WO2006023460A3 - Composes a activite agoniste pour recepteur ?2 adrenergique et antagoniste pour recepteur muscarinique - Google Patents

Composes a activite agoniste pour recepteur ?2 adrenergique et antagoniste pour recepteur muscarinique Download PDF

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Publication number
WO2006023460A3
WO2006023460A3 PCT/US2005/029024 US2005029024W WO2006023460A3 WO 2006023460 A3 WO2006023460 A3 WO 2006023460A3 US 2005029024 W US2005029024 W US 2005029024W WO 2006023460 A3 WO2006023460 A3 WO 2006023460A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
antagonist activity
receptor antagonist
receptor agonist
adrenergic receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/029024
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English (en)
Other versions
WO2006023460A2 (fr
Inventor
Mathai Mammen
Trevor Mischki
Adam Hughes
Yu-Hua Ji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innoviva Inc
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Priority to JP2007527922A priority Critical patent/JP2008510015A/ja
Priority to EP05785501A priority patent/EP1833822A2/fr
Publication of WO2006023460A2 publication Critical patent/WO2006023460A2/fr
Publication of WO2006023460A3 publication Critical patent/WO2006023460A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des composés de formule I, sachant que R1, R2, R3, R4, R5, R6, R7, R8a, R8b, W, a, b, c et m sont tels que définis dans la description, y compris un sel ou solvate ou stéréoisomère correspondant pharmaceutiquement acceptable. Les composés ont une activité agoniste pour récepteur ß2 adrénergique et antagoniste pour récepteur muscarinique. Il sont donc censés être utiles comme agents thérapeutiques pour le traitement de troubles pulmonaires, du type maladie pulmonaire obstructive chronique et asthme.
PCT/US2005/029024 2004-08-16 2005-08-15 Composes a activite agoniste pour recepteur ?2 adrenergique et antagoniste pour recepteur muscarinique Ceased WO2006023460A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2007527922A JP2008510015A (ja) 2004-08-16 2005-08-15 β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有する化合物
EP05785501A EP1833822A2 (fr) 2004-08-16 2005-08-15 Composes a activite agoniste pour recepteur beta2 adrenergique et antagoniste pour recepteur muscarinique

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60177904P 2004-08-16 2004-08-16
US60/601,779 2004-08-16

Publications (2)

Publication Number Publication Date
WO2006023460A2 WO2006023460A2 (fr) 2006-03-02
WO2006023460A3 true WO2006023460A3 (fr) 2006-04-06

Family

ID=35686492

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/029024 Ceased WO2006023460A2 (fr) 2004-08-16 2005-08-15 Composes a activite agoniste pour recepteur ?2 adrenergique et antagoniste pour recepteur muscarinique

Country Status (4)

Country Link
US (2) US7569586B2 (fr)
EP (1) EP1833822A2 (fr)
JP (1) JP2008510015A (fr)
WO (1) WO2006023460A2 (fr)

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GB0426164D0 (en) * 2004-11-29 2004-12-29 Novartis Ag Organic compounds
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TW201617343A (zh) 2014-09-26 2016-05-16 阿爾米雷爾有限公司 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物
TWI703138B (zh) 2015-02-12 2020-09-01 義大利商吉斯藥品公司 具有蕈毒鹼受體拮抗劑及β２腎上腺素受體促效劑活性之化合物
AR104828A1 (es) 2015-06-01 2017-08-16 Chiesi Farm Spa COMPUESTOS CON ACTIVIDAD ANTAGONISTA DE LOS RECEPTORES MUSCARÍNICOS Y ACTIVIDAD AGONISTA DEL RECEPTOR b2 ADRENÉRGICO
WO2017093208A1 (fr) 2015-12-03 2017-06-08 Chiesi Farmaceutici S.P.A. Composés ayant une activité d'antagoniste des récepteurs muscariniques et d'agoniste des récepteurs adrénergiques bêta2
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CH686869A5 (de) * 1991-04-05 1996-07-31 Sepracor Inc Beta (2) -bronchienerweiternde Arzneistoffe in Form ihrer Bronchienerweiternden Enantiomeren zur Verwendung fuer die Herstellung eines Mittels zur verbesserten Therapie.
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WO2004074246A2 (fr) * 2003-02-14 2004-09-02 Theravance Inc. Derives de biphenyle

Also Published As

Publication number Publication date
JP2008510015A (ja) 2008-04-03
EP1833822A2 (fr) 2007-09-19
US7569586B2 (en) 2009-08-04
US20060035933A1 (en) 2006-02-16
WO2006023460A2 (fr) 2006-03-02
US8143277B2 (en) 2012-03-27
US20090239904A1 (en) 2009-09-24

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