WO2005049059A1 - Parfum destine a ameliorer le comportement de personnes agees atteintes de demence - Google Patents

Parfum destine a ameliorer le comportement de personnes agees atteintes de demence Download PDF

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Publication number
WO2005049059A1
WO2005049059A1 PCT/JP2004/017321 JP2004017321W WO2005049059A1 WO 2005049059 A1 WO2005049059 A1 WO 2005049059A1 JP 2004017321 W JP2004017321 W JP 2004017321W WO 2005049059 A1 WO2005049059 A1 WO 2005049059A1
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WO
WIPO (PCT)
Prior art keywords
perfume
behavior
demented
elders
improving
Prior art date
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Ceased
Application number
PCT/JP2004/017321
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English (en)
Inventor
Satomi Kunieda
Hideo Jingu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takasago International Corp
Kanazawa Institute of Technology (KIT)
Original Assignee
Takasago International Corp
Kanazawa Institute of Technology (KIT)
Takasago Perfumery Industry Co
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Filing date
Publication date
Application filed by Takasago International Corp, Kanazawa Institute of Technology (KIT), Takasago Perfumery Industry Co filed Critical Takasago International Corp
Publication of WO2005049059A1 publication Critical patent/WO2005049059A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q13/00—Formulations or additives for perfume preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Definitions

  • the present invention relates to perfumes for improving the behavior of demented elders. More specifically, the present invention relates to perfumes for activating the behavior of demented elders and perfumes for suppressing the behavior of demented elders.
  • Demented aged persons hereinafter referred to as “demented elders” means those aged persons who have “dementia” (a condition in which mental functions are lowered because of some disease) separate from the physiological aging of mentality resulted from their advanced age.
  • “Dementia” is a condition in which once developed intelligence is lowered continuously because the brain has been destroyed for some reason, and in which an acquired symptom accompanying organic changes is in a stabilized or irreversible chronic state. Dementia may be classified into the following two cases: organic brain disease where the brain is damaged and functional disease called pseudodementia which is caused by mere changes of functions.
  • pseudodementia which is caused by mere changes of functions.
  • Various kinds of dementia are known, e.g.
  • cerebrovascular dementia such as dementia caused by chronic subdural hemorrhage, presenile Alzheimer's disease in which dementia is generated as a result of brain atrophy caused by degeneration/death of brain nerve cells, Alzheimer-type senile dementia, dementia such as Pick's disease or Creutzfeldt- Jakob disease caused by encephalatrophic atrophic change, dementia caused by disorder in the circulation of cerebrospinal fluid, or dementia associated with progressive paralysis, alcoholic dementia or bodily diseases, and dementia associated with infection or lesion.
  • cerebrovascular dementia such as dementia caused by chronic subdural hemorrhage, presenile Alzheimer's disease in which dementia is generated as a result of brain atrophy caused by degeneration/death of brain nerve cells
  • Alzheimer-type senile dementia dementia such as Pick's disease or Creutzfeldt- Jakob disease caused by encephalatrophic atrophic change
  • dementia caused by disorder in the circulation of cerebrospinal fluid or dementia associated with progressive paralysis
  • perfumes which not only influence the emotion of demented elders but also push their behavior associated with the emotion to thereby improve the behavior can be provided, it is believed that such perfumes can reduce the burden imposed on themselves or persons around them.
  • the industrial applicability of such perfumes is enormous. It is an object of the invention to provide a technique utilizing aroma (flavor and/or fragrance) as a technique of improving the emotion, consciousness and willingness of demented elders to thereby improve their behavior more simply and safely.
  • the present invention provides a perfume (flavor and/or fragrance) for improving the behavior of demented elders, containing one or more plant-derived essential oils.
  • the plant is preferably one or more plants selected from the group consisting of cinnamon (Cinnamomum zeylanicum), grapefruit (CitJ-us paradisi ⁇ jasmine (Jasminum officinale var.
  • the present invention also provides a perfume for activating the behavior of demented elders, containing one or more plant-derived essential oils.
  • the plant is preferably one or more plants selected from the group consisting of grapefruit (Citrus paradisi), peppermint (Mentha piperita var. vulgaris) and jasmine (Jasminum officinale var. gi'andiflorum).
  • the present invention also provides a perfume for suppressing the behavior of demented elders, containing one or more plant-derived essential oils.
  • the plant is preferably cinnamon (Cinnamomum ⁇ eylanicum).
  • the present invention also provides a method of use of a perfume containing one or more plant-derived essential oils, for improving the behavior of demented elders.
  • the present invention also provides a method of improving the behavior of demented elders, comprising using a perfume containing one or more plant-derived essential oils. According to the present invention, it becomes possible to enhance the consciousness and volition of demented elders simply and safely to thereby improve their behavior. Furthermore, it is possible to activate or suppress the behavior depending on the symptoms of the target demented elders.
  • Fig. 1A is a graph comparing the number of times the cinnamon perfumed maraca was shaken with the number of times the non-perfumed maraca was shaken (in the case of demented elder A).
  • Fig. IB is a graph comparing the number of times the cinnamon perfumed maraca was shaken with the number of times the non-perfumed maraca was shaken (in the case of demented elder B).
  • Fig. 2A is a graph comparing the number of times the grapefruit perfumed maraca was shaken with the number of times the non-perfumed maraca was shaken (in the case of demented elder A).
  • FIG. 2B is a graph comparing the number of times the grapefruit perfumed maraca was shaken with the number of times the non-perfumed maraca was shaken (in the case of demented elder B).
  • Fig. 3A is a graph comparing the number of times the jasmine perfumed maraca was shaken with the number of times the non-perfumed maraca was shaken (in the case of demented elder A).
  • Fig. 3B is a graph comparing the number of times the j asinine perfumed maraca was shaken with the number of times the non-perfumed maraca was shaken (in the case of demented elder B).
  • FIG. 4A is a graph comparing the number of times the peppermint perfumed maraca was shaken with the number of times the non-perfumed maraca was shaken (in the case of demented elder A).
  • Fig. 4B is a graph comparing the number of times the peppermint perfumed maraca was shaken with the number of times the non-perfumed maraca was shaken (in the case of demented elder B).
  • Fig. 5 shows the evaluation of impressions when perfumed maracas were used and when no-perfumed maracas were used.
  • the perfumes of the invention for improving the behavior of demented elders contain one or more plant-derived essential oils.
  • the term "demented elders” used herein refers to those elders who have a condition of "dementia” in which mental functions are lowered because of some disease, separate from the physiological aging of mentality resulted from their advanced age. As causes of "Dementia”, those described above may be given. However, in the present specification, the term “demented elders” refers to elders who present wide variety of dementia symptoms not limited to those resulted from the above-described causes.
  • Demented elders have the following disorders: they have bad memory and cannot remember new things (attentiveness disorder); they cannot remember previous experience (amnesia); they cannot calculate (calculation disorder); they cannot make correct judgment (judgment disorder). These disorders cause various failures in daily life. Further, the secondary effect of physical, environmental and mental factors accelerates the peripheral symptoms such as prowl, anxiety, hyperkinesia movement, insomnia, reversion of day and night, coprophilia, mysophilia, etc. These symptoms lead to compulsive suppression of the behavior of demented elders, which worsens the symptoms still further.
  • the "perfume for improving the behavior of demented elders" refers to a perfume which is used for the purpose of improving the behavior of demented elders.
  • a perfume which activates the behavior of demented elders whose willingness has been reduced, or a perfume which suppresses the behavior of demented elders whose behavior should be cared for may be enumerated.
  • activating the behavior of demented elders include letting them positively participate in events such as rehabilitation; letting them take positive actions to adapt to daily life; changing passive behavior to positive behavior; letting them act by their own will; etc.
  • suppressing the behavior of demented elders include calming down those who has poriomania (make wandering), who are hyperkinetic syndrome (make excessive movement) (i.e. having sleep disorder, anxiety, or fast mood swings) or who are in the state of extreme excitement, to suppress their behavior.
  • one or more plants selected from the group consisting of, for example, cinnamon (Cinnamomum zeylanicum), grapefruit (Citrus paradisi). jasmine (Jasminum officinale var. grandiflorum) and peppemiint (Mentha piperita var. vulgaris) may be used as the plant raw material.
  • the plant-derived essential oil used in the invention may be prepared by known methods, for example, the methods disclosed in the "Japanese Patent Office Gazette: Well-Known/Conventional Technologies (Perfumes) Part II: Flavors for Food” published by the Japanese Patent Office in 2000, pp. 7-8; or the methods disclosed in "Chemistry of Essential Oils” published by Flagrance Journal Co., 1st ed., in 2000, pp. 76-86.
  • essential oils may be obtained by drying various plant raw materials, cutting them into appropriate size, and then performing known operations such as pressing, solvent extraction, or steam distillation. For example, when the raw material is cinnamon [Cinnamomum zeylanicum
  • cinnamon essential oil (Lauraceae)] an essential oil may be obtained by crushing cinnamon bark and subjecting the resultant material to steam distillation.
  • the major cinnamon producing countries are Sri Lanka and Indonesia. Cinnamomum ⁇ eylanicum-de ⁇ ved essential oil is believed to be most elegant and excellent.
  • This essential oil is designated "cinnamon Ceylon bark oil", which is somewhat different in flavor from cassia oil derived from Cinamomum cassia and is discriminated from it in use.
  • the former has an aldehyde content of 55-78%, whereas the latter has an aldehyde content of 80% or more.
  • the thus obtained cinnamon essential oil has a sweet flagrance and a slightly astringent stimulatory taste.
  • cinnamic aldehyde, eugenol and pinene are mainly known.
  • the raw material is grapefruit [Citi'us paradisi (Rutaceae ].
  • most of its essential oil may be obtained simultaneously with its juice.
  • About 650 g of essential oil is obtained from 1 ton of fresh grapefruit on the average.
  • oil may be obtained by pressing grapefruit peel or by distilling peel alone, h addition, when juice is concentrated, recovery flagrance (oil layer: grapefruit essential oil; aqueous layer: grapefruit aroma) may be obtained secondarily.
  • grapefruit essential oil As components of grapefruit essential oil, d-limonene, nootkatone, octyl aldehyde, decyl aldehyde, citral, geraniol and acetates thereof, are mainly known.
  • jasmine flowers are extracted with a solvent such as petroleum ether (mainly hexane) and the resultant concrete (yield: 0.28-0.33%) are dewaxed with an alcohol such as ethanol, to thereby obtain jasmine oil (jasmine oil, jasmine absolute) in the form of absolute.
  • benzyl acetate, d-linalol, linalyl acetate, benzyl alcohol, jasmone, indole, methyl anthranilate, farnesol, methyl jasmonate, jasmine lactone, benzyl benzoate, phytols, cis-jasmone, and jasmonoid are mainly known.
  • peppemiint Mentha piperita var. vulgaris (Labiatae)
  • peppermint oil may be obtained by steam distillation of leaves or whole plant. Since oil yield is decreased and oil components are changed after flowering, it is preferable to harvest peppemiint on fine days in August or September when blossoms appear.
  • the harvested plant are dried on ground for a few days and then distilled in a semi-dried state.
  • vehicles containing harvested leaves are brought to field distillery; then, steam are blown directly into the vehicles that serve as distillation stills.
  • As components of peppermint essential oil 1 -menthol, menthyl ester, menthone, menthofuran, jasmone, and methyl jasmonate are mainly known.
  • water, lower alcohol, hydrous lower alcohol, hexane or the like may be used as a solvent for solvent extraction.
  • the term "lower alcohol” refers to C M alcohol, i.e.
  • Extraction operations are not particularly limited. Although the operation may vary depending of the above plant and the solvent used, usually, extraction is performed by dipping in the solvent at 4-100°C a plant raw material crushed in advance or by agitating the plant material gently in the solvent at 4-100°C. Further, use of a Soxhlet extractor which was well known before the filing of the present application enables efficient extraction operation. The time period required for extraction is usually about 30 minutes to 12 hours.
  • a multi-step extraction method which was known before the filing of the present application may also be employed.
  • the perfume for improving behavior containing essential oils therefrom may be used as a perfume for activating behavior.
  • cinnamon cinnamon (Cinnamomum zeylanicum)
  • the perfume for improving behavior containing an essential oil therefrom may be used as a perfume for suppressing behavior.
  • the perfume of the invention for improving the behavior of demented elders may be such a perfume that contains one or more components of plant-derived essential oil isolated by physical or chemical treatment or obtained by a method such as chemical synthesis. Alternatively, such components may be used jointly with a plant-derived essential oil.
  • Such components include one or more components selected from the group consisting of cinnamic aldehyde, eugenol, pinene, d-limonene, nootkatone, octyl aldehyde, decyl aldehyde, citral, geraniol and acetates thereof, benzyl acetate, d-linalol, linalyl acetate, benzyl alcohol, jasmone, indole, methyl anthranilate, famesol, methyl jasmonate, jasmine lactone, benzyl benzoate, phytols, cis-jasmone, jasmonoid, 1-menthol, menthyl ester, menthone, menthofuran and jasmone.
  • the perfume when the perfume contains one or more components selected from the group consisting of d-limonene, nootkatone, octyl aldehyde, decyl aldehyde, citral, geraniol and acetates thereof, 1-menthol, menthyl ester, menthone, menthofuran, jasmone, benzyl acetate, d-linalol, linalyl acetate, benzyl alcohol, jasmone, indole, methyl antliranilate, famesol, methyl jasmonate, jasmine lactone, benzyl benzoate, phytols, cis-jasmone and jasmonoid, that perfume for improving behavior may be used as a perfume for activating behavior.
  • the perfume when the perfume contains one or more components selected from the group consisting of cinnamic aldehyde, eugenol and pinene, that perfume for improving behavior may be used as a perfume for suppressing behavior.
  • the perfume of the invention for improving behavior may be used alone.
  • the perfume may be loaded to a product in such a manner that the product emits flagrance whenever demented elders make some action (event).
  • the product which may be loaded with the perfume of the invention for improving behavior is not particularly limited in kind or form, as long as the perfumed product emits flagrance whenever demented elders make some event.
  • the following products may be enumerated: Musical instruments (percussion instruments such as maracas, fruit shaker, triangle, cymbals, gong, rnetallophone, xylophone, marimba, castanets, bell, Japanese drum, tambourine, timpani and drum; string instruments such as violin, viola, cello, contrabass, guitar, mandolin, ukulele, harp and Japanese harp; wind instruments such as oboe, clarinet, saxophone, trumpet, hom, tuba, ocarina, flute, piccolo, harmonica and various pipes; keyed instruments such as organ, piano and accordion; various electronic musical instruments; etc.) Toiletry products (toilet soap, bath soap, transparent soap, etc.) Body washing agents (body shampoo, etc.) Household products (general detergents, liquid detergents, solid detergents, etc.) Sanitary products (towels, toilet paper, tissue paper, wet tissue paper, handkerchiefs, we, we
  • musical instruments are preferable.
  • key instruments such as organ and piano
  • percussion instruments such as xylophone, tambourine, castanets, bell, maracas and fruit shaker are preferable.
  • rhythm percussion instruments sometimes referred to as "rhythm instruments” in the invention
  • rhythm percussion instruments such as bell, maracas and fruit shaker are preferable.
  • rhythm percussion instruments such as bell, maracas and fruit shaker are preferable.
  • the method of loading is not particularly limited. Various methods may be used. For example, a method in which a porous material (such as paper, non-woven fabric, cotton, silica gel, wood, pumice, shell, sintered metal, calcium silicate, etc.) is impregnated with the perfume of the invention and then placed inside of a product; a method in which the perfume of the invention is prepared into microcapsules or dissolved in a solvent to prepare an ink-like or solution-type material, and then coated on the surface or inside of a product; a method in which the perfume of the invention is mixed with a thermoplastic resin such as ethylene-vinyl acetate copolymer resin or polyvinylchloride resin and shaped into a film or sheet, which is then placed on the surface or inside of a product; a method in which the perfume of the invention is kept at a specific part of a product or at a specific site around the product or in a container
  • perfume loading will be illustrated below for musical instruments.
  • key instruments such as organ and piano
  • a method may be used in which the perfume of the invention is kept in a container positioned below the keyboard or in front of the instrument, and flagrance is emitted by the air pressure, vibration or electric signal generated when keys are tapped with fingers.
  • the surface of the instrument which is beaten or the surface of parts of the drumsticks which beat may be coated with a solution, a dispersant or an ink containing the perfume of the invention prepared into microcapsules.
  • a film or a sheet containing the perfume of the invention may be placed on the surface of the instrument which is beaten or the surface of parts of the drumsticks which beat.
  • flagrance is generated when the instrument is beaten with drumsticks or the like.
  • strings are impregnated with a solution containing the perfume of the invention.
  • flagrance is generated by friction or vibration.
  • the perfume of the invention may be embedded in the microchip which electronically controls the instrument, and then the perfume-containing site may be stimulated with electronic signals to thereby generate flagrance.
  • the perfume of the invention or a solution containing the perfume of the invention prepared into microcapsules may be sprayed on the surfaces of granules to be contained inside of maracas, and then the thus treated granules may be placed inside of maracas.
  • fairly solid porous granules may be impregnated with the perfume of the invention, and then the resultant perfumed granules may be placed inside of maracas.
  • the perfume loading ratio is preferably a common ratio for loading products with perfume.
  • the intensity of perfume is so small that one cannot recognize what perfume is used. That is, a perfume loading ratio that does not allow discrimination of the kind of perfume is preferable.
  • the loading ratio is preferably 0.01 to 50% by weight, more preferably 0.1 to 50% by weight.
  • the perfume of the invention for improving behavior is loaded to cosmetics, hair cosmetics, toiletry products, body washing agents, bath agents, sanitary products or household products, the loading ratio is preferably 0.0001 to 50% by weight, more preferably 0.1 to 30% by weight.
  • the loading ratio is preferably 0.00001 to 0.1 % by weight, more preferably 0.001 to 0.1% by weight.
  • the loading ratio is preferably 0.00001 to 10% by weight, more preferably 0.001 to 5% by weight.
  • the loadmg ratio is preferably 0.00001 to 1%> by weight, more preferably 0.0001 to 0.1% by weight.
  • the perfume of the invention for improving behavior is loaded to tobacco, the loading ratio is preferably 0.0001 to 0.1% by weight, more preferably 0.0001 to 0.01%) by weight.
  • the thus perfumed products have wide range of use. Specifically, they may be used as daily products or teaching utensils. In particular, they may be used as utensils for improving the mental aspects of aged persons (e.g.
  • the present invention encompasses: utensils for improving the mental aspects of demented elders and utensils for preventing dementia, both of which are characterized by using products loaded with the perfume of the invention for improving behavior.
  • the present invention encompasses: a method of improving the volition and consciousness of demented elders, characterizing in using the perfumed product described above; a method of improving the behavior of demented elders, characterizing in usmg the perfumed product described above; a method of activating the behavior of demented elders, characterizing in using the perfumed product described above; and a method of suppressing the behavior of demented elders, characterizing in using the perfumed product described above.
  • Cinnamon Essential Oil Cinnamon (Cinnamomum zeylanicum) bark was steam distilled to thereby obtain cinnamon essential oil as Ceylon bark oil.
  • Jasmine Essential Oil Jasmine Jasmine (Jasminum officinale var. grandiflorum) flowers were extracted with hexane, and the oil was recovered. The resultant concrete was treated with ethanol to thereby obtain jasmine oil as an absolute (jasmine absolute).
  • maracas loaded with fluorite granules impregnated at a weight ratio of 1:1 with a 50% by weight solution of the grapefruit essential oil from (2) above in MCT; maracas loaded with fluorite granules impregnated at a weight ratio of 1 : 1 with a 5%> by weight solution of the jasmine essential oil from (3) above in MCT; and maracas loaded with fluorite granules impregnated at a weight ratio of 1 :1 with a 10%) by weight solution of the peppermint essential oil from (4) above in MCT.

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Abstract

La présente invention concerne une technique destinée à contrôler les émotions, la conscience et la volonté des personnes âgées atteintes de démence de manière plus simple et sûre, et à améliorer leur comportement. L'invention concerne un parfum destiné à améliorer le comportement des personnes âgées, contenant des huiles essentielles dérivées d'une ou de plusieurs plantes sélectionnées dans le groupe comprenant la cannelle (Cinnamomum zeylanicum), le pamplemousse (Citrus paradisi), le jasmin (Jasminum officinale var. grandiflorum) et la menthe poivrée (Mentha piperita var. vulgaris).
PCT/JP2004/017321 2003-11-21 2004-11-15 Parfum destine a ameliorer le comportement de personnes agees atteintes de demence Ceased WO2005049059A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003391964A JP2005154490A (ja) 2003-11-21 2003-11-21 痴呆高齢者向け行動改善用香料
JP2003-391964 2003-11-21

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WO2005049059A1 true WO2005049059A1 (fr) 2005-06-02

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JP5013659B2 (ja) * 2004-03-26 2012-08-29 アットアロマ株式会社 アセチルコリンエステラーゼ阻害剤
JP5212592B2 (ja) * 2007-01-12 2013-06-19 花王株式会社 活気向上香料組成物
JP2013014537A (ja) * 2011-07-04 2013-01-24 Tottori Univ 嗅覚機能改善剤
JP2019043065A (ja) * 2017-09-04 2019-03-22 株式会社サカモト 香り付き鉛筆

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US6268333B1 (en) * 1992-09-25 2001-07-31 Takasago International Corporation Sedative effect-providing fragrance modifier
JP2001278802A (ja) * 2000-03-30 2001-10-10 Hiroyuki Sumi 血栓予防剤
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