WO2009021978A3 - Carbaboranreste enthaltende verbindungen und deren verwendung in der medizin, insbesondere für die verwendung in der tumortherapie - Google Patents

Carbaboranreste enthaltende verbindungen und deren verwendung in der medizin, insbesondere für die verwendung in der tumortherapie Download PDF

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Publication number
WO2009021978A3
WO2009021978A3 PCT/EP2008/060649 EP2008060649W WO2009021978A3 WO 2009021978 A3 WO2009021978 A3 WO 2009021978A3 EP 2008060649 W EP2008060649 W EP 2008060649W WO 2009021978 A3 WO2009021978 A3 WO 2009021978A3
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WO
WIPO (PCT)
Prior art keywords
compounds
residue
glycosylamine
thioglycoside
glycoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/060649
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English (en)
French (fr)
Other versions
WO2009021978A2 (de
Inventor
Sven Stadlbauer
Evamarie Hey-Hawkins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitaet Leipzig
Original Assignee
Universitaet Leipzig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitaet Leipzig filed Critical Universitaet Leipzig
Publication of WO2009021978A2 publication Critical patent/WO2009021978A2/de
Publication of WO2009021978A3 publication Critical patent/WO2009021978A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6596—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having atoms other than oxygen, sulfur, selenium, tellurium, nitrogen or phosphorus as ring hetero atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Die Erfindung betrifft Verbindung der allgemeinen Formel (I) wobei A für Sauerstoff, Schwefel oder Selen steht, (CB)n und (CB)m stehen jeweils für ein Carbaboran oder eine Kette von Carbaboranen. R1 ist ausgewählt aus Hydroxy, Alkoxy, Alkenoxy, O-Glycosid, Thioglycosid und Glycosylamin, PO42- oder P2O73- und A-M+. R2 und R4 sind ausgewählt aus O-Glycosidrest, Thioglycosidrest, Glycosylaminrest, PO42- oder P2O73- und A-M+. R3 ist ausgewählt aus Alkoxy, Alkenoxy, O-Glycosid, Thioglycosid, Glycosylamin oder ein Phosphonatrest. Durch ihren Gehalt an Zuckerresten binden die erfindungsgemäßen Verbindungen spezifisch an Rezeptoren auf der Oberfläche von karzinogenen Zellen. Zusätzlich wirken die Verbindungen durch die Phosphonatgruppen als Phosphatmimetika, wodurch eine Bindung speziell an calciumreiches Tumorgewebe erfolgt. Vorteilhaft sind die Verbindungen selbst nicht toxisch, weisen eine geringe unspezifische Proteinbindung auf und sind gut wasserlöslich. Die Erfindung betrifft weiter die Verwendung dieser Verbindungen als Arzneimittel, insbesondere in der Radio-Onkologie, sowie Verfahren zu deren Herstellung und Zwischenprodukte, die während des Herstellungsverfahrens erhalten werden.
PCT/EP2008/060649 2007-08-13 2008-08-13 Carbaboranreste enthaltende verbindungen und deren verwendung in der medizin, insbesondere für die verwendung in der tumortherapie Ceased WO2009021978A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007038930A DE102007038930B4 (de) 2007-08-13 2007-08-13 Neue chemische Verbindung und deren Verwendung in der Medizin, insbesondere für die Verwendung in der Tumortherapie
DE102007038930.4 2007-08-13

Publications (2)

Publication Number Publication Date
WO2009021978A2 WO2009021978A2 (de) 2009-02-19
WO2009021978A3 true WO2009021978A3 (de) 2009-04-09

Family

ID=40090446

Family Applications (1)

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PCT/EP2008/060649 Ceased WO2009021978A2 (de) 2007-08-13 2008-08-13 Carbaboranreste enthaltende verbindungen und deren verwendung in der medizin, insbesondere für die verwendung in der tumortherapie

Country Status (2)

Country Link
DE (1) DE102007038930B4 (de)
WO (1) WO2009021978A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102775449B (zh) * 2012-08-20 2014-10-08 聊城大学 1,7-间位二碳十硼烷羧酸三苯基氯化锡化合物、制备方法及其应用
CN108884124A (zh) 2015-09-17 2018-11-23 俄亥俄州创新基金会 碳硼烷化合物及其使用方法
CA3122029A1 (en) * 2018-12-03 2020-06-11 Ohio State Innovation Foundation Carborane compounds, carborane analogs, and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068584A1 (de) * 1981-06-30 1983-01-05 THE PROCTER & GAMBLE COMPANY Bor enthaltende Polyphosphonate für die Behandlung von Verkalkungstumoren
DE3332068A1 (de) * 1983-09-06 1985-03-21 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von nukleosidalkyl-, aralkyl- und arylphosphoniten und -phosphonaten
EP1113020A2 (de) * 1993-12-02 2001-07-04 Emory University Bor-cluster enthaltende Nukleoside und Oligonukleoside

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5630786A (en) 1994-06-27 1997-05-20 Ionix Corporation Boron neutron capture enhancement of fast neutron therapy
JPH1180177A (ja) 1997-09-04 1999-03-26 Toray Ind Inc ホウ素含有ビスホスホン酸化合物、その製造方法、およびその医薬用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0068584A1 (de) * 1981-06-30 1983-01-05 THE PROCTER & GAMBLE COMPANY Bor enthaltende Polyphosphonate für die Behandlung von Verkalkungstumoren
DE3332068A1 (de) * 1983-09-06 1985-03-21 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von nukleosidalkyl-, aralkyl- und arylphosphoniten und -phosphonaten
EP1113020A2 (de) * 1993-12-02 2001-07-04 Emory University Bor-cluster enthaltende Nukleoside und Oligonukleoside

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALEXANDER, ROY P. ET AL: "Chemistry of decaborane-phosphorus compounds. VI. Phosphino-m-carboranes", INORGANIC CHEMISTRY (WASHINGTON, DC, UNITED STATES) , 5(3), 493-5 CODEN: INOCAJ; ISSN: 0020-1669, 1966, XP002508859 *
HILL, W. E. ET AL: "Preparation and characterization of di(tertiary phosphines) with electronegative substituents. 1. Symmetrical derivatives", INORGANIC CHEMISTRY , 17(9), 2495-8 CODEN: INOCAJ; ISSN: 0020-1669, 1978, XP002508858 *
S. STADLBAUER, P. LÖNNECKE, E. HEY-HAWKINS: "Phosphonate-substituted Carbaboranes for Potential Use in BNCT", ADVANCES IN NEUTRON CAPTURE THERAPY 2006, PROCEEDINGS OF ICNCT-12, CHEMISTRY AND PHARMACY, (EDS. Y. NAKAGAWA, T. KOBAYASHI, H. FUKUDA), 2006, pages 215 - 216, XP002513129, Retrieved from the Internet <URL:http://www.uni-leipzig.de/chemie/hh/index.php?lang=de&id=artik0507> [retrieved on 20090203] *
S. STADLBAUER, P. LÖNNECKE, E. HEY-HAWKINS: "Phosphonate-substituted Carbaboranes for Potential Use in BNCT", ADVANCES IN NEUTRON CAPTURE THERAPY, PROCEEDINGS OF ICNCT-12, CHEMISTRY AND PHARMACY, (EDS. Y. NAKAGAWA, T. KOBAYASHI, H. FUKUDA), 2006, pages 215 - 216, XP002513129 *

Also Published As

Publication number Publication date
DE102007038930B4 (de) 2013-12-05
DE102007038930A1 (de) 2009-02-19
WO2009021978A2 (de) 2009-02-19

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