WO2008100977A3 - Agents de libération thérapeutiques - Google Patents

Agents de libération thérapeutiques Download PDF

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Publication number
WO2008100977A3
WO2008100977A3 PCT/US2008/053785 US2008053785W WO2008100977A3 WO 2008100977 A3 WO2008100977 A3 WO 2008100977A3 US 2008053785 W US2008053785 W US 2008053785W WO 2008100977 A3 WO2008100977 A3 WO 2008100977A3
Authority
WO
WIPO (PCT)
Prior art keywords
carbamates
release agents
therapeutic release
inhibitors
faah
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/053785
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English (en)
Other versions
WO2008100977A2 (fr
Inventor
Olivier Dasse
Jeff A Parrott
David Putman
Julia Adam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Organon NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon NV filed Critical Organon NV
Publication of WO2008100977A2 publication Critical patent/WO2008100977A2/fr
Publication of WO2008100977A3 publication Critical patent/WO2008100977A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/56—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'inhibition pharmacologique de l'activité de l'amide hydrolase d'acides gras (FAAH) entraîne une augmentation des taux d'amides d'acides gras. L'invention concerne des esters d'acides alkylcarbamiques qui constituent des inhibiteurs de l'activité de la FAAH. Les composés décrits inhibent l'activité de la FAAH. L'invention concerne aussi des procédés de préparation d'esters de composés d'acides alkylcarbamiques, des compositions renfermant ceux-ci et des procédés d'utilisation de celles-ci.
PCT/US2008/053785 2007-02-14 2008-02-13 Agents de libération thérapeutiques Ceased WO2008100977A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US88990907P 2007-02-14 2007-02-14
US60/889,909 2007-02-14
US94808207P 2007-07-05 2007-07-05
US60/948,082 2007-07-05

Publications (2)

Publication Number Publication Date
WO2008100977A2 WO2008100977A2 (fr) 2008-08-21
WO2008100977A3 true WO2008100977A3 (fr) 2008-12-18

Family

ID=39595757

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/053785 Ceased WO2008100977A2 (fr) 2007-02-14 2008-02-13 Agents de libération thérapeutiques

Country Status (1)

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WO (1) WO2008100977A2 (fr)

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CN103027909B (zh) * 2011-11-28 2015-01-14 贵阳中医学院 香豆素类化合物的应用及其从瑞香中提取的方法
US11332459B2 (en) 2017-10-19 2022-05-17 Teijin Pharma Limited Benzimidazole derivatives and their uses

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RU2361581C2 (ru) * 2007-09-14 2009-07-20 Закрытое Акционерное Общество "Мастерклон" Фармацевтическая композиция, обладающая противодиабетической, гиполипидемической, гипогликемической и гипохолестеринемической активностью, способ ее получения и способы лечения указанных заболеваний
KR20160048222A (ko) 2007-12-17 2016-05-03 유나이티드 세러퓨틱스 코오포레이션 레모둘린?의 활성 성분인 트레프로스티닐의 개선된 제조 방법
WO2011085216A2 (fr) 2010-01-08 2011-07-14 Ironwood Pharmaceuticals, Inc. Utilisation d'inhibiteurs de faah pour traiter la maladie de parkinson et le syndrome des jambes sans repos
WO2011123719A2 (fr) 2010-03-31 2011-10-06 Ironwood Pharmaceuticals, Inc. Utilisation d'inhibiteurs de faah pour le traitement des douleurs abdominales, viscérales et pelviennes
CN103153307A (zh) * 2010-04-22 2013-06-12 默沙东公司 用作faah调节剂的噁唑衍生物
WO2011153363A1 (fr) 2010-06-03 2011-12-08 United Therapeutics Corporation Production de tréprostinil
EP2681204B1 (fr) 2011-03-02 2016-04-27 United Therapeutics Corporation Synthèse d'un intermédiaire pour la production de tréprostinil
ES2389070B1 (es) * 2011-03-24 2013-09-17 Universidad De La Laguna Derivados de policétidos dibenzofuránicos prenilados y su aplicación para el tratamiento de enfermedades infecciosas, parasitarias y tumores.
CN103204838B (zh) 2012-01-13 2017-06-09 北京盛诺基医药科技有限公司 多羟基苯并吡喃酮类化合物的合成及其抗肿瘤作用
US20130266643A1 (en) * 2012-04-10 2013-10-10 Hpo Life Sciences, Inc. Compositions comprising glyceryl-triacetate (GTA) and uses in human performance optimization and thermogenesis
CN103374050B (zh) * 2012-04-18 2015-09-23 昆明制药集团股份有限公司 一种制备5,6,4’-三羟基黄酮-7-0-d-葡萄糖醛酸的方法
CN103374049B (zh) * 2012-04-18 2016-04-06 昆药集团股份有限公司 一种制备5,6,4’-三羟基黄酮-7-0-d-葡萄糖醛酸的方法
ES2925071T3 (es) 2013-02-08 2022-10-13 Gen Mills Inc Productos alimentarios reducidos en sodio
US10568900B1 (en) 2013-03-15 2020-02-25 Suzanne Janine Paxton-Pierson Androgen effectors
CA3042642A1 (fr) 2013-08-12 2015-02-19 Pharmaceutical Manufacturing Research Services, Inc. Comprime extrude anti-abus a liberation immediate
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
ES2910455T3 (es) * 2014-05-28 2022-05-12 Univ Bern Compuestos de tiazolidinona y su uso en el tratamiento de condiciones psiquiátricas o trastornos neurológicos e inflamación, en particular neuroinflamación
CA2955229C (fr) 2014-07-17 2020-03-10 Pharmaceutical Manufacturing Research Services, Inc. Forme posologique remplie de liquide anti-abus a liberation immediate
WO2016064873A1 (fr) 2014-10-20 2016-04-28 Pharmaceutical Manufacturing Research Services, Inc. Forme galénique anti-abus de remplissage de liquide à libération prolongée
ES2778274T3 (es) 2014-10-20 2020-08-10 United Therapeutics Corp Síntesis de productos intermedios para producir derivados de prostaciclina
EP3885337B1 (fr) * 2015-06-23 2025-01-15 National Institute Of Biological Sciences, Beijing Inhibiteurs fto
US10532976B2 (en) * 2015-06-23 2020-01-14 National Institute Of Biological Sciences, Beijing FTO inhibitors
CN105147661B (zh) * 2015-08-07 2017-12-08 上海中医药大学 升麻素在制备防治溃疡性结肠炎的药物或食品中的应用
CN106673984B (zh) * 2015-11-11 2020-01-10 上海医药工业研究院 (e)-2,4-二羟基-6-丙烯基苯甲醛及其制备方法和用途
JP6600832B2 (ja) * 2015-12-11 2019-11-06 小林 裕司 脂肪吸着作用を呈するメチル化フラボノール誘導体
WO2017205939A1 (fr) * 2016-06-03 2017-12-07 Indigo Ridge Pty Ltd Formulations de vitamine d et leurs utilisations thérapeutiques
WO2018074879A1 (fr) * 2016-10-21 2018-04-26 주식회사 셀버틱스 Composition pharmaceutique pour la prévention ou le traitement du diabète et/ou de l'hyperlipidémie comprenant de la midorine ou un sel pharmaceutiquement acceptable de celle-ci en tant que principe actif
JP6814470B2 (ja) * 2017-02-10 2021-01-20 国立大学法人 筑波大学 モルヒナン誘導体
PH12018000077B1 (en) 2017-07-05 2021-07-09 Frimline Private Ltd A pharmaceutical composition for neuropathic pain
US11472787B2 (en) 2017-09-20 2022-10-18 The Board Of Trustees Of The University Of Illinois Docosahexaenoic acid endocannabinoid epoxide derivative compositions
WO2019060508A1 (fr) 2017-09-20 2019-03-28 The Board Of Trustees Of The University Of Illinois Dérivés d'époxydes d'endocannabinoïdes epa à titre de composés anti-inflammatoires, anticancéreux, anti-angiogènes et antiplaquettaires
CN110407741B (zh) * 2018-04-26 2023-03-21 启元生物(杭州)有限公司 一种抗炎化合物及其制备和应用
MX2021003156A (es) 2018-09-18 2021-05-14 1 Globe Biomedical Co Ltd Tratamiento para la enfermedad del higado graso no alcoholico.
CN117224541A (zh) 2018-09-18 2023-12-15 北京强新生物科技有限公司 肥胖症的治疗
CN109456268A (zh) * 2018-11-08 2019-03-12 中国药科大学 C1位取代的3，4－二氢异喹啉类生物碱的制备及其医药用途
CN109674807A (zh) * 2019-01-18 2019-04-26 中国医学科学院阜外医院 一种cse酶激活剂及其在与cse/h2s系统相关的疾病药物中的应用
KR102360675B1 (ko) * 2019-05-16 2022-02-08 단국대학교 천안캠퍼스 산학협력단 브루소닌 a 및 b를 유효성분으로 함유하는 혈관신생 억제용 조성물
US11026896B2 (en) * 2019-06-18 2021-06-08 Dyve Biosciences, Inc. Transdermal penetrant formulations containing cannabidiol
CN110850019B (zh) * 2019-11-29 2022-02-18 南京南医堂健康产业发展有限公司 明葛舒清饮指纹图谱的检测方法
WO2021243201A1 (fr) * 2020-05-29 2021-12-02 The University Of Mississippi Compositions topiques pour le traitement de la douleur neuropathique périphérique
US12569481B2 (en) 2020-06-12 2026-03-10 Vanderbilt University Methods of treatment for gastrointestinal motility disorders
WO2022020222A1 (fr) * 2020-07-21 2022-01-27 Neuritek Ltd. Utilisations d'inhibiteurs d'hydrolase d'amides d'acides gras dans le traitement de troubles psychiatriques associés à un traumatisme
CN111888350B (zh) * 2020-09-03 2022-01-25 中国科学院华南植物园 桑辛素n在制备防治铁死亡相关疾病的产品中的应用
CN112156091A (zh) * 2020-09-30 2021-01-01 中山大学附属第一医院 高车前素在制备治疗和/或预防心血管疾病的药物中的应用
CN112645913B (zh) * 2020-12-28 2023-11-24 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 一种对联三苯类化合物及其制备方法和应用
US20240366555A1 (en) * 2021-04-13 2024-11-07 Aliad Biopharma Selective mtorc2 inhibitor and uses thereof
CN113288879B (zh) * 2021-05-25 2022-09-02 四川永诺生物科技有限公司 一种卡巴匹林钙肠溶颗粒的制备方法
CN115554240B (zh) * 2021-07-02 2023-09-15 福建中医药大学 一种雷公藤红素/甘草次酸-羧甲基壳聚糖-酮缩硫醇-大黄酸胶束
CN113456626B (zh) * 2021-08-16 2022-05-06 吉林大学 一种黄嘌呤氧化酶抑制剂及其筛选方法和应用
CN114989180B (zh) * 2022-05-26 2024-06-04 广东海洋大学 杨叶肖槿内生真菌来源的化合物及其制备方法与应用
CN116098912B (zh) * 2023-02-24 2025-08-08 广西壮族自治区药用植物园 用于治疗慢性阻塞性肺疾病的黄酮苷组合
CN116139072A (zh) * 2023-04-07 2023-05-23 南京大学 一种丹酚酸a卡波姆凝胶剂及其应用
CN116251111A (zh) * 2023-04-28 2023-06-13 天津大学 一种抑制α-葡萄糖苷酶组合物及其应用
WO2025013019A1 (fr) * 2023-07-07 2025-01-16 Kapil Bhimani Formulation d'agent hémostatique
CN117298098A (zh) * 2023-11-15 2023-12-29 南通大学 氧化前胡素在制备治疗血管性痴呆药物中的应用
CN117820265A (zh) * 2023-12-29 2024-04-05 景洪宏臻农业科技有限公司 一种类绒盖牛肝菌酸化合物或其衍生物及其制备方法与应用
CN118490678B (zh) * 2024-05-29 2024-12-06 南通大学 一种山荷叶素在制备预防或治疗非酒精性脂肪肝炎药物中的用途
CN118750487B (zh) * 2024-09-06 2024-11-19 深圳市利云德生物技术有限公司 一种抗胃癌药物组合物及其应用

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Non-Patent Citations (3)

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Title
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103027909B (zh) * 2011-11-28 2015-01-14 贵阳中医学院 香豆素类化合物的应用及其从瑞香中提取的方法
US11332459B2 (en) 2017-10-19 2022-05-17 Teijin Pharma Limited Benzimidazole derivatives and their uses

Also Published As

Publication number Publication date
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