This change in translucency can be enhanced by having a black surface on the far side semi-annular surface of the tube.
  • a dry tube appears to be light gray color; and the tube having liquid appears to be black color. Therefore, this distinct change in color confirms that the liquid is present in the tube .
  • the present figures of the drawing show the tubes having a straight axis.
  • the tubes utilized in the present prototypes have an arcuate shaped axis. This inherent arcuate shape is a result of the method of storage of the tube. i.e. bulk storage on a roll. The radius of this arc is estimated to be about 13 cm.
  • the initial velocity of the pbod in Experiment X is approximately parallel to a gravity vector. Initial velocity meaning the speed and direction immediately below outlet (25) ..
  • Alternate liquids are capable to form a pbod. Including, water, i.e. AQUAFINA DRINKING WATER, (Bottling Group, LLC),
  • FIG.6 depicts a particular dispensing position. And in light of the results of Experiments V, H, and L, there are clearly many alternate orientations of the dispenser, which will dispense a pbod. For example, For a 3 ul pbod , FIG. 6 can be rotated by any desired angle, and this rotated - view of FIG. 6 depicts a dispensing position.
  • Experiments show that the most likely source of the overspray in Experiment X is residual liquid ejected immediately after the pbod is ejected. In light of the the results of Experiment Q, it is contemplated that variations of prototype R29 will have no overspray. Also, variations of the viscosity of the liquid may eliminate the overspray.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nozzles (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne plusieurs découvertes novatrices. Notamment, une dose entière (10) de gaz (60) formée essentiellement à partir d'un gaz moteur (65). La dose (10) étant sous forme de bulles (75). L'invention concerne également un PBOD pulvérisé à un n'importe quelle vitesse initiale, une succession de bulles identiques formée essentiellement à partir d'un gaz moteur, des systèmes PBOD transportant une dose de liquide et une dose de gaz vers une cible via le PBOD (70) et enfin des systèmes PBOD permettant de fournir une solution à divers problèmes dans diverses technologies.
PCT/US2004/026528 2004-08-16 2004-08-16 Systeme pbod (plusieurs corps sur demande) Ceased WO2004110128A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11/578,745 US20070257066A1 (en) 2004-08-16 2004-08-16 Pbod System
PCT/US2004/026528 WO2004110128A2 (fr) 2004-08-16 2004-08-16 Systeme pbod (plusieurs corps sur demande)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2004/026528 WO2004110128A2 (fr) 2004-08-16 2004-08-16 Systeme pbod (plusieurs corps sur demande)

Publications (3)

Publication Number Publication Date
WO2004110128A2 true WO2004110128A2 (fr) 2004-12-23
WO2004110128A8 WO2004110128A8 (fr) 2005-02-17
WO2004110128A3 WO2004110128A3 (fr) 2005-09-09

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PCT/US2004/026528 Ceased WO2004110128A2 (fr) 2004-08-16 2004-08-16 Systeme pbod (plusieurs corps sur demande)

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US (1) US20070257066A1 (fr)
WO (1) WO2004110128A2 (fr)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4671909A (en) * 1978-09-21 1987-06-09 Torobin Leonard B Method for making hollow porous microspheres
US4279632A (en) * 1979-05-08 1981-07-21 Nasa Method and apparatus for producing concentric hollow spheres
US4643854A (en) * 1982-04-26 1987-02-17 California Institute Of Technology Shell forming system
US4960351A (en) * 1982-04-26 1990-10-02 California Institute Of Technology Shell forming system
US6418177B1 (en) * 1984-08-09 2002-07-09 John E Stauffer Fuel pellets for thermonuclear reactions
US6206297B1 (en) * 1999-04-26 2001-03-27 Louis Arthur Coffelt, Jr. Apparatus and method for manufacturing a gasdrop

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WO2004110128A8 (fr) 2005-02-17
US20070257066A1 (en) 2007-11-08

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