WO2007018671A3 - Compositions et methodes de traitement d'etats associes a la signalisation de l'ephrine au moyen de cupredoxines - Google Patents

Compositions et methodes de traitement d'etats associes a la signalisation de l'ephrine au moyen de cupredoxines Download PDF

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Publication number
WO2007018671A3
WO2007018671A3 PCT/US2006/019684 US2006019684W WO2007018671A3 WO 2007018671 A3 WO2007018671 A3 WO 2007018671A3 US 2006019684 W US2006019684 W US 2006019684W WO 2007018671 A3 WO2007018671 A3 WO 2007018671A3
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WO
WIPO (PCT)
Prior art keywords
cupredoxins
compositions
methods
conditions related
treating conditions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/019684
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English (en)
Other versions
WO2007018671A2 (fr
Inventor
Ananda Chakrabarty
Gupta Tapas Das
Tohru Yamada
Anita Chaudhari
Arsenio Fialho
Yonghua Zhu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois at Urbana Champaign
University of Illinois System
Original Assignee
University of Illinois at Urbana Champaign
University of Illinois System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/244,105 external-priority patent/US7691383B2/en
Priority to EP06813192A priority Critical patent/EP1888106A4/fr
Priority to CA002608512A priority patent/CA2608512A1/fr
Priority to AU2006277009A priority patent/AU2006277009A1/en
Priority to JP2008512587A priority patent/JP2008539795A/ja
Priority to MX2007014598A priority patent/MX2007014598A/es
Application filed by University of Illinois at Urbana Champaign, University of Illinois System filed Critical University of Illinois at Urbana Champaign
Priority to BRPI0612424-0A priority patent/BRPI0612424A2/pt
Publication of WO2007018671A2 publication Critical patent/WO2007018671A2/fr
Priority to IL187138A priority patent/IL187138A0/en
Anticipated expiration legal-status Critical
Publication of WO2007018671A3 publication Critical patent/WO2007018671A3/fr
Priority to NO20076391A priority patent/NO20076391L/no
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des compositions et des méthodes d'utilisation de cuprédoxines, et de variants, de dérivés et d'équivalents structuraux de cuprédoxines qui interfèrent avec le système de signalisation de l'éphrine dans des cellules mammifères. De manière spécifique, l'invention concerne des compositions et des méthodes faisant intervenir des cuprédoxines, de type azurine, rusticyanine et plastocyanine, et des variants, dérivés et équivalents structuraux associés, pour le traitement du cancer chez des mammifères.
PCT/US2006/019684 2005-05-20 2006-05-19 Compositions et methodes de traitement d'etats associes a la signalisation de l'ephrine au moyen de cupredoxines Ceased WO2007018671A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
BRPI0612424-0A BRPI0612424A2 (pt) 2005-05-20 2006-05-19 composiÇÕes e mÉtodos para tratar condiÇÕes relacionadas com a sinalizaÇço da efrina com cupredoxinas
CA002608512A CA2608512A1 (fr) 2005-05-20 2006-05-19 Compositions et methodes de traitement d'etats associes a la signalisation de l'ephrine au moyen de cupredoxines
AU2006277009A AU2006277009A1 (en) 2005-05-20 2006-05-19 Compositions and methods for treating conditions related to ephrin signaling with cupredoxins
JP2008512587A JP2008539795A (ja) 2005-05-20 2006-05-19 キュプレドキシンを用いたエフリン信号伝達に関する症状を治療するための組成物および方法
MX2007014598A MX2007014598A (es) 2005-05-20 2006-05-19 Composiciones y metodos para tratar condiciones relacionadas con senalizacion de efrina con cupredoxinas.
EP06813192A EP1888106A4 (fr) 2005-05-20 2006-05-19 Compositions et méthodes de traitement d'états associés à la signalisation de l'éphrine au moyen de cuprédoxines
IL187138A IL187138A0 (en) 2005-05-20 2007-11-04 Compositions and methods for treating conditions related to ephrin signaling with cupredoxins
NO20076391A NO20076391L (no) 2005-05-20 2007-12-11 Sammensetninger og metoder for behandling av tilstander relatert til efrinsignaler med cupredoxin

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US68281205P 2005-05-20 2005-05-20
US60/682,812 2005-05-20
US11/244,105 US7691383B2 (en) 2004-10-07 2005-10-06 Cupredoxin derived transport agents and methods of use thereof
US11/244,105 2005-10-06
US76474906P 2006-02-03 2006-02-03
US60/764,749 2006-02-03

Publications (2)

Publication Number Publication Date
WO2007018671A2 WO2007018671A2 (fr) 2007-02-15
WO2007018671A3 true WO2007018671A3 (fr) 2007-11-22

Family

ID=37727776

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/019684 Ceased WO2007018671A2 (fr) 2005-05-20 2006-05-19 Compositions et methodes de traitement d'etats associes a la signalisation de l'ephrine au moyen de cupredoxines

Country Status (10)

Country Link
EP (1) EP1888106A4 (fr)
JP (1) JP2008539795A (fr)
KR (1) KR20080040631A (fr)
AU (1) AU2006277009A1 (fr)
BR (1) BRPI0612424A2 (fr)
CA (1) CA2608512A1 (fr)
IL (1) IL187138A0 (fr)
MX (1) MX2007014598A (fr)
NO (1) NO20076391L (fr)
WO (1) WO2007018671A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7556810B2 (en) 2005-07-19 2009-07-07 The Board Of Trustees Of The University Of Ilinois Compositions and methods to control angiogenesis with cupredoxins
US9096663B2 (en) 2001-02-15 2015-08-04 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating conditions related to ephrin signaling with cupredoxins and mutants thereof
US7381701B2 (en) 2001-02-15 2008-06-03 The Borad Of Trustees Of The University Of Illinois Compositions and methods for treating conditions related to ephrin signaling with cupredoxins
EA200700813A1 (ru) 2004-10-07 2008-10-30 Ананда Чакрабарти Транспортирующие вещества, производные купредоксина и способы их применения
WO2007024368A2 (fr) * 2005-07-19 2007-03-01 The Board Of Trustees Of The University Of Illinois Compositions et methodes de controle de angiogenese a l'aide de cupredoxines
CA2615617A1 (fr) 2005-07-19 2007-01-25 The Board Of Trustees Of The University Of Illinois Agents de transport utiles pour traverser la barriere hemato-encephalique et pour penetrer dans les cellules cancereuses du cerveau, methodes d'utilisation de ces derniers
EP2061498A4 (fr) * 2006-09-14 2009-11-04 Univ Illinois Compositions et procédés de prévention du cancer avec des cupredoxines
EP2117573A4 (fr) * 2007-01-11 2011-02-16 Univ Illinois Compositions et méthodes permettant de traiter des affections associées à la signalisation de l'éphrine avec des cuprexodines et des mutants de celles-ci
BRPI0816094A2 (pt) 2007-08-30 2015-03-03 Daiichi Sankyo Co Ltd Anticorpo, polipeptídeo, hibridoma, composição farmacêutica, método para inibir o desenvolvimento de tumor em um mamífero, polinucleotídeo, célula hospedeira, e, método para produzir um anticorpo.
KR101102829B1 (ko) * 2008-09-12 2012-01-05 재단법인 제주테크노파크 구멍갈파래 추출물과 그것의 항염증제로서의 용도
CN110090295B (zh) * 2018-01-29 2022-12-23 武汉康理通科技有限公司 Ephrin-B1在制备治疗炎症性肠病的药物中的用途
WO2023205752A2 (fr) * 2022-04-22 2023-10-26 University Of Miami Peptides mimétiques de ligand d'éphrine pour le traitement de maladies neurodégénératives
WO2025207820A2 (fr) * 2024-03-27 2025-10-02 Mediar Therapeutics, Inc. Anticorps anti-éphrine b2 et méthodes d'utilisation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4881536B2 (ja) * 2001-02-15 2012-02-22 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ 細胞死を調節する細胞障害性因子
US7491394B2 (en) * 2001-02-15 2009-02-17 The Board Of Trustees Of The University Of Illinois Cytotoxic factors for modulating cell death

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PUNJ V. ET AL.: "Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer", ONCOGENE, vol. 23, 2004, pages 2367 - 2378, XP003018759 *

Also Published As

Publication number Publication date
EP1888106A4 (fr) 2009-01-14
KR20080040631A (ko) 2008-05-08
BRPI0612424A2 (pt) 2009-01-27
EP1888106A2 (fr) 2008-02-20
AU2006277009A1 (en) 2007-02-15
WO2007018671A2 (fr) 2007-02-15
IL187138A0 (en) 2008-02-09
NO20076391L (no) 2008-02-15
JP2008539795A (ja) 2008-11-20
MX2007014598A (es) 2008-02-07
CA2608512A1 (fr) 2007-02-15

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