WO2005100373A3 - Derives du monosaccharide - Google Patents

Derives du monosaccharide Download PDF

Info

Publication number
WO2005100373A3
WO2005100373A3 PCT/IB2005/000974 IB2005000974W WO2005100373A3 WO 2005100373 A3 WO2005100373 A3 WO 2005100373A3 IB 2005000974 W IB2005000974 W IB 2005000974W WO 2005100373 A3 WO2005100373 A3 WO 2005100373A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
inflammatory
compounds
inflammatory agents
monosaccharide derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2005/000974
Other languages
English (en)
Other versions
WO2005100373A2 (fr
Inventor
Viswajanani Jitendra Sattigeri
Sudershan K Arora
Mohammad Salman
Venkata P Palle
Abhijit Ray
Raj Kumar Shirumalla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ranbaxy Laboratories Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Publication of WO2005100373A2 publication Critical patent/WO2005100373A2/fr
Publication of WO2005100373A3 publication Critical patent/WO2005100373A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/02—Monosaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des dérivés du monosaccharide en tant qu'agents anti-inflammatoires. Les composés de l'invention peuvent servir à inhiber et à prévenir une inflammation et des pathologies associées, y compris des maladies inflammatoires et auto-immunes telles que l'asthme, la polyarthrite rhumatoïde, le diabète de type I, la sclérose en plaques, le rejet de greffe allogénique, le psoriasis, les maladies entériques inflammatoires, la colite ulcéreuse, l'acné, l'athérosclérose, le cancer, la prurit ou la rhinite allergique. La présente invention porte également sur des compositions pharmaceutiques contenant les composés de l'invention et sur des méthodes pour traiter l'asthme, les maladies respiratoires obstructives, la polyarthrite rhumatoïde, le diabète de type I, la sclérose en plaques, le rejet de greffe allogénique, le psoriasis, les maladies entériques inflammatoires, la colite ulcéreuse, l'acné, l'athérosclérose, le cancer, la prurit ou la rhinite allergique, ainsi que d'autres troubles inflammatoires et/ou auto-immunes, au moyen des composés de l'invention.
PCT/IB2005/000974 2004-04-13 2005-04-13 Derives du monosaccharide Ceased WO2005100373A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56179104P 2004-04-13 2004-04-13
US60/561,791 2004-04-13

Publications (2)

Publication Number Publication Date
WO2005100373A2 WO2005100373A2 (fr) 2005-10-27
WO2005100373A3 true WO2005100373A3 (fr) 2006-04-06

Family

ID=34965503

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/000974 Ceased WO2005100373A2 (fr) 2004-04-13 2005-04-13 Derives du monosaccharide

Country Status (1)

Country Link
WO (1) WO2005100373A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012322095B2 (en) * 2011-10-14 2017-06-29 Ambit Biosciences Corporation Heterocyclic compounds and use thereof as modulators of type III receptor tyrosine kinases
US12043644B2 (en) 2020-06-23 2024-07-23 Biometrix Technology Inc Benzimidazole derivatives, preparation method thereof and use thereof as anti-cancer agent or anti-virus agent comprising the same
KR102449266B1 (ko) * 2020-06-23 2022-09-30 (주)바이오메트릭스 테크놀로지 항암 활성 그리고 항바이러스 활성을 갖는 신규한 벤지미다졸-탄수화물 결합체 화합물(Benzimidazole carbohydrate conjugate compound) 및 이의 제조 방법

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013117A2 (fr) * 1991-12-20 1993-07-08 Greenwich Pharmaceuticals Incorporated DERIVES 5- ou 6-AMINODESOXYFURANOSIDE A ACTIVITE ANTI-INFLAMMATOIRE ET ANTI-PROLIFERATIVE
US5298494A (en) * 1989-01-09 1994-03-29 Greenwich Pharmaceuticals Incorporated Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof
WO1994011381A1 (fr) * 1992-11-13 1994-05-26 Greenwich Pharmaceuticals Incorporated Composes antiproliferatifs et anti-inflammatoires: derives de monosaccharides de pentose
WO1994028910A1 (fr) * 1993-06-11 1994-12-22 Boston Life Sciences, Inc. Composes immunomodulateurs, anti-inflammatoires, et anti-proliferatifs: derives 5,6-didesoxy, 5-amino de l'idose et derives 6-desoxy, 6-amino du glucose
WO1996035431A1 (fr) * 1995-05-09 1996-11-14 Chemora Pharmochem Derives de l'acide 2,3:4,6-di-o-isopropylidene-alpha-l-xylo-2-hexulofluranosonique
WO2000042053A1 (fr) * 1999-01-12 2000-07-20 Ranbaxy Laboratories Limited Derives de monosaccharides en tant qu'inhibiteurs de l'adhesion cellulaire
WO2004071515A1 (fr) * 2003-02-12 2004-08-26 Ranbaxy Laboratories Limited Preparation de derives de monosaccharide

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298494A (en) * 1989-01-09 1994-03-29 Greenwich Pharmaceuticals Incorporated Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof
WO1993013117A2 (fr) * 1991-12-20 1993-07-08 Greenwich Pharmaceuticals Incorporated DERIVES 5- ou 6-AMINODESOXYFURANOSIDE A ACTIVITE ANTI-INFLAMMATOIRE ET ANTI-PROLIFERATIVE
WO1994011381A1 (fr) * 1992-11-13 1994-05-26 Greenwich Pharmaceuticals Incorporated Composes antiproliferatifs et anti-inflammatoires: derives de monosaccharides de pentose
WO1994028910A1 (fr) * 1993-06-11 1994-12-22 Boston Life Sciences, Inc. Composes immunomodulateurs, anti-inflammatoires, et anti-proliferatifs: derives 5,6-didesoxy, 5-amino de l'idose et derives 6-desoxy, 6-amino du glucose
WO1996035431A1 (fr) * 1995-05-09 1996-11-14 Chemora Pharmochem Derives de l'acide 2,3:4,6-di-o-isopropylidene-alpha-l-xylo-2-hexulofluranosonique
WO2000042053A1 (fr) * 1999-01-12 2000-07-20 Ranbaxy Laboratories Limited Derives de monosaccharides en tant qu'inhibiteurs de l'adhesion cellulaire
WO2004071515A1 (fr) * 2003-02-12 2004-08-26 Ranbaxy Laboratories Limited Preparation de derives de monosaccharide

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
COAT J.P. ET AL.: "Préparation et couplage sur des polypeptides de 5'-O-carboxyméthyl-ribonucléosides", CARBOHYDRATE RESEARCH, vol. 12, 1970, Belgium, pages 335 - 346, XP002360609 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1985, PAULSEN, HANS ET AL: "Branched and chain-extended sugars, XXVIII. Synthesis of 6-amino-6-deoxyhepturonic acids", XP002360612, retrieved from STN Database accession no. 102:149685 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1998, TOIKKA, MERJA ET AL: "Lignin-carbohydrate model compounds. Formation of lignin-methyl arabinoside and lignin-methyl galactoside benzyl ethers via quinone methide intermediates", XP002344213, retrieved from STN Database accession no. 130:139518 *
JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY , (22), 3813-3818 CODEN: JCPRB4; ISSN: 0300-922X, 1998 *
KATIYAR D ET AL: "Synthesis and antimycobacterial activities of glycosylated amino alcohols and amines", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 40, no. 4, April 2005 (2005-04-01), pages 351 - 360, XP004814470, ISSN: 0223-5234 *
LIEBIGS ANNALEN DER CHEMIE , (1), 113-28 CODEN: LACHDL; ISSN: 0170-2041, 1985 *
MASJOST B ET AL: "Structure based design, synthesis and in vitro evaluation of bisubstrate inhibitors for catechol O-methyltransferase (COMT)", CHEMISTRY - A EUROPEAN JOURNAL, VCH PUBLISHERS, US, vol. 6, no. 6, 2000, pages 971 - 982, XP002978173, ISSN: 0947-6539 *
MISHRA, R. C. ET AL: "Synthesis of glycosylated .beta.-Amino hydroxamates as new class of antimalarials", BIOORGANIC & MEDICINAL CHEMISTRY , 11(24), 5363-5374 CODEN: BMECEP; ISSN: 0968-0896, 2003, XP002360610 *

Also Published As

Publication number Publication date
WO2005100373A2 (fr) 2005-10-27

Similar Documents

Publication Publication Date Title
WO2005123692A8 (fr) Derives de pyridazin-3(2h)-one et leur utilisation en tant qu'inhibiteurs de la pde4
SG155943A1 (en) Pyridazin-3(2h)-one derivatives and their use as pde4 inhibitors
EA018670B9 (ru) Производные пиразоло[3,4-в]пиридина в качестве ингибиторов фосфодиэстеразы
WO2007089904A3 (fr) Composes de pyridylphenyl destines a traiter une inflammation et utilisations liees a l'immunite
NO20070994L (no) N-hydroksamid derivater og anvendelse derav
WO2006044732A3 (fr) Amino-pyridimidine 2, 6-substituee-4-monosubstituee en tant qu'antagonistes de recepteur de la prostaglandine d2
IL190835A0 (en) Sulfonamide derivatives, their preparation and use
MX2008011369A (es) Compuestos de amino-pirimidina 2,6-sustituidos-4-monosustituidos como antagonistas del receptor de prostaglandina d2.
WO2009085880A8 (fr) Thioéthers c-21 utilisés en tant qu'agonistes du récepteur de glucocorticoïde
WO2008035315A3 (fr) Inhibiteurs de la phosphodiesterase type iv
WO2007114848A3 (fr) Composés chimiques
WO2007102883A3 (fr) Composés chimiques
MX2010008750A (es) Nuevos macrolidos y su uso.
WO2005100373A3 (fr) Derives du monosaccharide
EP1842855A3 (fr) Dérivés de monosaccharide en tant qu'agnets antiinflammaotoires et/ou agents anticancéreux
TW200635932A (en) New pyridothienopyrimidine derivatives
WO2005051931A3 (fr) Inhibiteurs de la phosphodiestérase
WO2006016237A3 (fr) Dérivés hétérocycliques faisant office d’agents anti-inflammatoires
WO2007062318A3 (fr) Composes chimiques
IL180681A0 (en) Pyridine derivatives, their preparation and use
WO2005092907A3 (fr) Derives de monosaccharide
TW200631954A (en) New pyridothienopyrimidine derivatives
WO2007063356A3 (fr) Derives de monosaccharides
IL184538A0 (en) N-hydroxyamide derivatives and use thereof
WO2008035316A3 (fr) Inhibiteurs de phosphodiestérase

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

122 Ep: pct application non-entry in european phase