WO2007103531A3 - Modèles de prédiction cellulaire permettant de détecter des toxicités - Google Patents

Modèles de prédiction cellulaire permettant de détecter des toxicités Download PDF

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Publication number
WO2007103531A3
WO2007103531A3 PCT/US2007/005980 US2007005980W WO2007103531A3 WO 2007103531 A3 WO2007103531 A3 WO 2007103531A3 US 2007005980 W US2007005980 W US 2007005980W WO 2007103531 A3 WO2007103531 A3 WO 2007103531A3
Authority
WO
WIPO (PCT)
Prior art keywords
toxicities
predictive models
models
stimuli
subset
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2007/005980
Other languages
English (en)
Other versions
WO2007103531A2 (fr
Inventor
Eugeni Vaisberg
Vadim Kutsyy
Jeffrey Finer
Gregg Peter Solar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytokinetics Inc
Original Assignee
Cytokinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0605358A external-priority patent/GB2435924A/en
Application filed by Cytokinetics Inc filed Critical Cytokinetics Inc
Publication of WO2007103531A2 publication Critical patent/WO2007103531A2/fr
Anticipated expiration legal-status Critical
Publication of WO2007103531A3 publication Critical patent/WO2007103531A3/fr
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders

Landscapes

  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Databases & Information Systems (AREA)
  • Data Mining & Analysis (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Primary Health Care (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)

Abstract

L'invention concerne des procédés permettant de générer des modèles destinés à prédire l'activité biologique d'une population cellulaire test soumise à des stimuli. Les modèles de l'invention peuvent être utilisés pour classer ou pour prédire l'effet des stimuli sur les cellules. Dans certains modes de réalisation, les procédés de l'invention consistent à: recevoir des données comprenant des valeurs de variables dépendantes associées aux stimuli; préparer un ensemble de populations cellulaires en fonction des données reçues; identifier un sous-ensemble de populations cellulaires à utiliser pour générer un modèle à partir des données associées à ce sous-ensemble. Ce modèle permet de prédire l'activité d'une population test.
PCT/US2007/005980 2006-03-09 2007-03-07 Modèles de prédiction cellulaire permettant de détecter des toxicités Ceased WO2007103531A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US78107906P 2006-03-09 2006-03-09
US60/781,079 2006-03-09
US78257306P 2006-03-14 2006-03-14
US60/782,573 2006-03-14
GB0605358.1 2006-03-17
GB0605358A GB2435924A (en) 2006-03-09 2006-03-17 Cellular predictive models for steatosis

Publications (2)

Publication Number Publication Date
WO2007103531A2 WO2007103531A2 (fr) 2007-09-13
WO2007103531A3 true WO2007103531A3 (fr) 2008-10-16

Family

ID=38475580

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/005980 Ceased WO2007103531A2 (fr) 2006-03-09 2007-03-07 Modèles de prédiction cellulaire permettant de détecter des toxicités

Country Status (1)

Country Link
WO (1) WO2007103531A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8114615B2 (en) 2006-05-17 2012-02-14 Cernostics, Inc. Method for automated tissue analysis
ES2739623T3 (es) 2011-03-17 2020-02-03 Cernostics Inc Sistemas y composiciones para diagnosticar el esófago de Barrett y métodos para usarlos
US9772325B2 (en) 2013-06-14 2017-09-26 Biotranex, Llc Method for measuring bile salt export transport and/or formation activity
JP7201981B2 (ja) * 2017-06-30 2023-01-11 学校法人 明治薬科大学 予測装置、予測方法および予測プログラム
WO2019237015A1 (fr) * 2018-06-08 2019-12-12 The Trustees Of Columbia University In The City Of New York Procédés et systèmes de prédiction de taux de réussite d'essais cliniques
CN114694770B (zh) * 2020-12-30 2025-12-19 中国人民解放军军事科学院军事医学研究院 一种构建药物肝毒性预测模型的方法及其用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040086873A1 (en) * 2002-10-31 2004-05-06 Johnson Peter C. System and method of generating and storing correlated hyperquantified tissue structure and biomolecular expression datasets
US20050014217A1 (en) * 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays
US6873914B2 (en) * 2001-11-21 2005-03-29 Icoria, Inc. Methods and systems for analyzing complex biological systems

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6873914B2 (en) * 2001-11-21 2005-03-29 Icoria, Inc. Methods and systems for analyzing complex biological systems
US20040086873A1 (en) * 2002-10-31 2004-05-06 Johnson Peter C. System and method of generating and storing correlated hyperquantified tissue structure and biomolecular expression datasets
US20050014217A1 (en) * 2003-07-18 2005-01-20 Cytokinetics, Inc. Predicting hepatotoxicity using cell based assays

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DE LONGUEVILLE ET AL.: "Use of a Low-Density Microarray for Studying Gene Expression Patterns Induced by Hepatotoxicants on Primary Cultures of Rat Hepatocytes", TOXICOLOGICAL SCIENCES, vol. 75, no. 2, 2003, pages 378 - 372, XP002489829 *
ERLER ET AL.: "A Study of Hepatocellular Carcinoma Using Morphometric and Densitometric Image Analysis", AMERICAN JOURNAL OF CLINICAL PATHOLOGY, vol. 100, 1993, pages 151 - 157 *
ERLER ET AL.: "Methods in Laboratory Investigation: Image Analysis and Diagnostic Classification of Hepatocellular Carcinoma Using Neural Networks and Multivariate Discriminant Functions", LABORATORY INVESTIGATION, vol. 71, no. 3, 1994, pages 446 - 451 *
PRESTON ET AL.: "Differentiation of Cells in Abnormal Human Liver Tissue by Computer Image Processing: A Preliminary Investigation into Its Potential Application to Diagnostic Microscopy", ANALYTICAL AND QUANTITATIVE CYTOLOGY, vol. 2, no. 3, 1980, pages 203 - 220 *
YEH W.C. ET AL.: "Liver Steatosis Classification Using High-Frequency Ultrasound", ULTRASOUND IN MEDICINE AND BIOLOGY, vol. 31, no. 5, 2005, pages 599 - 605, XP004871206 *

Also Published As

Publication number Publication date
WO2007103531A2 (fr) 2007-09-13

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